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| 1 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 2 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 3 | Chip-scale broadband spectroscopic chemical sensing using an integrated supercontinuum source in a chalcogenide glass waveguide显示文摘On-chip spectroscopic sensors have attracted increasing attention for portable and field-deployable chemical detection applications. So far, these sensors largely rely on benchtop tunable lasers for spectroscopic interrogation. Large footprint and mechanical fragility of the sources, however, preclude compact sensing system integration. In this paper, we address the challenge through demonstrating, for the first time to our knowledge, a supercontinuum source integrated on-chip spectroscopic sensor, where we leverage nonlinear Ge_(22)Sb_(18)Se_(60) chalcogenide glass waveguides as a unified platform for both broadband supercontinuum generation and chemical detection. A home-built, palm-sized femtosecond laser centering at 1560 nm wavelength was used as the pumping source. Sensing capability of the system was validated through quantifying the optical absorption of chloroform solutions at 1695 nm. This work represents an important step towards realizing a miniaturized spectroscopic sensing system based on photonic chips. | QINGYANG DU ZHENGQIAN LUO HUIKAI ZHONG YIFEI ZHANG YIZHONG HUANG TUANJIE DU WEI ZHANG TIAN GU JUEJUN HU | 2018 | Photonics Research2018，6，6： | 9 |
| 4 | Modeling of oil near-infrared spectroscopy based on similarity and transfer learning algorithm显示文摘Near-infrared spectroscopy mainly reflects the frequency-doubled and total-frequency absorption information of hydrogen-containing groups (0 -H, C-H, N-H, S-H) in organic molecules for near-infrared lights with different wavelengths, so it is applicable to testing of most raw materials and products in the field of petrochemicals. However, the modeling process needs to collect a large number of laboratory analysis data. There are many oil sources in China, and oil properties change frequently. Modeling of each raw material is not only unfeasible but also will affect its engineering application efficiency. In order to achieve rapid modeling of near-infrared spectroscopy and based on historical data of different crude oils under different detection conditions, this paper discusses about the feasibility of the application of transfer learning algorithm and makes it possible that transfer learning can assist in rapid modeling using certain historical data under similar distributions under a small quantity of new data. In consideration of the requirement of transfer learning for certain similarity of different datasets, a transfer learning method based on local similarity feature selection is proposed. The simulation verification of spectral data of 13 crude oils measured by three different probe detection methods is performed. The effectiveness and application scope of the transfer modeling method under different similarity conditions are analyzed. | Yifei Wang Kai Wang Zhao Zhou Wenli Du | 2019 | Frontiers of Chemical Science and Engineering2019，13，3： | 4 |
| 5 | Mixed-cation perovskite solar cells in space显示文摘The metal halide perovskite materials demonstrate outstanding performance in photovoltaics because of their excellent optoelectronic properties (1-7)The perovskite solar cells (PSCs) exhibiting outstanding efficiency [8,9], high power-per-weight [10], and excellent radiation resistance[11-13] are considered to be promising for developing the new-generation energy technology for space application. | YongGuang Tu GuoNing Xu XiaoYu Yang YiFei Zhang ZhaoJie Li Rui Su DeYing Luo WenQiang Yang Ying Miao Rong Cai LuHua Jiang XiaoWei Du YanChu Yang QianShi Liu Yang Gao Shuai Zhao Wei Huang QiHuang Gong Rui Zhu | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，7： | 4 |
| 6 | Regulatory mechanisms of endometrial decidualization and pregnancy-related diseases显示文摘Endometrial decidualization is one of the earlest changes by which the uterus adapts to pregnancy.During this period,the endometrium undergoes complex changes in its biochemistry,physiology,and function at various levels,providing a suitable microenvironment for embryo implantation and development.Favorable decidualization lays an essential foundation for subsequent gestation,without which pregnancy failure or pregnancy complications may occur.The interaction between pregnancy-related hormones and cytokines produced by embryonic and uterine cells is known to be essential for decidualization,in which some transcription factors also play pivotal roles.Increasing evidence has revealed the importance of metabolism in regulating decidualization.Here,we summarize and discuss these crucial elements in decidualization and the relationship between decidualization and pregnancy complications.A better comprehension of these issues should help to improve the prediction of pregnancy outcomes and the use of appropriate intervention. | Yifei Sang Yanhong Li Ling Xu Dajin Li Meirong Du | 2020 | Acta Biochimica et Biophysica Sinica2020，52，2： | 4 |
| 7 | Trends in Leisure-Time Physical Activity Among Chinese Adults--China,2000-2015显示文摘What is already known about this topic?The monitoring report on nutrition and health status of Chinese residents from 2010 to 2013 reported that the participation rate of leisure-time physical activity(LTPA)was 13.8% among those 6 years and older.What is added by this report?Among 18 years old and older,the age-standardized LTPA prevalence increased from 7.13% in 2000 to 11.79% in 2011 before dropping to 7.33% in 2015.What are the implications for public health practice?As levels of LTPA participation are low,further research is necessary to develop and test valid interventions to encourage people to take part in more LTPA especially for residents in rural areas and with low-income. | Qinpei Zou Huijun Wang Wenwen Du Chang Su Yifei Ouyang Zhihong Wang Gangqiang Ding Bing Zhang | 2020 | China CDC weekly2020，2，9： | 3 |
| 8 | Derivation and characterization of human embryonic stem cell lines from poor quality embryos显示文摘Poor quality embryos discarded from in vitro fertilization (IVF) laboratories are good sources for deriving human embryonic stem cell (hESC) lines. In this study, 166 poor quality embryos donated from IVF centers on day 3 were cultured in a blastocyst medium for 2 days, and 32 early blastocysts were further cultured in a blastocyst optimum culture medium for additional 2 days so that the inner cell masses (ICMs) could be identified and isolated easily. The ICMs of 17 blastocysts were isolated by a mechanical method, while those of the other 15 blastocysts were isolated by immunosurgery. All isolated ICMs were inoculated onto a feeder layer for subcultivation. The rates of ICM at- tachment, primary ICM colony formation and the efficiency of hESC derivation were similar between the ICMs isolated by the two methods (P>0.05). As a result, four new hESC lines were established. Three cell lines had normal karyotypes and one had an unbalanced Robertsonian translocation. All cell lines showed normal hESC characteristics and had the differentiation ability. In conclusion, we established a stable and effective method for hESC isolation and culture, and it was confirmed that the mechanical isolation was an effective method to isolate ICMs from poor embryos. These results further indicate that hESC lines can be derived from poor quality embryos discarded by IVF laboratories. | Weiqiang Liu, Yifei Yin, Xiaolin Long, Yumei Luo, Yonghua Jiang, Wenhong Zhang, Hongzi Du, Shaoying Li, Yuhong Zheng, Qing Li, Xinjie Chen, Baoping Liao, Guohong Xiao, Weihua Wang, Xiaofang Sun Guangzhou Key Laboratory of Reproductive and Genetics Institute of Gynecology and Obstetrics, The Third Affiliated Hospital of Guangzhou Medical College, Guangzhou 510150, China | 2009 | Journal of Genetics and Genomics2009，36，4： | 3 |
| 9 | The inhibitory effects of siRNA expression vector on CXCR4 expression in prostate carcinoma cell lines显示文摘Objective: To investigate the inhibitory effects of RNAi (RNA interference, RNAi) expression vector on CXCR4 expression in prostate carcinoma cell lines. Methods: Small interference RNA(siRNA) expression vectors for CXCR4 gene were constructed and transfected into prostate carcinoma cell lines(PC-3m and LNCaP)with liposomes. The expression of CXCR4 was detected by RT-PCR and western blot. Results: The expression of CXCR4 mRNA and protein in the PC-3m and LNCaP cells was reduced by RNAi expression vectors. The inhibitory rate of CXCR4 mRNA expression in the PC-3m cells was 87.81%±10.20%,56.10%±9.32% at the 24th hour and the 48th hour, compared with 56.93%±8.78%,49.24%±11.23% in LNCaP cells. The inhibitory rate of the expression of CXCR4 protein was 64.71%±6.68%,58.66%±11.56% respectively. Conclusion: The expression of CXCR4 gene can effectively be inhibited by RNAi expression vectors. | Yuefeng Du Yifei Xing Fuqing Zeng Peng Lu Xianyin Liu | 2006 | Journal of Nanjing Medical University2006，20，2： | 3 |
| 10 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 11 | Taking the pulse of COVID-19:a spatiotemporal perspective显示文摘The sudden outbreak of the Coronavirus disease(COVID-19)swept across the world in early 2020,triggering the lockdowns of several billion people across many countries,including China,Spain,India,the U.K.,Italy,France,Germany,Brazil,Russia,and the U.S.The transmission of the virus accelerated rapidly with the most confirmed cases in the U.S.,India,Russia,and Brazil.In response to this national and global emergency,the NSF Spatiotemporal Innovation Center brought together a taskforce of international researchers and assembled implementation strategies to rapidly respond to this crisis,for supporting research,saving lives,and protecting the health of global citizens.This perspective paper presents our collective view on the global health emergency and our effort in collecting,analyzing,and sharing relevant data on global policy and government responses,human mobility,environmental impact,socioeconomical impact;in developing research capabilities and mitigation measures with global scientists,promoting collaborative research on outbreak dynamics,and reflecting on the dynamic responses from human societies. | Chaowei Yang Dexuan Sha Qian Liu Yun Li Hai Lan Weihe Wendy Guan Tao Hu Zhenlong Li Zhiran Zhang John Hoot Thompson Zifu Wang David Wong Shiyang Ruan Manzhu Yu Douglas Richardson Luyao Zhang Ruizhi Hou You Zhoua Cheng Zhong Yifei Tian Fayez Beaini Kyla Carte Colin Flynn Wei Liu Dieter Pfoser Shuming Bao Mei Li Haoyuan Zhang Chunbo Liu Jie Jiang Shihong Du Liang Zhao Mingyue Lu Lin Li Huan Zhou Andrew Ding | 2020 | International Journal of Digital Earth2020，13，10： | 2 |
| 12 | Energy Aware Spectrum Access in Cognitive Radio Networks with Imperfect Channel Sensing显示文摘Due to the problem of spectrum underutilization and energy inefficiency in wireless communications,the research on energy efficient Cognitive Radio Networks (CRNs) has received significant attention in both industry and academia.In this paper,we consider the problem of optimal spectrum selection and transmission parameters design with the objective of minimizing energy consumption in CRNs.Since the system state cannot be directly observed due to miss detections and estimation errors,we formulate the optimal spectrum access problem as a Partially Observable Markov Decision Process (POMDP).In particular,the proposed scheme selects the optimal spectrum,modulation and coding scheme,transmission power,and link layer frame size in each time slot according to the belief state,which captures all the history information of past actions and observations.The optimal policy can be acquired by solving POMDP problem with linear programming based algorithm.Simulation results show that significant energy savings can be achieved by the proposed scheme. | Wei Yifei Du Chenhui Feng Ruijun F. Richard Yu | 2012 | China Communications2012，9，9： | 2 |
| 13 | Industiral Vertical Definiation显示文摘 | DU YIFEI JIANG GUOJ UN LI SHIMING | 2004 | Journal of System Science and Informaton2004，2，2： | 1 |
| 14 | Cytosolic phospholi- pase A2 and eyclo-oxygenase expression in human oral mucosa, dys- lasias and squamous celt carcinomas and their significance 显示文摘 | Shuangyue Zhang Yifei Du Ning Chen | 2008 | ORL Journal for Oto-Rhino-Laryngology and its Related Specialties2008，70，： | 1 |
| 15 | Determinants of Industrial Innovation in China: Evidence from its Recent Economic Census 显示文摘 | Sun Yifei Du Debin | 2010 | Technovation2010，，30： | 1 |
| 16 | Cytosolic phospholi- pase A2 and cyelo-oxygenase expression in human oral mueosa, dys- lasias and squamous cell carcinomas and their significance 显示文摘 | Shuangyue Zhang Yifei Du Ning Chen | 2008 | ORL Journal for Oto-Rhino-Laryngology and its Related Specialties2008，70，： | 1 |
| 17 | Foreign R&D in developing countries:empirical evidence from Shanghai,China显示文摘 | Sun Yifei Du Debin Huang Li | 2006 | China Review2006，6，1： | 1 |
| 18 | Self-Navigated 3D Acoustic Tweezers in Complex Media Based on Time Reversal显示文摘Acoustic tweezers have great application prospects because they allow noncontact and noninvasive manipulation of microparticles in a wide range of media.However,the nontransparency and heterogeneity of media in practical applications complicate particle trapping and manipulation.In this study,we designed a 1.04 MHz 256-element 2D matrix array for 3D acoustic tweezers to guide and monitor the entire process using real-time 3D ultrasonic images,thereby enabling acoustic manipulation in nontransparent media.Furthermore,we successfully performed dynamic 3D manipulations on multiple microparticles using multifoci and vortex traps.We achieved 3D particle manipulation in heterogeneous media(through resin baffle and ex vivo macaque and human skulls)by introducing a method based on the time reversal principle to correct the phase and amplitude distortions of the acoustic waves.Our results suggest cutting-edge applications of acoustic tweezers such as acoustical drug delivery,controlled micromachine transfer,and precise treatment. | Ye Yang Teng Ma Sinan Li Qi Zhang Jiqing Huang Yifei Liu Jianwei Zhuang Yongchuan Li Xuemin Du Lili Niu Yang Xiao Congzhi Wang Feiyan Cai Hairong Zheng | 2021 | Research2021，，1： | 1 |
| 19 | Foreign R&D in Developing Countries: Empirical Evidence from Shanghai, China显示文摘 | Yifei Sun Debin Du and Li Huang | 2006 | The China Review2006，6，1： | 1 |
| 20 | Domestic firm innovation and networking with foreign firms in China's ICTindustry显示文摘 | Sun Yifei Debin Du | 2011 | Environment and Planning A2011，43，： | 1 |
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