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| 1 | Differential expression of serum miR-126,miR-141 and miR-21 as novel biomarkers for early detection of liver metastasis in colorectal cancer显示文摘Objective:MicroRNAs(miRNAs) have potential as diagnostic biomarkers in cancer.Evaluation of the association between miRNA expression patterns and early detection of liver metastasis in colorectal cancer(CRC) has not been reported.Methods:We investigated the expression of metastasis-associated miRs-31,335,206,141,126,200b,200c,21,Let7a,Let7b and Let7c in localized,liver-metastatic and other organ-metastatic CRC(OM-CRC).Expressions of target miRNAs in serum were evaluated in 116 consecutive localized CRC(L-CRC),72 synchronous liver-metastatic CRC(SLM-CRC) and 36 other OM-CRC by quantitative real-time PCR.Results:Seven of 11 tested miRNAs could be detected from serum.Four miRNAs,miR-126,Let-7a,miR-141 and miR-21 were identified as metastasis-associated miRNAs.Compared with L-CRC,significant upregulated expression was observed for miR-141 and miR-21 in SLM-CRC and OM-CRC,down-regulated expression was observed for miR-126 in SLM-CRC and OM-CRC,and up-regulated expression of Let-7a in OM-CRC.The receiver operating characteristic(ROC) curve showed serum miR-126 had a cut-off [log 10 relative quantity(log 10 RQ)=–0.2005] with 77.78% sensitivity and 68.97% specificity with an area under curve(AUC) of 0.7564,miR-141 had a cut-off(log 10 RQ=–0.2285) with 86.11% sensitivity and 76.11% specificity with an AUC of 0.8279,and miR-21 had a cut-off(log 10 RQ=–0.1310) with 73.61% sensitivity and 66.38% specificity with an AUC of 0.7479.Conclusions:We identified liver metastasis-associated miRNAs,suggesting serum miR-126,miR-141 and miR-21 may be novel biomarkers for clinical diagnosis of early stage liver-metastatic CRC. | Jie Yin Zhigang Bai Jianning Song Yun Yang Jin Wang Wei Han Jun Zhang Hua Meng Xuemei Ma Yao Yang Tingting Wang Weirong Li Zhongtao Zhang | 2014 | Chinese Journal of Cancer Research2014，26，1： | 22 |
| 2 | Meta-analyses on prevalence of selected Parkinson’s nonmotor symptoms before and after diagnosis显示文摘Background:Nonmotor symptoms are common among patients with Parkinson’s disease(PD)and some may precede disease diagnosis.Methods:We conducted a meta-analysis on the prevalence of selected nonmotor symptoms before and after PD diagnosis,using random-effect models.We searched PubMed(1965 through October/November 2012)for the following symptoms:hyposmia,constipation,rapid eye movement sleep behavior disorder,excessive daytime sleepiness,depression,and anxiety.Eligible studies were publications in English with original data on one or more of these symptoms.Results:The search generated 2,373 non-duplicated publications and 332 met the inclusion criteria,mostly(n=320)on symptoms after PD diagnosis.For all symptoms,the prevalence was substantially higher in PD cases than in controls,each affecting over a third of the patients.Hyposmia was the most prevalent(75.5%in cases vs.19.1%in controls),followed by constipation(50%vs.17.7%),anxiety(39.9%vs.19.1%),rapid eye movement sleep behavior disorder(37.0%vs.7.0%),depression(36.6%vs.14.9%),and excessive daytime sleepiness(33.9%vs.10.5%).We observed substantial heterogeneities across studies and meta-regression analyses suggested that several factors might have contributed to this.However,the prevalence estimates were fairly robust in several sensitivity analyses.Only 20 studies had data on any symptoms prior to PD diagnosis,but still the analyses revealed higher prevalence in future PD cases than in controls.Conclusion:These symptoms are common among PD patients both before and after diagnosis.Further studies are needed to understand the natural history of nonmotor symptoms in PD and their etiological and clinical implications. | Honglei Chen Edward J Zhao Wen Zhang Yi Lu Rui Liu Xuemei Huang Anna J Ciesielski-Jones Michele A Justice Deborah S Cousins Shyamal Peddada | 2015 | Translational Neurodegeneration2015，4，1： | 18 |
| 3 | Impact of nitrogen addition on plant community in a semi-arid temperate steppe in China显示文摘Increased nitrogen (N) deposition will often lead to a decline in species richness in grassland ecosystems but the shifts in functional groups and plant traits are still poorly understood in China.A field experiment was conducted at Duolun,Inner Mongolia,China,to investigate the effects of N addition on a temperate steppe ecosystem.Six N levels (0,3,6,12,24,and 48 g N/(m 2 a)) were added as three applications per year from 2005 to 2010.Enhanced N deposition,even as little as 3 g N/(m 2 a) above ambient N deposition (1.2 g N/(m 2 a)),led to a decline in species richness of the whole community.Increasing N addition can significantly stimulate aboveground biomass of perennial bunchgrasses (PB) but decrease perennial forbs (PF),and induce a slight change in the biomass of shrubs and semi-shrubs (SS).The biomass of annuals (AS) and perennial rhizome grasses (PR) accounts for only a small part of the total biomass.Species richness of PF decreased significantly with increasing N addition rate but there was a little change in the other functional groups.PB,as the dominant functional group,has a relatively higher height than others.Differences in the response of each functional group to N addition have site-specific and species-specific characteristics.We initially infer that N enrichment stimulated the growth of PB,which further suppressed the growth of other functional groups. | Ling SONG XueMei BAO XueJun LIU FuSuo ZHANG | 2012 | Journal of Arid Land2012，4，1： | 18 |
| 4 | Particle number concentration, size distribution and chemical composition during haze and photochemical smog episodes in Shanghai显示文摘The aerosol number concentration and size distribution as well as size-resolved particle chemical composition were measured during haze and photochemical smog episodes in Shanghai in 2009.The number of haze days accounted for 43%,of which 30%was severe(visibility<2 km)and moderate(2 km≤visibility<3 km)haze,mainly distributed in winter and spring.The mean particle number concentration was about 17,000/cm3in haze,more than 2 times that in clean days.The greatest increase of particle number concentration was in 0.5–1μm and 1–10μm size fractions during haze events,about 17.78times and 8.78 times those of clean days.The largest increase of particle number concentration was within 50–100 nm and 100–200 nm fractions during photochemical smog episodes,about 5.89 times and 4.29 times those of clean days.The particle volume concentration and surface concentration in haze,photochemical smog and clean days were102,49,15μm3/cm3and 949,649,206μm2/cm3,respectively.As haze events got more severe,the number concentration of particles smaller than 50 nm decreased,but the particles of 50–200 nm and 0.5–1μm increased.The diurnal variation of particle number concentration showed a bimodal pattern in haze days.All soluble ions were increased during haze events,of which NH4+,SO42-and NO3-increased greatly,followed by Na+,K+,Ca2+and Cl-.These ions were very different in size-resolved particles during haze and photochemical smog episodes. | Xuemei Wang Jianmin Chen Tiantao Cheng Renyi Zhang Xinming Wang | 2014 | Journal of Environmental Sciences2014，26，9： | 17 |
| 5 | Assessment of diurnal variation of summer precipitation over the Qilian Mountains based on an hourly merged dataset from 2008 to 2014显示文摘调查日报在在向东北西藏的高原的 Qilian 山的夏天降水的变化,时时,为这个区域的降水数量在 0.1 点用一个时时合并的降水产品在 2008-2014 的夏天期间被分析 ? 湵慦潶慲汢? 諟D禎澞?汣浩瑡 ? 档湡敧椠?? | LIU Xuemei ZHANG Mingjun WANG Shengjie WANG Jie ZHAO Peipei ZHOU Panpan | 2017 | Journal of Geographical Sciences2017，27，3： | 14 |
| 6 | Molecular mechanism of SCARB2-mediatec attachment and uncoating of EV71显示文摘 | Minghao Dang Xiangxi Wang Quan Wang Yaxin Wang Jianping Lin Yuna Sun Xuemei Li Liguo Zhang Zhiyong Lou Junzhi Wang Zihe Rao | 2014 | Protein & Cell2014，5，9： | 13 |
| 7 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 8 | Recently duplicated sesterterpene(C25) gene clusters in Arabidopsis thaliana modulate root microbiota显示文摘Land plants co-speciate with a diversity of continually expanding plant specialized metabolites(PSMs) and root microbial communities(microbiota).Homeostatic interactions between plants and root microbiota are essential for plant survival in natural environments.A growing appreciation of microbiota for plant health is fuelling rapid advances in genetic mechanisms of controlling microbiota by host plants.PSMs have long been proposed to mediate plant and single microbe interactions.However,the effects of PSMs,especially those evolutionarily new PSMs,on root microbiota at community level remain to be elucidated.Here,we discovered sesterterpenes in Arabidopsis thaliana,produced by recently duplicated prenyltransferase-terpene synthase(PT-TPS) gene clusters,with neo-functionalization.A single-residue substitution played a critical role in the acquisition of sesterterpene synthase(sesterTPS) activity in Brassicaceae plants.Moreover,we found that the absence of two root-specific sesterterpenoids,with similar chemical structure,significantly affected root microbiota assembly in similar patterns.Our results not only demonstrate the sensitivity of plant microbiota to PSMs but also establish a complete framework of host plants to control root microbiota composition through evolutionarily dynamic PSMs. | Qingwen Chen Ting Jiang Yong-Xin Liu Haili Liu Tao Zhao Zhixi Liu Xiangchao Gan Asis Hallab Xuemei Wang Juan He Yihua Ma Fengxia Zhang Tao Jin M. Eric Schranz Yong Wang Yang Bai Guodong Wang | 2019 | Science China(Life Sciences)2019，62，7： | 11 |
| 9 | Impact of climate factors on runoff in the Kaidu River watershed:path analysis of 50-year data显示文摘Runoff formation is a complex meteorological-hydrological process impacted by many factors,especially in the inland river basin.Based on the data of daily mean air temperature,precipitation and runoff during the period of 1958-2007 in the Kaidu River watershed,this paper analyzed the changes in air temperature,precipitation and runoff and revealed the direct and indirect impacts of daily air temperature and precipitation on daily runoff by path analysis.The results showed that mean temperature time series of the annual,summer and autumn had a significant fluctuant increase during the last 50 years(P < 0.05).Only winter precipitation increased significantly(P < 0.05) with a rate of 1.337 mm/10a.The annual and winter runoff depthes in the last 50 years significantly increased with the rates of 7.11 mm/10a and 1.85 mm/10a,respectively.The driving function of both daily temperature and precipitation on daily runoff in annual and seasonal levels is significant in the Kaidu River watershed by correlation analysis.The result of path analysis showed that the positive effect of daily air temperature on daily runoff depth is much higher than that of daily precipitation in annual,spring,autumn and winter,however,the trend is opposite in summer. | XueMei LI LanHai LI LingPeng GUO FeiYun ZHANG Suwannee ADSAVAKULCHAI Ming SHANG | 2011 | Journal of Arid Land2011，3，2： | 10 |
| 10 | NEW PRODUCT DESIGN STRATEGIES WITH SUBSIDY POLICIES显示文摘工业开发能充实民族生活,但是它也引起环境污染,它是在政府,消费者,和公司之中的重要担心的一个区域。政府们提出一些环境政策,它由为绿产品开发提供更大的刺激激发工业。消费者们根据他们的环境了解和态度被分类进平常的二个组和绿市场片断。在这方面,公司需要重新考虑他们的主要产品设计策略。由在顾客偏爱,公司产品策略,和政府津贴政策之中调查相互作用,这份报纸为新产品设计策略论述一个理论模型。在如此的策略的详细理论分析以后,我们发现了那激发公司选择环境地友好的产品设计策略,政府们应该使有效津贴政策就职。在同时考虑环境问题和公司好处以后,我们设计了一条津贴政策。与如此的一条政策,公司能改变他们的主要产品设计策略并且开发绿、平常的产品,从而增加公司利润并且改进全部的环境质量。 | Xuemei ZHANG Xiaoyan XU Ping HE | 2012 | Journal of Systems Science and Systems Engineering2012，21，3： | 10 |
| 11 | Effects of essential oils on performance,egg quality, nutrient digestibility and yolk fatty acid profile in laying hens显示文摘The study was conducted to investigate the effect of essential oils on performance, egg quality, nutrient digestibility and yolk fatty acid profile in laying hens. A total of 960 Lohmann laying hens aged 53 weeks were enrolled, under 4 different treatment diets supplemented with 0, 50.100 and 150 mg/kg essential oils(Enviva EO, Dupont Nutrition Biosciences ApS, Denmark), respectively. Each treatment was replicated8 times with 30 birds each. Birds were fed dietary treatment diets for 12 weeks(54 to 65 weeks). For data recording and analysis, a 12-week period was divided into 3 periods of 4 weeks' duration each: period 1(54 to 57 weeks), period 2(58 to 61 weeks), and period 3(62 to 65 weeks). For the diet supplemented with Enviva EO, hen-day egg production and the feed conversion ratio(FCR) were significantly improved(P < 0.05) at weeks 58 to 61, and the eggshell thickness was significantly increased(P < 0.05) at week 65.However, egg production, egg weight, feed intake, FCR and other egg quality parameters(albumen height, Haugh unit, egg yolk color and eggshell strength) were not affected by the dietary treatment. In addition, compared with the control diet, protein digestibility in the 100 mg/kg Enviva EO treatment group was significantly increased(P < 0.05), and fat digestibility in the 100 and 150 mg/kg Enviva EO treatment groups was significantly decreased(P < 0.05), but Enviva EO had no effect on energy apparent digestibility. Saturated fatty acid(SFA) and monounsaturated fatty acid(MUFA) gradually decreased and polyunsaturated fatty acid(PUFA) increased with Enviva EO supplementation, but the difference was not significant. The data suggested that the supplementation of essential oils(Enviva EO) in laying hen diet did not show a significant positive effect on performance and yolk fatty acid composition but it tended to increase eggshell thickness and protein digestibility, especially at the dose of 50 mg/kg. | Xuemei Ding Yang Yu Zhuowei Su Keying Zhang | 2017 | Animal Nutrition2017，，2： | 10 |
| 12 | Study on crustal, lithospheric and asthenospheric thickness beneath the Qinghai-Tibet Plateau and its adjacent areas显示文摘Based on the results of pure dispersions of Rayleigh wave tomography in the Qinghai-Tibet Plateau and its adjacent areas, taking S wave velocities from previous linear inversion as the initial model, us-ing the simulated annealing algorithm, a nonlinear simultaneous inversion has been carried out for S wave velocity and thickness of different layers, including the crust, the lithosphere and the astheno-sphere. The results indicate: The crustal thickness shows strong correlation with geology structures sketched by the sutures and major faults. The crust is very thick in the Qinghai-Tibet Plateau, varying from 60 km to 80 km. The lithospheric thickness in the Qinghai-Tibet Plateau is thinner (130―160 km) than its adjacent areas. And two blocks can be recognized, divided by an NNE strike boundary running between 90°E―92°E inside the plateau. Its asthenosphere is relatively thick, varies from 150 km to 230 km, and the thickest area is located in the western Qiangtang. India has a thinner crust (32―38 km), a thicker lithosphere of 190 km and a rather thin asthenosphere of only 60 km. Sichuan and Tarim basins have the crust thickness less than 50 km. Their lithospheres are thicker than the Qinghai-Tibet Plateau, and their asthenospheres are thinner. A discussion has been made on the character and formation mechanism of the typical crust-mantle transition zone in the western Qiangtang block. | ZHANG XueMei SUN RuoMei TENG JiWen | 2007 | Chinese Science Bulletin2007，52，6： | 9 |
| 13 | Environmental factors influencing snowfall and snowfall prediction in the Tianshan Mountains, Northwest China显示文摘Snowfall is one of the dominant water resources in the mountainous regions and is closely related to the development of the local ecosystem and economy. Snowfall predication plays a critical role in understanding hydrological processes and forecasting natural disasters in the Tianshan Mountains, where meteorological stations are limited. Based on climatic, geographical and topographic variables at 27 meteorological stations during the cold season(October to April) from 1980 to 2015 in the Tianshan Mountains located in Xinjiang of Northwest China, we explored the potential influence of these variables on snowfall and predicted snowfall using two methods: multiple linear regression(MLR) model(a conventional measuring method) and random forest(RF) model(a non-parametric and non-linear machine learning algorithm). We identified the primary influencing factors of snowfall by ranking the importance of eight selected predictor variables based on the relative contribution of each variable in the two models. Model simulations were compared using different performance indices and the results showed that the RF model performed better than the MLR model, with a much higher R^2 value(R^2=0.74; R^2, coefficient of determination) and a lower bias error(RSR=0.51; RSR, the ratio of root mean square error to standard deviation of observed dataset). This indicates that the non-linear trend is more applicable for explaining the relationship between the selected predictor variables and snowfall. Relative humidity, temperature and longitude were identified as three of the most important variables influencing snowfall and snowfall prediction in both models, while elevation, aspect and latitude were of secondary importance, followed by slope and wind speed. These results will be beneficial to understand hydrological modeling and improve management and prediction of water resources in the Tianshan Mountains. | ZHANG Xueting LI Xuemei LI Lanhai ZHANG Shan QIN Qirui | 2019 | Journal of Arid Land2019，11，1： | 8 |
| 14 | Impacts of algal blooms removal by chitosan-modified soils on zooplankton community in Taihu Lake,China显示文摘It is important to assess the eflect on zooplankton when perform the environmental protection or restoration technology,especially removing algal blooms,because algae were the major primary producer in algal lakes.The influence on zooplankton community after half a year of algal blooms removed by chitosan-modified soils in Taihu Lake was assessed and the rationality of carrying out the process semiannually was evaluated in the present study.Morphological composition and genetic diversity of zooplankton community were investigated by microscope checkup and polymerase chain reaction-denatured gradient gel electrophoresis(PCR-DGGE) .A total of 44 zooplankton taxa(23 protozoa,17 rotifers,3 copepoda and 1 cladocera) were detected by microscope checkup,and a total of 91 bands(28 bands amplified by primers F1427-GC and R1616,63 bands amplified by primers Fung-GC and NS1) were detected by PCR-DGGE.The results of cluster analysis or detrended correspondence analysis indicated that there was no considerable diflerence in morphological composition of zooplankton and DGGE profiles between experimental and control sites,and DGGE profiles could represent the biologic diversity.The study showed that zooplankton community could recover original condition after half year of algal blooms removed by chitosan-modified soils and it was acceptable to apply this process semiannually.In addition,the results revealed that PCR-DGGE could be applied to investigate the impacts of the environmental protection or restoration engineering on zooplankton community diversity. | Jiajia Ni Yuhe Yu Weisong Feng Qingyun Yan Gang Pan Bo Yang Xiang Zhang Xuemei Li | 2010 | Journal of Environmental Sciences2010，22，10： | 8 |
| 15 | Which climatic factors limit radial growth of Qilian juniper at the upper treeline on the northeastern Tibetan Plateau?显示文摘正在不同关于在东北西藏的高原上在上面的 treelines 限制 Qilian 杜松属(Juniperus przewalskii Kom ) 的光线的生长的气候的因素的看法。在这研究,从在东北西藏的高原的 Anyemaqen 山的一个上面的 treeline 地点的树被选择介绍低温度限制 Qilian 杜松属的光线的生长的新证据。用没有信号的地区性的曲线标准化(SF-RCS ) 方法,为 Qilian 杜松属的一张戒指宽度年表被开发从广告 1082 ~ 2010 延长。在树戒指索引和仪器的气候的变量之间的关联分析的结果两个都显示出那冬季(在上一年的 12 月和当前的年里的 1 月) 和夏天(当前的年里的 7 月和 8 月) 温度显著地并且断然与树戒指索引被相关。在 6 月的降水显著地并且断然也与树戒指索引被相关,但是不象在控制树生长的低温度一样重要。测试为树限制气候的因素的钥匙在不同高度的光线的生长,指示物称为到上面的 treeline (RDUT ) 的相对距离被开发确定代表性为森林收集了样品上面的 treeline。RDUT 证明上面 20% 森林带可以以在东北西藏的高原上在上面的 treelines 从树戒指宽度捕获温度信号是一条重要边界。我们的调查结果提高温度是在东北西藏的高原上的上面的 treelines 的限制因素的存在理解,并且将在在未来研究的过去的温度的重建有用。 | ZHANG Hui SHAO Xuemei ZHANG Yong | 2015 | Journal of Geographical Sciences2015，25，10： | 8 |
| 16 | Reinforcement effect of fiber and deoiled asphalt on high viscosity rubber/SBS modified asphalt mortar显示文摘In this paper we investigate the reinforcement mechanism of high viscosity rubber/SBS modified asphalt mortar mixed with fiber(mineral, lignin or carbon fiber) and deoiled asphalt(DOA). The softening point, penetration and viscosity tests were conducted to characterize the engineering properties of asphalt-fiber mortar. The microstructure of fiber was observed using scanning electron microscopy(SEM), and the results indicated that fiber can effectively improve the toughness of asphalt matrix through forming a spatial network structure, and then adhesion and stabilization of asphalt binder. The cone penetration test was designed to study the rheological property of fiber modified asphalt. The results indicated that the reinforcement effect increased with fibers and DOA fraction increasing to a certain threshold, and the optimal fiber content was dependent on the fiber type and its length. Fiber content and filler-asphalt ratio had significant effects on the softening point, penetration, viscosity and cone penetration of asphalt mortar. | Wu Mengmeng Li Rui Zhang Yuzhen Wei Jianming Lv Yuchao Ding Xuemei | 2014 | Petroleum Science2014，11，3： | 8 |
| 17 | The Glutamatergic Postrhinal Cortex–Ventrolateral Orbitofrontal Cortex Pathway Regulates Spatial Memory Retrieval显示文摘A deficit in spatial memory has been taken as an early predictor of Alzheimer’s disease(AD) or mild cognitive impairment(MCI). The uncinate fasciculus(UF) is a long-range white-matter tract that connects the anterior temporal lobe with the orbitofrontal cortex(OFC)in primates. Previous studies have shown that the UF impairment associated with spatial memory deficits may be an important pathological change in aging and AD, but its exact role in spatial memory is not well understood. The pathway arising from the postrhinal cortex(POR) and projecting to the ventrolateral orbitofrontal cortex(vlOFC)performs most of the functions of the UF in rodents.Although the literature suggests an association between spatial memory and the regions connected by the POR–vlOFC pathway, the function of the pathway in spatialmemory is relatively unknown. To further illuminate the function of the UF in spatial memory, we dissected the POR–vlOFC pathway in mice. We determined that the POR–vlOFC pathway is a glutamatergic structure, and that glutamatergic neurons in the POR regulate spatial memory retrieval. We also demonstrated that the POR–vlOFC pathway specifically transmits spatial information to participate in memory retrieval. These findings provide a deeper understanding of UF function and dysfunction related to disorders of memory, as in MCI and AD. | Xinyang Qi Zhanhong Jeff Du Lin Zhu Xuemei Liu Hua Xu Zheng Zhou Cheng Zhong Shijiang Li Liping Wang Zhijun Zhang | 2019 | Neuroscience Bulletin2019，35，3： | 7 |
| 18 | An observation-based perspective of winter haze days in four major polluted regions of China显示文摘An observation-based approach is used to examine key characteristics of winter haze days in four major polluted regions in China.Major findings in this study are:first,there was no significant trend in the number of winter haze days in most provinces and districts in eastern China from 1973 to 2012,contrary to the 2.5-fold increase in the emissions of particulate matter and its precursors(PM emissions)in the same period of time.Second,meteorological and climate conditions rather than PM emissions are in control of the interannual variabilities and trends of winter haze days.These interannual variabilities(ranging from 24 to 125%)pose a substantial masking effect that must be overcome by any control of PM emissions before its impact becomes statistically detectable.Finally,we find that global warming may have contributed significantly to the trend of winter haze days in eastern China. | Lu Mao Run Liu Wenhui Liao Xuemei Wang Min Shao Shaw Chen Liu Yuanhang Zhang | 2019 | National Science Review2019，6，3： | 7 |
| 19 | A Resource for Inactivation of MicroRNAs Using Short Tandem Target Mimic Technology in Model and Crop Plants显示文摘microRNAs (miRNAs)are endogenous small non-coding RNAs that bind to mRNAs and target them for cleavage and/or translational repression,leading to gene silencing.We previously developed short tandem target mimic (STTM)technology to deactivate endogenous miRNAs in Arabidopsis.Here,we created hundreds of STTMs that target both conserved and species-specific miRNAs in Arabidopsis,tomato,rice,and maize,providing a resource for the functional interrogation of miRNAs.We not only revealed the functions of several miRNAs in plant development,but also demonstrated that tissue-specific inactivation of a few miRNAs in rice leads to an increase in grain size without adversely affecting overall plant growth and development.RNA-seq and small RNAseq analyses of STTM156/157 and STTM165/166 transgenic plants revealed the roles of these miRNAs in plant hormone biosynthesis and activation,secondary metabolism,and ion-channel activity-associated electrophysiology,demonstrating that STTM technology is an effective approach for studying miRNA functions.To facilitate the study and application of STTM transgenic plants and to provide a useful platform for storing and sharing of information about miRNA-regulated gene networks,we have established an online Genome Browser (http://gffzzc750bc0108fa4044skvxnn699b9bo6vow.ffgz.tsg.suse.edu.cn/designindex2.php) to display the transcriptomic and miRNAomic changes in STTMinduced miRNA knockdown plants. | Ting Peng Mengmeng Qiao Haiping Liu Sachin Teotia Zhanhui Zhang Yafan Zhao Bobo Wang Dongjie Zhao Lina Shi Cui Zhang Brandon Le Kestrel Rogers Chathura Gunasekara Haitang Duan Yiyou Gu Lei Tian Jinfu Nie Jian Qi Fanrong Meng Lan Huang Qinghui Chen Zhenlin Wang Jinshan Tang Xiaoqing Tang Ting Lan Xuemei Chen Hairong Wei Quanzhi Zhao Guiliang Tang | 2018 | Molecular Plant2018，11，11： | 7 |
| 20 | Traditional Chinese Medicine syndrome-related herbal prescriptions in treatment of malignant tumors显示文摘OBJECTIVE: To investigate the distribution characteristics of TCM syndromes and the related herbal prescriptions for malignant tumors (MT). METHODS: A clinical database of the TCM syndromes and the herbal prescriptions in treatment of 136 MT patients were established. The data were then analyzed using cluster and frequency analysis. RESULTS: According to the cluster analysis, the TCM syndromes in MT patients mainly included two patterns: deficiency of both Qi and Yin and internal accumulation of toxic heat. The commonly-prescribed herbs were Huangqi (Astraglus), Nüzhen-zi (Fructus Ligustri Lucidi), Lingzhi (Ganoderma Lucidum), Huaishan (Dioscorea Opposita), Xiakucao (Prunella Vulgaris), and Baihuasheshecao (Herba Hedyotidis). CONCLUSION: Deficiency of Qi and Yin is the primary syndrome of MT, and internal accumulation of toxic heat is the secondary syndrome. The herbs for Qi supplementation and Yin nourishment are mainly used, with the assistance of herbs for heat-clearance and detoxification. | Zhizhen Liu Songyi Chen Jing Cai Enda Zhang Lan Lan Junting Zheng Lianming Liao Xuemei Yang Changen Zhou Jian Du | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 7 |
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