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| 1 | Analysis of Paraquat Intoxication Epidemic (2002-2011) within China显示文摘Paraquat, is a Bipy herbicide have been widely used in last decade in China. Because of its high human toxicity and mortality characteristics, paraquat has been gained considerable attention in recent years. In order to evaluate the epidemic status of paraquat harm to human health in China, | YIN Yu GUO Xiang ZHANG Shou Lin SUN Cheng Ye | 2013 | Biomedical and Environmental Sciences2013，26，6： | 43 |
| 2 | Serum vaspin level in relation to postprandial plasma glucose concentration in subjects with diabetes显示文摘背景 Vaspin 是与肥胖和胰岛素 sensitivity.However 有关的最新识别的 adipocytokine ,它在人的 pathophysiologic 角色大部分留下我们的学习的 unknown.The 目的 123 个题目是在中国 adults.Methods A 调查在浆液 vaspin 水平和葡萄糖新陈代谢或肥胖之间的关系全部的,包括有正常葡萄糖忍耐( NGT )的 84 个题目和有糖尿病的 39 个题目,在这 study.Anthropometric 被注册参数,腹的胖区域。 | YE Yin HOU Xu-hong PAN Xiao-ping LU Jun-xi JIA Wei-ping | 2009 | Chinese Medical Journal2009，，21： | 40 |
| 3 | Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients显示文摘AIM: To investigate the effect of omega-3 fatty acid parenteral supplementation postoperatively on clinical outcomes and immunomodulation in colorectal cancer patients. METHODS: Forty-two patients undergoing radical colorectal cancer resection with an indication for total parenteral nutrition postoperatively were enrolled in this prospective, double-blind, randomized, controlled study. Patients received total parenteral nutrition supplemented with either soybean oil (LCT; Intralipid, Fresenius-Kabi, SO group, n = 21) or a combination of omega-3 fish oil and soybean oil (LCT:fish oil = 5:1, fish oil; Omegaven, Fresenius-Kabi, FO group, n = 21), up to a total of 1.2 g lipid/kg per day for 7 d postoperatively. A same volume calorie and nitrogen was administrated. Routine blood test, biochemistry, systemic levels of IL-6 and TNF-α, percentage of CD3+, CD4+, and CD8+ lymphocytes were evaluated preoperatively and on postoperative d 1 and 8. Patient outcome was evaluated considering mortality during the hospital stay, length of postoperative hospital stay, and occurrence of infectious complications. RESULTS: Both lipid regimens were well tolerated. No differences between the two groups were noticed in demographics, baseline blood test, biochemistry, serum levels of IL-6 and TNF-α, percentage of CD4+, CD8+ lymphocytes, and ratios of CD4+/CD8+. Compared with those on postoperative d 1, serum IL-6 levels onpostoperative d 8 were significantly depressed in the FO group than in the reference group (-44.43 ± 30.53 vs -8.39 ± 69.08, P = 0.039). Simultaneously, the ratios of CD4+/CD8+ were significantly increased in the FO group (0.92 ± 0.62 vs 0.25 ± 1.22, P = 0.035). In addition, depression of serum TNF-α levels (-0.82 ± 2.71 vs 0.27 ± 1.67, P = 0.125) and elevation of CD3+ and CD4+ lymphocyte percentage (12.85 ± 11.61 vs 3.84 ± 19.62, P = 0.081, 17.80 ± 10.86 vs 9.66 ± 17.55, P = 0.084, respectively) were higher in the FO group than in the reference group. Patients in the FO group trended to need a shorter postoperative hospital stay (17.45 ± 4.80 d vs 19.62 ± 5.59 d, P = 0.19). No statistically significant difference was found when stratified to mortality and occurrence of infectious complications. CONCLUSION: Postoperative supplementation of omega-3 fatty acids may have a favorable effect on the outcomes in colorectal cancer patients undergoing radical resection by lowering the magnitude of inflammatory responses and modulating the immune response. | Bin Liang, Shan Wang, Ying-Jiang Ye, Xiao-Dong Yang, You-Li Wang, Jun Qu, Qi-Wei Xie, Mu-Jun Yin, Division of Surgical Oncology and Division of Gastroenterological Surgery, Peking University People’s Hospital, Beijing 100044, China Author contributions: Liang B and Wang S contributed equally to this work Liang B and Wang S designed the research Liang B, Ye YJ, Yang XD, Wang YL, Qu J, Xie QW, Yin MJ performed the research and collected the data Wang S and Ye YJ supervised the research Liang B and Ye YJ analyzed the data Liang B wrote the paper and revised the manuscript. | 2008 | World Journal of Gastroenterology2008，14，15： | 31 |
| 4 | The willow genome and divergent evolution from poplar after the common genome duplication显示文摘 | Xiaogang Dai Quanjun Hu Qingle Cai Kai Feng Ning Ye Gerald A Tuskan Richard Milne Yingnan Chen Zhibing Wan Zefu Wang Wenchun Luo Kun Wang Dongshi Wan Mingxiu Wang Jun Wang Jianquan Liu Tongming Yin | 2014 | Cell Research2014，24，10： | 28 |
| 5 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 6 | Recent Advances in the Regulation of Brassinosteroid Signaling and Biosynthesis Pathways显示文摘Brassinosteroids(BRs) play important roles in plant growth,develop-ment and responses to environmental cues.BRs signal through plasma membrane receptor BRI1 and co-receptor BAK1,and several positive(BSK1,BSU1,PP2A) and negative(BKI1,BIN2 and 14-3-3) regulators to control the activities of BES1 and BZR1 family transcription factors,which regulate the expression of hundreds to thousands of genes for various BR responses.Recent studies identified novel signaling components in the BR pathways and started to establish the detailed mechanisms on the regulation of BR signaling.In addition,the molecular mechanism and transcriptional network through which BES1 and BZR1 control gene expression and various BR responses are beginning to be revealed.BES1 recruits histone demethylases ELF6 and REF6 as well as a transcription elongation factor IWS1 to regulate target gene expression.Identification of BES1 and BZR1 target genes established a transcriptional network for BR response and crosstalk with other signaling pathways.Recent studies also revealed regulatory mechanisms of BRs in many developmental processes and regulation of BR biosynthesis.Here we provide an overview and discuss some of the most recent progress in the regulation of BR signaling and biosynthesis pathways. | Huaxun Ye Lei Li Yanhai Yin | 2011 | Journal of Integrative Plant Biology2011，53，6： | 21 |
| 7 | Establishment of a Highly Efficient Regeneration System for the Mature Embryo Culture of Wheat显示文摘Establishment of a highly efficient regeneration system for the mature embryo of wheat will provide a convenient tool for wheat tissue culture and transformation, thereby facilitating the transformation of foreign genes into wheat. By using the mature embryos derived from 20 different wheat lines including Shi 4185, Yumai 66, Lunxuan 987, CB037, Yangmai 6, Xinchun 9, Bobwhite, Han 6172, Zheng 9023, Jimai 20, Ningchun 4, and Jing 411, the effects of some factors including inoculation methods, initiating culture media, organic additives, antioxidants, and auxins on the regeneration from the explants were evaluated. The results indicated that the scraping embryo culture was better than the whole embryo culture, the Aa medium was better than the SD2 medium and dicamba was better than 2,4-D in increasing the regeneration frequency. An Adi medium was established in this study by adding silver nitrate, cysteine, ascorbic acid, dicamba, glutamine into the Aa medium at the concentration of 4 , 40, 100, 2, and 5 mg L-1, respectively. By using the Adi medium and the scraping technique, the regeneration frequencies of the mature embryos of CB037, Lunxuan 987, Han 6172, Yangmai 6, Bobwhite, Zheng 9023, Shi 4185, and Jimai 20 became 85.6, 60.1, 46.0, 42.1, 42.0, 34.0, 33.0, and 32.0%, respectively, which were about 5-8 times higher than that obtained from the conventional culture mediums and techniques. This novel regeneration system could be helpful in wheat transformation. | YIN Gui-xiang WANG Yan-li SHE Mao-yun DU Li-pu XU Hui-jun MA Jing-xiu YE Xing-guo | 2011 | Agricultural Sciences in China2011，10，1： | 19 |
| 8 | Advanced Space-based Solar Observatory(ASO-S):an overview显示文摘The Advanced Space-based Solar Observatory(ASO-S)is a mission proposed for the 25 th solar maximum by the Chinese solar community.The scientific objectives are to study the relationships between the solar magnetic field,solar flares and coronal mass ejections(CMEs).Three payloads are deployed:the Full-disk vector Magneto Graph(FMG),the Lyman-αSolar Telescope(LST)and the Hard X-ray Imager(HXI).ASO-S will perform the first simultaneous observations of the photospheric vector magnetic field,non-thermal imaging of solar flares,and the initiation and early propagation of CMEs on a single platform.ASO-S is scheduled to be launched into a 720 km Sun-synchronous orbit in 2022.This paper presents an overview of the mission till the end of Phase-B and the beginning of Phase-C. | Wei-Qun Gan Cheng Zhu Yuan-Yong Deng Hui Li Yang Su Hai-Ying Zhang Bo Chen Zhe Zhang Jian Wu Lei Deng Yu Huang Jian-Feng Yang Ji-Jun Cui Jin Chang Chi Wang Ji Wu Zeng-Shan Yin Wen Chen Cheng Fang Yi-Hua Yan Jun Lin Wei-Ming Xiong Bin Chen Hai-Chao Bao Cai-Xia Cao Yan-Ping Bai Tao Wang Bing-Long Chen Xin-Yu Li Ye Zhang Li Feng Jiang-Tao Su Ying Li Wei Chen You-Ping Li Ying-Na Su Hai-Yan Wu Mei Gu Lei Huang Xue-Jun Tang | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 17 |
| 9 | Self-Assembly and Photocatalysis of Mesoporous TiO2 Nanocrystal Clusters显示文摘有大表面区域和提高的 photocatalytic 活动的锐钛矿 TiO2 的 Mesoporous nanocrystal 簇成功地被综合了。合成包含进亚微米簇,有硅石层的这些簇的涂层,移开器官的 ligands 并且改进簇的 crystallinity 的热处理,和暴露 mesoporous 催化剂的最后搬迁的硅石的恐水病的 TiO2 nanocrystals 自己组装。在硅石涂层的帮助下,簇不仅维持他们的小谷物尺寸而且在高温度在锻烧以后保留他们的 mesoporous 结构(与象 277 m2/g 一样高的赌注表面区域) 。蚀刻 SiO2 也导致在水里有高 dispersity 的簇。我们能识别最佳的锻烧温度生产拥有高 crystallinity 和大表面区域的 TiO2 nanocrystal 簇,因此由紫外光在照明下面在器官的分子的分解显示出优秀催化效率。与氮的方便的做在可见的光和自然日光把这些 nanocrystal 簇变换成活跃光催化剂。用 nanocrystals 形成明确的 mesoporous 簇的策略为与提高的活动和稳定性设计光催化剂答应一个万用、有用的方法。 | Qiao Zhang Ji-Bong Joo Zhenda Lu Michael Dahl Diana Q. L. Oliveira Miaomiao Ye Yadong Yin | 2011 | Nano Research2011，4，1： | 17 |
| 10 | Recurrent gain-of-function USP8 mutations in Cushing's disease显示文摘库欣的疾病,引起过量皮质醇生产的也已知的同样促肾上腺皮质的荷尔蒙(ACTH )-secreting 垂体腺瘤(舞步) ,占多达 85%corticotrophin 依赖的库欣的症候群盒子。然而,在这疾病的基因改变是不清楚的。这里,我们执行了从 12 秘密 ACTH 舞步导出并且匹配血样品的 DNA 定序的 whole-exome,它在候选人基因揭示了体的变化的三种类型, USP8 (编码 ubiquitin 特定的朊酶 8 ) ,专门在 exon 14 在 12 秘密 ACTH 舞步中的 8 个。我们进一步评估了体的 USP8 变化在另外由定序的 Sanger 的 258 舞步。进一步定序指向在 108 秘密 ACTH 舞步(62.04%) 中的 67 个识别了 USP8 变体的 17 种类型的一个总数。然而,任何一个都没在舞步的另外的类型这些变化被检测(n = 150 ) 。这些变化在 USP8 的 14-3-3 绑定主题以内聚集并且破坏在 USP8 和 14-3-3 蛋白质之间的相互作用,导致保护 EGFR 免受 lysosomal 降级的伤害的一个提高的能力。因此,有 EGFR 表示,提高的 EGFR 蛋白质丰富和 mRNA 表示的更高的发生 POMC 铺平的变异的 USP8 显示的舞步,它编码 ACTH 的先锋。有变异的 USP8 的舞步在尺寸是显著地更小的并且比野类型的舞步有更高的 ACTH 生产。在里面通过手术 resected 主要变异 USP8 的肿瘤房间, USP8 击倒或堵住的 EGFR 有效地稀释 ACTH 分泌物。一起拿,体的 gain-of-function USP8 变化是普通的并且在库欣的疾病贡献 ACTH 生产过剩。USP8 或 EGFR 的抑制为对待变异 USP8 的 corticotrophin 腺瘤是有希望的。我们的学习在库欣的疾病加亮潜在地功能的变异的基因并且提供卓见进这疾病的治疗学。 | Zeng-Yi Ma Zhi-Jian Song Jian-Hua Chen Yong-Fei Wang Shi-Qi Li Liang-Fu Zhou Ying Mao Yi-Ming Li Rong-Gui Hu Zhao-Yun Zhang Hong-Ying Ye Ming Shen Xue-Fei Shou Zhi-Qiang Li Hong Peng Qing-Zhong Wang Dai-Zhan Zhou Xiao-Lan Qin Jue Ji Jie Zheng Hong Chen Yin Wang Dao-Ying Geng Wei-Jun Tang Chao-Wei Fu Zhi-Feng Shi Yi-Chao Zhang Zhao Ye Wen-Qiang He Qi-Lin Zhang Qi-Sheng Tang Rong Xie Jia-Wei Shen Zu-Jia Wen Juan Zhou Tao Wang Shan Huang Hui-Jia Qiu Ni-Dan Qiao Yi Zhang Li Pan Wei-Min Bao Ying-Chao Liu Chuan-Xin Huang Yong-Yong Shi Yao Zhao | 2015 | Cell Research2015，25，3： | 16 |
| 11 | Phosphorus recovery from wastewater by struvite crystallization:Property of aggregates显示文摘Struvite crystallization is a promising method to remove and recover phosphorus from wastewater to ease both the scarcity of phosphorus rock resources and water eutrophication worldwide. To date, although various kinds of reactor systems have been developed, supporting methods are required to control the struvite fines flushing out of the reactors. As an intrinsic property, aggregation is normally disregarded in the struvite crystallization process, although it is the key factor in final particle size and therefore guarantees phosphorus recovery efficiency. The present study developed a method to analyze the characteristics of struvite aggregates using fractal geometry, and the influence of operational parameters on struvite aggregation was evaluated. Due to its typical orthorhombic molecular structure, struvite particles are prone to crystallize into needle or rod shapes, and aggregate at the corners or edges of crystals. The determined fractal dimension(Dpf) of struvite aggregates was 1.52–1.31, with the corresponding range of equivalent diameter(d0.5) at 295.9–85.4 μm. Aggregates formed in relatively low phosphorus concentrations(3.0–5.0 mmol/L) and mildly alkaline conditions(pH 9.0–9.5) displayed relatively compact structures, large aggregate sizes and high aggregation strength. Increasing pH values led to continuous decrease of aggregate sizes, while the variation of Dpfwas insignificant. As to the aggregate evolution, fast growth in a short time followed by a long steady stage was observed. | Zhilong Ye Yin Shen Xin Ye Zhaoji Zhang Shaohua Chen Jianwen Shi | 2014 | Journal of Environmental Sciences2014，26，5： | 16 |
| 12 | Burden of colorectal cancer in China, 1990-2017: Findings from the Global Burden of Disease Study 2017显示文摘Objective: Our goal is to analyze the trend of colorectal cancer(CRC) regarding the death, incidence and prevalence rates over time, and to provide epidemiological knowledge basis for health policy revision by comparing data about fatal outcomes of CRC in 2017 to those data in 1990, which was extracted from the Global Burden of Disease(GBD).Methods: The time trend and changes of CRC burden from 1990 to 2017 were measured by using the methods and results from the Institute for Health Metrics and Evaluation(IHME) GBD 2017, based on the rates of death,incidence and prevalence.Results: The death rate of CRC is 13.24/100,000, accounting for 1.79% of total deaths in China in 2017. In1990, CRC ranked 21 st in all causes of death in China compared to its 11 th ranking in 2017. The death, incidence and prevalence rate of CRC were standardized by the age scale of the global population in 2010, the change of standardized death rate of CRC was not significant, from 9.33/100,000 in 1990 to 10.10/100,000 in 2017. The standardized incidence rate of CRC significantly increased from 12.18/100,000 in 1990 to 22.42/100,000 in 2017.The standardized prevalence rate of CRC significantly increased from 44.55/100,000 in 1990 to 118.40/100,000 in2017. The trend of the prevalence rate in both genders grow higher in 2017 compared to the 1990, resulting in141.6%, 209.8% and 189.0% for the studied three age groups(15-49, 50-69 and 70+ years old), respectively. The death rate increased in the age groups of 50-69 and 70+ years in both genders(8.6% and 31.0% respectively), in contrast to a decrease of death rate in the age group of 15-49 years old(-10.8%).Conclusions: China experienced a stunning increase in terms of incidence and prevalence rate of CRC from1990 to 2017. To decrease the burden of CRC, prevention and management of known risk factors should be promoted through national polices. | Jie Yin Zhigang Bai Jun Zhang Zhi Zheng Hongwei Yao Pengpeng Ye Jun Li Xin Gao Zhongtao Zhang | 2019 | Chinese Journal of Cancer Research2019，31，3： | 16 |
| 13 | Recent Progress Using High-throughput Sequencing Technologies in Plant Molecular Breeding显示文摘High-throughput sequencing is a revolutionary technological innovation in DNA sequencing.This technology has an ultra-low cost per base of sequencing and an overwhelmingly high data output.High-throughput sequencing has brought novel research methods and solutions to the research fields of genomics and post-genomics.Furthermore,this technology is leading to a new molecular breeding revolution that has landmark significance for scientific research and enables us to launch multi-level,multi-faceted,and multi-extent studies in the fields of crop genetics,genomics,and crop breeding.In this paper,we review progress in the application of high-throughput sequencing technologies to plant molecular breeding studies. | Qiang Gao Guidong Yue Wenqi Li Junyi Wang Jiaohui Xu Ye Yin | 2012 | Journal of Integrative Plant Biology2012，54，4： | 15 |
| 14 | Lymphocyte Subsets and Sister-chromatid Exchanges in the Students Exposed to Formaldehyde Vapor显示文摘The present report evaluates the effects of formaldehyde (FA) exposure on peripheral lymphocytes by using heth genetic and immunological parameters. Twenty-three non-smoking students in the study had inhalation exposure to 0.508 ±0. 299 mg/m3 of FA for a Period of 8 weeks (3h × 3 times each week) during anatomy classes. As for composition of lymphocyte subsets after FA exposare,significant increase was found in the percentage of CD19(B cells), while sighficant decrease was observed in CD3(total T cells), CD4(T helper-inducer cells), and CD8(T cytotoxic-suppressior cells) with a P<0 .01. Increase in the ratio of T-helper-inducer cells to T-cytotoxic-suppressor cells (T4 / T8) was also observed with statistical sighcance after exposure (P < 0.001). In the meanwhile,no significant difference (P > 0 .05) was reported between lymphocyte prolifendion rate and sisterchromatid exchange (SCE) at the exposure level and duration. It is suggested that the lymphocyte subsets may be most susceptible to the effects of FA, though a single immunological endpoint is rarely related with pathophysiological interpretation. | YING CHEN-JIANG YE XIAO-LEI XIE HONG YAN WEN-SHENG ZHAO MEI-YING XIA TONG AND YIN SHU-YI.(Department of Environmental Health, Tongji Medical University, Wuhan 430030, China Department of Public Health, Wenzhou Medical College, Wenzhou 317400, China Department of Anatomy,Tongji Medical University, Wuhan 430030, China) | 1999 | Biomedical and Environmental Sciences1999，12，2： | 15 |
| 15 | Lobaplatin inhibits growth of gastric cancer cells by inducing apoptosis显示文摘AIM:To assess the anti-cancer effect of lobaplatin on human gastric cancer cells,and to explore the underlying molecular mechanisms.METHODS:The human gastric cancer cell lines MKN-28,AGS and MKN-45 were used.The cytotoxicity of lobaplatin was detected using an MTS cell proliferation assay.Flow cytometry was used to detect cell apoptosis using Annexin V-FITC Apoptosis Detection Kit.The expression of apoptosis-regulated genes was examined at the protein level using Western blot.RESULTS:Lobaplatin inhibited the proliferation of human gastric cancer cells and induced apoptosis,which may be associated with the up-regulation of Bax expression,poly(ADP-ribose)polymerase(PARP)cleavage,p53 expression and the reduction of Bcl-2 expression.CONCLUSION:The cytotoxicity of lobaplatin may be due to its ability of inducing apoptosis of gastric cancer cells,which would support the potential use of lobaplatin for the therapy of gastric cancer. | Chu-Yang Yin Xiao-Lin Lin Lei Tian Ming Ye Xin-Ying Yang Xiu-Ying Xiao | 2014 | World Journal of Gastroenterology2014，20，46： | 13 |
| 16 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 17 | Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in mice显示文摘 | Li-qing WENG Wen-bin ZHANG Yong YE Pei-pei YIN Jie YUAN Xing-xu WANG Le KANG Sha-sha JIANG Jie-yun YOU Jian WU Hui GONG Jun-bo GE Yun-zeng ZOU | 2014 | Acta Pharmacologica Sinica2014，35，8： | 12 |
| 18 | Melatonin attenuates acute pancreatitis-associated lung injury in rats by modulating interleukin 22显示文摘AIM:To investigate whether therapeutic treatment with melatonin could protect rats against acute pancreatitis and its associated lung injury.METHODS:Seventy-two male Sprague-Dawley rats were randomly divided into three groups:the sham operation(SO),severe acute pancreatitis(SAP),and melatonin treatment(MT) groups.Acute pancreatitis was induced by infusion of 1 mL/kg of sodium taurocholate(4% solution) into the biliopancreatic duct.Melatonin(50 mg/kg) was administered 30 min before pancreatitis was induced,and the severity of pancreatic and pulmonary injuries was evaluated 1,4 and 8 h after induction.Serum samples were collected to measure amylase activities,and lung tissues were removed to measure levels of mRNAs encoding interleukin 22(IL-22) and T helper cell 22(Th22),as well as levels of IL-22.RESULTS:At each time point,levels of mRNAs encoding IL-22 and Th22 were significantly higher(P < 0.001) in the MT group than in the SAP group(0.526 ± 0.143 vs 0.156 ± 0.027,respectively,here and throughout,after 1 h;0.489 ± 0.150 vs 0.113 ± 0.014 after 4 h;0.524 ± 0.168 vs 0.069 ± 0.013 after 8 h,0.378 ± 0.134 vs 0.122 ± 0.015 after 1 h;0.205 ± 0.041 vs 0.076 ± 0.019 after 4 h;0.302 ± 0.108 vs 0.045 ± 0.013 after 8 h,respectively) and significantly lower(P < 0.001) in the SAP group than in the SO group(0.156 ± 0.027 vs 1.000 ± 0.010 after 1 h;0.113 ± 0.014 vs 1.041 ± 0.235 after 4 h;0.069 ± 0.013 vs 1.110 ± 0.213 after 8 h,0.122 ± 0.015 vs 1.000 ± 0.188 after 1 h;0.076 ± 0.019 vs 0.899 ± 0.125 after 4 h;0.045 ± 0.013 vs 0.991 ± 0.222 after 8 h,respectively).The mean pathological scores for pancreatic tissues in the MT group were significantly higher(P < 0.01) than those for samples in the SO group(1.088 ± 0.187 vs 0.488 ± 0.183 after 1 h;2.450 ± 0.212 vs 0.469 ± 0.242 after 4 h;4.994 ± 0.184 vs 0.513 ± 0.210 after 8 h),but were significantly lower(P < 0.01) than those for samples in the SAP group at each time point(1.088 ± 0.187 vs 1.969 ± 0.290 after 1 h;2.450 ± 0.212 vs 3.344 ± 0.386 after 4 h;4.994 ± 0.184 vs 6.981 ± 0.301 after 8 h).The severity of SAP increased significantly(P < 0.01) over time in the SAP group(1.088 ± 0.187 vs 2.450 ± 0.212 between 1 h and 4 h after inducing pancreatitis;and 2.450 ± 0.212 vs 4.994 ± 0.184 between 4 and 8 h after inducing pancreatitis).CONCLUSION:Melatonin protects rats against acute pancreatitis-associated lung injury,probably through the upregulation of IL-22 and Th22,which increases the innate immunity of tissue cells and enhances their regeneration. | Jia-Ping Huai Xue-Cheng Sun Meng-Jun Chen Yin Jin Xiao-Hua Ye Jian-Sheng Wu Zhi-Ming Huang | 2012 | World Journal of Gastroenterology2012，18，36： | 12 |
| 19 | A novel method for preparing and characterizing graphene nanoplatelets/aluminum nanocomposites显示文摘Graphene nanoplatelets/aluminum (GNPs/Al ) nanocomposites 用一个新奇二拍子的圆舞方法被制作。高分辨率传播电子显微镜( HRTEM ),拉曼,领域排放扫描电子显微镜学( FESEM ),X光检查衍射( XRD ),精力散X光检查光谱学(版本),版本印射,并且机械严峻的系统(山)被使用描绘微观结构和 GNPs/Al nanocomposites 的机械性质。GNP 同类地在 GNPs/Al nanocomposites 被驱散,并且介绍了好接口行为和微观结构特征。一个有害阶段,铝碳化物(Al4C3 ) ,没在 nanocomposite 在重要数量被观察。与纯铝相比,包含 GNP 的低卷部分的 GNPs/Al nanocomposites 的机械性质严厉地被改进。当 0.5 vol.% , 1.0 vol.% ,和 2.0 vol.% GNP 被加到铝矩阵时,分别地, GNPs/Al nanocomposites 的平均压缩力量是 297, 345,和 527 MPa 它显著地在原来的铝上增加了力量 330% ~ 586% 。 | Duosheng Li Yin Ye Xiaojun Liao Qing H. Qin | 2018 | Nano Research2018，11，3： | 11 |
| 20 | Expression of lens-related microRNAs in transparent infant lenses and congenital cataract显示文摘AIM:To identify the expression of lens-related micro RNAs(miRNAs)in the central epithelium of transparent infant lenses and congenital cataract. METHODS:Lens-related mi RNAs were retrieved from Pub Med database. The expression levels of these mi RNAs in transparent infant lenses and congenital cataract were determined by stem-loop reverse transcription-polymerase chain reaction(RT-PCR). mi Randa algorithm was used to predict the target genes of these differentially expressed mi RNAs. The target m RNA was validated.RESULTS:Six lens-related mi RNAs were retrieved from screening Pub Med database. The most abundant mi RNA in transparent infant lenses according to stem-loop RT-PCR was mi R-184. miR-182 was up-regulated in congenital cataract. Contrarily,miR-204 and miR-124 was down-regulated.mi R-204 exhibited a more significant decrease in expression than mi R-124. In addition,Meis2 was predicted to be the target of mi R-204 using mi Randa algorithm. mi R-204mimic/antagomir transfection experiments suggested the negative correlation between the expression of mi R-204 and Meis2.CONCLUSION:The expression levels of miR-182,miR-204 and mi R-124 differ between the central epithelium of transparent infant lens and congenital cataract,suggesting their involvement in the pathogenesis of congenital cataract. miR-204 may act via silencing Meis2 to regulate lens development and congenital cataract formation. | Chang-Rui Wu Min Ye Li Qin Yue Yin Cheng Pei | 2017 | International Journal of Ophthalmology(English edition)2017，10，3： | 11 |
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