|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 2 | In-situ fabrication of particulate reinforced aluminum matrix composites under high-frequency pulsed electromagnetic field显示文摘Pulsed magnetic field is generated when imposing pulse signal on high-frequency magnetic field. Distribution of the inner magnetic intensity in induction coils tends to be uniform. Furthermore oscillation and disturbance phenomena appear in the melt. In-situ Al2O3 and Al3Zr particulate reinforced aluminum matrix composites have been synthesized by direct melt reaction using Al-Zr(CO3)2 components under a foreign field. The size of reinforced particulates is 2-3 μm. They are well distributed in the matrix. Thermodynamic and kinetic analysis show that high-frequency pulsed magnetic field accelerates heat and mass transfer processes and improves the kinetic condition of in-situ fabrication. | Guirong Li Yutao Zhao Qixun Dai Hongjie Zhang Hongming Wang | 2007 | Journal of University of Science and Technology Beijing2007，14，5： | 8 |
| 3 | Integrated transcriptomic and metabolomic analyses of a wax deficient citrus mutant exhibiting jasmonic acid-mediated defense against fungal pathogens显示文摘Naturally,resistant crop germplasms are important resources for managing the issues of agricultural product safety and environment deterioration.We found a spontaneous mutant of‘Newhall’navel orange(Citrus sinensis Osbeck)(MT)with broad-spectrum protections against fungal pathogens in the orchard,postharvest-storage,and artificial inoculation conditions.To understand the defense mechanism of MT fruit,we constructed a genome-scale metabolic network that integrated metabolome and transcriptome datasets.The coordinated transcriptomic and metabolic data were enriched in two sub-networks,showing the decrease in very long chain fatty acid(by 41.53%)and cuticular wax synthesis(by 81.34%),and increase in the synthesis of jasmonic acid(JA)(by 95.23%)and JA-induced metabolites such as 5-dimethylnobietin(by 28.37%)in MT.Furthermore,cytological and biochemical analyses confirmed that the response to fungal infection in MT was independent of wax deficiency and was correlated with the levels of jasmonates,and the expression of plant defensin gene PDF1.2.Results of exogenous application of MeJA and JA inhibitors such as propyl gallate proved that JA-mediated defense contributes to the strong tolerance against pathogens in MT.Our results indicated that jasmonate biosynthesis and signaling are stimulated by the fatty acid redirection of MT,and participate in the tolerance of pathogenic fungi. | Yizhong He Jingwen Han Runsheng Liu Yuduan Ding Jinqiu Wang Li Sun Xiaoming Yang Yunliu Zeng Weiwei Wen Juan Xu Hongming Zhang Xiang Yan Zhaoxing Chen Zuliang Gu Hong Chen Huanqing Tang Xiuxin Deng Yunjiang Cheng | 2018 | Horticulture Research2018，5，1： | 8 |
| 4 | High-Resolution Genome-wide Association Study Identifies Genomic Regions and Candidate Genes for Important Agronomic Traits in Wheat显示文摘Wheat(Triticum aestivum)is a major staple food crop worldwide.Genetic dissection of important agronomic traits is essential for continuous improvement of wheat yield to meet the demand of the world's growing population.We conducted a large-scale genome-wide association study(GWAS)using a panel of 768 wheat cultivars that were genotyped with 327609 single-nucleotide polymorphisms generated by genotyping-by-sequencing and detected 395 quantitative trait loci(QTLs)for 12 traits under 7 environments.Among them,273 QTLs were delimited to≤1.0-Mb intervals and 7 of them are either known genes(Rht-D,Vrn-B1,and Vrn-D1)that have been cloned or known QTLs(TaGA2ox8,APO1,TaSus1-7B,and Rht12)that were previously mapped.Eight putative candidate genes were identified for three QTLs that enhance spike seed setting and grain size using gene expression data and were validated in three bi-parental populations.Protein sequence analysis identified 33 putative wheat orthologs that have high identity with rice genes in QTLs affecting similar traits.Large r^2 values for additive effects observed among the QTLs for most traits indicated that the phenotypes of these identified QTLs were highly predictable.Results from this study demonstrated that significantly increasing GWAS population size and marker density greatly improves detection and identification of candidate genes underlying a QTL,solidifying the foundation for large-scale QTL fine mapping,candidate gene validation,and developing functional markers for genomics-based breeding in wheat. | Yunlong Pang Chunxia Liu Danfeng Wang Paul St.Amand Amy Bernardo Wenhui Li Fang He Linzhi Li Liming Wang Xiufang Yuan Lei Dong Yu Su Huirui Zhang Meng Zhao Yunlong Liangi Hongze Jia Xitong Shen Yue Lu Hongming Jiang Yuye Wu Anfei Li Honggang Wang Lingrang Kong Guihua Bai Shubing Liu | 2020 | Molecular Plant2020，13，9： | 8 |
| 5 | Recent Progress in Automotive Gasoline Direct Injection Engine Technology显示文摘Gasoline direct injection(GDI)engines are currently the dominant powertrains for passenger cars.With the implementation of increasingly stringent fuel consumption and emission regulationsworldwide,GDI engines are facing challenges owing to high particulate matter emissions and a tendency to knock,leading to a change in the research and design(R&D)issues compared with those in the twentieth century.This paper reviews the progress in research regarding GDI engine technologies over the past 20 years,focusing on combustion system configurations,and also highlights common issues in GDI R&D,including pre-ignition and deto-knock,soot formation and PM emissions,injector deposits and gasoline compression ignition(GCI).First,an overview of recent developments in the field as driven by regulations is provided,following which progress in injection and combustion systems is examined.Third,the review addresses the occurrence and mechanism of deto-knock and considers means of suppressing this phenomenon.The fourth section discusses soot formation mechanisms and particulate matter emission characteristics of GDI engines and describes the application of gasoline particulate filter(GPF)after-treatment.The subsequent section summarizes studies regarding injector deposit formation,as well as pioneering research into GCI combustion modes.Finally,a summary and future prospects for GDI engine technologies are provided. | Shijin Shuai Xiao Ma Yanfei Li Yunliang Qi Hongming Xu | 2018 | Automotive Innovation2018，1，2： | 8 |
| 6 | Bevacizumab plus capecitabine and cisplatin in Chinese patients with inoperable locally advanced or metastatic gastric or gastroesophageal junction cancer: randomized, double-blind, phase III study (AVATAR study)显示文摘 | Lin Shen Jin Li Jianming Xu Hongming Pan Guanghai Dai Shukui Qin Liwei Wang Jinwan Wang Zhenzhou Yang Yongqian Shu Ruihua Xu Lei Chen Yunpeng Liu Shiying Yu Lilian Bu Yongzhe Piao | 2015 | Gastric Cancer2015，，1： | 7 |
| 7 | Progress and prospect for NASICON-type Na3V2(PO4)3 forelectrochemical energy storage显示文摘Sodium-ion batteries(SIBs) have attracted increasing attention in the past decades, because of high overall abundance of precursors, their even geographical distribution, and low cost. Na_3V_2(PO_4)_3(NVP), a typical sodium super ion conductor(NASICON)-based electrode material, exhibits pronounced structural stability, exceptionally high ion conductivity, rendering it a most promising electrode for sodium storage.However, the comparatively low electronic conductivity makes the theoretical capacity of NVP cannot be fully accessible even at comparatively low rates, presenting a major drawback for further practical applications, especially when high rate capability is especially important. Thus, many endeavors have been conformed to increase the surface and intrinsic electrical conductivity of NVP by coating the active materials with a conductive carbon layer, downsizing the NVP particles, combining the NVP particle with various carbon materials and ion doping strategy. In this review, to get a better understanding on the sodium storage in NVP, we firstly present 4 distinct crystal structures in the temperature range of -30°C^225°C namely α-NVP, β-NVP, β-NVP and γ-NVP. Moreover, we give an overview of recent approaches to enhance the surface electrical conductivity and intrinsic electrical conductivity of NVP. Finally, some potential applications of NVP such as in all-climate environment and PHEV, EV fields have been prospected. | Qiong Zheng Hongming Yi Xianfeng Li Huamin Zhang | 2018 | Journal of Energy Chemistry2018，27，6： | 7 |
| 8 | Size-controlled MoS2 nanodots supported on reduced graphene oxide for hydrogen evolution reaction and sodium-ion batteries显示文摘转变金属 dichalcogenide nanodots (ND ) 收到了可观的兴趣。我们由在 oleylamine 把铝 pentachloride 和 L 半胱氨酸用作先锋为瞬间 2 ND 报导一条灵巧的自底向上的合成线路。有从 2.2 ~ 5.3 nm 的狭窄的尺寸分布的 ND 的合成,被控制反应时间定制。因为它的涂层特征, oleyalmine 导致 ND 的一致性和 monodispersity。而且, ND 综合了有大特定的表面区域提供活跃地点。Graphene 拥有突出的电导率。联合二材料的优点,因为 2D, 0D/2D 材料展出优异电气化学的性能为离子吸附,精力存储,和变换的可渗透的隧道。同样准备的瞬间 2/rGO (~ 2.2 nm ) 显示出 220 mAhroscopy 分析的一个稳定的能力。与另外的报导金属 oxide/CN composites 比较,有 TiO 2 nanoparticles 的 ultrathin CN-NSs 层的强壮的相互作用制止他们的重新叠,哪个导致 234.0 m 2 的一个大特定的表面区域吗? | Weiyi Sun Pan Li Xue Liu Jiajia Shi Hongming Sun Zhanliang Tao Fujun Li Jun Chen | 2017 | Nano Research2017，10，7： | 6 |
| 9 | Healthcare data analytics:using a metadata annotation approach for integrating electronic hospital records显示文摘The data in electronic medical records(EMR)are complex in structure.They are independent,yet related to each other.In order to improve information access through the use of EMR,annotating work on these data is necessary.The annotation on metadata,the resource data which contain a meta-model of the database,is the basis of the annotating work if a semi-automated or an automated annotating approach which aims at making the database more accessible is expected.In this study,a method has been proposed to transform the terms which cannot be matched directly by changing them literally but maintaining their semantics,and then annotating them indirectly.After the transforming work,a refinement method which is reducible to phrase sense disambiguation(PSD)is employed to ensure accuracy.A pilot study on a hospital database has been conducted to test the accuracy and effectiveness of the proposed method. | Boyi Xu Ke Xu LiuLiu Fu Ling Li Weiwei Xin Hongming Cai | 2016 | Journal of Management Analytics2016，3，2： | 6 |
| 10 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 11 | Influence of CeO2 loading on structure and catalytic activity for NH3-SCR over TiO2-supported CeO2显示文摘A series of supported CeO2/TiO2 catalysts were prepared to explore the influence of CeO2 loading on these catalysts for the selective catalytic reduction of NO3 by NH3(NH3-SCR).The catalysts were investigated in detail by means of XRD,Raman,H2-TPR,NH3-TPD,XPS,in situ DRIFTS,and NH3-SCR reaction.The activity of the catalyst is closely related to the content of CeO2.When the loading of CeO2 is near the dispersion capacity(1.16 mmol Ce4+/100 m^2 TiO2),the catalytic activity is better.This may be because that the dispersed CeO2 is the active species and the catalyst has appropriate redox property,along with the larger amounts of surface Ce content and surface adsorbed oxygen species.Finally,a possible reaction mechanism via the Langmuir-Hinshelwood(L-H)mechanism is tentatively proposed to further understand the NH3-SCR reaction. | Hongliang Zhang Long Ding Hongming Long Jiaxin Li Wei Tan Jiawei Ji Jingfang Sun Changjin Tang Lin Dong | 2020 | Journal of Rare Earths2020，38，8： | 5 |
| 12 | Deep carbon recycling and isotope tracing:Review and prospect显示文摘Deep carbon recycling is an essential part of the global carbon cycle.The carbonates at the bottom of the ocean are brought to the mantle by subduction.Subsequently, deep carbon is released to the atmosphere in the form of CO2 through volcanism.At present, research on deep carbon recycling is still at its early stage.The proportion of subduction-related carbon and primary mantle-derived carbon in CO2 released by volcano is an important issue.Carbon isotopes can easily distinguish organic carbon from inorganic carbon.However, ~95% of subduction-related and primary mantle-derived carbon released by volcano is inorganic, which carbon isotopes find difficult to distinguish.Recently, Ca and Mg isotope geochemistry has provided important tools for tracing crust-derived material recycling.Here we focus on this topic by introducing the principles of C, Ca, and Mg isotopes in tracing deep carbon recycling and previous research results.We also summarize the research progress on the total storage and phases of deep carbon, CO2 fluxes which depend on the release via volcanism, the partial melting of the carbon-bearing mantle, and carbon behaviour during oceanic subduction. | ZHANG HongMing LI ShuGuang | 2012 | Science China Earth Sciences2012，55，12： | 4 |
| 13 | Selective depression action of taurine in flotation separation of specularite and chlorite显示文摘Chlorite,as the most representative gangue mineral associated with specularite,of which the separation of these two minerals is difficult.This paper investigated the depression effect of taurine on specularite/chlorite separation via flotation experiments,adsorption tests,contact angle measurements,Zeta potential detection,FT-IR measurements,and XPS analyses.The results of single mineral flotation indicated that chlorite could be depressed selectively by taurine with the recovery of less than 30%,but the floatability of specularite remains high with recovery rate of 81.77%at pH 10.The artificial mixed mineral flotation results confirmed the effectiveness of taurine as a depressant.Surface adsorption,contact angle,and Zeta potential detection revealed taurine primarily adsorbs on the chlorite surface,which hampered the DDA’s subsequent adsorption and results in the chlorite’s poor floatability.The FT-IR spectra and XPS analyses provided further proof that taurine adsorbed on chlorite surface as an electron donor,and part of the electrons transferred from the sulfonic acid group of taurine to metal ions during the adsorption process.In addition,the hydrogen bond between amino-group of taurine and O ions in chlorite surface was also formed in the adsorption process.Finally,optimized adsorption configurations of taurine on chlorite surfaces were proposed. | Mingyang Li Cheng Yang Zhaoyang Wu Xiangpeng Gao Xiong Tong Xiankun Yu Hongming Long | 2022 | International Journal of Mining Science and Technology2022，32，3： | 4 |
| 14 | Detection of Citrus yellow vein clearing virus by Quantitative Real-time RT-PCR显示文摘To develop a rapid and reliable detection method for Citrus yellow vein clearing virus(CYVCV), a quantitative real-time reverse transcriptionpolymerase chain reaction(q RT-PCR) system based on SYBR Green I was established by using a pair of specific primers designed from its conserved coat protein gene. The sensitivity, specificity, and applicability of the system were evaluated accordingly. The results showed that amplicons were produced from CYVCV isolates, whereas no amplicons from non-CYVCV citrus virus samples, including Citrus tristeza virus(CTV) and Citrus tatter leaf virus(CTLV), were obtained. The sensitivity of the q RT-PCR was 100-fold higher than that of conventional RT-PCR. An excellent linear correlation(R2= 0.999) was obtained from two standard curves of c RNA, and the amplification efficiency was 102%. The data from field citrus samples detection showed that the q RT-PCR system could be used in determining the concentration of CYVCV in different citrus species. | CHEN Hongming ZHOU Yan WANG Xuefeng ZHOU Changyong YANG Xiuyan LI Zhongan | 2016 | Horticultural Plant Journal2016，2，4： | 4 |
| 15 | Preparation,Thermal Stability and Electrochemical Properties of LiODFB显示文摘Lithium oxalyldifluoroborate (LiODFB) was synthesized in dimethyl carbonate solvent and purified by the method of solvent-out crystallization. The structure characterization and thermal stability of LiODFB were performed by Fourier transform infrared (FTIR) spectrometry, nuclear magnetic resonance (NMR) spectrometry and thermogravimetric analyzer (TGA). LiODFB was exposed to 50% humid air at 25 C for different time, then dried at 80 C for 12 h, and the electrochemical properties of the cells using 1 mol/L dried LiODFB in ethylene carbonate + dimethyl carbonate + ethyl(methyl)carbonate were investigated. The results showed that, pure crystallization LiODFB was obtained; it had good thermal stability with a thermal decomposition temperature of 248 C; when it was exposed to humid air, it was firstly converted into LiODFB·H2O; with increasing exposure time, more and stronger impurity peaks in the X-ray diffraction (XRD) patterns of LiODFB were observed, and both the discharge specific capacity and the capacity retention decreased gradually. | Hongming Zhou Furong Liu Jian Li | 2012 | Journal of Materials Science & Technology2012，28，8： | 4 |
| 16 | Quality of terrestrial data derived from UAV photogrammetry:A case study of Hetao irrigation district in northern China显示文摘Most crops in northern China are irrigated,but the topography affects the water use,soil erosion,runoff and yields.Technologies for collecting high-resolution topographic data are essential for adequately assessing these effects.Ground surveys and techniques of light detection and ranging have good accuracy,but data acquisition can be time-consuming and expensive for large catchments.Recent rapid technological development has provided new,flexible,high-resolution methods for collecting topographic data,such as photogrammetry using unmanned aerial vehicles(UAVs).The accuracy of UAV photogrammetry for generating high-resolution Digital Elevation Model(DEM)and for determining the width of irrigation channels,however,has not been assessed.A fixed-wing UAV was used for collecting high-resolution(0.15 m)topographic data for the Hetao irrigation district,the third largest irrigation district in China.112 ground checkpoints(GCPs)were surveyed by using a real-time kinematic global positioning system to evaluate the accuracy of the DEMs and channel widths.A comparison of manually measured channel widths with the widths derived from the DEMs indicated that the DEM-derived widths had vertical and horizontal root mean square errors of 13.0 and 7.9 cm,respectively.UAV photogrammetric data can thus be used for land surveying,digital mapping,calculating channel capacity,monitoring crops,and predicting yields,with the advantages of economy,speed and ease. | Hongming Zhang Jiangtao Yang Jantiene E.M.Baartman Shuqin Li Bei Jin Wenting Han Xiaomei Yang Lingtong Gai Coen J.Ritsema Violette Geissen | 2018 | International Journal of Agricultural and Biological Engineering2018，11，3： | 4 |
| 17 | Lymphopenia predicts disease severity of COVID-19:a descriptive and predictive study显示文摘Dear Editor,An outbreak of an unknown infectious pneumonia has recently occurred in Wuhan,China.1 The pathogen of the disease was quickly identified as a novel coronavirus(SARS-CoV-2,severe acute respiratory syndrome coronavirus 2),and the disease was named coronavirus disease-19(COVID-19).2 The virus has so far caused 78,959 confirmed cases and 2791 deaths in China according to the reports of government.COVID-19 has been spreading in many countries such as Japan,Korea,Singapore,Iran,and Italia. | Li Tan Qi Wang Duanyang Zhang Jinya Ding Qianchuan Huang Yi-Quan Tang Qiongshu Wang Hongming Miao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 18 | Can semipermeable membranes coating materials influence in vivo performance for paliperidone tri-layer ascending release osmotic pump tablet:In vitro evaluation and in vivo pharmacokinetics study显示文摘One purpose of this study was to develop a paliperidone(PAL)tri-layer ascending release pushepull osmotic pump(TA-PPOP)tablet which could meet the needs of clinical applications.And another purpose was to investigate whether different coating materials influenced in vivo performance of TA-PPOP.The ascending release mechanism of this trilayer delivery system on theory was elaborated.TA-PPOP was prepared by means of coating with cellulose acetate(CA)or ethyl cellulose(EC).Several important influence factors such as different core tablet compositions and different coating solution ingredients involved in the formulation procedure were investigated.The optimization of formulation and process was conducted by comparing different in vitro release behaviors of PAL.In vitro dissolution studies indicated that both the two formulations of different coating materials were able to deliver PAL at an ascending release rate during the whole 24 h test.The in vivo pharmacokinetics study showed that both self-made PPOP tablets with different coating had a good in vitro-in vivo correlation(IVIVC)and were bioequivalent with the brand product,which demonstrated no significant influence of the coating materials on the in vivo release acceleration of TA-PPOP. | Guangjing Li Yongjun Wang Hongming Chen Donglei Leng Panqin Ma Yanjie Dong Lifang Gao Zhonggui He | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，2： | 4 |
| 19 | Recent advances in multifunctional electrochromic energy storage devices and photoelectrochromic devices显示文摘Multifunctional devices integrated with electrochromism and energy storage or energy production functions are attractive because these devices can be used as an effective approach to address the energy crisis and environmental pollution in society today. In this review, we explain the operation principles of electrochromic energy storage devices including electrochromic supercapacitors,electrochromic batteries, and the photoelectrochromic devices. Furthermore, the material candidates and structure types of these multifunctional devices are discussed in detail. The major challenges of these devices along with a further outlook are highlighted at the end. | Zhongqiu Tong Yanlong Tian Hongming Zhang Xingang Li Junyi Ji Huiying Qu Na Li Jiupeng Zhao Yao Li | 2017 | Science China Chemistry2017，60，1： | 3 |
| 20 | Development and validation of a rapid and sensitive UHPLCeMS/MS method for the determination of paliperidone in beagle dog plasma显示文摘In order to evaluate the pharmacokinetic profile of paliperidone extended-release tablets in vivo,a simple and rapid ultra-high performance liquid chromatographyetandem mass spectrometry(UHPLCeMS/MS)method was developed and validated for the determination of paliperidone in beagle dog plasma.Paliperidone and diazepam(internal standard)were extracted from plasma samples with diethyl ether,and then separated on a C_(18) column(2.1×50 mm,2.6 mm)under gradient elution with methanol-0.1%formic acid at a flow rate of 0.3 ml/min.The compounds were detected using a triple-quadrupole mass spectrometer equipped with an electrospray ionization(ESI)source.The validated method was linear over the concentration range of 1.00-1000.00 ng/ml and the lower limit of quantitation was 1.00 ng/ml.The intra-day and inter-day precision values were not more than 15%(relative standard deviation<20%at low levels),while the accuracy was within±10%of nominal values.The validated UHPLC-MS/MS method was successfully applied to an oral pharmacokinetic study of paliperidone extended-release tablets in a beagle dog. | Hongming Chen Longshan Zhao Guangjing Li Donglei Leng Panqin Ma Lijin Tong Tianhong Zhang | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，5： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员