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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Effects of nitrogen ion implantation on lily pollen germination and the distribution of the actin cytoskeleton during pollen germination显示文摘The effects of low energy nitrogen ion implantation on lily (Lilium davidii Duch.) pollen germination and the distribution of the actin cytoskeleton during pollen germination have been studied. Preliminary results showed that the ratio of pollen germination increased from (16.0±1.6)% to (27.0±2.1)% when implanted with nitrogen ions by 100 keV and a dose of 1013 ions/cm2. Further experiments were performed by staining the actin filaments in pollen with rhodamine-phalloidin and detected by using laser confocol microscopy. After hydration for 10 h, the actin filaments in ion implanted pollen grains tended to form thick bundles oriented in parallel or ring shape at the germinal furrow, indicating that the effect of nitrogen ion implantation on the germination of pollen might be mediated by reorganization of the actin cytoskeleton. | REN Haiyun HUANG Zhonglian CHEN Zhiling YUAN Ming LU Ting | 2000 | Chinese Science Bulletin2000，45，18： | 7 |
| 3 | Advances in the application of quantum dots in tumor markers investigation显示文摘Tumor markers have been of vital importance in cancer diagnosis,treatment and monitoring. However,the sen-sitivity of current tumor markers for early diagnosis is low,reducing the clinical usefulness of tumor markers. Quantum dots are new fluorescent nanoparticles with unique photophysical and chemical properties,thus having a great potential impact on the investigation of cancer pathogenesis,early diagnosis,targeted therapy,prognosis and monitoring,when combined with tumor markers. The current research is focused on the detection of specific tumor markers or molecules based on tangible carriers such as cells and tissues. One of the most promising clinical applications would be to explore the potential of this highly sensitive labeling technique for the detecting and imagining tumor markers in serum and other body fluids,where some progresses have already been made recently. How to detect early cancer based solely on invisible carriers would be the next step of quantum dots bio-probes in clinical use,so as to develop a new detection technique with greater sensitivity,specificity,rapidity and availability. | Chuang Chen Liangdong Chen Zhiling Zhang Yan Li | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，3： | 6 |
| 4 | Isolation, characterization and functional analysis of a cdc48 homologue from tobacco BY-2 cells显示文摘分裂酵母 Schizosaccharomyces pombe 被用来从可以在房间周期规定起作用的烟草 BY-2 房间识别基因。编码对酵母 CDC48 相应的蛋白质的 cDNA 被孤立,基因被指定为 NtCDC48。cDNA 包含为二个 twical ATPase 模块包括的 808 氨基酸的预言的蛋白质编码的一个开的读物框架(一 245-374 并且一 518-646 ) 。NtCDC48in 烟草 BY-2 房间的 Overexpression 在有丝分裂的索引以及到传播有丝分裂的锭子的形成导致了增加。NtCDC48-GFP 熔化蛋白质还通过 G1 无所不在地被散布到 M 阶段的家他们细胞的本地化与房间周期前进一起定期改变了的潜水艇。这些结果显示 NtCDC48 可以在 BY-2 房间在房间周期的规定起一个重要作用。 | CHEN Zhiling Yu Yi LIU Lina XIA Guixian | 2007 | Progress in Natural Science:Materials International2007，17，2： | 6 |
| 5 | Synthesis of chain-like MoS_2 nanoparticles in W/O reverse microemulsion and application in photocatalysis显示文摘Chain-like MoS2assemblies consisting of hexagonal MoS2nanoparticles(20-60 nm) have been successfully synthesized in a Triton X-100/cyclohexane/hexanol/water W/O reverse microemulsion in the presence of(NH 4)2MoS 4 as the molybdenum source and NH2OH·HCl as the reducing agent.The products were characterized by X-ray powder diffraction(XRD),transmission electron microscopy(TEM) and UV-vis diffuse reflectance absorption spectra.The influence of synthetic parameters such as acidity,water/oil ratio(0),aging time and annealing temperature on the formation of MoS2assemblies was investigated.TEM analysis showed that these synthetic factors played important roles in controlling the size of MoS2nanoparticles and the length of the chain-like MoS2assemblies.XRD analysis indicated that the well-crystallized MoS2nanoparticles could be obtained by annealing the precursors at 700 C for2h under a flow of N2atmosphere.In addition,the as-prepared chain-like MoS2nanoparticles exhibited excellent photocatalytic H2activity in Ru(bpy) 3 2+-MoS2-H2A three-component molecular systems under visible light irradiation. | LIU MeiYing LI XiaoQian XU ZhiLing LI BoNa CHEN LinLin SHAN NanNan | 2012 | Chinese Science Bulletin2012，57，30： | 6 |
| 6 | Characterization and pilot functional study of a root-specific MYB transcription factor of Arabidopsis显示文摘An MYB transcription factor (AtMYB305) of Arabidopsis was structurally characterized. The biochemical activity of the protein was tested and its in vivo function was preliminarily analyzed. AtMYB305 contains two imperfect repeats (R2, R3) in its DNA binding domain. Gel mobility shift assay demonstrated that GST-AtMYB305 fusion pro-tein bound specifically to the DNA fragment that included a consensus MYB recognition sequence (TAACTG). Overex-pression of AtMYB305 in the fission yeast caused the forma-tion of elongated cells with one condensed nucleus. Semi-quantitative RT-PCR analysis revealed that AtMYB305 was expressed specifically in the roots of Arabidopsis. | Dong Wang Lihong Li Zhiling Chen Guixian Xia | 2002 | Chinese Science Bulletin2002，47，4： | 4 |
| 7 | Fabrication of superstable gold nanorod-carbon nanocapsule as a molecule loading material显示文摘In this work, we fabricated a monodisperse nanocomposite by coating gold nanorods(Au NRs) with a layer of biocompatible, stable carbon, obtaining Au NR@Carbon core–shell nanocapsules, which without any functionalization could be used as a molecule loading material due to its high surface areas. In this system, the Au NR core had a high-absorption cross section for conversion of near-infrared light to heat, which could be explored for local hyperthermia. The carbon shell, which was biocompatible and stable even under concentrated acidic and alkaline conditions, was able to adsorb molecules with p–p interactions or electrostatic interactions. In comparison with Au NR@Si O2, Au NR@Carbon nanocapsules demonstrate the following merits:(1) simple and green synthesis method,(2) far more stable with respect to high-temperature stability and(3) larger molecule loading capacity,which indicate great potential in the biomedical applications. | Wei Gao Xuewei Wang Huanhuan Fan Zhiling Song Xiaofang Lai Zhuo Chen Weihong Tan | 2015 | Science Bulletin2015，60，12： | 3 |
| 8 | Effectiveness of moxibustion alone on lumbar disc herniation:a Meta-analysis of randomized controlled trials显示文摘OBJECTIVE:To evaluate the available evidence from randomized controlled trials(RCTs)of moxibustion alone for lumbar disc herniation(LDH)treatment.METHODS:A systematic search of 10 databases(until August 30,2021)was used to identify studies that reported the response rate,visual analogue scale(VAS)score,Japanese Orthopedic Association(JOA)score,and Oswestry Disability Index(ODI)score.Study selection and data extraction were independently performed by two reviewers.Cochrane criteria for risk of bias were used to assess the methodological quality of the trials.The Grading of Recommendations Assessment,Development,and Evaluation Methodology(GRADE)were also used to test the quality of the result evidence.RESULTS:Nineteen RCTs,including 1888 patients,met the inclusion criteria.Five studies showed no difference between moxibustion and acupuncture on response rate[risk ratio(RR)=1.07,95%CI(0.98,1.16),P=0.11].Meanwhile,six studies suggested that there is no significant difference between moxibustion and acupuncture on VAS score[mean difference(MD)=-0.43,95%CI(-0.91,0.05),P=0.08].Eight studies implied that there is no significant difference between moxibustion and acupuncture on JOA score[MD=0.84,95%CI(-1.27,2.96),P=0.44].Two studies indicated that moxibustion may have equivalent effects for treating LDH in the VAS score in comparison with drug therapy[MD=-1.16,95%CI(-2.63,0.31),P=0.12].The evidence level of results was determined to be very low to low.CONCLUSIONS:Based on the existing evidence,moxibustion may not be suitable for treating LDH alone,but it may be applied as an adjuvant treatment.Furthermore,well-designed RCTs with high quality and larger samples are still needed to evaluate the efficacy and safety of moxibustion alone for LDH treatment. | YAO Yao ZHAO Zhenni CHEN Fengqin LENG Yufei PANG Xiangtian XU Xiao SUN Zhiling | 2023 | Journal of Traditional Chinese Medicine2023，43，1： | 3 |
| 9 | Monolithic superaligned carbon nanotube composite with integrated rewriting, actuating and sensing multifunctions显示文摘Multifunctionality has become a mainstream trend in the development of smart clothing and flexible wearable devices.Nevertheless,it remains a grand challenge to realize multiple functions,such as sensing,actuating and information displaying,in one single multifunctional material.Here,we present one multifunctional integration strategy by employing monolithic superaligned carbon nanotube(SACNT)composite,which can leverage three different functions through fascinating features of SACNT.Firstly,by using thermochromic dye as a color-memorizing component and SACNT as a photothermal converter,the composite film can be utilized as a flexible rewritable medium.It demonstrates excellent rewriting performances(reversibility>500 times).Secondly,the composite can be tailored to fabricate an actuator,when its length direction is along the SACNT alignment.The actuator shows a bending-morphing when illuminated by near-infrared light.The morphing is attributed to a large difference in volume change between the SACNT and polymer when the SACNT absorbs the optical energy and heats the composite.Thirdly,owing to the unique anisotropy of SACNT,the composite is easily to be stretched in the direction perpendicular to the SACNT alignment,accompanied by a change in electrical resistance.Therefore,the composite is able to be used as a strain sensor.Finally,we fabricate two smart wearable devices to demonstrate the applications,which realize the functions of human-motion detection(sensing)and rewritable information display(rewriting)simultaneously.This multifunctional SACNT composite is expected to have potential applications in the next-generation wearable devices,smart clothing and so on. | Peidi Zhou Wei Zhang Luzhuo Chen Jian Lin Zhiling Luo Changhong Liu Kaili Jiang | 2021 | Nano Research2021，14，7： | 2 |
| 10 | WiFi CSI Gesture Recognition Based on Parallel LSTM-FCN Deep Space-Time Neural Network显示文摘In this study,we developed a system based on deep space–time neural networks for gesture recognition.When users change or the number of gesture categories increases,the accuracy of gesture recognition decreases considerably because most gesture recognition systems cannot accommodate both user differentiation and gesture diversity.To overcome the limitations of existing methods,we designed a onedimensional parallel long short-term memory–fully convolutional network(LSTM–FCN)model to extract gesture features of different dimensions.LSTM can learn complex time dynamic information,whereas FCN can predict gestures efficiently by extracting the deep,abstract features of gestures in the spatial dimension.In the experiment,50 types of gestures of five users were collected and evaluated.The experimental results demonstrate the effectiveness of this system and robustness to various gestures and individual changes.Statistical analysis of the recognition results indicated that an average accuracy of approximately 98.9% was achieved. | Zhiling Tang Qianqian Liu Minjie Wu Wenjing Chen Jingwen Huang | 2021 | China Communications2021，18，3： | 2 |
| 11 | Stable and unique graphitic Raman internal standard nanocapsules for surface-enhanced Raman spectroscopy quantitative analysis显示文摘Graphitic nanomaterials 有的独特、强壮、稳定的拉曼颤动广泛地在化学和 biomedicine 被使用了。然而,作为内部标准(ISs ) 利用他们改进提高表面的拉曼的精确性光谱学(重量的单位) 分析没被尝试。此处,我们报导设计一唯一是由很多金牌组成的 nanostructure nanoparticles (AuNPs ) 在 multilayered graphitic 上装饰了磁性的 nanocapsules (AGN ) 确定 analyte 并且消除与传统的 ISs 联系的问题。AGN 从 graphitic 部件表明了一个独特拉曼乐队,它在拉曼是局部性的 biomolecules 的沉默区域,没有任何背景干扰,使他们成为理想为量的拉曼分析。是从也显示的 AGN 的信号优异稳定性,甚至在严厉条件下面。与装饰 AuNPs 的改进, AGN nanostructures 极大地改进了重量的单位,特别地量的错误源于收集损失的排除和 analytes 的不一致的分发的量的精确性。AGN 进一步为房间染色和拉曼成像被利用,并且他们在 biomedicine 为应用显示出大诺言。 | Yuxiu Zou Long Chen Zhiling Song Ding Ding Yiqin Chen Yiting Xu Shanshan Wang Xiaofang Lai Yin Zhang Yang Sun Zhuo Chen Weihong Tan | 2016 | Nano Research2016，9，5： | 2 |
| 12 | Effects of hydrophilic room temperature ionic liquid 1 butyl-3-methy limidazolium tetrafluoroborate on direct electrochemistry and bioelectrocatalysis of heme proteins entrapped in agarose hy drogel films显示文摘 | Wang Shengfu Chen Ting Zhang Zhiling | 2007 | Electrochemistry Communications2007，9，7： | 1 |
| 13 | Redox responsive nanoparticle encapsulating black phosphorus quantum dots for cancer theranostics显示文摘Effective cancer treatment puts high demands for cancer theranostics.For cancer diagnostics,optical coherence tomography(OCT)technology(including photothermal optical coherence tomography(PT-OCT))has been widely investigated since it induces changes in optical phase transitions in tissue through environmental changes(such as temperature change for PT-OCT).In this report,redox responsive nanoparticle encapsulating black phosphorus quantum dots was developed as a robust PT-OCT agent.Briefly,black phosphorus quantum dots(BPQDs)are incorporated into cysteine-based poly-(disulfide amide)(Cys-PDSA)to form stable and biodegradable nanoagent.The excellent photothermal feature allows BPQD/Cys-PDSA nanoparticles(NPs)as a novel contrast agent for high-resolution PT-OCT bioimaging.The Cys-PDSA can rapidly respond to glutathione and effectively release BPQDs and drugs in vitro and in vivo.And the obtained NPs exhibit excellent near-infrared(NIR)photothermal transduction efficiency and drug delivery capacity that can serve as novel therapeutic platform,with very low chemo drug dosage and side effects.Both of the polymer and BPQD are degradable,indicating this platform is a rare PT-OCT agent that is completely biodegradable.Overall,our research highlights a biodegradable and biocompatible black phosphorus-based nanoagent for both cancer diagnosis and therapy. | Haolin Chen Zhiming Liu Bo Wei Jun Huang Xinru You Jingyang Zhang Zhiling Yuan Zhilie Tang Zhouyi Guo Jun Wu | 2021 | Bioactive Materials2021，6，3： | 1 |
| 14 | Direct elec- trochemistry and eleetrocatalysis of heme proteins entrapped in agarose hydrogel films in room temperature ionic liquids显示文摘 | Wang Shengfu Chen Ting Zhang Zhiling | 2005 | Langmuir2005，21，20： | 1 |
| 15 | On quasipolar rings 显示文摘 | Ying Zhiling Chen Jianlong | 2012 | Algebra Colloq2012，19，4： | 1 |
| 16 | Untangling the increasing elevation of cropland in China from 1980 to 2020显示文摘The redistribution of cropland to areas of higher elevation in China has long affected agricultural development and could seriously threaten national food security.However,there is currently little research reported on this phenomenon,which may limit the improvement of cropland protection policies.To fill this gap,we analyzed the spatiotemporal characteristics and driving mechanisms of increased cropland elevation in China during the period 1980-2020.The average cropland elevation in China increased by 17.38 m from 1980 to 2020.The gravity center of the cropland area and average cropland elevation in China moved to the northwest by 81.00 km and 51.47 km,respectively.The amount of newly added cropland in eastern China was less than that in occupied regions;however,the average elevation of newly added cropland was greater than that of occupied cropland,though the opposite phenomenon was observed in western China.Slope,temperature,land-use intensity,population,economic density,and distance to main roads were the main factors affecting the redistribution of cropland to areas of higher elevation.The effects of these major driving factors exhibited significant spatial and temporal variations in China.This study has important implications for improving existing cropland protection policies and developing more effective cropland management systems in China. | Wanxu Chen Liyan Yang Jie Zeng Jintao Yuan Tianci Gu Zhiling Liu | 2023 | Geography and Sustainability2023，4，4： | 1 |
| 17 | In situ spectral imaging of marker proteins in gastric cancer with near-infrared and visible quantum dots probes显示文摘 | Yue He Hao Xu Chuang Chen Jun Peng Hongwu Tang Zhiling Zhang Yan Li Daiwen Pang | 2011 | Talanta2011，，1： | 1 |
| 18 | A linear voltage regulator for PLL in SOC applieation显示文摘 | Chen Jia Qin Zhiling | 2006 | IEEE Journal of Solid-state Circuits2006，1，： | 1 |
| 19 | Comparison of rawand processed Radix Polygoni Multiflori ( Heshouwu) by high per-formance liquid chromatography and mass spectrometry 显示文摘 | Liang Zhi tao Chen Hubiao Yu Zhiling | 2010 | ChinMed2010，5，： | 1 |
| 20 | Synthesis and characterization of water borne intumescent fire retard- ant varnish based on phosphate resin acid cold cured amino resin显示文摘 | MA Zhiling WANG Jiangjiang CHEN Shu | 2012 | Progress in Organic Coatings2012，，74： | 1 |
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