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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Geochemistry and zircon U-Pb geochronology of the rhyolitic tuff on Port Island, Hong Kong: Implications for early Cretaceous tectonic setting显示文摘Early Cretaceous rhyolitic tuffs,widely distributed on Port Island,provide insights into the volcanism and tectonic setting of Hong Kong.In this paper we present petrological,geochronological and geochemical data of the rhyolitic tuff to constrain the diagenesis age and petrogenesis of the rocks,tectonic setting and early Cretaceous volcanism of Hong Kong.The first geochronological data show that the zircons in the volcanic rocks have U-Pb age of 141.1-139.5 Ma,which reveals that the rhyolitic tuff on Port Island was formed in the early Cretaceous(K_1).Geochemically,these acid rocks,which are enriched in large ion lithophile elements(LILEs) and light rare earth elements(LREEs),and depleted in high field strength elements(HFSEs),belong to the high K calc-alkaline to shoshonite series with strongly-peraluminous characteristic.The geochemical analyses suggest that the volcanic rocks were derived from deep melting in the continental crust caused by basaltic magma underplating.Based on the geochemical analysis and previous studies,we concluded that the rhyolitic tuffs on Port Island were formed in a backarc extension setting in response to the subduction of the Paleo-Pacific Plate beneath the Eurasian Plate. | Longlong Zhao Lulin Wang Mingzhong Tian Fadong Wu | 2017 | Geoscience Frontiers2017，8，3： | 4 |
| 3 | Acrolein Aggravates Secondary Brain Injury After Intracerebral Hemorrhage Through Drp1-Mediated Mitochondrial Oxidative Damage in Mice显示文摘Clinical advances in the treatment of intracranial hemorrhage(ICH)are restricted by the incomplete understanding of the molecular mechanisms contributing to secondary brain injury.Acrolein is a highly active unsaturated aldehyde which has been implicated in many nervous system diseases.Our results indicated a significant increase in the level of acrolein after ICH in mouse brain.In primary neurons,acrolein induced an increase in mitochondrial fragmentation,loss of mitochondrial membrane potential,generation of reactive oxidative species,and release of mitochondrial cytochrome c.Mechanistically,acrolein facilitated the translocation of dynaminrelated protein 1(Drpl)from the cytoplasm onto the mitochondrial membrane and led to excessive mitochondrial fission.Further studies found that treatment with hydralazine(an acrolein scavenger)significantly reversed Drpl translocation and the morphological damage of mitochondria after ICH.In parallel,the neural apoptosis,brain edema,and neurological functional deficits induced by ICH were also remarkably alleviated.In conclusion,our results identify acrolein as an important contributor to the secondary brain injury following ICH.Meanwhile,we uncovered a novel mechanism by which Drpl-mediated mitochondrial oxidative damage is involved in acroleininduced brain injury. | Xun Wu Wenxing Cui Wei Guo Haixiao Liu Jianing Luo Lei Zhao Hao Guo Longlong Zheng Hao Bai Dayun Feng Yan Qu | 2020 | Neuroscience Bulletin2020，36，10： | 3 |
| 4 | MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways显示文摘 | Longlong Bao Yan Yan Can Xu Weidan Ji Shuwen Shen Gaoya Xu Yong Zeng Bin Sun Haihua Qian Lei Chen Mengchao Wu Changqing Su Jie Chen | 2013 | Cancer Letters2013，，2： | 3 |
| 5 | Adaptive Attitude Control for a Coaxial Tilt-Rotor UAV via Immersion and Invariance Methodology显示文摘Dear Editor,This letter is concerned with the attitude control for a novel tiltrotor unmanned aerial vehicle with two pairs of tiltable coaxial rotors and one rear rotor.An immersion and invariance-based adaptive attitude controller for the tilt-rotor unmanned aerial vehicle is proposed.In the proposed control strategy,an adaptive update law is specially designed to compensate for the uncertainties of damping coefficients.The stability of the resulting closed-loop coaxial tiltrotor unmanned aerial vehicle(CTRUAV)system is proved by the Lyapunov methodology and LaSalle’s invariance theory.Finally。 | Longlong Chen Zongyang Lv Xiangyu Shen Yuhu Wu Xi-Ming Sun | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，9： | 2 |
| 6 | Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance显示文摘Latent membrane protein 1(LMP1)is a major Epstein–Barr virus(EBV)-encoded oncoprotein involved in latency infection that regulates mitochondrial functions to facilitate cell survival.Recently,mitochondrial fission has been demonstrated as a crucial mechanism in oncovirus-mediated carcinogenesis.Mitochondrial dynamin-related protein 1(Drp1)-mediated mitochondrial fission has an impact on the chemoresistance of cancers.However,the mechanism by which oncogenic stress promotes mitochondrial fission,potentially contributing to tumorigenesis,is not entirely understood.The role of Drp1 in the oncogenesis and prognosis of EBV-LMP1-positive nasopharyngeal carcinoma(NPC)was determined in our study.We show that EBV-LMP1 exhibits a new function in remodeling mitochondrial morphology by activating Drp1.A high level of p-Drp1(Ser616)or a low level of p-Drp1(Ser637)correlates with poor overall survival and disease-free survival.Furthermore,the protein level of p-Drp1(Ser616)is related to the clinical stage(TNM stage)of NPC.Targeting Drp1 impairs mitochondrial function and induces cell death in LMP1-positive NPC cells.In addition,EBV-LMP1 regulates Drp1 through two oncogenic signaling axes,AMPK and cyclin B1/Cdk1,which promote cell survival and cisplatin resistance in NPC.Our findings provide novel insight into the role of EBV-LMP1-driven mitochondrial fission in regulating Drp1 phosphorylation at serine 616 and serine 637.Disruption of Drp1 could be a promising therapeutic strategy for LMP1-positive NPC. | Longlong Xie Feng Shi Yueshuo Li We Li Xinfang Yu Lin Zhao Min Zhou Jianmin Hu Xiangjian Luo Min Tang Jia Fan Jian Zhou Qiang Gao Weizhong Wu Xin Zhang Weihua Liao Ann MBode Ya Cao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 7 | MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways显示文摘 | Longlong Bao Yan Yan Can Xu Weidan Ji Shuwen Shen Gaoya Xu Yong Zeng Bin Sun Haihua Qian Lei Chen Mengchao Wu Changqing Su Jie Chen | 2013 | Cancer Letters2013，，2： | 1 |
| 8 | Analysis for magnetic field disturbance of hybrid DC circuit breaker during breaking显示文摘The high current of hybrid DC circuit breaker(HCB)in the process of breaking generates strong transient magnetic field(MF),which may interfere with the normal operation of driver control units(DCUs).Therefore,the analysis for transient MF disturbance is of great significance.Due to the large space scale of HCB,with the large number of power electronic devices,the numerical calculation method has the disadvantages of large consumption of resources and slow calculation speed in solving the transient MF inside the HCB.In this study,the current generation mechanism of a 500 kV HCB is analysed,and the equivalent current path is obtained by considering the skin effect.Combined with the temporal and spatial distribution of transient current,the multi-process transient equivalent model of transient MF calculation is established,and the model has the advantages of high precision and high speed.Then,the breaking experiment of HCB is carried out,and the transient MF near the DCU is measured.The experiment results verify the validity of the model.Furthermore,the disturbance of transient MF at the DCU of the transfer branch during breaking 25 kA current is analysed. | Sihang Wu Hong Shen Lei Qi Bei Zhang Xiang Cui Xiangyu Zhang Xiaoguang Wei Longlong Chen | 2022 | High Voltage2022，7，3： | 1 |
| 9 | Simplified graphical determination of disk-cam curvature显示文摘 | Wu Longlong Wu Hiauhuei Yan Hongsen | 1999 | Mechanism and Machine Theory1999，34，7： | 1 |
| 10 | The stationary configurations of planar six-bar kinematic chains显示文摘 | YAN Hongsen WU Longlong | 1988 | Mechanism and Machine Theory1988，23，4： | 1 |
| 11 | Late Jurassic to Early Cretaceous volcanism of Hong Kong: Insights from the Ping Chau Formation显示文摘The vast expanse of Mesozoic igneous rocks in Hong Kong contain important geological records of late Mesozoic magmatic events and tectonic processes from the coastal region of Southeast China. Of these,the Ping Chau Formation in the northwestern New Territories is the youngest known stratum. We perform a detailed study of the volcanic rocks of the Ping Chau Formation utilizing zircon U-Pb dating,with major and trace elements geochemistry. LA-ICP-MS zircon U-Pb data reveal Early Cretaceous age from two volcanic rock samples, with zircon crystallization from magmas at 140.3 ± 0.8 Ma and 139.3 ± 0.9 Ma,respectively. These rocks have high contents of total alkalis(Na_2O + K_2O = 5.58-9.45 wt.%), high-field-strength elements and light rare earth elements, conspicuous negative Eu anomalies, and depletions in Nb, Ta, Ti, Sr, Ba and P. Using this data, in combination with previous studies on the late Mesozoic volcanic belt in Southeast China, we propose that the volcanic rocks of the Ping Chau Formation probably originated from deep melting of the crust in a back-arc extensional setting induced by the subduction of the paleo-Pacific Plate. This formation represents the final stages of Early Cretaceous volcanic activity in Hong Kong, as associated with large-scale lithospheric extension, thinning and magmatism. Our results provide new information that can be used in evaluating the significance of Early Cretaceous volcanism and tectonics in Southeast China. | Lulin Wang Longlong Zhao Mingzhong Tian Fadong Wu Xujiao Zhang | 2019 | Geoscience Frontiers2019，10，2： | 1 |
| 12 | Understanding the geometric and electronic factors of PtNi bimetallic surfaces for efficient and selective catalytic hydrogenation of biomass-derived oxygenates显示文摘Ni-base catalysts are promising candidate for the hydrogenation of furfural(FAL) to high-value chemicals.However,slow intermediate desorption and low selectivity limit its implementation.Identifying the catalytic performance of each active sites is vital to design hydrogenation catalyst,and tuning the geometrical sites at molecule level in PtNi could lead to the modification of electronic structure,and thus the selectity for the hydrogenation of FAL was modulated.Herein,PtNi hollow nanoframes(PtNi HNFs) with three dimensional(3 D) molecular accessibility were synthesized,EDX results suggested that Ni was evenly distributed inside of the hollow nanoframes,whereas Pt was relatively concentrated at the edges.DFT calculation demonstrated that PtNi significant decrease the desorption energy of the intermediates.This strategy could not only enhance the desorption of intermediates to improve the catalytic performance,but also transfer the adsorption mode of FAL on catalyst surface to selective hydrogenation of FAL to FOL or THFA.The PtNi HNFs catalyst afforded excellent catalytic performance for selective hydrogenation of a broad range of biomass-derived platform chemicals under mild conditions,especially of FAL to furfuryl alcohol(FOL),in quantitative FOL yields(99%) with a high TOF of 2.56 h^(-1).It is found that the superior performance of PtNi HNFs is attributed to its 3 D hierarchical structure and synergistic electronic effects between Pt and Ni.Besides,the kinetic study demonstrated that the activation energy for hydrogenation of FAL was as low as 54.95 kJ mol^(-1). | Jingcheng Wu Chuangwei Liu Yuting Zhu Xiangbo Song Chengyan Wen Xinghua Zhang Chenguang Wang Longlong Ma | 2021 | Journal of Energy Chemistry2021，30，9： | 1 |
| 13 | The Geological Significance of a Tuffite Interlayer in the Cretaceous Port Island Formation in Northeastern Hong Kong显示文摘The Port Island Formation(PIF), a typical Cretaceous red bed in Hong Kong, is dominated by non-fossiliferous, reddish clastic rocks, making it difficult to determine the sedimentary age of PIF precisely. Previous studies assigned the PIF to Late Cretaceous provisionally only on the basis of its stratigraphic sequence and lithology. This study identified a tuffite interlayer in the PIF and a zircon UPb age of 128.2±2.7 Ma by LA-ICP-MS method was obtained. It's the first time to date the depositional age of the PIF with a reliable chronological constraint. With the support of stratigraphic evidence, we concluded that the geological age of PIF should be Early Cretaceous rather than Late Cretaceous. Based on the volcanic history of Hong Kong and Southeast China and the distribution of the PIF in Mirs Bay, it is believed that there was no volcanic activity in Hong Kong in ca. 128 Ma. The tuffite interlayer discovered in PIF was formed by the deposition of volcanic ash, which might originate from remote region outside Hong Kong, in an aquatic environment on Port Island. The identification of the tuffite interlayer, as the response to a volcanic event, has great significance not only to the studies of establishment and regional correlation of the strata system and the geological evolution in Hong Kong,but also to the study of volcanic activities in Southeast China. | ZHAO Longlong WANG Lulin TIAN Mingzhong WU Fadong | 2018 | Acta Geologica Sinica(English Edition)2018，92，3： | 1 |
| 14 | Electrostatic Structure of the Electron Phase-space Holes Generated by the Electron Two-stream Instability with a Finite Width显示文摘Space satellite observations in an electron phase-space hole(electron hole) have shown that bipolar structures are discovered at the parallel cut of parallel electric field, while unipolar structures spring from the parallel cut of perpendicular electric field. Particle-in-cell(PIC) simulations have demonstrated that the electron bi-stream instability induces several electron holes during its nonlinear evolution. However, how the unipolar structure of the parallel cut of the perpendicular electric field formed in these electron holes is still an unsolved problem,especially in a strongly magnetized plasma(Ω_e >ω_(pe), where Ω_e is defined as electron gyrofrequency and ω_(pe) is defined as plasma frequency, respectively). In this paper, with two-dimensional(2D) electrostatic PIC simulations, the evolution of the electron two-stream instability with a finite width in strongly magnetized plasma is investigated. Initially, those conditions lead to monochromatic electrostatic waves, and these waves coalesce with each other during their nonlinear evolution. At last, a solitary electrostatic structure is formed. In such an electron hole, a bipolar structure is formed in the parallel cut. of parallel electric field, while a unipolar structure presents in the parallel cut of perpendicular electric field. | SANG Longlong WU Mingyu LU Quanming | 2017 | 空间科学学报2017，37，5： | 1 |
| 15 | Three-dimensional coherent X-ray diffraction imaging via deep convolutional neural networks显示文摘As a critical component of coherent X-ray diffraction imaging(CDI),phase retrieval has been extensively applied in X-ray structural science to recover the 3D morphological information inside measured particles.Despite meeting all the oversampling requirements of Sayre and Shannon,current phase retrieval approaches still have trouble achieving a unique inversion of experimental data in the presence of noise.Here,we propose to overcome this limitation by incorporating a 3D Machine Learning(ML)model combining(optional)supervised learning with transfer learning.The trained ML model can rapidly provide an immediate result with high accuracy which could benefit real-time experiments,and the predicted result can be further refined with transfer learning.More significantly,the proposed ML model can be used without any prior training to learn the missing phases of an image based on minimization of an appropriate‘loss function’alone.We demonstrate significantly improved performance with experimental Bragg CDI data over traditional iterative phase retrieval algorithms. | Longlong Wu Shinjae Yoo Ana F.Suzana Tadesse A.Assefa Jiecheng Diao Ross J.Harder Wonsuk Cha Ian K.Robinson | 2021 | npj Computational Materials2021，，1： | 1 |
| 16 | Gas-phase Chemistry of Carbonyl Complexes Formed in Hot-atom Reactions with Short-lived Isotopes of Mo显示文摘 | Wang Yang Qin Zhi Fan Fangli Cao Shiwei Wu Xiaolei Fan Fuyou Tian Longlong Zhao Liang Guo Junsheng H. W. Gaeggeler | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 17 | Chemical Properties of Volatile Mo, Tc and Ru Carbonyl Complexes显示文摘 | Wang Yang Qin Zhi Fan Fangli Cao Shiwei Wu Xiaolei Fan Fuyou Tian Longlong Zhao Liang Guo Junsheng H. W. Gaeggeler | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 18 | Melanin precursors mediated adaption to temperature changes in fungus and animal via inhibition of lipid-mediated ferroptosis显示文摘The discovery of biological activities of natural products plays a vital part in drug development.The mechanism by which organisms respond to temperature changes via biosynthesis of natural products remained largely cryptic.A thermophilic fungus under cold stress turned black and accumulated a polyketide metabolite 1 and lipid mass.Deficiency in 1 caused melanin loss and accumulated extra lipid mass,unexpectedly leading to seriously damaged mitochondria diagnostic for ferroptosis.Further analysis revealed that lipid mass induced by cold stress intensively increased ferroptosis risk and 1 functioned as cell wall reinforcer against mass lipid accumulation and as reactive oxygen species scavenger against lipid peroxidation.We also found that melanin in mice lowered lipid level but enhanced animal resistance to cold stress.Treatment with melanin precursors significantly increased mouse cell survival rate under cold stress.Our results unveiled a metabolite-lipid-ferroptosis-cold relationship,which provided mechanistic insights into the functions of most common metabolites and into diseases related to cold stress.These findings opened a perspective for developing anti-cold and anti-ferroptosis therapeutics and agents. | Xiaoyu Yang Yonghong Chen Longlong Zhang Jiangbo He Qunfu Wu Shuhong Li Donglou Wang Jianghui Gou Zhuang Wu Keqin Zhang Shenghong Li Xuemei Niu | 2023 | Science China(Life Sciences)2023，66，8： | 0 |
| 19 | Modeling and simulation of biomass air-steam gasification in a fluidized bed显示文摘By considering the features of fluidized-bed reactors and the kinetic mechanism of biomass gasification,a steady-state,isothermal,one-dimensional and twophase mathematical model of biomass gasification kinetics in bubbling fluidized beds was developed.The model assumes the existence of two phases–a bubble and an emulsion phase–with chemical reactions occurring in both phases.The axial gas dispersion in the two phases is accounted for and the pyrolysis of biomass is taken to be instantaneous.The char and gas species CO,CO_(2),H_(2),H_(2)O,CH_(4) and 8 chemical reactions are included in the model.The mathematical model belongs to a typical boundary value problem of ordinary differential equations and its solution is obtained by a Matlab program.Utilizing wood powder as the feedstock,the calculated data show satisfactory agreement with experimental results and proves the effectiveness and reliability of the model. | Pengmei Lü Xiaoying KONG Chuangzhi WU Zhenhong YUAN Longlong MA Jie CHANG | 2008 | Frontiers of Chemical Science and Engineering2008，2，2： | 0 |
| 20 | Correction:Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance显示文摘Correction to:Signal Transduction and Targeted Therapy(2020)5:56,http://gffzzd3cc09b8251d45dfsuuc6pw9pxcow6ub9.ffgz.tsg.suse.edu.cn/10.1038/s41392-020-0151-9,published online 20 May 2020 In this article1 an error was noticed in Fig.3d left(p-Drp1 Ser637).The images were misassigned.And one writing error was found in Fig.S1c.The correct figures are given.The authors confirm that these corrections do not change the result interpretation or conclusions of the article. | Longlong Xie Feng Shi Yueshuo Li We Li Xinfang Yu Lin Zhao Min Zhou Jianmin Hu Xiangjian Luo Min Tang Jia Fan Jian Zhou Qiang Gao Weizhong Wu Xin Zhang Weihua Liao Ann M.Bode Ya Cao | 2023 | Signal Transduction and Targeted Therapy2023，8，1： | 0 |
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