|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Endothelial cells-targeted soluble human Delta-like 4 suppresses both physiological and pathological ocular angiogenesis显示文摘Due to its essential roles in angiogenesis, Notch pathway has emerged as an attractive target for the treatment of pathologic angiogenesis. Although both activation and blockage of Notch signal can impede angiogenesis, activation of Notch signal may be more promising because it was shown that long-term Notch signal blockage resulted in vessel neoplasm. However, an in vivo deliverable Notch ligand with highly efficient Notch-activating capacity has not been developed. Among all the Notch ligands, Delta-like4(Dll4) is specifically involved in angiogenesis. In this study, we generated a novel soluble Notch ligand h D4 R, which consists of the Delta-Serrate-Lag-2 fragment of human Dll4 and an arginine-glycine-aspartate(RGD) motif targeting endothelial cells(ECs). We demonstrated that h D4 R could bind to ECs through its RGD motif and effectively triggered Notch signaling in ECs. Further, we confirmed that h D4 R could suppress angiogenesis in vitro as manifested by network formation assay and sprouting assay. More importantly, h D4 R efficiently repressed neonatal retinal angiogenesis and laser-induced choroidal neovascularization(CNV) as well in vivo. In conclusion, we have developed an in vivo deliverable Notch ligand h D4 R, which suppresses angiogenesis both in vitro and in vivo, thus providing a new approach to tackle excessive angiogenesis relevant disease such as CNV. | YAN XianChun YANG ZiYan CHEN Yan LI Na WANG Li DOU GuoRui LIU Yuan DUAN JuanLi FENG Lei DENG SanMing HAN Hua ZHANG Ping | 2015 | Science China(Life Sciences)2015，58，5： | 5 |
| 2 | pH- and H_(2)O_(2)-sensitive drug delivery system based on sodium xanthate:Dual-responsive supramolecular vesicles from one functional group显示文摘Nano-drug delivery systems with multiple stimulus-responsive capabilities have superior response performance and efficient drug release.Nevertheless,it is sophisticated to construct multiple stimulus-responsive systems where the two or more functional groups need to be introduced simultaneously.Xanthate,one functional group with pH and H2O2 stimulus responsiveness,has significant potential applications for building dual-responsive drug delivery system.Herein,we present a novel dual stimuli-responsive supramolecular drug delivery system by using sodium xanthate derivative(SXD)as guest molecule and quaternary ammonium capped pillar[5]arene(QAP5)as host molecule through host-guest interaction on the basis of electrostatic interaction.The amphiphile QAP5⊃SXD could self-assemble into vesicles to efficiently load the anti-cancer drug DOX.The experimental results showed that QAP5⊃SXD nanoparticles could achieve efficient drug delivery and controlled release in the tumor microenvironment.Cytotoxicity experiments proved that DOX@QAP5⊃SXD nanoparticles could significantly improve the anticancer efficiency of free DOX on cancer cells.The present study provides an efficient strategy to develop supramolecular nanocarriers with dual-responsiveness in one functional group for controlled drug release. | Ziyan Shen Ning Ma Feng Wang Jiaming Ren Chenxi Hou Shuang Chao Yuxin Pei Zhichao Pei | 2022 | Chinese Chemical Letters2022，33，10： | 1 |
| 3 | Silver-catalyzed decarboxylative C-H functionalization of cyclic aldimines with aliphatic carboxylic acids显示文摘Silver-catalyzed decarboxylative C–H alkylation of cyclic aldimines with abundant aliphatic carboxylic acids has been realized under mild reaction conditions generating the corresponding products in moderate to good yields(32%–91%).In addition,a gram-scale reaction,late-stage modification of drug,synthetic transformation of the product,and further application of the catalytic strategy were also performed.Preliminary studies indicate that the reaction undergoes a radical process. | Jingjing Wang Xue Liu Ziyan Wu Feng Li Tingting Qin Siyuan Zhang Weiguang Kong Lantao Liu | 2021 | Chinese Chemical Letters2021，32，9： | 1 |
| 4 | The Promotion of Deep Integration of Modern Service Industry and Advanced Manufacturing Industry显示文摘Industry integration is a significant trend in modern economic system and industrial development.It has been proved by both theory and practice that choosing the path of integrated development is the inevitable course for expanding the modern industrial system,extending the industry boundary and improving industry competitiveness.The modern service industry and advanced manufacturing industry with the core feature of innovation and development under the leadership of technology need to satisfy the high standard and requirement of development quality,comprehensive competitiveness,demand shift and green development.Under the development trend of“integration of two industries”,profound changes have taken place in the status,industrial form and agglomeration mode of producer services.New models are emerging in the integrated development of advanced manufacturing and modern service industries in the aspects of innovation,input,output,demand and region.To accelerate the in-depth development of“integration of two industries”,under the precondition of respecting the choice of market supply and demand and industrial development trends,the government needs to exert targeted force in supporting key integrated areas,organizing working mechanisms orderly and standardizing market access regulations,and fostering diversified integration development entities and establishing talent systems. | Ziyan Xu Xiaoxu Feng Jiechang Xia | 2021 | China Finance and Economic Review2021，10，1： | 1 |
| 5 | Iterative technique for circular thin plates on Gibson elastic foundation using modified Vlasov model显示文摘In this paper, to investigate the influence of soil inhomogeneity on the bending of circular thinplates on elastic foundations, the static problem of circular thin plates on Gibson elasticfoundation is solved using an iterative method based on the modified Vlasov model. On the basisof the principle of minimum potential energy, the governing differential equations and boundaryconditions for circular thin plates on modified Vlasov foundation considering the characteristics ofGibson soil are derived. The equations for the attenuation parameter in bending problem are alsoobtained, and the issue of unknown parameters being difficult to determine is solved using theiterative method. Numerical examples are analyzed and the results are in good agreement withthose form other literatures. It proves that the method is practical and accurate. Theinhomogeneity of modified Vlasov foundations has some influence on the deformation andinternal force behavior of circular thin plates. The effects of various parameters on the bending ofcircular plates and characteristic parameters of the foundation are discussed. The modified modelfurther enriches and develops the elastic foundations. Relevant conclusions that are meaningful toengineering practice are drawn. | Feng Yue Ziyan Wu Haifeng Yang Mengying Li | 2019 | Theoretical & Applied Mechanics Letters2019，9，5： | 1 |
| 6 | Metal-free synthesis of N-sulfonylformamidines via skeletal reconstruction of sulfonyl oximonitriles显示文摘We developed for the first time an unprecedented domino reaction of sulfonyl oximonitriles with secondary amines to streamline the synthesis of N-sulfonylformamidines in decent to high yields under mild reaction conditions.In addition,scale-up experiments and late-stage functionalization of drugs were also performed.Preliminary studies indicate that the loss of a cyano-/benzyloxy-group and a sulfonyl migration process are involved in this reaction. | Feng Li Ziyan Wu Jingjing Wang Siyuan Zhang Jiaxin Yu Zhen Yuan Jingya Liu Renzeng Shen Yao Zhou Lantao Liu | 2022 | Organic Chemistry Frontiers2022，9，3： | 0 |
| 7 | Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO显示文摘The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector.Some of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator detectors.In this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/g.With ten years of data acquisition,approximately 60,000 signal and 30,000 background events are expected.This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework.IfDelta m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith angle.Moreover,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment. | Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera Daojin Hong YuenKeung Hor Shaojing Hou Yee Hsiung Bei-Zhen Hu Hang Hu Jianrun Hu Jun Hu Shouyang Hu Tao Hu Zhuojun Hu Chunhao Huang Guihong Huang Hanxiong Huang Qinhua Huang Wenhao Huang Xingtao Huang Yongbo Huang Jiaqi Hui Wenju Huo Cédric Huss Safeer Hussain Antonio Insolia Ara Ioannisian Daniel Ioannisyan Roberto Isocrate Kuo-Lun Jen Xiaolu Ji Xingzhao Ji Huihui Jia Junji Jia Siyu Jian Di Jiang Xiaoshan Jiang Ruyi Jin Xiaoping Jing Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Kampmann Li Kang Michael Karagounis Narine Kazarian Amir Khan Waseem Khan Khanchai Khosonthongkee Patrick Kinz Denis Korablev Konstantin Kouzakov Alexey Krasnoperov Svetlana Krokhaleva Zinovy Krumshteyn Andre Kruth Nikolay Kutovskiy Pasi Kuusiniemi Tobias Lachenmaier Cecilia Landini Sébastien Leblanc Frederic Lefevre Liping Lei Ruiting Lei Rupert Leitner Jason Leung Demin Li Fei Li Fule Li Haitao Li Huiling Li Jiaqi Li Jin Li Kaijie Li Mengzhao Li Nan Li Nan Li Qingjiang Li Ruhui Li Shanfeng Li Shuaijie Li Tao Li Weidong Li Weiguo Li Xiaomei Li Xiaonan Li Xinglong Li Yi Li Yufeng Li Zhibing Li Ziyuan Li Hao Liang Hao Liang Jingjing Liang Jiajun Liao Daniel Liebau Ayut Limphirat Sukit Limpijumnong Guey-Lin Lin Shengxin Lin Tao Lin Jiajie Ling Ivano Lippi Fang Liu Haidong Liu Hongbang Liu Hongjuan Liu Hongtao Liu Hu Liu Hui Liu Jianglai Liu Jinchang Liu Min Liu Qian Liu Qin Liu Runxuan Liu Shuangyu Liu Shubin Liu Shulin Liu Xiaowei Liu Yan Liu Alexey Lokhov Paolo Lombardi Claudio Lombardo Kai Loo Chuan Lu Haoqi Lu Jingbin Lu Junguang Lu Shuxiang Lu Xiaoxu Lu Bayarto Lubsandorzhiev Sultim Lubsandorzhiev Livia Ludhova Fengjiao Luo Guang Luo Pengwei Luo Shu Luo Wuming Luo Vladimir Lyashuk Qiumei Ma Si Ma Xiaoyan Ma Xubo Ma Jihane Maalmi Yury Malyshkin Fabio Mantovani Francesco Manzali Xin Mao Yajun Mao Stefano MMari Filippo Marini Sadia Marium Cristina Martellini Gisele Martin-Chassard Agnese Martini Davit Mayilyan Axel Müller Ints Mednieks Yue Meng Anselmo Meregaglia Emanuela Meroni David Meyhöfer Mauro Mezzetto Jonathan Miller Lino Miramonti Salvatore Monforte Paolo Montini Michele Montuschi Nikolay Morozov Pavithra Muralidharan Massimiliano Nastasi Dmitry VNaumov Elena Naumova Igor Nemchenok Alexey Nikolaev Feipeng Ning Zhe Ning Hiroshi Nunokawa Lothar Oberauer Juan Pedro Ochoa-Ricoux Alexander Olshevskiy Domizia Orestano Fausto Ortica Hsiao-Ru Pan Alessandro Paoloni Nina Parkalian Sergio Parmeggiano Teerapat Payupol Yatian Pei Nicomede Pelliccia Anguo Peng Haiping Peng Frédéric Perrot Pierre-Alexandre Petitjean Fabrizio Petrucci Luis Felipe Piñeres Rico Oliver Pilarczyk Artyom Popov Pascal Poussot Wathan Pratumwan Ezio Previtali Fazhi Qi Ming Qi Sen Qian Xiaohui Qian Hao Qiao Zhonghua Qin Shoukang Qiu Muhammad Rajput Gioacchino Ranucci Neill Raper Alessandra Re Henning Rebber Abdel Rebii Bin Ren Jie Ren Taras Rezinko Barbara Ricci Markus Robens Mathieu Roche Narongkiat Rodphai Aldo Romani Bedřich Roskovec Christian Roth Xiangdong Ruan Xichao Ruan Saroj Rujirawat Arseniy Rybnikov Andrey Sadovsky Paolo Saggese Giuseppe Salamanna Simone Sanfilippo Anut Sangka Nuanwan Sanguansak Utane Sawangwit Julia Sawatzki Fatma Sawy Michaela Schever Jacky Schuler Cédric Schwab Konstantin Schweizer Dmitry Selivanov Alexandr Selyunin Andrea Serafini Giulio Settanta Mariangela Settimo Muhammad Shahzad Vladislav Sharov Gang Shi Jingyan Shi Yongjiu Shi Vitaly Shutov Andrey Sidorenkov FedorŠimkovic Chiara Sirignano Jaruchit Siripak Monica Sisti Maciej Slupecki Mikhail Smirnov Oleg Smirnov Thiago Sogo-Bezerra Julanan Songwadhana Boonrucksar Soonthornthum Albert Sotnikov Ondrej Sramek Warintorn Sreethawong Achim Stahl Luca Stanco Konstantin Stankevich DušanŠtefánik Hans Steiger Jochen Steinmann Tobias Sterr Matthias Raphael Stock Virginia Strati Alexander Studenikin Gongxing Sun Shifeng Sun Xilei Sun Yongjie Sun Yongzhao Sun Narumon Suwonjandee Michal Szelezniak Jian Tang Qiang Tang Quan Tang Xiao Tang Alexander Tietzsch Igor Tkachev Tomas Tmej Konstantin Treskov Andrea Triossi Giancarlo Troni Wladyslaw Trzaska Cristina Tuve Stefan van Waasen Johannes van den Boom Guillaume Vanroyen Nikolaos Vassilopoulos Vadim Vedin Giuseppe Verde Maxim Vialkov Benoit Viaud Cristina Volpe Vit Vorobel Lucia Votano Pablo Walker Caishen Wang Chung-Hsiang Wang En Wang Guoli Wang Jian Wang Jun Wang Kunyu Wang Lu Wang Meifen Wang Meng Wang Ruiguang Wang Siguang Wang Wei Wang Wenshuai Wang Xi Wang Xiangyue Wang Yangfu Wang Yaoguang Wang Yi Wang Yifang Wang Yuanqing Wang Yuman Wang Zhe Wang Zheng Wang Zhimin Wang Zongyi Wang Apimook Watcharangkool Lianghong Wei Wei Wei Yadong Wei Liangjian Wen Christopher Wiebusch Steven Chan-Fai Wong Bjoern Wonsak Diru Wu Fangliang Wu Qun Wu Wenjie Wu Zhi Wu Michael Wurm Jacques Wurtz Christian Wysotzki Yufei Xi Dongmei Xia Yuguang Xie Zhangquan Xie Zhizhong Xing Benda Xu Donglian Xu Fanrong Xu Jilei Xu Jing Xu Meihang Xu Yin Xu Yu Xu Baojun Yan Xiongbo Yan Yupeng Yan Anbo Yang Changgen Yang Huan Yang Jie Yang Lei Yang Xiaoyu Yang Yifan Yang Haifeng Yao Zafar Yasin Jiaxuan Ye Mei Ye Ugur Yegin Frédéric Yermia Peihuai Yi Xiangwei Yin Zhengyun You Boxiang Yu Chiye Yu Chunxu Yu Hongzhao Yu Miao Yu Xianghui Yu Zeyuan Yu Chengzhuo Yuan Ying Yuan Zhenxiong Yuan Ziyi Yuan Baobiao Yue Noman Zafar Andre Zambanini Pan Zeng Shan Zeng Tingxuan Zeng Yuda Zeng Liang Zhan Feiyang Zhang Guoqing Zhang Haiqiong Zhang Honghao Zhang Jiawen Zhang Jie Zhang Jingbo Zhang Peng Zhang Qingmin Zhang Shiqi Zhang Tao Zhang Xiaomei Zhang Xuantong Zhang Yan Zhang Yinhong Zhang Yiyu Zhang Yongpeng Zhang Yuanyuan Zhang Yumei Zhang Zhenyu Zhang Zhijian Zhang Fengyi Zhao Jie Zhao Rong Zhao Shujun Zhao Tianchi Zhao Dongqin Zheng Hua Zheng Minshan Zheng Yangheng Zheng Weirong Zhong Jing Zhou Li Zhou Nan Zhou Shun Zhou Xiang Zhou Jiang Zhu Kejun Zhu Honglin Zhuang Liang Zong Jiaheng Zou | 2021 | Chinese Physics C2021，45，2： | 0 |
| 8 | Fast modeling of gravity gradients from topographic surface data using GPU parallel algorithm显示文摘The gravity gradient is a secondary derivative of gravity potential,containing more high-frequency information of Earth’s gravity field.Gravity gradient observation data require deducting its prior and intrinsic parts to obtain more variational information.A model generated from a topographic surface database is more appropriate to represent gradiometric effects derived from near-surface mass,as other kinds of data can hardly reach the spatial resolution requirement.The rectangle prism method,namely an analytic integration of Newtonian potential integrals,is a reliable and commonly used approach to modeling gravity gradient,whereas its computing efficiency is extremely low.A modified rectangle prism method and a graphical processing unit(GPU)parallel algorithm were proposed to speed up the modeling process.The modified method avoided massive redundant computations by deforming formulas according to the symmetries of prisms’integral regions,and the proposed algorithm parallelized this method’s computing process.The parallel algorithm was compared with a conventional serial algorithm using 100 elevation data in two topographic areas(rough and moderate terrain).Modeling differences between the two algorithms were less than 0.1 E,which is attributed to precision differences between single-precision and double-precision float numbers.The parallel algorithm showed computational efficiency approximately 200 times higher than the serial algorithm in experiments,demonstrating its effective speeding up in the modeling process.Further analysis indicates that both the modified method and computational parallelism through GPU contributed to the proposed algorithm’s performances in experiments. | Xuli Tan Qingbin Wang Jinkai Feng Yan Huang Ziyan Huang | 2021 | Geodesy and Geodynamics2021，12，4： | 0 |
| 9 | Targeted screening of an anti-inflammatory polypeptide from Rhopilema esculentum Kishinouye cnidoblasts and elucidation of its mechanism in alleviating ulcerative colitis based on an analysis of the gut microbiota and metabolites显示文摘Ulcerative colitis(UC)is a recurrent inflammatory bowel disease that imposes a severe burden on families and society.In recent years,exploiting the potential of marine bioactive peptides for the treatment of diseases has become a topic of intense research interest.This study revealed the mechanism underlying the protective effect of the dominant polypeptide PKKVV(Pro-Lys-Lys-Val-Val)of Rhopilema esculentum cnidoblasts against DSS-induced UC through a combined analysis of the metagenome and serum metabolome.Specifically,the polypeptide composition of R.esculentum cnidoblasts was determined by matrix-assisted laser desorption ionization time-of-flight mass spectrometry(MALDI-TOF/TOF-MS).Molecular docking showed that the dominant peptide PKKVV could bind better with tumor necrosis factor-α(TNF-α)than the original ligand.Subsequent animal experiments suggested that PKKVV could modulate disorganized gut microorganisms in mice with UC;affect serum metabolites through the arachidonic acid,glycerophospholipid and linoleic acid metabolism pathways;and further alleviate UC symptoms.This study provides a reference for the comprehensive development of marine bioactive substances and nonpharmaceutical treatments for UC. | Ziyan Wang Qiuyue Shi Ying Feng Jiaojiao Han Chenyang Lu Jun Zhou Zhonghua Wang Xiurong Su | 2024 | Food Science and Human Wellness2024，13，3： | 0 |
| 10 | Localization and Degree of Damage Based on Relative Curvature Difference and Frequency Perturbation显示文摘This study proposed a damage identification method compared with the existing ones,based on relative curvature difference and frequency perturbation theory,showing sensitivity to local damage by changes in the curvature mode and high recognition accuracy of frequencies.Considering the relative curvature difference as a damage index,numerical simulation is used for a simply supported beam under single and multiple damage conditions for different damage degrees.The damage is located according to the curvature mode curves,and the damage degree is qualitatively determined.Based on the perturbation theory,the damage equations are established by the changes between frequencies before and after damage,and the damage localization and degree are verified and determined.Effectiveness of the proposed method for identifying damage at different conditions is numerically investigated.This method potentially promotes the development of damage identification of beam structures. | Mengying Li Ziyan Wu Haifeng Yang Feng Yue | 2020 | Acta Mechanica Solida Sinica2020，33，2： | 0 |
| 11 | Soil microbiome mediated nutrients decline during forest degradation process显示文摘Degradation succession in forests is an important and serious land use/cover change problem in ecology,and during these processes soil microbial communities mediate the recycling of most important nutrients.To reveal the effect of degradation succession processes on soil microbial community diversity,structure,and species interrelationships,we collected abundant samples(21 per vegetation type)in broad-leaved forest,coniferous forest,and meadow to observe the microbial community dynamics.The results showed that diversity and structure of soil prokaryotic and fungal communities responded differently to different forest degradation processes,diversity of soil microbial communities increased during degradation processes.Soil microbial communities abundance changes may indicate that prokaryotic communities showed a living strategies change as an ecological adaption to harsh conditions during forest degradation process.While for fungal communities,their abundance changes may indicate that environmental selection pressure and plant selectivity during forest degradation process.Changes in soil prokaryotic communities and fungal communities were both correlated with soil carbon and nitrogen loss.The soil microbial interaction network analysis indicated more complex species interrelationships formed due to the loss of soil nutrients during degradation succession processes,suggesting soil microbial communities might form more complex and stable networks to resist the external disturbance of soil nutrient loss.All results suggested soil microorganisms,including bacteria,archaea and fungi,all involved in the soil nutrient decline during the forest degradation process. | Yangying Liu Shang Wang Zhujun Wang Zhaojing Zhang Huayu Qin Ziyan Wei Kai Feng Shuzhen Li Yueni Wu Huaqun Yin Hui Li Ye Deng | 2019 | Soil Ecology Letters2019，1，1： | 0 |
| 12 | Recent progress in theranostic microbubbles显示文摘Ultrasonography is an important complement to clinical diagnosis,and the application of microbubbles effectively improved diagnostic accuracy in echography.In scientific research,the sizes of microbubbles range from nanometers to microns.By optimizing the fabrication process,bubble sizes and ultrasound parameters,microbubbles can also be used for drug delivery and therapeutic monitoring.In this review,we summarize the recent advances in the diagnosis and treatment of microbubbles according to their different components.Modification of microbubble shells allows for more accurate imaging and detection and the combined utilization of US-targeted MB destruction(UTMD)allows for non-invasive,precise and targeted delivery of drug molecules to pathological tissues.These features pave the way for the emerge of theranostic microbubbles by combination of functional compositions and the application of multifunctional materials.Theranostic microbubbles allow for the simultaneous process of diagnosis,visualization of drug delivery and therapeutic monitoring.Ultimately,theranostic microbubbles are promising in clinical practice and would enhance contrast-enhanced US(CEUS)to a new qualitative level. | Ziyao Wang Ziyan Feng Fangxue Du Xi Xiang Xinyi Tang Li Qiu Zhiyong Qian | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员