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| 1 | Anatomical distribution of pelvic deep infiltrating endometriosis and its relationship with pain symptoms显示文摘背景子宫内膜增生是渗入子宫内膜增生的争论、神秘的 disease.Deep (死)为痛苦的症状负责并且是 endometriosis.Little 工作的最少的理解的类型被奉献了定义地点死有 pain.The 的损害和它的关系学习瞄准是调查在解剖分发之间的关系死损害和疼痛 symptoms.Methods 从在2003年5月和2007年12月与之间的 354 个病人的临床的数据 | Dai Yi Leng Jin-hua Lang Jing-he Li Xiao-yan Zhang Jun-ji | 2012 | Chinese Medical Journal2012，，2： | 43 |
| 2 | Breast magnetic resonance imaging in patients with occult breast carcinoma: evaluation on feasibility and correlation with histopathological findings显示文摘是的背景一个不平常的演讲,秘密主要乳癌在临床的实践仍然是诊断、治疗学的挑战。这研究试图回顾地估计胸的可行性在有恶意的腋的 lymphadenopathy 和未知主要恶意的病人的磁性的回声成像(MRI ) ,和与有秘密的胸癌的 35 个女人全部的组织病理学说的 characteristics.Methods A 的关联与动态提高对比的胸 MRI 被评估。完全使连续节在所有情况中被使用。MRI 性能被估计并且与 35 个病人中的 21 个被发现组织学地有主要的胸癌的组织病理学说的 findings.Results 相关。21 个病人中的二十个有反常先生调查结果, 1 个病人让正常 MRI 学习。留下 14 个病人, 10 在 MRI 和外科上是否定的。MRI 和没有相应肿瘤上的四有的可疑改进被发现。在 45% 的改进在 55% 被发现的有质量的损害(11/20 ) 和 ductual 和部分改进。主要肿瘤的平均直径是 15 公里。侵略 ductal 癌在 81% 被发现(17/21 ) 。17 侵略 ductual 癌之一太小,不能被分级。留下中的十四个 16 作为等级 II 被分类并且 2 是等级我。35 个病人中的 32 个收到了雌激素受体,孕酮受体和人表皮的生长因素受体 2 考试并且 32 中的 12 个是有小尺寸的三元组否定的胸 carcinoma.Conclusions 团损害,有 ductal 或片断改进的损害是在有秘密乳癌的病人的普通 MRI 特征。主要肿瘤的主导的类型是有中等组织病理学说的等级的侵略 ductal 癌。三元组否定的胸癌的率可能在秘密乳癌是更高的。 | LU Hong XU Yi-lin ZHANG Shu-ping LANG Rong-gang Chi S. Zee LIU Pei-fang FU Li | 2011 | Chinese Medical Journal2011，，12： | 31 |
| 3 | Temporal and spatial variation of nitrogen and phosphorus and eutrophication assessment for a typical arid river - Fuyang River in northern China显示文摘Based on water quality surveys over 2 years(July to December,in 2014 and 2015) in a typical arid river in northern China the Xingtai segment of the Fuyang River basin — the variation of nitrogen(N) and phosphorus(P) was analyzed.The extent of water eutrophication of this segment was also assessed using a universal index formula for eutrophic evaluation and a logarithmic power function.The results showed that the average concentration of total N(TN) was 27.2 mg/L(NH_3-N,63.5%),total P(TP) was 2.0 mg/L(solution reactive phosphorus,68.8%).Temporal and spatial variations of N and P in this segment were observed.Concentrations of N and P in the arid season were higher than those in the rainy season.Spatially,the N and P concentrations followed the same trend;i.e.,higher in the city segment than in the suburbs,and decreasing along the river.The water eutrophication in the studied segment reached extremely high levels at all times(eutrophication index ≥76.3).Spatially,its trend was clearly linked with N and P.Water shortage,pollution accumulation and a weak self-purification function are the main reasons for the prominent eutrophication in this segment. | Wenqiang Zhang Xin Jin Dong Liu Chao Lang Baoqing Shan | 2017 | Journal of Environmental Sciences2017，29，5： | 30 |
| 4 | Astragalus polysaccharide stimulates glucose uptake in L6 myotubes through AMPK activation and AS160/TBCID4 phosphorylation显示文摘 | Jian LIU Jing-fang ZHANG Jin-zhi LU De-ling ZHANG Ke LI Ke SU Jing WANG Ye-min ZHANG Nian WANG Si-tu YANG Lang BU Jing-ping OU-YANG | 2013 | Acta Pharmacologica Sinica2013，34，1： | 26 |
| 5 | Prevalence and Factors Associated with Female Sexual Dysfunction in Beijing, China显示文摘 | Wen-Jia Lou Bo Chen Lan Zhu Shao-Mei Han Tao Xu Jing-He Lang Lei Zhang | 2017 | Chinese Medical Journal2017，，12： | 25 |
| 6 | Energy-Efficient Multi-UAV Coverage Deployment in UAV Networks:A Game-Theoretic Framework显示文摘UAV cooperative control has been applied in many complex UAV communication networks. It remains challenging to develop UAV cooperative coverage and UAV energy-efficient communication technology. In this paper, we investigate current works about UAV coverage problem and propose a multi-UAV coverage model based on energy-efficient communication. The proposed model is decomposed into two steps: coverage maximization and power control, both are proved to be exact potential games(EPG) and have Nash equilibrium(NE) points. Then the multi-UAV energy-efficient coverage deployment algorithm based on spatial adaptive play(MUECD-SAP) is adopted to perform coverage maximization and power control, which guarantees optimal energy-efficient coverage deployment. Finally, simulation results show the effectiveness of our proposed approach, and confirm the reliability of proposed model. | Lang Ruan Jinlong Wang Jin Chen Yitao Xu Yang Yang Han Jiang Yuli Zhang Yuhua Xu | 2018 | China Communications2018，15，10： | 24 |
| 7 | A high-quality genome assembly of quinoa provides insights into the molecular basis of salt bladder-based salinity tolerance and the exceptional nutritional value显示文摘 | Changsong Zou Aojun Chen Lihong Xiao Heike M Muller Peter Ache Georg Haberer Meiling Zhang Wei Jia Ping Deng Ru Huang Daniel Lang Feng Li Dongliang Zhan Xiangyun Wu Hui Zhang Jennifer Bohm Renyi Liu Sergey Shabala Rainer Hedrich Jian-Kang Zhu Heng Zhang | 2017 | Cell Research2017，27，11： | 22 |
| 8 | EFFECTS OF SPECIFIED BLANK SIZE ON BODY WRINKLING DURING HYDRODYNAMIC DEEP DRAWING OF TAPERED RECTANGULAR BOX显示文摘In this paper, the forming features of tapered rectangular box during hydrodynamic deep drawing are studied by means of FEM.The effect rules of square blank corner corner amount on body wrinkling are recognized and corresponding methods are discussed. At last, the results of FEM are verified by experi- ment. | L. H. Lang, D. C. Kang, S. H. Zhang, Z. R. Wang, S. J. Yuan, K. B. Nielsen and J. Dancket 1) Department of Materials Engineering, Harbin Institute of Technology, Harbin 150001, China 2) Aalberg University, Denmark | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，2： | 21 |
| 9 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 10 | Valproic acid reduces autophagy and promotes functional recovery after spinal cord injury in rats显示文摘Secondary damage is a critical determinant of the functional outcome in patients with spinal cord injury (SCI), and involves multiple mechanisms of which the most important is the loss of nerve cells mediated by multiple factors. Autophagy can result in cell death, and plays a key role in the development of SCI. It has been recognized that valproic acid (VPA) is neuroprotective in certain experimental animal models, however, the levels of autophagic changes in the process of neuroprotection by VPA treatment following SCI are still unknown. In the present study, we determined the extent of autophagy after VPA treatment in a rat model of SCI. We found that both the mRNA and protein levels of Beclin-1 and LC3 were significantly increased at 1, 2, and 6 h after SCI and peaked at 2 h; however, Western blot showed that autophagy was markedly decreased by VPA treatment at 2 h post-injury. Besides, post-SCI treatment with VPA improved the Basso-Beattie-Bresnahan scale, increased the number of ventral horn motoneurons, and reduced myelin sheath damage compared with vehicle-treated animals at 42 days after SCI. Together, our results demonstrated the characteristics of autophagy expression following SCI, and found that VPA reduced autophagy and enhanced motor function. | Hai-Hu Hao Li Wang Zhi-Jian Guo Lang Bai Rui-Ping Zhang Wei-Bing Shuang Yi-Jia Jia Jie Wang Xiao-Yu Li Qiang Liu | 2013 | Neuroscience Bulletin2013，29，4： | 19 |
| 11 | Characteristics of atmospheric single particles during haze periods in a typical urban area of Beijing:A case study in October,2014显示文摘To investigate the composition and possible sources of particles, especially during heavy haze pollution, a single particle aerosol mass spectrometer(SPAMS) was deployed to measure the changes of single particle species and sizes during October of 2014, in Beijing. A total of 2,871,431 particles with both positive and negative spectra were collected and characterized in combination with the adaptive resonance theory neural network algorithm(ART-2a). Eight types of particles were classified: dust particles(dust, 8.1%), elemental carbon(EC, 29.0%), organic carbon(OC, 18.0%), EC and OC combined particles(ECOC, 9.5%),Na-K containing particles(Na K, 7.9%), K-containing particles(K, 21.8%), organic nitrogen and potassium containing particles(KCN, 2.3%), and metal-containing particles(metal,3.6%). Three haze pollution events(P1, P2, P3) and one clean period(clean) were analyzed,based on the mass and number concentration of PM_(2.5)and the back trajectory results from the hybrid single particle Lagrangian integrated trajectory model(Hysplit-4 model). Results showed that EC, OC and K were the major components of single particles during the three haze pollution periods, which showed clearly increased ratios compared with those in the clean period. Results from the mixing state of secondary species of different types of particles showed that sulfate and nitrate were more readily mixed with carbon-containing particles during haze pollution episodes than in clean periods. | Lang Liu Yanli Wang Shiyong Du Wenjie Zhang Lujian Hou Sverre Vedal Bin Han Wen Yang Mindong Chen Zhipeng Bai | 2016 | Journal of Environmental Sciences2016，28，2： | 19 |
| 12 | Cas9-NG Greatly Expands the Targeting Scope of the Genome-Editing Toolkit by Recognizing NG and Other Atypical PAMs in Rice显示文摘CRISPR technologies enabling precise genome manipulation are valuable for gene function studies and molecular crop breeding. However, the requirement of a protospacer adjacent motif (PAM)y such as NGG and TTN, for Cas protein recognition restricts the selection of targetable genomic loci in practical applications of CRISPR technologies. Recently Cas9-NG, which recognizes a minimal NG PAM, was reported to expand the targeting space of genome editing in human cells, but it remains unclear whether this Cas9 variant can be used in plants. In this study, we evaluated the nuclease activity of Cas9-NG toward various NGN PAMs by targeting endogenous genes in transgenic rice. We found that Cas9-NG edits all NGG, NGA, NGT, and NGC sites with impaired activity, while the gene-edited plants were dominated by monoallelic mutations. Cas9-NG-engineered base editors were then developed and used to generate O s B Z R I gainof- function plants that can not be created by other available Cas9-engineered base editors. Moreover, we showed that a Cas9-NG-based transcriptional activator efficiently upregulated the expression of endogenous target genes in rice. In addition, we discovered that Cas9-NG recognizes NAC, NTG, NTT, and NCG apart from NG PAM. Together, these findings demonstrate that Cas9-NG can greatly expand the targeting scope of genome-editing tools, showing great potential for targeted genome editing, base editing, and genome regulation in plants. | Bin Ren Lang Liu Shaofang Li Yongjie Kuang Jingwen Wang Dawei Zhang Xueping Zhou Honghui Lin Huanbin Zhou | 2019 | Molecular Plant2019，12，7： | 18 |
| 13 | A credit risk assessment model based on SVM for small and medium enterprises in supply chain finance显示文摘Background:Supply chain finance(SCF)is a series of financial solutions provided by financial institutions to suppliers and customers facing demands on their working capital.As a systematic arrangement,SCF utilizes the authenticity of the trade between(SMEs)and their“counterparties”,which are usually the leading enterprises in their supply chains.Because in these arrangements the leading enterprises are the guarantors for the SMEs,the credit levels of such counterparties are becoming important factors of concern to financial institutions’risk management(i.e.,commercial banks offering SCF services).Thus,these institutions need to assess the credit risks of the SMEs from a view of the supply chain,rather than only assessing an SME’s repayment ability.The aim of this paper is to research credit risk assessment models for SCF.Methods:We establish an index system for credit risk assessment,adopting a view of the supply chain that considers the leading enterprise’s credit status and the relationships developed in the supply chain.Furthermore,We conducted two credit risk assessment models based on support vector machine(SVM)technique and BP neural network respectly.Results:(1)The SCF credit risk assessment index system designed in this paper,which contained supply chain leading enterprise’s credit status and cooperative relationships between SMEs and leading enterprises,can help banks to raise their accuracy on predicting a small and medium enterprise whether default or not.Therefore,more SMEs can obtain loans from banks through SCF.(2)The SCF credit risk assessment model based on SVM is of good generalization ability and robustness,which is more effective than BP neural network assessment model.Hence,Banks can raise the accuracy of credit risk assessment on SMEs by applying the SVM model,which can alleviate credit rationing on SMEs.Conclusions:(1)The SCF credit risk assessment index system can solve the problem of banks incorrectly labeling a creditworthy enterprise as a default enterprise,and thereby improve the credit rating status in the process of SME financing.(2)By analyzing and comparing the empirical results,we find that the SVM assessment model,on evaluating the SME credit risk,is more effective than the BP neural network assessment model.This new assessment model based on SVM can raise the accuracy of classification between good credit and bad credit SMEs.(3)Therefore,the SCF credit risk assessment index system and the assessment model based on SVM,is the optimal combination for commercial banks to use to evaluate SMEs’credit risk. | Lang Zhang Haiqing Hu Dan Zhang | 2015 | Financial Innovation2015，1，1： | 17 |
| 14 | Efficacy and safety of Cimicifuga foetida extract on menopausal syndrome in Chinese women显示文摘 | ZHENG Ting-ping SUN Ai-jun XUE Wei WANG Ya-ping JIANG Ying ZHANG Ying LANG Jing-he | 2013 | Chinese Medical Journal2013，，11： | 15 |
| 15 | Laparoscopic cystogastrostomy for the treatment of pancreatic pseudocysts: A case report显示文摘Pancreatic pseudocysts(PPs) are collections o pancreatic secretions that are lined by fibrous tissue and may contain necrotic debris or blood. The interventions including percutaneous, endoscopic o surgical approaches are based on the size, location symptoms and complications of a pseudocyst With the availability of advanced imaging system and cameras, better hemostatic equipments and excellent laparoscopic techniques, most pseudocyst can be found and managed by laparoscopy. We describe a case of a 30-year-old male patient with a pancreatic pseudocyst amenable to laparoscopi cystogastrostomy. An incision was made through the anterior gastric wall to expose the posterior gastri wall in close contact with the pseudocyst using an ultrasonically activated scalpel. Then, another incision was made for cystogastrostomy to obtain complete and unobstructed drainage. The patient recovered well after operation and was symptom-free during a 6-mo follow-up, suggesting that laparoscopi cystogastrostomy is a safe and effective alternative to open cystogastrostomy for minimally invasive management of PPs. | Qin-song Sheng Da-Zhi Chen Ren Lang Zhong-Kui Jin Dong-Dong Han Li-Xin Li Yong-Jiu Yang Ping Li Fei Pan Dong Zhang Zhao-Wei Qu Qiang He | 2008 | World Journal of Gastroenterology2008，14，30： | 15 |
| 16 | Ubi1 intron-mediated enhancement of the expression of Bt cry1Ah gene in transgenic maize (Zea mays L.)显示文摘The cry1Ah gene was one of novel insecticidal genes cloned from Bacillus thuringiensis isolate BT8. Two plant expression vectors containing cry1Ah gene were constructed. The first intron of maize ubiqutin1 gene was inserted between the maize Ubiquitin promoter and cry1Ah gene in one of the plant expressing vectors (pUUOAH). The two vectors were introduced into maize immature embryonic calli by microprojectile bombardment, and the reproductively plants were acquired. PCR and Southern blot analysis showed that foreign genes had been integrated into maize genome and inherited to the next generation stably. The ELISA assay to T1 and T2 generation plants showed that the expression of Cry1Ah protein in the construct containing the ubi1 intron (pUUOAH) was 20% higher than that of the intronless construct (pUOAH). Bioassay results showed that the transgenic maize harboring cry1Ah gene had high resistance to the Asian corn borers and the insecticidal activity of the transgenic maize containing the ubi1 intron was higher than that of the intronless construct. These results indicated that the maize ubi1 intron can enhance the expression of the Bt cry1Ah gene in transgenic maize | WANG YueBing LANG Zhihong ZHANG Jie HE KangLai SONG FuPing HUANG DaFang | 2008 | Chinese Science Bulletin2008，53，20： | 15 |
| 17 | Self-cleaving ribozymes enable the production of guide RNAs from unlimited choices of promoters for CRISPR/Cas9 mediated genome editing显示文摘Development of tools for targeted modifications of specific DNA sequences in plants is of great importance to basic plant biology research as well as crop improvement.The ability to cut DNA at specific locations in the genome to generate doublestrand breaks(DSBs)in vivo is a prerequisite for any genome editing efforts.Several engineered nucleases including zinc finger nucleases(ZFNs)and transcriptional activator-like nucleases(TALENs)have been successfully used to edit genomes.However, | Yubing He Tao Zhang Ning Yang Meilian Xu Lang Yan Lihao Wang Rongchen Wang Yunde Zhao | 2017 | Journal of Genetics and Genomics2017，44，9： | 14 |
| 18 | Expression of two types of acetylcholinesterase gene from the silkworm, Bombyx mori, in insect cells显示文摘编码乙酰胆碱酯酶(疼痛) 的二种类型的互补 DNA 从蚕被孤立, Bombyx 粗腐殖质 i。类型 1 (Bmace1 ) 并且类型 2 (Bmace2 ) ORF 分别地是在长度的 2052 和 1917 bp。两个都, Bmaces 和 C 终端的完全的 ORF 截断了形式在 polyhedrin 倡导者的控制下面被重新结合进 Bacmid baculovirus 向量并且在 Trichoplusia 表示了 ni (Tn-5B1-4 ) 房间。产生产品展出了疼痛活动和表示蛋白质的 glycosylation。抑制试金显示 ace2 类型酶比对由 eserine 和 paraoxon 的抑制的 ace1 类型酶更敏感。 | JIN-YAN SHANG YA-MING SHAO GUO-JUN LANG GAN YUAN ZHEN-HUA TANG CHUAN-XI ZHANG | 2007 | Insect Science2007，14，6： | 14 |
| 19 | Effect of Autotoxicity and Soil Microbes in Continuous Cropping Soil on Angelica sinensis Seedling Growth and Rhizosphere Soil Microbial Population显示文摘Objective To study the effect of autotoxicity and the co-effect of autotoxicity and soil microbes from continuous cropping soil on Angelica sinensis growth, root yield and content of essential oils, and soil microbal population. Methods The pot experiments were conducted upon A. sinensis seedlings in continuous cropping soil. At the different growth stages, we determined the seedlings in growth parameters, root yield, content of essential oils, ethanol extract, and cultivable microbial populations in rhizosphere soil. Results A. sinensis seedlings were significantly inhibited in growth, root yield and quality. Compared with the control, the composition and structure of soil microbes were changed and the diversity indexes of bacteria functional groups were reduced in rhizosphere soil of A. sinensis. A. sinensis cropping problems were more seriously after the treatment with combination of autotoxicity and soil microbes than with autotoxicity alone. Conclusion The autotoxicity and soil microbes from continuous cropping soil of A. sinensis could cause the continuous cropping obstacle together. | Xin-hui Zhang Duo-yong Lang En-he Zhang Zhi-sheng Wang | 2015 | Chinese Herbal Medicines2015，7，1： | 14 |
| 20 | dentification of Circular RNAs as a Novel Biomarker for Ovarian Endometriosis显示文摘 | Xiao-Xuan Xu Shuang-Zheng Jia Yi Dai Jun-Ji Zhang Xiao-Yan Li Jing-Hua Shi Jin-Hua Leng Jing-He Lang | 2018 | Chinese Medical Journal2018，，5： | 14 |
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