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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | H2S protects PC12 cells against toxicity of corticosterone by modulation of BDNF-TrkB pathway显示文摘 | Shenglan Gao Wenting Li Wei Zou Ping Zhang Ying Tian Fan Xiao Hongfeng Gu Xiaoqing Tang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，11： | 6 |
| 3 | Understanding the molecular structure of HSW coal at atomic level:A comprehensive characterization from combined experimental and computational study显示文摘In this work,the coal samples from Hongshiwan(HSW)mining area,Ningxia,northwest of China,are characterized by using several modern materials characterization techniques,such as proximate and ultimate analyses,solid state 13C nuclear magnetic resonance(13C NMR),X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy(FT-IR).Then the key information about elements,valence,and chemical bonding for coal molecular structural construction is obtained.The results reveal that the main structure of HSW coal has 75.96%aromatic skeleton in mass.The ratio of aromatic bridge carbon to aromatic peripheral carbon of HSW coal is 0.315,indicating more naphthalene than benzene and anthracene in coal structures.Oxygen predominantly presents in the forms of ether(C–O),carbonyl(C=O)and carboxyl(–COO).Nitrogen presents in the forms of both pyridine and pyrrole.Methyl(–CH_(3))group is predominant in cyclic and aliphatic hydrocarbons.Based on obtained structural information and the approaches of average molecular structure,the single molecular formula of HSW coal is defined as C_(221)H_(148)O_(28)N_(2),with a molecular weight of 3142.32.Also,the 2D and 3D molecular model of HSW coal are built with computeraided modeling.The model is optimized and further verified by FT-IR and^(13)C NMR spectra simulation with quantum chemical calculations.Besides,a more complicated structure of complex model for HSW coal containing 10 single-molecules is also obtained.Therefore,molecular structure of HSW coal has been comprehensively depicted and understood at atomic level from both experimental and quantum chemical approaches in the current work. | Wei Feng Zhuangmei Li Hongfeng Gao Qiang Wang Hongcun Bai Ping Li | 2021 | Green Energy & Environment2021，6，1： | 3 |
| 4 | Rapid phenotypic evolution with shallow genomic differentiation during early stages of high elevation adaptation in Eurasian Tree Sparrows显示文摘Known as the‘third polar region’,the Qinghai-Tibet Plateau represents one of the harshest highland environments in the world and yet a number of organisms thrive there.Previous studies of birds,animals and humans have focused on well-differentiated populations in later stages of phenotypic divergence.The adaptive processes during the initial phase of highland adaptation remain poorly understood.We studied a human commensal,the Eurasian Tree Sparrow,which has followed human agriculture to the Qinghai-Tibet Plateau.Despite strong phenotypic differentiation at multiple levels,in particular in muscle-related phenotypes,highland and lowland populations show shallow genomic divergence and the colonization event occurred within the past few thousand years.In a one-month acclimation experiment investigating phenotypic plasticity,we exposed adult lowland tree sparrows to a hypoxic environment and did not observe muscle changes.Through population genetic analyses,we identified a signature of polygenic adaptation,whereby shifts in allele frequencies are spread across multiple loci,many of which are associated with muscle-related processes.Our results reveal a case of positive selection in which polygenic adaptation appears to drive rapid phenotypic evolution,shedding light on early stages of adaptive evolution to a novel environment. | Yanhua Qu Chunhai Chen Ying Xiong Huishang She Yong E Zhang Yalin Cheng Shane DuBay Dongming Li Per G P Ericson Yan Hao Hongyuan Wang Hongfeng Zhao Gang Song Hailin Zhang Ting Yang Chi Zhang Liping Liang Tianyu Wu Jinyang Zhao Qiang Gao Weiwei Zhai Fumin Lei | 2020 | National Science Review2020，7，1： | 2 |
| 5 | Local delivery of superagonist gene based on polymer nanoparticles for cancer immunotherapy显示文摘Cancer is the leading cause that threatens human life expectancy due to the lack of effective therapies.Cancer immunotherapy has been explored to improve the body's immune system against cancer and accompanied by promising results in recent years.Interleukin 15(IL-15),a pleiotropic immunomodulator,is critical for immune cells development and displays great anti-tumor potential in both preclinical and clinical trials.In this study,superagonist IL-15 plasmid(psIL-15)consisting of IL-15Rα-sushi-linker-IL-15 was constructed in order to secret superagonist IL-15(sIL-15)in tumor site.A gene delivery system through self-assembly by methylated polyethylene glycol-b-polylactic acid-b-methylated polyethylene glycol(m PEG-PLA-m PEG)and 1,2-dioleoyl-3-trimethylammonium-propane(DOTAP),named DMAM,was designed to deliver psIL-15.Further study showed that DMAM/psIL-15 could successfully deliver psIL-15 to tumor cells and the supernatants of the tumor cells could further stimulate lymphocytes proliferation as well as activation in vitro.Local delivery of DMAM/psIL-15 in animal models demonstrated significant tumor inhibition through enhancing immune cells responses,reducing angiogenesis,promoting tumor cell apoptosis and inhibiting proliferation,with no evidence of system toxicities.These results indicate that DMAM/psIL-15 may be a promising strategy for cancer immunotherapy. | Zehua Hong Xin Zan Ting Yu Yuzhu Hu Hongfeng Gou Songping Zheng Xiang Gao Peizhi Zhou | 2023 | Chinese Chemical Letters2023，34，3： | 1 |
| 6 | Semaphorin3A Regulates Neuronal Polarization by Suppressing Axon Formation and Promoting Dendrite Growth显示文摘 | Maya Shelly Laura Cancedda Byung Kook Lim Andrei T. Popescu Pei-lin Cheng Hongfeng Gao Mu-ming Poo | 2011 | Neuron2011，，： | 1 |
| 7 | Regulation of autophagic flux by CHIP显示文摘Autophagy is a major degradation system which processes substrates through the steps of autophagosome formation, autophagosome-lysosome fusion, and substrate degradation. Aberrant autophagic flux is present in many pathological conditions including neurodegeneration and tumors. CHIP/STUB1, an E3 ligase, plays an important role in neurodegeneration. In this study, we identified the regulation of autophagic flux by CHIP(carboxy-terminus of Hsc70-interacting protein). Knockdown of CHIP induced autophagosome formation through increasing the PTEN protein level and decreasing the AKT/m TOR activity as well as decreasing phosphorylation of ULK1 on Ser757. However, degradation of the autophagic substrate p62 was disturbed by knockdown of CHIP, suggesting an abnormality of autophagic flux. Furthermore, knockdown of CHIP increased the susceptibility of cells to autophagic cell death induced by bafilomycin A1. Thus, our data suggest that CHIP plays roles in the regulation of autophagic flux. | Dongkai Guo Zheng Ying Hongfeng Wang Dong Chen Feng Gao Haigang Ren Guanghui Wang | 2015 | Neuroscience Bulletin2015，31，4： | 1 |
| 8 | Improving Hydration Resistance of MgO-CaO Clinkers by Depositing MgO Coating显示文摘By carbothermal reduction of Mg O with black carbon as reduction agent at a high temperature,Mg O was deposited on the surface of Mg O- Ca O clinker( as coating) to improve the clinker 's hydration resistance. In the paper,effect of deposition temperature and holding time on the hydration resistance of the treated Mg O-Ca O,the deposition mechanism and Mg O coating kinetics were investigated with hydration resistance test,X-ray diffractometry( XRD) and scanning electronic microscope( SEM). Results showed Mg O coating grew in a2D mode on the surface of Mg O- Ca O particles; the Mg O coating improved the hydration resistance of the coated Mg O- Ca O clinker,and the coated clinker would become stronger when coated at higher deposition temperature and longer holding time. The measurements also found that Mg O deposition process varied with the deposition temperature: it was mainly a chemical-controlled process at temperatures between 1 400- 1 500 ℃,with an apparent activation energy( AAE) of 97. 8kJ·mol^(-1); it would change into a diffusion-controlled process when the temperature rising to 1 500- 1 600 ℃,with apparent activation energy of 19. 2kJ·mol^(-1). | YIN Hongfeng LI Botao GAO Kui DING Songxiong | 2016 | China's Refractories2016，25，3： | 0 |
| 9 | Circularly polarized luminescence switch based on a photochromic europium(Ⅲ) helicate derived coordination polymer显示文摘Chiroptical switches based on circularly polarized luminescence(CPL)have shown the promising applications in advanced information technologies.Herein,a pair of lanthanide coordination polymer enantiomers[Eu_(2)(L^(R))_(3)(BTFPO)_(2)]_(n) and[Eu_(2)(L^(S))_(3)(BTFPO)_(2)]_(n) with light-regulated CPL property are designed,which are assembled by a chiral binuclear triple-stranded Eu^(3+) helicates[Eu_(2)(L^(R/S))_(3)]coordinated with two photochromic triphenylphosphine oxides(BTFPO).Upon the alternative UV and 526 nm light irradiation,the complexes show the reversible photochromism,PL and CPL responses.Notably,the luminescence dissymmetry factor,g lum of ^(5)D_(0)→^(7)F_(1)(591 nm)transition shows an obvious increase from 0.19 to 0.29 before and after 275 nm light irradiation.Additionally,the emission from Eu^(3+) center is not completely quenched in closed-ring state due to the low photocyclization(Ф_(o-c))quantum yield of the polymer.The partial maintenance of emissive intensity is of essential importance for the monitor of CPL signal.More importantly,the CPL photo-switching property of the complexes in solid hybrid film is maintained,and still displays the enhanced CPL emission in photostationary state.Further,the potential applications of the doping film in logic gate and anti-counterfeiting were investigated. | Mei Li Yanyan Zhou Jingya Li Wenru Huang Zhiwei Yao Yuying Li Ting Gao Pengfei Yan Hongfeng Li | 2024 | Chinese Chemical Letters2024，35，2： | 0 |
| 10 | Subunit composition and chromophore content of R-phycocyanin and allophycocyanin from Porphyra haitanensis显示文摘SubunitcompositionandchromophorecontentofR-phycocyaninandallophycocyaninfromPorphyrahaitanensis￥GaoHongfeng;CaoWendaandJiMing... | Gao Hongfeng Cao Wenda and Ji Minghou | 1994 | Acta Oceanologica Sinica1994，13，2： | 0 |
| 11 | Isolation and analysis of SSEA-4 positive cells derived from fetal marrow mesenchymal stem cells显示文摘A big issue in stem cell research is to derive prospective totipotential stem cells. In this study, fMSC-SSEA-4 cells expressing SSEA-4 anti- gen were isolated from fetal marrow masenchymal stem cells (fMSCs) using immunomagnetic bead sorting technique. The totipotent cells were identified and their biological characteristics were further stud- ied. The expression of Oct-4 and SSEA-4, carcino- genicity, and the ability to differentiation of fMSC- SSEA-4 cells were evaluated to verify the totipotent potential. fMSC-SSEA-4 cells were isolated suc- cessfully from fMSCs (2.5% among fMSCs), while no obvious differences were seen in morphology, growth curve, cell cycle and immunophenotype, Oct-4 and SSEA-4 expression between fMSC-SSEA-4 cells and fMSCs. fMSC-SSEA-4 cells showed normal diploid chromosome karyotype and no carcinoma was in- duced after inoculation into nude mice. fMSC- SSEA-4 cells could be induced to fat cells, osteo- genic cells and neuron-like cells in vitro with different induced factors. The results indicated that there may be a few totipotent cells among the fMSCs and it may offer the experimental basis for the further study and application of fMSCs. | LIU Daqing YANG Yinxiang GAO Yanhong YUAN Hongfeng QIN Lipeng WANG Yunfang NAN Xue SHI Shuangshuang YUE Wen PEI Xuetao | 2006 | Chinese Science Bulletin2006，51，12： | 0 |
| 12 | Insights into the intrinsic interaction between series of C1 molecules and surface of NiO oxygen carriers involved in chemical looping processes显示文摘Understanding and modulating the interaction between various reactive molecules and oxygen carriers are the key issue to achieve process intensification of chemical looping technology.C1 chemical molecules play an important role in many reactions involved with chemical looping processes.However,up to now,there is still a lack of systematic and in-depth understanding of the adsorption mechanism of C1 molecules on the surface of oxygen carriers(OCs).In this work,the intrinsic interaction between a series of C1 molecules composed of CH4,CO,CO2,CH3OH,HCHO and HCOOH and surface of Ni O OCs in the chemical looping process have been studied using density functional theory calculations.Various adsorption configurations of C1 molecules and also different adsorption sites of Ni O have been considered.The structural features of stable configuration of C1 molecules on the surface of NiO OCs have been obtained.Further,the interacted sites,types and strengths of C1 molecules on the surface of NiO have been directly pictured by the independent gradient model methods.Also,the nature of the interaction between C1 molecule and Ni O surface has been investigated with the aid of energy decomposition analysis from a quantitative view. | Jinpeng Zhang Hongfeng Gao Nini Yuan QiangWang YuhuaWu Yanli Sun Hongcun Bai | 2020 | Chinese Journal of Chemical Engineering2020，28，11： | 0 |
| 13 | Heterogeneity of clinical features, EEG and brain imaging findings in anti‑leucine‑rich glioma‑inactivated protein 1 autoimmune encephalitis: a retrospective case series study and review of the literature显示文摘Background Anti-leucine-rich glioma-inactivated 1(LGI-1)autoimmune encephalitis(AE),characterized by rapid decline of memory,seizures,and neuropsychiatric abnormalities,is a rare but devastating disorder.Early diagnosis and treatment are essential to prevent long-term sequelae.In this report,we provide a detailed description of clinical characteristics,laboratory test results,imaging,and electroencephalography(EEG)findings,as well as treatment responses of eight patients with anti-LGI-1 AE treated at our center.Case presentation At the onset,all eight patients presented with confusion/memory deterioration,seizures(including faciobrachial dystonic seizures or other types of seizure),and behavioral changes such as hallucination,paranoia,and anxiety.Four patients were found with severe hyponatremia.Anti-LGI1 antibodies were detected in the cerebrospinal fluid and/or serum of all patients.For patients with faciobrachial dystonic seizures,no discernible scalp EEG change was detected,while EEG recording of patients experiencing other types of seizure showed focal slowing,focal epileptiform discharges,and focal onset seizures.All patients showed abnormal brain magnetic resonance imaging signals,mainly involving the mesial temporal lobe and the hippocampus.In addition,one patient also experienced fulminant cerebral edema during the acute phase of the illness.All patients received immunotherapy and anti-seizure medications and achieved good seizure control.Nevertheless,these patients continued to experience cognitive impairment during their long-term follow-ups.Conclusions The care of anti-LGI1 AE patients requires rapid evaluation,prompt initiation of immunotherapy,and long-term follow-up.The long-term presence of neurocognitive complications observed in these patients underline the importance of developing reliable biomarkers that can distinguish between different subtypes of this disease with heterogeneous clinico-electrographico-radiological features.Further research is needed to understand the molecular mechanisms underlying the heterogeneity,in order to facilitate development of more effective treatments for anti-LGI1 AE. | Emily Yixuan Huang Hongfeng Gao Ning Zhong | 2023 | Acta Epileptologica2023，6，3： | 0 |
| 14 | DBKEM-AACS:a distributed key escrow model in blockchain with anonymous authentication and committee selection显示文摘Dear editor,Key security is of great practical significance and demand to guarantee the security of digital assets in the blockchain system.At present,users prefer to escrow their assets on centralized institutions,but this phenomenon has gone against the unique characteristics of decentralization and anonymity in the blockchain.Among them,the suspense incidents of assets lock or lost are enough to prove that the security of escrowed keys on the exchanges is questionable. | Axin XIANG Hongfeng GAO Youliang TIAN Liang WAN | 2023 | Science China(Information Sciences)2023，66，3： | 0 |
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