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| 1 | Metabolism-independent chemotaxis of Pseudomonas sp. strain WBC-3 toward aromatic compounds显示文摘Pseudomonas sp. strain WBC-3 utilized methyl parathion or para-nitrophenol (PNP) as the sole source of carbon, nitrogen, and energy, and methyl parathion hydrolase had been previously characterized. Its chemotactic behaviors to aromatics were investigated. The results indicated that strain WBC-3 was attracted to multiple aromatic compounds, including metabolizable or transformable substrates PNP, 4-nitrocatechol, and hydroquinone. Disruption of PNP catabolic genes had no e?ect on its chemotactic behaviors with the same substrates, indicating that the chemotactic response in this strain was metabolism-independent. Furthermore, it was shown that strain WBC-3 had a constitutive β-ketoadipate chemotaxis system that responded to a broad range of aromatic compounds, which was different from the inducible β-ketoadipate chemotaxis described in other Pseudomonas strains. | ZHANG, Junjie XIN, Yufeng LIU, Hong WANG, Shujun ZHOU, Ningyi | 2008 | Journal of Environmental Sciences2008，20，10： | 3 |
| 2 | Acupuncture stimulation of Yamen(GV 15), Fengfu(GV 16), Baihui(GV 20), Shuigou(GV 26) and Hegu(LI 4) reduces brain microglia activation in a traumatic brain injury rat model显示文摘OBJECTIVE: To evaluate the effect of acupuncture on neuroinflammation in traumatic brain injury(TBI) rats by stimulating Yamen(GV 15), Fengfu(GV16), Baihui(GV 20), Shuigou(GV 26) and Hegu(LI 4)acupoints and to investigate the mechanism underpinning this effect.METHODS: A TBI model was induced in SpragueDawley rats using Feeney's freefall impact method.Acupuncture to stimulate the Yamen(GV 15), Fengfu(GV 16), Baihui(GV 20), Shuigou(GV 26) and Hegu(LI 4) acupoints was performed on the TBI rats. After 3 consecutive days of acupuncture treatment, we investigated signal molecules, receptors and microglia related to neuroinflammation in brain tissue of the TBI rats and analyzed the possi-ble mechanism underlying the effect of acupuncture on neuroinflammation.RESULTS: After the acupuncture treatment, ionized calcium binding adaptor molecule 1(Iba1), a protein specific to microglia, was investigated. In the cortical layer of damaged brain tissue in TBI rats,the Iba1-positive area was 3.3% ± 0.9% in the rats that received acupuncture compared with 5.2% ±1.4% in the TBI rats that did not receive acupuncture, and the microglia were smaller with more slender protrusions in the acupuncture-treated rats.This result indicates that acupuncture can significantly reduce microglia activation in TBI rats. A possible mechanism for this effect is that acupuncture reduces the expression of autotaxin and lysophosphatidic acid. Together, these constitute the autotaxin-lysophosphatidic acid axis, which induces microglial activation in the brains of TBI rats. Acupuncture treatment may downregulate the expression of Lysophosphatidic acid(LPA) receptor(LPAR) 1 and LPAR2 on the microglial cytomembrane, which affects the microglia activation process.CONCLUSION: Acupuncture stimulating the Yamen(GV 15), Fengfu(GV 16), Baihui(GV 20),Shuigou(GV 26) and Hegu(LI 4) acupoints can effectively inhibit the development of neuroinflammation after TBI. One possible mechanism for this effect is that acupuncture downregulates LPA synthesis and affects the LPA-LPAR pathway by inhibiting LPAR1 and LPAR2, thereby inhibiting microglial activation and reducing neuroinflammation. | Lin Shujun Zhu Mingmin Chen Weihao Zhang Yujuan Lin Jihuan Pu Liu Chen Shulian Zhang Yimin Liu Xin | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 3 |
| 3 | Four-protein model for predicting prognostic risk of lung cancer显示文摘Patients with lung cancer at the same stage may have markedly different overall outcome and a lack of specific biomarker to predict lung cancer outcome.Heat-shock protein 90β(HSP90β)is overexpressed in various tumor cells.In this study,the ELISA results of HSP90βcombined with CEA,CA125,and CYFRA21-1 were used to construct a recursive partitioning decision tree model to establish a four-protein diagnostic model and predict the survival of patients with lung cancer.Survival analysis showed that the recursive partitioning decision tree could distinguish the prognosis between high-and low-risk groups.Results suggested that the joint detection of HSP90β,CEA,CA125,and CYFRA21-1 in the peripheral blood of patients with lung cancer is plausible for early diagnosis and prognosis prediction of lung cancer. | Xiang Wang Minghui Wang Lin Feng Jie Song Xin Dong Ting Xiao Shujun Cheng | 2022 | Frontiers of Medicine2022，16，4： | 2 |
| 4 | CD4+T cells memorize obesity and promote weight regain显示文摘Body weight regain often causes failure of obesity therapies while the underlying mechanism remains largely unknown.In this study,we report that immune cells,especially CD4+T cells,mediate the‘memory’of previous obese status.In a weight gain-loss-regain model,we found that C57BL/6J mice with an obesity history showed a much faster rate of body weight regain.This obesity memory could last for at least 2 months after previously obese mice were kept at the same body weight as non-obese mice.Surprisingly,such obesity memory was abrogated by dexamethasone treatment,whereas immunodeficient Rag1−/−and H2A−/−mice failed to establish such memory.Rag1−/−mice repossessed the obesity memory when immune cells or CD4+T cells isolated from previously obese mice were transferred.Furthermore,depletion of CD4+T cells led to obesity memory ablation.Taken together,we conclude that CD4+T cells mediate obesity memory and promote weight regain. | Jianghuan Zou Beibei Lai Mingzhu Zheng Qin Chen Shujun Jiang Anying Song Zan Huang Peiliang Shi Xin Tu Di Wang Linrong Lu Zhaoyu Lin Xiang Gao | 2018 | Cellular & Molecular Immunology2018，15，6： | 2 |
| 5 | Facile synthesis of gold nanoflowers as SERS substrates and their morphological transformation induced by iodide ions显示文摘我们报导新策略用一个二拍子的圆舞准备金 nanoflowers (AuNFs ) 调停种子的方法。同样准备的 AuNFs 作为散布的表面提高拉曼(重量的单位) 被采用底层,出现强壮的信号改进。我们进一步发现那碘化物离子(我 -) 能有选择地导致 AuNFs 的词法转变到范围,导致一局部性的表面电浆子蓝移动回声(LSPR ) 乐队,红的从蓝色的 AuNFs 答案的一个颜色变化,和减少的重量的单位活动。这行为允许 AuNFs 在决心被过去常我 - 。 | Shujun Zhen Tong Wu Xin Huang Yuanfang Li Chengzhi Huang | 2016 | Science China Chemistry2016，59，8： | 2 |
| 6 | Rapid-charging navigation of electric vehicles based on real-time power systems and traffic data显示文摘 | GUO Qinglai XIN Shujun SUN Hongbin | 2014 | IEEE Transactions on Smart Grid2014，5，4： | 1 |
| 7 | Scavenging effect of extracts of green tea and natural antioxidants on active oxygen radicals显示文摘 | Baolu Zhao Xiaojie Li Rungen He Shujun Cheng Xin Wenjuan | 1989 | Cell Biophysics1989，，2： | 1 |
| 8 | Evaluation of Multidisciplinary Collaborative Care in Patients with Acute Coronary Syndrome and Depression and/or Anxiety Disorders显示文摘Objective:To evaluate the effect of multidisciplinary collaborative care(MCC)in patients with both acute coronary syndrome(ACS)and depression and/or anxiety disorders compared with usual physician care(UPC).Methods:Depression and/or anxiety were screened by using SDS and SAS,ACS patients with depression and/or anxiety disorders were randomized into MCC and UPC groups.The cardiac outcomes and the life quality were evaluated at1year follow-up.Results:Overall,30.19%(96/318)patients had positive screen results.At1year,Cardiac outcome measures for patients in MCC group were significantly better for composite events of cardiac death and non-fatal MI(6.12% vs23.40%,p=0.016),cardiac function(NYHA functional classifi cation III or IV,0% vs 25%,p=0.05),and angina pectoris(21.28% vs 85%,p<0.0005),than patients in UPC group;the life quality were improved in patients in MCC group.Conclusion:After ACS,30.19% of patients had depression and/or anxiety disorders,MCC had better effects on cardiac outcomes and quality of life in ACS patients with Psychiatric disorders. | Feng Liang Xiuhua Ma Liuzhuang Zhao Chengwei Xing Xin Li Dongjing Zhao Da-Yi Hu Shuoqiang Hu Wenbin Wang Lantang Han Shujun Cao Huifang Liu Zhengyu Bian | 2017 | Cardiovascular Innovations and Applications2017，，B05： | 1 |
| 9 | Optimization of working parameters of tobacco transplanter to achieve higher erectness ofblock seedlings显示文摘 | JIN Xin LI Shujun YAN Hua | 2012 | International Agricultural Engineering Journal2012，21，2： | 1 |
| 10 | Scavenging effect of extracts of green tea and natural antioxidants on active oxygen radicals显示文摘 | Baolu Zhao Xiaojie Li Rungen He Shujun Cheng Xin Wenjuan | 1989 | Cell Biophysics1989，，2： | 1 |
| 11 | Electrochemical behavior of open-cellular structured Ti-6Al-4V alloy fabricated by electron beam melting in simulated physiological fluid:the significance of pore characteristics显示文摘The cellular structured titanium alloys have attracted significant attention for implants because of their lower Young’s modulus,which is comparable to human bone and has the capability of providing space for bone tissue in-growth.However,there is a gap in the knowledge in regard to the relationship between the pore characteristics and the electrochemical performance of open-cellular structured titanium alloys.In this study,we elucidate the influence of pore characteristics on the electrochemical performance of open-cellular structured Ti-6Al-4V alloys produced by electron beam melting(EBM).Intriguingly,the passive film formed on cellular structured Ti-6Al-4V alloy with a larger pore size was more stable and protective,and the corrosion performance was superior compared to the samples with a smaller pore size in phosphate buffered saline(PBS),mainly because of relatively smaller exposed surface area and unlimited flow of electrolyte.However,in acidic PBS containing fluoride ions,the pore characteristics did not play an important role in the corrosion resistance.It was considered that the protective film breaks down such that the corrosion performance of cellular structured alloys was comparable to each other in this harsh environment. | Xin Gai Rui Liu Yun Bai Shujun Li Yang Yang Shenru Wang Jianguo Zhang Wentao Hou Yulin Hao Xing Zhang Rui Yang R.D.K.Misra | 2022 | Journal of Materials Science & Technology2022，，2： | 1 |
| 12 | Rapid-charging navigation of electric vehicles based on real-time power systems and traffic data显示文摘 | GUO Qinglai XIN Shujun SUN Hongbin | 2014 | IEEE Transactions on Smart Grid2014，5，4： | 1 |
| 13 | Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO显示文摘The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector.Some of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator detectors.In this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/g.With ten years of data acquisition,approximately 60,000 signal and 30,000 background events are expected.This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework.IfDelta m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith angle.Moreover,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment. | Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera Daojin Hong YuenKeung Hor Shaojing Hou Yee Hsiung Bei-Zhen Hu Hang Hu Jianrun Hu Jun Hu Shouyang Hu Tao Hu Zhuojun Hu Chunhao Huang Guihong Huang Hanxiong Huang Qinhua Huang Wenhao Huang Xingtao Huang Yongbo Huang Jiaqi Hui Wenju Huo Cédric Huss Safeer Hussain Antonio Insolia Ara Ioannisian Daniel Ioannisyan Roberto Isocrate Kuo-Lun Jen Xiaolu Ji Xingzhao Ji Huihui Jia Junji Jia Siyu Jian Di Jiang Xiaoshan Jiang Ruyi Jin Xiaoping Jing Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Kampmann Li Kang Michael Karagounis Narine Kazarian Amir Khan Waseem Khan Khanchai Khosonthongkee Patrick Kinz Denis Korablev Konstantin Kouzakov Alexey Krasnoperov Svetlana Krokhaleva Zinovy Krumshteyn Andre Kruth Nikolay Kutovskiy Pasi Kuusiniemi Tobias Lachenmaier Cecilia Landini Sébastien Leblanc Frederic Lefevre Liping Lei Ruiting Lei Rupert Leitner Jason Leung Demin Li Fei Li Fule Li Haitao Li Huiling Li Jiaqi Li Jin Li Kaijie Li Mengzhao Li Nan Li Nan Li Qingjiang Li Ruhui Li Shanfeng Li Shuaijie Li Tao Li Weidong Li Weiguo Li Xiaomei Li Xiaonan Li Xinglong Li Yi Li Yufeng Li Zhibing Li Ziyuan Li Hao Liang Hao Liang Jingjing Liang Jiajun Liao Daniel Liebau Ayut Limphirat Sukit Limpijumnong Guey-Lin Lin Shengxin Lin Tao Lin Jiajie Ling Ivano Lippi Fang Liu Haidong Liu Hongbang Liu Hongjuan Liu Hongtao Liu Hu Liu Hui Liu Jianglai Liu Jinchang Liu Min Liu Qian Liu Qin Liu Runxuan Liu Shuangyu Liu Shubin Liu Shulin Liu Xiaowei Liu Yan Liu Alexey Lokhov Paolo Lombardi Claudio Lombardo Kai Loo Chuan Lu Haoqi Lu Jingbin Lu Junguang Lu Shuxiang Lu Xiaoxu Lu Bayarto Lubsandorzhiev Sultim Lubsandorzhiev Livia Ludhova Fengjiao Luo Guang Luo Pengwei Luo Shu Luo Wuming Luo Vladimir Lyashuk Qiumei Ma Si Ma Xiaoyan Ma Xubo Ma Jihane Maalmi Yury Malyshkin Fabio Mantovani Francesco Manzali Xin Mao Yajun Mao Stefano MMari Filippo Marini Sadia Marium Cristina Martellini Gisele Martin-Chassard Agnese Martini Davit Mayilyan Axel Müller Ints Mednieks Yue Meng Anselmo Meregaglia Emanuela Meroni David Meyhöfer Mauro Mezzetto Jonathan Miller Lino Miramonti Salvatore Monforte Paolo Montini Michele Montuschi Nikolay Morozov Pavithra Muralidharan Massimiliano Nastasi Dmitry VNaumov Elena Naumova Igor Nemchenok Alexey Nikolaev Feipeng Ning Zhe Ning Hiroshi Nunokawa Lothar Oberauer Juan Pedro Ochoa-Ricoux Alexander Olshevskiy Domizia Orestano Fausto Ortica Hsiao-Ru Pan Alessandro Paoloni Nina Parkalian Sergio Parmeggiano Teerapat Payupol Yatian Pei Nicomede Pelliccia Anguo Peng Haiping Peng Frédéric Perrot Pierre-Alexandre Petitjean Fabrizio Petrucci Luis Felipe Piñeres Rico Oliver Pilarczyk Artyom Popov Pascal Poussot Wathan Pratumwan Ezio Previtali Fazhi Qi Ming Qi Sen Qian Xiaohui Qian Hao Qiao Zhonghua Qin Shoukang Qiu Muhammad Rajput Gioacchino Ranucci Neill Raper Alessandra Re Henning Rebber Abdel Rebii Bin Ren Jie Ren Taras Rezinko Barbara Ricci Markus Robens Mathieu Roche Narongkiat Rodphai Aldo Romani Bedřich Roskovec Christian Roth Xiangdong Ruan Xichao Ruan Saroj Rujirawat Arseniy Rybnikov Andrey Sadovsky Paolo Saggese Giuseppe Salamanna Simone Sanfilippo Anut Sangka Nuanwan Sanguansak Utane Sawangwit Julia Sawatzki Fatma Sawy Michaela Schever Jacky Schuler Cédric Schwab Konstantin Schweizer Dmitry Selivanov Alexandr Selyunin Andrea Serafini Giulio Settanta Mariangela Settimo Muhammad Shahzad Vladislav Sharov Gang Shi Jingyan Shi Yongjiu Shi Vitaly Shutov Andrey Sidorenkov FedorŠimkovic Chiara Sirignano Jaruchit Siripak Monica Sisti Maciej Slupecki Mikhail Smirnov Oleg Smirnov Thiago Sogo-Bezerra Julanan Songwadhana Boonrucksar Soonthornthum Albert Sotnikov Ondrej Sramek Warintorn Sreethawong Achim Stahl Luca Stanco Konstantin Stankevich DušanŠtefánik Hans Steiger Jochen Steinmann Tobias Sterr Matthias Raphael Stock Virginia Strati Alexander Studenikin Gongxing Sun Shifeng Sun Xilei Sun Yongjie Sun Yongzhao Sun Narumon Suwonjandee Michal Szelezniak Jian Tang Qiang Tang Quan Tang Xiao Tang Alexander Tietzsch Igor Tkachev Tomas Tmej Konstantin Treskov Andrea Triossi Giancarlo Troni Wladyslaw Trzaska Cristina Tuve Stefan van Waasen Johannes van den Boom Guillaume Vanroyen Nikolaos Vassilopoulos Vadim Vedin Giuseppe Verde Maxim Vialkov Benoit Viaud Cristina Volpe Vit Vorobel Lucia Votano Pablo Walker Caishen Wang Chung-Hsiang Wang En Wang Guoli Wang Jian Wang Jun Wang Kunyu Wang Lu Wang Meifen Wang Meng Wang Ruiguang Wang Siguang Wang Wei Wang Wenshuai Wang Xi Wang Xiangyue Wang Yangfu Wang Yaoguang Wang Yi Wang Yifang Wang Yuanqing Wang Yuman Wang Zhe Wang Zheng Wang Zhimin Wang Zongyi Wang Apimook Watcharangkool Lianghong Wei Wei Wei Yadong Wei Liangjian Wen Christopher Wiebusch Steven Chan-Fai Wong Bjoern Wonsak Diru Wu Fangliang Wu Qun Wu Wenjie Wu Zhi Wu Michael Wurm Jacques Wurtz Christian Wysotzki Yufei Xi Dongmei Xia Yuguang Xie Zhangquan Xie Zhizhong Xing Benda Xu Donglian Xu Fanrong Xu Jilei Xu Jing Xu Meihang Xu Yin Xu Yu Xu Baojun Yan Xiongbo Yan Yupeng Yan Anbo Yang Changgen Yang Huan Yang Jie Yang Lei Yang Xiaoyu Yang Yifan Yang Haifeng Yao Zafar Yasin Jiaxuan Ye Mei Ye Ugur Yegin Frédéric Yermia Peihuai Yi Xiangwei Yin Zhengyun You Boxiang Yu Chiye Yu Chunxu Yu Hongzhao Yu Miao Yu Xianghui Yu Zeyuan Yu Chengzhuo Yuan Ying Yuan Zhenxiong Yuan Ziyi Yuan Baobiao Yue Noman Zafar Andre Zambanini Pan Zeng Shan Zeng Tingxuan Zeng Yuda Zeng Liang Zhan Feiyang Zhang Guoqing Zhang Haiqiong Zhang Honghao Zhang Jiawen Zhang Jie Zhang Jingbo Zhang Peng Zhang Qingmin Zhang Shiqi Zhang Tao Zhang Xiaomei Zhang Xuantong Zhang Yan Zhang Yinhong Zhang Yiyu Zhang Yongpeng Zhang Yuanyuan Zhang Yumei Zhang Zhenyu Zhang Zhijian Zhang Fengyi Zhao Jie Zhao Rong Zhao Shujun Zhao Tianchi Zhao Dongqin Zheng Hua Zheng Minshan Zheng Yangheng Zheng Weirong Zhong Jing Zhou Li Zhou Nan Zhou Shun Zhou Xiang Zhou Jiang Zhu Kejun Zhu Honglin Zhuang Liang Zong Jiaheng Zou | 2021 | Chinese Physics C2021，45，2： | 0 |
| 14 | Influence of Component Size on the Corrosion Behavior of Ti6Al4V Alloy Fabricated by Electron Beam Powder Bed Fusion显示文摘The electrochemical behavior of Ti-6Al-4V with 1 mm and 16 mm thickness prepared by electron beam powder bed fusion(EB-PBF)was investigated in phosphate buffered saline.Electrochemical results showed that EB-PBF Ti-6Al-4V with a larger component size was more resistant to corrosion compared to the smaller component,because of less acicularαʹphase content and moreβphase content.As a non-equilibrium phase in the“high-energy state”,αʹphase has a greater susceptibility to corrode and reduces the corrosion resistance of the material,whileβphase improves corrosion resistance of titanium alloys.The results show that the phase composition has a more significant effect on the corrosion performance than the grain size. | Hongyu Zheng Xin Gai Yun Bai Wentao Hou Shujun Li Yulin Hao R.D.K.Misra Rui Yang | 2024 | Acta Metallurgica Sinica(English Letters)2024，37，1： | 0 |
| 15 | The kinase OsSK41/OsGSK5 negatively regulates amylose content in rice endosperm by affecting the interaction between OsEBP89 and OsBP5显示文摘Amylose content(AC) is the main factor determining the palatability, viscosity, transparency, and digestibility of rice(Oryza sativa)grains. AC in rice grains is mainly controlled by different alleles of the Waxy(Wx) gene. The AP2/EREBP transcription factor OsEBP89 interacts with the MYC-like protein OsBP5 to synergistically regulate the expression of Wx.Here, we determined that the GLYCOGEN SYNTHASE KINASE 5(OsGSK5, also named SHAGGY-like kinase 41 [OsSK41]) inhibits the transcriptional activation activity of OsEBP89 in rice grains during amylose biosynthesis. The loss of OsSK41 function enhanced Wx expression and increased AC in rice grains. By contrast, the loss of function of OsEBP89 reduced Wx expression and decreased AC in rice grains. OsSK41 interacts with OsEBP89 and phosphorylates four of its sites(Thr-28,Thr-30, Ser-238, and Thr-257), which makes OsEBP89 unstable and attenuates its interaction with OsBP5. Wx promoter activity was relatively weak when regulated by the phosphomimicvariantOsEBP89E–OsBP5but relatively strong when regulated by the nonphosphorylatable variant OsEBP89A–OsBP5.Therefore, OsSK41-mediated phosphorylation of OsEBP89 represents an additional layer of complexity in the regulation of amylose biosynthesis during rice grain development. In addition, our findings provide four possible sites for regulating rice grain AC via precise gene editing. | Zejun Hu Fuan Niu Peiwen Yan Kai Wang Lixia Zhang Ying Yan Yu Zhu Shiqing Dong Fuying Ma Dengyong Lan Siwen Liu Xiaoyun Xin Ying Wang Jinshui Yang Liming Cao Shujun Wu Xiaojin Luo | 2023 | Journal of Integrative Plant Biology2023，65，7： | 0 |
| 16 | Review on analytical technologies and applications in metabolomics显示文摘Over the past decade,the swift advancement of metabolomics can be credited to significant progress in technologies such as mass spectrometry,nuclear magnetic resonance,and multivariate statistics.Currently,metabolomics garners widespread application across diverse fields including drug research and development,early disease detection,toxicology,food and nutrition science,biology,prescription,and chinmedomics,among others.Metabolomics serves as an effective characterization technique,offering insights into physiological process alterations in vivo.These changes may result from various exogenous factors like environmental conditions,stress,medications,as well as endogenous elements including genetic and protein-based influences.The potential scientific outcomes gleaned from these insights have catalyzed the formulation of innovative methods,poised to further broaden the scope of this domain.Today,metabolomics has evolved into a valuable and widely accepted instrument in the life sciences.However,comprehensive reviews focusing on the sample preparation and analytical methodologies employed in metabolomics within the life sciences are surprisingly scant.This review aims to fill that gap,providing an overview of current trends and recent advancements in metabolomics.Particular emphasis is placed on sample preparation,sophisticated analytical techniques,and their applications in life science research. | XIN MENG YAN LIU SHUJUN XU LIANRONG YANG RUI YIN | 2024 | BIOCELL2024，48，1： | 0 |
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