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| 1 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 2 | Disease profile and plasma neutralizing activity of postvaccination Omicron BA.1 infection in Tianjin,China:a retrospective study显示文摘Dear Editor,SARS-CoV-2 Omicron variant BA.1 first emerged on the Chinese mainland on January 8,2022,in Tianjin and caused a large wave of infections.1 Four rounds of mass testing of its~14 million residents were launched on January 9,12,15,and 20,respectively.As of February 7,2022,a total of 430 individuals were tested positive for Omicron BA.1,with no new infections detected for the following 16 days.In the Chinese mainland,the most delivered vaccines are inactivated vaccines.As of January 8,2022,up to 93.2%of Tianjin’s residents had been vaccinated with at least one dose.2 We investigated the protection conferred by vaccination against Omicron BA.1 by examining the breakthrough infections among vaccinees as compared with unvaccinated cases.Our study population comprised all 430 cases during the outbreak of Omicron BA.1 in Tianjin. | Hong Zheng Yunlong Cao Xiaosu Chen Fengmei Wang Ye Hu Weiliang Song Yangyang Chai Qingqing Gu Yansong Shi Yingmei Feng Shuxun Liu Yan Xie Xiaoliang Sunney Xie Wentao Jiang Zhongyang Shen | 2022 | Cell Research2022，32，8： | 12 |
| 3 | Humoral immunogenicity and reactogenicity of CoronaVac or ZF2001 booster after two doses of inactivated vaccine显示文摘Dear Editor,COVID-19 vaccination campaigns are being conducted in countries worldwide,and 47.4% of the world population has received at least one dose of a COVID-19 vaccine.1 Although vaccination has shaped COVID-19 epidemic curves,waning antibody levels and relatively short-duration protection provided by current COVID-19 vaccines have been observed,especially against SARS-CoV-2 variants of concern(VOCs)and among older individuals. | Yunlong Cao Xiaohua Hao Xi Wang Qianhui Wu Rui Song Dong Zhao Weiliang Song Yao Wang Ayijiang Yisimayi Wei Wang Juan Du Hongjie Yu Xiaoliang Sunney Xie Ronghua Jin | 2022 | Cell Research2022，32，1： | 8 |
| 4 | Fe_3O_4@C nanoparticles as high-performance Fenton-like catalyst for dye decoloration显示文摘Water pollution has become serious environmental problem nowadays. Advanced oxidation processes(AOP) have been widely applied in water treatment.However, traditional Fenton reaction based on Fe2﹢-H2O2 system has obvious drawbacks, which limit its applications In this study, magnetic Fe3O4core-C shell nanoparticles(Fe3O4@C NPs) were prepared for the decoloration of methylene blue(MB) via the co-precipitation followed by the hydrothermal dehydrogenation of glucose. Fe3O4@C NPs showed high catalytic activity of the decoloration of MB through the decomposition of H2O2 in Fenton-like reactions. Fe3O4@C NPs had much higher activity than bare Fe3O4 cores, suggesting the coating of carbon enhanced the catalytic activity. The performance of Fe3O4@C NPs was better at lower pH and higher temperature, but was significantly inhibited in the presence of radical scavenger tertiary butanol. Fe3O4@C NPs could be magnetic separated and regenerated, and maintained with very good catalytic activity. The implication for the applications of Fe3O4@C NP-catalyzed Fenton-like reactions in water treatment was discussed. | Xiaoliang Zhang Manli He Jia-Hui Liu Rong Liao Lianqin Zhao Jingru Xie Ruijue Wang Sheng-Tao Yang Haifang Wang Yuanfang Liu | 2014 | Chinese Science Bulletin2014，59，27： | 8 |
| 5 | Off-axis multi-wavelength dispersion controllingmetalens for multi-color imaging显示文摘Dispersion control is crucial in optical systems,and chromatic aberration is an important factor affecting imaging quality in imaging systems.Due to the inherent property of materials,dispersion engineering is complex and needs to trade off other aberration in traditional ways.Although metasurface offers an effective method to overcome these limits and results in well-engineered dispersion,off-axis dispersion control is still a challenging topic.In this paper,we design a single-layer metalens which is capable of focusing at three wavelengths(473 nm,532 nm,and 632 nm)with different incident angles(0°,-17°and 17°)into the same point.We also demonstrate that this metalens can provide an alternative for the bulky color synthetic prism in a 3-chips digital micromirror device(DMD)laser projection system.Through this approach,various off-axis dispersion controlling optical devices could be realized. | Kaihua Dou Xin Xie Mingbo Pu Xiong Li Xiaoliang Ma Changtao Wang Xiangang Luo | 2020 | Opto-Electronic Advances2020，3，4： | 7 |
| 6 | Preparation and investigation of Pd doped Cu catalysts for selective hydrogenation of acetylene显示文摘A series of PdCu bimetallic catalysts with low Cu and Pd loadings and different Cu:Pd atomic ratios were prepared by conventionally sequential impregnation(CSD)and modified sequential impregnation(MSI)of Cu and Pd for selective hydrogenation of acetylene.Characterization indicates that the supported copper(I)nitrate in the PdCu bimetallic catalysts prepared by MSI can be directly reduced to Cu metal particles due to the hydrogen spillover from Pd to Cu(NO3)2 crystals.In addition,for the catalysts prepared by MSI,Pd atoms can form PdCu alloy on the surface of metal particles,however,for the catalysts prepared by CSI,Pd tends to migrate and exist below the surface layer of Cu.Reaction results indicate that compared with CSI,the MSI method enables samples to possess preferable stability as well as comparable reaction activity.This should be due to the MSI method in favor of the formation of PdCu alloy on the surface of metal particles.Moreover,even Pd loading is super low,<0.045 wt-%in this study,by through adjusting Cu loading to an appropriate value,attractive reactivity and selectivity still can be achieved. | Xinxiang Cao Tengteng Lyu Wentao Xie Arash Mirjalili Adelaide Bradicich Ricky Huitema Ben W.-L.Jang Jong K.Keum Karren More Changjun Liu Xiaoliang Yan | 2020 | Frontiers of Chemical Science and Engineering2020，14，4： | 4 |
| 7 | TiO_2-doped Fe_3O_4 nanoparticles as high-performance Fenton-like catalyst for dye decoloration显示文摘Fenton reaction based on Fe2+-H2O2 system has been widely applied in water remediation, but the obvious drawbacks largely hinder its practical uses. Alternatively, heterogeneous nanomaterials with proper surface modification could be used as Fenton-like catalysts. Surface doping of Ti O2 could concentrate the pollutants surrounding the Fe3O4 catalyst, which might benefit the catalytic performance of Fe3O4. Herein, we reported that Ti O2-doped Fe3O4 nanoparticles(NPs) could be used as high-performance Fenton-like catalyst for dye decoloration in near neutral environment, where the doping of Ti O2 on Fe3O4 surface dramatically improved the catalytic activity of Fe3O4 in Fenton-like reaction. Ti O2-doped Fe3O4 NPs catalyzed the decomposition of H2O2 to oxidize methylene blue without external energy supply, resulting in effective decoloration. Ti O2-doped Fe3O4 NPs showed high catalytic activity under various p H values and even in the presence of radical scavenger. More catalysts and H2O2 would facilitate the decoloration. At higher temperature, the decoloration became faster and more effective. The implication to the environmental applications of Ti O2-doped Fe3O4 NPs is discussed. | YANG ShengTao YANG LiJun LIU XiaoYang XIE JingRu ZHANG XiaoLiang YU BaoWei WU RuiHan LI HongLiang CHEN LingYun LIU JiaHui | 2015 | Science China(Technological Sciences)2015，58，5： | 3 |
| 8 | Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants显示文摘Dear Editor,The spread of the SARS-CoV-2 variants,especially the global variants of concern(VOCs),could seriously dampen our efforts to tackle the COVID-19 pandemic.The SARS-CoV-2 spike protein recognizes the host angiotensin-converting enzyme 2(ACE2)via its receptor-binding domain(RBD)to mediate viral entry into the cells.Several notorious mutations have been identified in the spike RBD of the VOCs.For example,B.1.1.7(Alpha),B.1.351(Beta),and P.1(Gamma)all contain the N501Y mutation,which increases the binding affinity for human ACE2 and confers higher infectivity in mice. | Shuo Du Pulan Liu Zhiying Zhang Tianhe Xiao Ayijiang Yasimayi Weijin Huang Youchun Wang Yunlong Cao Xiaoliang Sunney Xie Junyu Xiao | 2021 | Cell Research2021，31，10： | 3 |
| 9 | Dual-band and ultra-broadband photonic spin-orbit interaction for electromagnetic shaping based on single-layer silicon metasurfaces显示文摘Achieving electromagnetic wave scattering manipulation in the multispectral and broad operation band has been a long pursuit in stealth applications. Here, we present an approach by using single-layer metasurfaces composed of space-variant amorphous silicon ridges tiled on a metallic mirror, to generate high-efficiency dual-band and ultra-wideband photonic spin-orbit interaction and geometric phase. Two scattering engineered metasurfaces have been designed to reduce specular reflection;the first one can suppress both specular reflectances at 1.05–1.08 μm and 5–12 μm below 10%. The second one is designed for an ultra-broadband of 4.6–14 μm, which is actually implemented by cleverly connecting two bands of 4.6–6.1 μm and 6.1–14 μm. Furthermore, the presented structures exhibit low thermal emission at the same time due to the low absorption loss of silicon in the infrared spectrum, which can be regarded as an achievement of laser–infrared compatible camouflage.We believe the proposed strategy may open a new route to implement multispectral electromagnetic modulation and multiphysical engineering applications. | XIN XIE MINGBO PU XIONG LI KAIPENG LIU JINJIN JIN XIAOLIANG MA XIANGANG LUO | 2019 | Photonics Research2019，7，5： | 2 |
| 10 | A simulator with an elastic guidewire and vascular system for minimally invasive vascular surgery显示文摘Simulators play an important role in minimally invasive vascular surgery training. A challenging task for the simulator is to model an elastic guidewire and an elastic vascular system, both of which are important aspects for vascular surgery.However, many simulators treat the virtual vascular system as a rigid object, which reduces the immersion of operators. In this study, a virtual guidewire is first modeled based on Cosserat | Xiaoran CHENG Xiaoliang XIE Guibin BIAN Zengguang HOU Shiqi LIU Zhanjie GAO | 2018 | Science China(Information Sciences)2018，61，10： | 2 |
| 11 | Application of Box-Behnken design in optimisation for polysaccharides extraction from cultured mycelium of Cordyceps sinensis显示文摘 | DONG Caihong XIE Xueqing WANG Xiaoliang | 2009 | Food and Bioproducts Processing2009，87，2： | 1 |
| 12 | Periodic solutions of second order discrete Hamiltonian systemswith potential indefinite in sign 显示文摘 | DENG Xiaoqing SHI Haiping XIE Xiaoliang | 2011 | Appl Math Comput2011，218，1： | 1 |
| 13 | Safety and Effectiveness of SA58 Nasal Spray Against COVID-19 Infection in Medical Personnel:An Open-Label,Blank-Controlled Study—Hohhot City,Inner Mongolia Autonomous Region,China,2022显示文摘Summary What is already known about this topic?The active ingredient of the SA58 Nasal Spray is a broad-spectrum neutralizing antibody with a high neutralizing capacity against different Omicron subvariants in vitro studies.What is added by this report?This study demonstrated the safety and effectiveness of SA58 Nasal Spray against coronavirus disease 2019(COVID-19)infection in medical personnel for the first time.What are the implications for public health practice?This study provides an effective approach for the public to reduce their risk of COVID-19 infection.The findings of this research have the potential to significantly reduce the risk of infection and limit human-to-human transmission in the event of a COVID-19 outbreak. | Shujie Si Canrui Jin Jianping Li Yunlong Cao Biao Kan Feng Xue Xiaoliang Sunney Xie Liang Fang Gang Zeng Shuo Zhang Yaling Hu Xiaoping Dong | 2023 | China CDC weekly2023，5，10： | 1 |
| 14 | Application ofBox-Behnken design in optimisation for polysaccharides extraction fromcultured mycelium of Cordyceps sinensis显示文摘 | DONG Caihong XIE Xueqing WANG Xiaoliang | 2009 | Food and BioproductsProcessing2009，87，2： | 1 |
| 15 | The effects of CES1A2 A(?816)C and CYP2C19 loss-of-function polymorphisms on clopidogrel response variability among Chinese patients with coronary heart disease显示文摘 | Cheng Xie Xiaoliang Ding Jie Gao Haipeng Wang Yongfu Hang Hua Zhang Jingjing Zhang Bin Jiang Liyan Miao | 2014 | Pharmacogenetics and Genomics2014，，4： | 1 |
| 16 | Distributed Geospatial Analysis through Web Processing Service: A Case Study of Earthquake Disaster Assessment显示文摘 | Xiaoliang Meng Yichun Xie Fuling Bian | 2010 | Journal of Software2010，，6： | 1 |
| 17 | Epigenetic silencing of SFRP1 and SFRP5 by hepatitis B virus X protein enhances hepatoma cell tumorigenicity through Wnt signaling pathway显示文摘 | Qing Xie Linlin Chen Xuefeng Shan Xiaoliang Shan Jia Tang Fan Zhou Qingmei Chen Huiqin Quan Dan Nie Wenlu Zhang Ai‐Long Huang Ni Tang | 2014 | Int. J. Cancer2014，，3： | 1 |
| 18 | Late Quaternary Activity and Strong Earthquake Recurrence Interval along the North Segment of the Longling-Ruili Fault显示文摘According to field investigation and interpretation of remote sensing images,the north segment of the Longling-Ruili fault is a Holocene dextral strike-slip fault with a small amount of normal faulting.Based on large-scale geological mapping at some typical locations and quantitative geomorphologic deformation measurement and dating analysis,this fault is a Holocene active fault.The strike-slip rate of the Longling-Ruili fault is 2.2 ~2.5mm / a and vertical slip rate is 0.6mm /a since the late Pleistocene epoch.The strike-slip rate of the Longling-Ruili fault is 1.8~3.0mm /a and vertical slip rate is 0.5mm /a since the Holocene epoch.Based on the Poisson model,lognormal model and BPT model,the occurrence probability of strong earthquakes in 50 years is estimated to be 6.32%,0.08%and 0.05%,respectively.Then,a 1.82% probability of occurrence of characteristic earthquake for the north segment of the Longling-Ruili fault is obtained by setting a weight of 0.28,0.36 and 0.36 to the Poisson model,lognormal model and BPT model,respectively. | Du Yi Zhang Xiaoliang Huang Xuemeng Du Yuben Xie Furen | 2013 | Earthquake Research in China2013，27，3： | 0 |
| 19 | Combining methylated SEPTIN9 and RNF180 plasma markers for diagnosis and early detection of gastric cancer显示文摘Dear Editor,Early diagnosis is critical for successful treatment of gastric adenocarcinoma(GA).However,the sensitivities of tumor markers carcinoembryonic antigen(CEA),cancer antigen 19-9(CA19-9)and CA72-4 for GA detection are approximately 20%[1],and the sensitivities of all markers combined for early gastric cancer detection is still very low[2].DNA methylation plays a major role in tumorigenesis and therefore has obvious potential as a non-invasive biomarker for cancer detection[3].Through genome-wide methylation analysis and histological verification,we previously identified ring finger protein 180(RNF180)as a novel preferentially methylated gene in GA[4,5]. | Yongzhan Nie Xianchun Gao Xiqiang Cai Zhen Wu Qiaoyi Liang Guobing Xu Na Liu Peng Gao Jingyu Deng Hongzhi Xu Zhanlong Shen Changqi Cao Fenrong Chen Nannan Zhang Yongxi Song Mingjun Sun Chengyin Liu Guangpeng Zhou Weili Han Jianhua Dou Huahong Xie Liping Yao Zhiguo Liu Gang Ji Xin Wang Qingchuan Zhao Lei Shang Daiming Fan Xiaoliang Han Jianlin Ren Han Liang Zhenning Wang Jinhai Wang Qi Wu Jun Yu Kaichun Wu the MAGIS Study Group | 2023 | Cancer Communications2023，43，11： | 0 |
| 20 | Research on dent resistance of lightweight three-piece cans显示文摘An experimental apparatus and a numerical simulation model were built for investigating the dent resistance of lightweight three-piece cans.The dent resistance of raw materials 0.19 mm T4 and 0.17 mm DR7M was compared.It was found that when the thickness reduced from0.19 to 0.17 mm,the dent resistance became about 80%of that before thinning.This provides a guidance for the continuous thinning of three-piece cans. | LUO Xiaoliang DU Chuanjun XIE Yingxiu | 2014 | Baosteel Technical Research2014，8，1： | 0 |
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