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| 1 | Chromosomal localization of the major ribosomal RNA genes in scallop Chlamys farreri显示文摘The chromosomes of Chlamys farreri were analyzed by means of silver staining and fluorescence in situ hybridization (FISH) with 18S—28S rDNA probe. Probe was made by PCR amplification of a DNA fragment containing internal transcribed spacers ITS1 between 18S and 5.8S ribosomal RNA gene, ITS2 between 5.8S and 28S ribosomal RNA gene and 5.8S rRNA gene, and labeled by PCR incorporation of bio-16-dUTP. FISH signals were located on the short arm of subtelocentric chromosome 10. After silver-staining, nucleolus organizer regions (NORs) could be observed on the telomere of the short arm of chromosome 10. However, one metaphase spread displayed an additional silver spot on the short arm of subtelocentric chromosome 12. | HUANG Xiaoting BAO Zhenmin BI Ke HU Jingjie ZHANG Can ZHANG Quanqi HU Xiaoli | 2006 | Acta Oceanologica Sinica2006，25，3： | 10 |
| 2 | Relationship Between 2:1 Mineral Structure and the Fixation and Release of Cations显示文摘The effects of different structures of 2:1 layer minerals, layer charge location, and changes of structure and charge during the weathering process on the fixation and release of interlayer cations are reviewed. It could be concluded that the fixation capacity is determined by the total amount of interlayer charge originating from both octahedral and tetrahedral sheets. The relationship between interlayer cation fixation and octahedral structure of the secondary minerals may be different from that of the primary minerals. The oxidation and reduction of cations with variable valence can greatly influence the cation-fixation capacity. | FENG KE, WANG XIAOLI, WANG XIAOZHI and TANG YANAgricultural College, Yangzhou University, Yangzhou 225009 (China) | 2003 | Pedosphere2003，13，1： | 9 |
| 3 | Stock index adjustments, analyst coverage and institutional holdings: Evidence from China显示文摘Using 231 pairs of matched firms from 2009 to 2012 in Chinese stock market,we find that the stock index adjustment significantly affects the analyst coverage, which in addition to the stock index leads to more analyst coverage, while deletion from the stock index has no significant effect, indicating that stock index adjustment can significantly change the information environments of firms that are added to the index. An index adjustment also affects institutional holdings in consideration of new information(e.g., changes in fundamentals and information environments). Changes in institutional holdings are partially due to changes in analyst coverage, and both index funds and other types can change their portfolios in response to changes in the target firms' informativeness. | Song Zhu Xiaoyu Jiang Xiaoli Ke Xiaoyu Bai | 2017 | China Journal of Accounting Research2017，，3： | 5 |
| 4 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 5 | Puromycin A, B and C, cryptic nucleosides identified from Streptomyces alboniger NRRL B-1832 by PPtase-based activation显示文摘Natural product discovery is pivot for drug development,however,this endeavor is often challenged by the wide inactivation or silence of natural products biosynthetic pathways.We recently developed a highly efficient approach to activate cryptic/silenced biosynthetic pathways through augmentation of the phosphopantetheinylation of carrier proteins.By applying this approach in the Streptomyces alboniger NRRL B-1832,we herein identified three cryptic nucleosides products,including one known puromycin A and two new derivatives(puromycin B and C).The biosynthesis of these products doesn't require the involvement of carrier protein,indicating the phosphopantetheinyl transferase(PPtase)indeed plays a fundamental regulatory role in metabolites biosynthesis.These results demonstrate that the PPtasebased approach have a much broader effective scope than the previously assumed carrier proteininvolving pathways,which will benefit future natural products discovery and biosynthetic studies. | Xiaoli Yan Benyin Zhang Wenya Tian Qi Dai Xiaoqin Zheng Ke Hu Xinxin Liu Zixin Deng Xudong Qu | 2018 | Synthetic and Systems Biotechnology2018，3，1： | 3 |
| 6 | Function and mechanism of traditional Chinese medicine in the prevention and treatment of Parkinson's disease显示文摘 | Ting Zhang Ke Wang Limin Liu Wei Wang Li Zhang Jun Jia Xiaoli Gong Xiaomin Wang | 2017 | Journal of Translational Neuroscience2017，2，4： | 2 |
| 7 | Deficiency of two-pore segment channel 2 contributes to systemic lupus erythematosus via regulation of apoptosis and cell cycle显示文摘Background:Systemic lupus erythematosus(SLE)is a complex autoimmune disease,and the mechanism of SLE is yet to be fully elucidated.The aim of this study was to explore the role of two-pore segment channel 2(TPCN2)in SLE pathogenesis.Methods:Quantitative reverse transcription polymerase chain reaction(qRT-PCR)was used to detect the expression ofTPCN2 in SLE.We performed a loss-of-function assay by lentiviral construct in Jurkat and THP-1 cell.Knockdown ofTPCN2 were confirmed at the RNA level by qRT-PCR and protein level by Western blotting.Cell Count Kit-8 and flow cytometry were used to analyze the cell proliferation,apoptosis,and cell cycle ofTPCN2-deficient cells.In addition,gene expression profile ofTPCN2-deficient cells was analyzed by RNA sequencing(RNA-seq).Results:TPCN2 knockdown with short hairpin RNA(shRNA)-mediated lentiviruses inhibited cell proliferation,and induced apoptosis and cell-cycle arrest of G2/M phase in both Jurkat and THP-1 cells.We analyzed the transcriptome of knockdown-TPCN2-Jurkat cells,and screened the differential genes,which were enriched for the G2/M checkpoint,complement,and interleukin-6-Janus kinase-signal transducer and activator of transcription pathways,as well as changes in levels of forkhead box O,phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin,and T cell receptor pathways;moreover,TPCN2 significantly influenced cellular processes and biological regulation.Conclusion:TPCN2 might be a potential protective factor against SLE. | Keke Li Jingkai Xu Ke Xue Ruixing Yu Chengxu Li Wenmin Fei Xiaoli Ning Yang Han Ziyi Wang Jun Shu Yong Cui | 2022 | Chinese Medical Journal2022，，4： | 2 |
| 8 | Improved plasmid-based recovery of coxsackievirus A16 infectious clone driven by human RNA polymerase I promoter显示文摘Dear Editor,Coxsackievirus A16(CA16)is one of the major viral pathogens associated with hand,foot,and mouth disease.CA16 belongs to the Enterovirus genus of the Picornaviridae family and possesses a single-stranded positivesense RNA genome(Mao et al.,2014).Reverse genetics is an important tool for CA16 research.Previously,a reverse genetics T7 polymerase-based system was de- | xiaoli wang chaoyun shen tan chen ke lan zhong huang yunfang zhang qingwei liu | 2016 | Virologica Sinica2016，31，4： | 2 |
| 9 | Nickel single atom overcoordinated active sites to accelerate the electrochemical reaction kinetics for Li-S cathode显示文摘Lithium-sulfur(Li-S)batteries with high theoretical energy density are promising advanced energy storage devices.However,shuttling of dissolute lithium polysulfide(LiPSs)and sluggish conversion kinetics impede their applications.Herein,single nickel(Ni)atoms on two-dimensional(2D)nitrogen(N)-doped carbon with Ni-N_(4)-O overcoordinated structure(SANi-N_(4)-O/NC)are prepared and firstly used as a sulfur host of Li-S batteries.Due to the efficient polysulfides traps and highly LiPSs conversion effect of SANi-N_(4)-O/NC,the electrochemical performance of Li-S batteries obviously improved.The batteries can well operate even under high sulfur loading(5.8 mg cm^(-2))and lean electrolyte(6.1μL mg^(-1))condition.Meanwhile,density functional theory(DFT)calculations demonstrate that Ni single atom’s active sites decrease the energy barriers of conversion reactions from Li_(2)S_(8)to Li2S due to the strong interaction between SANi-N_(4)-O/NC and LiPSs.Thus,the kinetic conversion of LiPSs was accelerated and the shuttle effect is suppressed on SANi-N_(4)-O/NC host.This study provides a new design strategy for a 2D structure with single-atom overcoordinated active sites to facilitate the fast kinetic conversion of LiPSs for Li-S cathode. | Juan Zhu Xinyue Wang Tian Ke Mingji Jia Biyu Jin Yuanyuan Li Qiwei Yang Lanhui Ren Yongyuan Ren Dangguo Cheng Jianguo Lu Xiang Gao Qinggang He Yang Hou Xiaoli Zhan Qinghua Zhang | 2023 | Journal of Energy Chemistry2023，，3： | 2 |
| 10 | Sustainability of SARS-CoV-2 Induced Humoral Immune Responses in COVID-19 Patients from Hospitalization to Convalescence Over Six Months显示文摘Understanding the persistence of antibody in convalescent COVID-19 patients may help to answer the current major concerns such as the risk of reinfection,the protection period of vaccination and the possibility of building an active herd immunity.This retrospective cohort study included 172 COVID-19 patients who were hospitalized in Wuhan.A total of404 serum samples were obtained over six months from hospitalization to convalescence.Antibodies in the specimens were quantitatively analyzed by the capture chemiluminescence immunoassays(CLIA).All patients were positive for the anti-SARS-Co V-2 Ig M/Ig G at the onset of COVID-19 symptoms,and the Ig G antibody persisted in all the patients during the convalescence.However,only approximately 25%of patients can detect the Ig M antibodies,Ig M against N protein(NIg M)and receptor binding domain of S protein(RBD-Ig M)at the 27 th week.The titers of Ig M,N-Ig M and RBD-Ig M reduced to 16.7%,17.6%and 15.2%of their peak values respectively.In contrast,the titers of Ig G,N-Ig G and RBD-Ig G peaked at 4–5 th week and reduced to 85.9%,62.6%and 87.2%of their peak values respectively at the end of observation.Dynamic behavior of antibodies and their correlation in age,gender and severity groups were investigated.In general,the COVID-19 antibody was sustained at high levels for over six months in most of the convalescent patients.Only a few patients with antibody reducing to an undetectable level which needs further attention.The humoral immune response against SARS-Co V-2 infection in COVID-19 patients exhibits a typical dynamic of acquired immunity. | Yang Zheng Qing Zhang Ashaq Ali Ke Li Nan Shao Xiaoli Zhou Zhiqin Ye Xiaomin Chen Shanshan Cao Jing Cui Juan Zhou Dianbing Wang Baidong Hou Min Li Mengmeng Cui Lihua Deng Xinyi Sun Qian Zhang Qinfang Yang Yong li Hui Wang Yake Lei Bo Yu Yegang Cheng Xiaolin Tong Dong Men Xian-En Zhang | 2021 | Virologica Sinica2021，36，5： | 1 |
| 11 | Effect of Potassium on Ammonium Fixation and Adsorption of Vermiculite in Binary and Ternary Systems显示文摘Ammonium fixation and adsorption experiments were conducted to study the effect of potassium on ammonium fixation into interlayer of vermiculite and ammonium adsorption at the surface of vermiculite both in the binary (NH-4~(+)-Ca~(2+)) and ternary (NH-4~(+)-K~(+)-Ca~(2+)) systems. In the ammonium fixation experiment, 5 mmol NH-4~(+) kg~(-1) was added alone, or after, before or simultaneously with 5 mmol K~(+) kg~(-1) to the vermiculite (vermiculite:solution = 1:1), and the incubation was conducted for 3 days under constant 20℃. In the adsorption experiment, after addition of 10 mmol Ca~(2+) L~(-1) as matrix ions, either NH-4~(+) alone with a concentration series from 0.1 to 5.0 mmol NH-4~(+) L~(-1) (binary exchange system of NH-4~(+) and Ca~(2+) or NH-4~(+) together with 5 mmol K~(+) L~(-1) (ternary exchange system of NH-4 ~(+), K~(+) and Ca~(2+) was added to vermiculite at a vermiculite to solution ratio of l:10 for 24-h equilibrium. The results of the fixation experiment showed that the presence of K~(+) increased NH-4~(+) fixation for all the treatments, regardless of the addition orders. For ammonium adsorption a linear relationship between activity ratios of NH-4~(+) to Ca~(2+) and Mg~(2+) in the equilibrium solutions (ARNH-4) and increases of exchangeable NH-4~(+) at the surface of vermiculite after 24- h equilibrium (△Ex-NH-4) was shown for almost the whole concentration ranges tested. Compared with the binary system, the slope of the curve of the ternary system was steeper, indicating a more intensive adsorption of NH-4~(+) in the presence of K~(+). It was demonstrated that K ~(+) did not reduce the ammounium fixation into the interlayer and ammonium adsororption at the surface of vermiculite, which indicated that, under the experimental conditions of this study, K~(+) did neither occupy the sites for NH-4~(+)-fixation in the interlayer nor the sites for NH-4~(+)-adsorption at the surface of vermiculite. | FENG KE, WANG XIAOZHI, TANG YAN and WANG XIAOLI Agricultural College, Yangzhou University, Yangzhou 225009 (China) | 2001 | Pedosphere2001，11，4： | 1 |
| 12 | Plastic supported platinum modified nickel electrode and its high electrocatalytic activity for sodium borohydride electrooxidation显示文摘A novel plastic/multi-walled carbon nanotube(MWNTs)-nickel(Ni)-platinum(Pt) electrode(PMNP) is prepared by chemical-reducing Pt onto the surface of Ni film covered plastic/MWNTs(PM) substrate. The MWNTs are adhered by a piece of commercial double faced adhesive tape on the surface of plastic paper and the Ni film is prepared by a simple electrodeposition method. The morphology and phase structure of the PMNP electrode are characterized by scanning electron microscopy,transmission electron microscope and X-ray diffractometer. The catalytic activity of the PMNP electrode for Na BH4 electrooxidation is investigated by means of cyclic voltammetry and chronoamperometry. The catalyst combines tightly with the plastic paper and exhibits a good stability. MWNTs serve as both conductive material and hydrogen storage material and the Ni film and Pt are employed as electrochemical catalysts. The PMNP electrode exhibits a high electrocatalytic performance and the oxidation current density reaches to 10.76 A/(mg·cm) in 0.1 mol/dm3 Na BH4at0 V,which is much higher than those in the previous reports. The using of waste plastic reduces the discarding of white pollution and consumption of metal resources. | Bin Wang Dongming Zhang Ke Ye Kui Cheng Dianxue Cao Guiling Wang Xiaoli Cheng | 2015 | Journal of Energy Chemistry2015，24，4： | 1 |
| 13 | New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein显示文摘 | Xiujie Liu Xiaoli Huang Wanhua Lin Dongye Wang Yanyan Diao Honglin Li Xiaoyan Hui Yu Wang Aimin Xu Donghai Wu Ding Ke | 2011 | Bioorganic & Medicinal Chemistry Letters2011，，10： | 1 |
| 14 | Construction of an artificial intelligence system in dermatology: effectiveness and consideration of Chinese Skin Image Database (CSID)显示文摘After more than 60 years of development,artificial intelligence(AI)has been widely used in various fields.Especially in recent years,with the development of deep learning,AI has made many remarkable achievements in the medical field.Dermatology,as a clinical discipline with morphology as its main feature,is particularly suitable for the development of AI.The rapid development of skin imaging technology has helped dermatologists to assist in the diagnosis of diseases and has greatly improved the accuracy of diagnosis.Skin imaging data have natural big data attributes,which is important for AI research.The establishment of the Chinese Skin Image Database(CSID)has solved many problems such as isolated data islands and inconsistent data quality.Based on the CSID,many pioneering achievements have been made in the research and development of AI-assisted decision-making software,the establishment of expert organizations,personnel training,scientific research,and so on.At present,there are still many problems with AI in the field of dermatology,such as clinical validation,medical device licensing,interdisciplinary,and standard formulation,which urgently need to be solved by joint efforts of all parties. | Chengxu Li Wenmin Fei Yang Han Xiaoli Ning Ziyi Wang Keke Li Ke Xue Jingkai Xu Ruixing Yu Rusong Meng Feng Xu Weimin Ma Yong Cui | 2021 | Intelligent Medicine2021，1，2： | 1 |
| 15 | Effects of restoration modes on the spatial distribution of soil physical properties after land consolidation: a multifractal analysis显示文摘Soil physical properties(SPP)are considered to be important indices that reflect soil structure,hydrological conditions and soil quality.It is of substantial interest to study the spatial distribution of SPP owing to the high spatial variability caused by land consolidation under various land restoration modes in excavated farmland in the loess hilly area of China.In our study,three land restoration modes were selected including natural restoration land(NR),alfalfa land(AL)and maize land(ML).Soil texture composition,including the contents of clay,silt and sand,field capacity(FC),saturated conductivity(Ks)and bulk density(BD)were determined using a multifractal analysis.SPP were found to possess variable characteristics,although land consolidation destroyed the soil structure and decreased the spatial autocorrelation.Furthermore,SPP varied with land restoration and could be illustrated by the multifractal parameters of D1,ΔD,ΔαandΔf in different modes of land restoration.Owing to multiple compaction from large machinery in the surface soil,soil particles were fine-grained and increased the spatial variability in soil texture composition under all the land restoration modes.Plough numbers and vegetative root characteristics had the most significant impacts on the improvement in SPP,which resulted in the best spatial distribution characteristics of SPP found in ML compared with those in AL and NR.In addition,compared with ML,Δαvalues of NR and AL were 4.9-and 3.0-fold that of FC,respectively,andΔαvalues of NR and AL were 2.3-and 1.5-fold higher than those of Ks,respectively.These results indicate that SPP can be rapidly improved by increasing plough numbers and planting vegetation types after land consolidation.Thus,we conclude that ML is an optimal land restoration mode that results in favorable conditions to rapidly improve SPP. | KE Zengming LIU Xiaoli MA Lihui TU Wen FENG Zhe JIAO Feng WANG Zhanli | 2021 | Journal of Arid Land2021，13，12： | 0 |
| 16 | Status of transjugular intrahepatic portosystemic shunt for portal hypertension in China:A national survey analysis显示文摘Aim:The transjugular intrahepatic portosystemic shunt(TIPS)procedure has been performed in China for 30 years,but our understanding of the status and difficulties associated with the use of TIPS for portal hypertension is incomplete.This study aims to investigate the current situation of the use of TIPS for portal hypertension,which should aid the development of TIPS in China.Methods:This study involved a questionnaire survey,initiated by the China Portal Hypertension Alliance(CHESS)to investigate the use of TIPS for portal hypertension in China.Questionnaires were released on the Internet between August 16,2022 and September 16,2022.Detailed information was collected from 545 hospitals contracted by the CHESS in China,which performed TIPS surgery in 2021.Results:The 545 hospitals covers the majority of hospitals in China that conduct TIPS intervention.In the survey,a total of 13,527 TIPS interventions were carried out with 94.1%(498/545)of them had a system of routine follow‐up after TIPS.The majority(42.6%[232/545])believed that the main indication of TIPS was the control of acute bleeding.Overall,48.1%(262/545)carried out early or pre‐emptive TIPS,53.0%(289/545)carried out TIPS for cavernous transformation of the portal vein,and 81.0%(441/545)chose routine embolization of collateral circulation during operation.Most used coils(97.0%[475/490])and biological glue(72.0%[353/490])as embolic materials,and 78.5%(428/545)routinely performed intraoperative portal pressure gradient measurements.When selecting TIPS stents,57.1%(311/545)chose viator‐specific stents,and 57.2%(312/545)chose conventional anticoagulation after TIPS.Conventional anticoagulation after TIPS is over a time interval of 3–6 months(55.4%[173/312]).The limitation of TIPS surgery is mainly its cost(72.3%[394/545])and insufficient understanding of the procedure by doctors in other related departments(77.4%[422/545]).Most of the hospital teams accept the use of domestic instruments in TIPS surgery(92.7%[505/545]).Conclusions:This survey shows that TIPS is an essential part of the treatment of portal hypertension in China.TIPS is widely used in Chinese patients with portal hypertension,and this survey presents a more comprehensive picture of the options and difficulties encountered in the implementation of TIPS.In the future,it is necessary to promote TIPS technology and further standardize surgical indications,routine operations,and instrument application. | Haibo Shao Xinwei Han Jianbo Zhao Junhui Sun Zhuting Fang Bin Xiong Xiaoli Zhu Weixin Ren Min Yuan Shiping Yu Meng Niu Weifu Lv Xueqiang Zhang Chunqing Zhang Lei Li Xuefeng Luo Yusheng Song Yilong Ma Tong Dang Hua Xiang Yun Jin Hui Xue Guiyun Jin Xiao Li Jiarui Li Shi Zhou Changlu Yu Song He Lei Yu Hongmei Zu Jun Ma Yanming Lei Ke Xu Xiaolong Qi | 2023 | Portal Hypertension & Cirrhosis2023，2，1： | 0 |
| 17 | Advances in Mathematical Modeling of NFκB Signal Transduction in Mammals显示文摘NFκB is a basic transcription factor of cell signal transduction in mammals. Mathematical modeling can be used to simulate NFκB signal transduction and investigate the molecular mechanism. The initial IκB-NFκB signal transduction model emphasized the effects of negative feedback on NFκB temporal dynamics and gene expression control,while subsequent studies are concentrated on other feedback loops,input-output behaviors of modules,crosslinking of several NFκB activation paths and NFκB oscillation. Computer technology will continue to contribute to studies of NFκB signaling pathway. Finally,several potential development trends were discussed in this paper. | Jinshan ZHAO Ke JIANG Zhenghao DAI Xiaoli REN Yumei WANG Yongping JIANG Mingtuan LIU Yonglian DAI Lele HOU Hegang LI | 2013 | Agricultural Biotechnology2013，2，4： | 0 |
| 18 | A Systematic Approach for Designing Analytical Dynamics and Servo Control of Constrained Mechanical Systems显示文摘A systematic approach for designing analytical dynamics and servo control of constrained mechanical systems is proposed. Fundamental equation of constrained mechanical systems is first obtained according to Udwadia-Kalaba approach which is applicable to holonomic and nonholonomic constrained systems no matter whether they satisfy the D’Alember’s principle.The performance specifications are modeled as servo constraints.Constraint-following servo control is used to realize the servo constraints. For this inverse dynamics control problem, the determination of control inputs is based on the Moore-Penrose generalized inverse to complete the specified motion. Secondorder constraints are used in the dynamics and servo control.Constraint violation suppression methods can be adopted to eliminate constraint drift in the numerical simulation. Furthermore,this proposed approach is applicable to not only fully actuated but also underactuated and redundantly actuated mechanical systems. Two-mass spring system and coordinated robot system are presented as examples for illustration. | Xiaoli Liu Shengchao Zhen Kang Huang Han Zhao Ye-Hwa Chen Ke Shao | 2015 | IEEE/CAA Journal of Automatica Sinica2015，2，4： | 0 |
| 19 | Application of Artificially Induced Double-strand Breaks (DSB) and Triplex-forming Oligonucleotides (TFO) in the Improvement of Gene Targeting Efficiency显示文摘Gene targeting technology is an important means to investigate gene functions,but its efficiency of gene targeting is very low,especially for somatic cell targeting. Artificially induced double-strand breaks (DSB) and triplex forming oligonucleotide (TFO) are currently developed methods to improve the targeting efficiency. This paper summarized the basic principles,design ideas and application in gene targeting efficiency improvement of these two methods,analyzed and compared their characteristics,and finally proposed prospects for their future development. | Hegang LI Wenke CHENG Ke JIANG Xiaoli REN Yongping JIANG Lele HOU Xiaojing HAO Jinshan ZHAO | 2013 | Agricultural Biotechnology2013，2，1： | 0 |
| 20 | miR-204 ameliorates osteoarthritis pain by inhibiting SP1-LRP1 signaling and blocking neuro-cartilage interaction显示文摘Osteoarthritis(OA)is a painful degenerative joint disease and is the leading cause of chronic disability among elderly individuals.To improve the quality of life for patients with OA,the primary goal for OA treatment is to relieve the pain.During OA progression,nerve ingrowth was observed in synovial tissue and articular cartilage.These abnormal neonatal nerves act as nociceptors to detect OA pain signals.The molecular mechanisms for transmitting OA pain in the joint tissues to the central nerve system(CNS)is currently unknown.MicroRNA miR-204 has been demonstrated to maintain the homeostasis of joint tissues and have chondro-protective effect on OA pathogenesis.However,the role of miR-204 in OA pain has not been determined.In this study,we investigated interactions between chondrocytes and neural cells and evaluated the effect and mechanism of miR-204 delivered by exosome in the treatment of OA pain in an experimental OA mouse model.Our findings demonstrated that miR-204 could protect OA pain by inhibition of SP1-LDL Receptor Related Protein 1(LRP1)signaling and blocking neuro-cartilage interaction in the joint.Our studies defined novel molecular targets for the treatment of OA pain. | Ke Lu Qingyun Wang Liuzhi Hao Guizheng Wei Tingyu Wang William WLu Guozhi Xiao Liping Tong Xiaoli Zhao Di Chen | 2023 | Bioactive Materials2023，，8： | 0 |
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