|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Chinese consensus guidelines for diagnosis and management of gastrointestinal stromal tumor显示文摘In order to further promote the standardization of diagnosis and treatment of gastrointestinal stromal tumor(GIST) in China, the members of Chinese Society of Clinical Oncology(CSCO) Expert Committee on GIST thoroughly discussed the key contents of the consensus guidelines, and voted on the controversial issue. In final, the Chinese consensus guidelines for the diagnosis and management of GIST(2017 edition) was formed on the basis of 2013 edition consensus guidelines, which is hereby announced. The consensus included the pathological diagnosis,recurrence risk classification evaluation, targeted agent therapy, surgery and principles of surveillance of GIST. | jian li yingjiang ye jian wang bo zhang shukui qin yingqiang shi yulong he xiaobo liang xiufeng liu ye zhou xin wu xinhua zhang ming wang zhidong gao tianlong lin hui cao lin shen | 2017 | Chinese Journal of Cancer Research2017，29，4： | 104 |
| 2 | Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model显示文摘人的间充质的干细胞(hMSCs ) 装家到肿瘤地点并且禁止肿瘤细胞的生长。很少对内在的分子的机制被知道连接 hMSCs 到肿瘤房间的指向的抑制。在这研究,我们从 hMSCs 用一个动物移植模型,一个合作文化系统和调节媒介在二根人的 hepatoma 房间线(H7402 和 HepG2 ) 上调查了 hMSCs 的效果。当 SCID 老鼠与 H7402 细胞和 Z3 hMSCs 的一个相等的数字被注射时,动物移植研究证明肿瘤形成的潜伏的时间被延长并且肿瘤尺寸更小。当 co 有教养时与 Z3 房间, H7402 细胞增殖减少了,增加的 apoptosis,和 Bcl-2 的表示, c-Myc,原子抗原(PCNA ) 和 survivin 低是的增殖的房间调整了。在有调节媒介的处理源于 Z3 hMSC 文化以后, H4702 房间出现了减少的形成殖民地的能力和减少的增长。Immunoblot 分析证明 beta-catenin, Bcl-2, c-Myc, PCNA 和 survivin 表示是在 H7402 和 HepG2 房间调整的 down。总起来说,我们的调查结果证明 hMSCs 禁止 H7402 和 HepG2 人的肝癌症房间线的恶意的显型,它包括增长,形成殖民地的能力和 oncogene 表示试管内和体内。而且,我们的研究提供表明小径的 Wnt 可以在调停 hMSC 的指向和肿瘤房间抑制有一个角色的证据。 | Ling Qiao Zhili Xu Tiejun Zhao Zhigang Zhao Mingxia Shi Robert C Zhao Lihong Ye Xiaodong Zhang | 2008 | Cell Research2008，18，4： | 68 |
| 3 | SHRIMP zircon U-Pb age and Nd isotopic study on the Nyainqêntanglha Group in Tibet显示文摘The Nyainqêntanglha Group is traditionally viewed as the oldest metamorphic basement in the Lhasa block, but its formation age and tectonic setting remain debate. Zircons extracted from the metamorphic sequence of volcanics and intrusions of the Nyainqêntanglha Group, 10 km west of Nam Co in northern Lhasa block, have been investigated by cathodolu- minescence (CL), backscattered (BSE) and dated by ion microprobe (SHRIMP). We conclude that the U-Pb age of 787±9 Ma of zircons from the trondhjemite imposes a constraint on maxi- mum protolith age, and minimum formation age of the Nyainqêntanglha Group is constrained by U-Pb age of 748±8 Ma of zircons from the granite. The formation age of the Nyainqêntanglha Group is consistent with sedimentary age of Greater Himalayan rocks, showing that they devel- oped coevally in an arc-basin tectonic setting of Neoproterozoic active continental margin along the northern margin of the India shield. The inherited zircons from the tholetiite and granite give older 207Pb/206Pb ages from 947 to 1766 Ma. The positive εNd( t ) value indicates that the mafic rocks were derived from the depleted mantle, but contaminated by the older continental crustal material. Integrated Nd model age and U-Pb age data provide excellent evidence for the exis- tence of Mesoproterozoic basement in the Lhasa block during Neoproterozoic time. | HU Daogong1, WU Zhenhan1, JIANG Wan1, SHI Yuruo2, YE Peisheng1 & LIU Qisheng1 1. Institute of Geomechanics, Chinese Academy of Geological Sciences, Beijing 100081, China 2. Institute of Geology, Chinese Academy of Geological Sciences, Beijing SHRIMP Centre, Beijing 100037, China | 2005 | Science China Earth Sciences2005，48，9： | 49 |
| 4 | Combined detections of interleukin 27, interferon-γ, and adenosine deaminase in pleural effusion for diagnosis of tuberculous pleurisy显示文摘 | WU Yan-bin YE Zhi-jian QIN Sou-ming WU Cong CHEN Yi-qiang SHI Huan-zhong | 2013 | Chinese Medical Journal2013，，17： | 41 |
| 5 | BZR1 Positively Regulates Freezing Tolerance via CBF-Dependent and CBF-Independent Pathways in Arabidopsis显示文摘冷应力是不利地影响植物生长和开发的一个主要环境因素。C 重复有约束力的 factor/DRE 绑定因素 1 (CBF/DREB1 ) 规章的串联被显示出在对的植物反应起重要作用的 transcriptional 冷。这里,我们证明发信号的 brassinosteroid (BR ) 的二个关键部件调制 Arabidopsis 植物的结冰忍耐。象 GSK3 一样 kinases 的 loss-of-function 异种在 BR 发信号包含了, bin2-3 bil1 bil2,显示出的增加的结冰公差,而 BIN2 的 overexpression 导致了超敏性到结冰,在 non-acclimated 和 acclimated 下面的应力调节。由对比,显示的抄写因素 BZR1 和 BES1 的 gain-of-function 异种提高了结冰忍耐,和一致地冷的处理能导致 dephosphorylated BZR1 的累积。生物化学、基因的分析证明 BZR1 行动 CBF1 和 CBF2 到在上游直接调整他们的表示。而且,我们发现 BZR1 也调整了另外的英国管基因与 CBF 解开了例如 WKRY6, PYL6, SOC1, JMT,和 SAG21,种反应调制到冷应力。一致地, wrky6 异种显示出减少的结冰忍耐。一起拿,我们的结果显示 BZR1 断然调制通过 CBF 依赖、 CBF 独立的小径冻结忍耐的植物。 | Hui Li Keyi Ye Yiting Shi Jinkui Cheng Xiaoyan Zhang Shuhua Yang | 2017 | Molecular Plant2017，10，4： | 37 |
| 6 | Therapeutic potential of siRNA-mediated combined knockdown of the lAP genes (Livin, XIAP, and Survivin) on human bladder cancer T24 cells显示文摘Livin, apoptosis (XIAP ) 的 X 连接禁止者,和 Survivin 几乎是 apoptosis 的三个著名禁止者在癌症房间只过去表示并且为癌症治疗被认为有势力目标。在现在的学习,我们发现 Livin, XIAP,和 Survivin 同时在膀胱癌症房间被表示。我们推测了那 Livin, XIAP,和 Survivin 可能在房间生长和 apoptosis 上有 synergistic 效果。我们的结果证实了联合那所有这三基因击倒能 synergistically 禁止增长和高级膀胱癌症 T24 房间的转变能力并且把房间 apoptotic 敏感提升到化疗。而且,联合了 Livin, XIAP,和 Survivin 罐头击倒显著地增加许多活跃 caspase-3,活跃 caspase-7,活跃 caspase-9,和 cytosolic Smac。我们的调查结果暗示 Livin, XIAP,和 Survivin 的那联合 silencing 可以是一个有势力为膀胱癌症的多指向的基因治疗。 | Deyong Yang Xishuang Song Jianing Zhang Lin Ye Shujing Wang Xiangyu Che Jianbo Wang Zhiwei Zhang Lina Wang Wei Shi | 2010 | Acta Biochimica et Biophysica Sinica2010，42，2： | 29 |
| 7 | Facile Synthesis and Application of Ag-Chemically Converted Graphene Nanocomposite显示文摘An in situ chemical synthesis approach has been employed to prepare an Ag-chemically converted graphene (CCG) nanocomposite. The reduction of graphene oxide sheets was accompanied by generation of Ag nanoparticles. The structure and composition of the nanocomposites were confirmed by means of transmission electron microscopy (TEM), atomic force microscopy (AFM) and X-ray diffraction. TEM and AFM results suggest a homogeneous distribution of Ag nanoparticles (5-10 nm in size) on CCG sheets. The intensities of the Raman signals of CCG in such nanocomposites are greatly increased by the attached silver nanoparticles, i.e., there is surface-enhanced Raman scattering activity. In addition, it was found that the antibacterial activity of free Ag nanoparticles is retained in the nanocomposites, which suggests they can be used as graphene-based biomaterials. | Jianfeng Shen Min Shi Na Li Bo Yan Hongwei Ma Yizhe Hu Mingxin Ye | 2010 | Nano Research2010，3，5： | 29 |
| 8 | The application of large volume airgun sources to the onshore-offshore seismic surveys: implication of the experimental results in northern South China Sea显示文摘Onshore-offshore seismic experiments were carried out for the first time in northern South China Sea using large volume airgun sources at sea and seismic stations on land. The experimental results indicate that seismic signals from the new airgun array of R/V Shiyan 2 can be detected as far as 255 km. The signal effective area reaches nearly 50000 km2, which covers Hong Kong and Pearl River Delta. Compared with the old airgun array, the signal amplitude, propagation distance and effective area of the new airgun array have been increased notably, which demonstrates that the upgrade of the airgun source was successful. Comparisons with previous experimental results in other regions show that the shooting effect of the new airgun array is similar to those best airgun sources in the world. Especially, it is a new breakthrough in using the permanent seismic stations onshore to record long distance airgun signals offshore, which has great significance to the realization of the 'seismic radar' concept and the 3D seismic surveys of crustal structure in coastal areas. | QIU XueLin CHEN Yong ZHU RiXiang XU HuiLong SHI XiaoBin YE ChunMing ZHAO MingHui XIA ShaoHong | 2007 | Chinese Science Bulletin2007，52，4： | 27 |
| 9 | Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4显示文摘最近的尖铁 glycoprotein (S) 鉴别中东呼吸症候群 coronavirus (MERS-CoV ) 指向细胞的受体, dipeptidyl peptidase 4 (DPP4 ) 。顺序比较和当模特儿的分析在病毒的尖铁上揭示了一个通常认为的受体绑定领域(RBD ) ,它调停这个相互作用。我们报导 3.0 Å MERS-CoV RBD 的决定水晶结构跳了到人的 DPP4 的细胞外的领域。我们的结果证明 MERS-CoV RBD 由一个核心和受体绑定子域组成。受体绑定子域与 DPP4 β 交往;推进器然而并非它的内在的 hydrolase 领域。MERS-CoV RBD 和相关 SARS-CoV RBD 分享他们的核心子域的结构的类似的高度,但是在受体绑定子域是尤其是分叉的。Mutagenesis 研究在为到 DPP4 和入口的病毒的绑定是批评的进目标房间的受体绑定子域识别了几关键残余。在在 MERS-CoV RBD 和 DPP4 之间的接口的原子细节提供病毒和受体相互作用的结构的理解,它能对 MERS-CoV 感染指导治疗学和疫苗的开发。 | Nianshuang Wang Xuanling Shi Liwei Jiang Senyan Zhang Dongli Wang Pei Tong Dongxing Guo Lili Fu Ye Cui Xi Liu Kelly C Arledge Ying-Hua Chen Linqi Zhang Xinquan Wang | 2013 | Cell Research2013，23，8： | 26 |
| 10 | Hydrogen sulfide regulates abiotic stress tolerance and biotic stress resistance in Arabidopsis显示文摘Hydrogen sulfide(H_2S) is an important gaseous molecule in various plant developmental processes and plant stress responses.In this study,the transgenic Arabidopsis thaliana plants with modulated expressions of two cysteine desulfhydrases,and exogenous H_2S donor(sodium hydrosulfide,NaHS) and H_2S scavenger(hypotaurine,HT) pre-treated plants were used to dissect the involvement of H_2S in plant stress responses.The cysteine desulfhydrases overexpressing plants and NaHS pre-treated plants exhibited higher endogenous H_2S level and improved abiotic stress tolerance and biotic stress resistance,while cysteine desulfhydrases knockdown plants and HT pre-treated plants displayed lower endogenous H_2S level and decreased stress resistance.Moreover,H_2S upregulated the transcripts of multiple abiotic and biotic stress-related genes,and inhibited reactive oxygen species(ROS) accumulation.Interestingly,MIR393-mediated auxin signaling including MIR393a/b and their target genes(TIR1,AFB1,AFB2,and AFB3) was transcriptionally regulated by H_2S,and was related with H_2S-induced antibacterial resistance.Moreover,H_2S regulated 50 carbon metabolites including amino acids,organic acids,sugars,sugar alcohols,and aromatic amines.Taken together,these results indicated that cysteine desulfhydrase and H_2S conferred abiotic stress tolerance and biotic stress resistance,via affecting the stress-related gene expressions,ROS metabolism,metabolic homeostasis,and MIR393-targeted auxin receptors. | Haitao Shi Tiantian Ye Ning Han Hongwu Bian Xiaodong Liu Zhulong Chan | 2015 | Journal of Integrative Plant Biology2015，57，7： | 26 |
| 11 | KRAS and BRAF gene mutations and DNA mismatch repair status in Chinese colorectal carcinoma patients显示文摘AIM:To investigate gene mutations and DNA mismatch repair(MMR) protein abnormality in Chinese colorectalcarcinoma(CRC) patients and their correlations with clinicopathologic features.METHODS:Clinical and pathological information for 535 patients including 538 tumors was reviewed and recorded.Mutation analyses for exon 2 of KRAS gene and exon 15 of BRAF gene were performed by Sanger sequencing except that in 9 tumors amplification refractory mutation system PCR was used.Expression of MMR proteins including MHL1,MSH2,MSH6 and PMS2 was evaluated by immunohistochemistry.Correlations of KRAS and BRAF mutation status and the expression status of MMR proteins with age,gender,cancer stage,location,and histology were analyzed.Correlations between KRAS or BRAF mutations and MMR protein expression were also explored.RESULTS:The overall frequencies of KRAS and BRAF mutations were 37.9% and 4.4%,respectively.KRAS mutations were more common in patients ≥ 50 years old(39.8% vs 22% in patients < 50 years old,P < 0.05).The frequencies of BRAF mutants were higher in tumors from females(6.6% vs males 2.8%,P < 0.05),located in the right colon(9.6% vs 2.1% in the left colon,1.8% in the rectum,P < 0.01),with mucinous differentiation(9.8% vs 2.8% without mucinous differentiation,P < 0.01),or being poorly differentiated(9.5% vs 3.4% well/moderately differentiated,P < 0.05).MMR deficiency was strongly associated with proximal location(20.5% in the right colon vs 9.2% in the left colon and 5.1% in the rectum,P < 0.001),early cancer stage(15.0% in stages Ⅰ-Ⅱ vs 7.7% in stages Ⅲ-Ⅳ,P < 0.05),and mucinous differentiation(20.2% vs 9.2% without mucin,P < 0.01).A higher frequency of MLH1/PMS2 loss was found in females(9.2% vs 4.4% in males,P < 0.05),and MSH2/MSH6 loss tended to be seen in younger(<50 years old) patients(12.0% vs 4.0% ≥ 50 years old,P < 0.05).MMR deficient tumors were less likely to have KRAS mutations(18.8% vs 41.7% in MMR proficient tumors,P < 0.05) and tumorswith abnormal MLH1/PMS2 tended to harbor BRAF mutations(15.4% vs 4.2% in MMR proficient tumors,P < 0.05).CONCLUSION:The frequency of sporadic CRCs having BRAF mutation,MLH1 deficiency and MSI in Chinese population may be lower than that in the Western population. | Ju-Xiang Ye Yan Liu Yun Qin Hao-Hao Zhong Wei-Ning Yi Xue-Ying Shi | 2015 | World Journal of Gastroenterology2015，21，5： | 26 |
| 12 | Geospatial-temporal analysis of land-use changes in the Yellow River Delta during the last 40 years显示文摘Comprehensive study on land-use change of spatial pattern and temporal process is the key component in land use/land cover changes (LUCC) study nowadays. According to the theories and methods of Geo-information Tupu (Carto-methodology in Geo-information, CMGI) for geospatial and temporal analysis and integration models of spatial pattern and temporal processes in GIS, the paper puts forward Tupu methodology of land-use change and names the basic synthetic unit of spatial-temporal information Tupu unit. Tupu unit is the synthetic unit for geospatial-temporal analysis, which is synthesized by “space·attribute·process”features and composed of relatively homogeneous geographic unit and temporal unit. Based on the spatial features of 4 stages of land-use change in 1956, 1984, 1991, and 1996, a series of Tupu on land-use change in the Yellow River Delta (YRD) are created and studied in the paper, which includes 3 temporal units of spatial-temporal Tupu, process Tupu of land-use changes during the last 40 years, and reconstructions of a series of “arisen”Tupu, “arisen”process Tupu and pattern Tupu on land-use changes in the last 40 years by remapping tables of a reclassifying system. There are 3 methods of Tupu analysis on land-use change that are used to disclose change processes of land-use spatial conversion in YRD, such as spatial query and statistics, order of Tupu units by area and land-use conversion matrixes. In order to reveal the spatial pattern of land-use change processes, we analyze spatial-temporal changes of each Tupu above in various temporal units and spatial difference of pattern Tupu in the last 40 years by dynamic Tupu units. Tupu analysis on regional land-use is a promising trial on the comprehensive research of “spatial pattern of dynamic process”and “temporal process of spatial pattern”in LUCC research. The geo-information Tupu methodology would be a powerful and efficient tool on integrated studies of spatial pattern and temporal process in geoscience. | YE Qinghua1,3,4,LIU Gaohuan2,TIAN Guoliang1,CHEN Shenliang3,HUANG Chong2,CHEN Shupeng1,2,LIU Qingshen2,CHANG Jun2 & SHI Yanan2 1.State Key Laboratory of Remote Sensing Science,Institute of Remote Sensing Applications(IRSA),Chinese Academy of Science(CAS),Beijing 100101,China 2.Institute of Geographic Sciences and Natural Resources Research,CAS,Beijing 100101,China 3.State Key Laboratory of Estuarine and Coastal Research,East China Normal University,Shanghai 200062,China 4.Institute of Tibetan Plateau Research(ITPR),CAS,Beijing 100085,China Correspondence should be addressed to Ye Qinghua(email: yeqh@itpcas.ac.cn) | 2004 | Science China Earth Sciences2004，47，11： | 22 |
| 13 | Involvement of microRNA-21 in mediating chemoresistance to docetaxel in androgen-independent prostate cancer PC3 cells显示文摘 | Guo-hai SHI | 2010 | Acta Pharmacologica Sinica2010，31，7： | 22 |
| 14 | Short-term outcomes of laparoscopic total mesorectal excision compared to open surgery显示文摘AIM:To investigate the short-term outcome of laparoscopic total mesorectal excision(TME) in patients with mid and low rectal cancers.METHODS:A consecutive series of 138 patients with middle and low rectal cancer were randomly assigned to either the laparoscopic TME(LTME) group or the open TME(OTME) group between September 2008 and July 2011 at the Department of Colorectal Cancer of Shanghai Cancer Center,Fudan University and pathological data,as well as surgical technique were reviewed retrospectively.Short-term clinical and oncological outcome were compared in these two groups.Patients were followed in the outpatient clinic 2 wk after the surgery and then every 3 mo in the first year if no adjuvant chemoradiation was indicated.Statistical analysis was performed using SPSS 13.0 software.RESULTS:Sixty-seven patients were treated with LTME and 71 patients were treated with OTME(sex ratio 1.3:1vs 1.29:1,age 58.4 ± 13.6 years vs 59.6 ± 9.4 years,respectively).The resection was considered curative in all cases.The sphincter-preserving rate was 65.7%(44/67) vs 60.6%(43/71),P = 0.046;mean blood loss was 86.9 ± 37.6 mL vs 119.1 ± 32.7 mL,P = 0.018;postoperative analgesia was 2.1 ± 0.6 d vs 3.9 ± 1.8 d,P = 0.008;duration of urinary drainage was 4.7 ± 1.8 d vs 6.9 ± 3.4 d,P = 0.016,respectively.The conversion rate was 2.99%.The complication rate,circumferential margin involvement,distal margins and lymph node yield were similar for both procedures.No port site recurrence,anastomotic recurrence or mortality was observed during a median follow-up period of 21 mo(range:9-56 mo).CONCLUSION:Laparoscopic TME is safe and feasible,with an oncological adequacy comparable to the open approach.Further studies with more patients and longer follow-up are needed to confirm the present results. | Jing Gong De-Bing Shi Xin-Xiang Li San-Jun Cai Zu-Qing Guan Ye Xu | 2012 | World Journal of Gastroenterology2012，18，48： | 23 |
| 15 | Epidemiology of Diabetes in Adults Aged 35 and Older from Shanghai,China显示文摘Objective This study aimed to investigate the epidemiology of diabetes in adults from Shanghai, aged 35 and older, in 2013. Methods We estimated the diabetes prevalence in a representative sample of 18,736 adults who were selected through a multistage stratified cluster sampling process. A standard questionnaire containing questions about demographic characteristics and lifestyle factors was distributed. After an overnight fast of at least 10 hours, a venous blood sample was collected from each participant. For each patient without a history of diabetes, another blood sample was drawn 120 min after an oral glucose tolerance test to identify undiagnosed diabetes and prediabetic condition. Results Among Shanghai residents aged 35 and above, the overall weighted prevalence of diabetes was 17.6% [95% confidence interval(CI): 16.4%-18.8%]. The prevalences were 19.3% in men and 15.8% in women as well as 19.1%, 15.4%, and 16.1% in urban, suburban, and rural residents, respectively. In addition, the weighted prevalence of prediabetes was 16.5%(95% CI: 15.3%-17.8%), with the prevalences of 16.5% in men, 16.6% in women, 15.2% in urban residents, 18.0% in suburban residents, and 18.5% in rural residents. Among all patients with diabetes, 68.1%(95% CI: 64.3%-71.6%) were aware of their status, 63.5%(95% CI: 60.0%-66.9%) received diabetes treatment, but only 35.1%(95% CI: 32.4%-37.8%) had adequate glycemic control. Conclusion In Shanghai, diabetes and prediabetes are highly prevalent. However, 1/3rd of diabetes cases are undiagnosed, and the rate of glycemic control is low. | RUAN Ye YAN Qing Hua XU Ji Ying YANG Qun Di YAO Hai Hong LI Rui SHI Yan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 22 |
| 16 | The second natural gas hydrate production test in the South China Sea显示文摘Clayey silt reservoirs bearing natural gas hydrates(NGH)are considered to be the hydrate-bearing reservoirs that boast the highest reserves but tend to be the most difficult to exploit.They are proved to be exploitable by the first NGH production test conducted in the South China Sea in 2017.Based on the understanding of the first production test,the China Geological Survey determined the optimal target NGH reservoirs for production test and conducted a detailed assessment,numerical and experimental simulation,and onshore testing of the reservoirs.After that,it conducted the second offshore NGH production test in 1225 m deep Shenhu Area,South China Sea(also referred to as the second production test)from October 2019 to April 2020.During the second production test,a series of technical challenges of drilling horizontal wells in shallow soft strata in deep sea were met,including wellhead stability,directional drilling of a horizontal well,reservoir stimulation and sand control,and accurate depressurization.As a result,30 days of continuous gas production was achieved,with a cumulative gas production of 86.14×104 m3.Thus,the average daily gas production is 2.87×10^4 m^3,which is 5.57 times as much as that obtained in the first production test.Therefore,both the cumulative gas production and the daily gas production were highly improved compared to the first production test.As indicated by the monitoring results of the second production test,there was no anomaly in methane content in the seafloor,seawater,and atmosphere throughout the whole production test.This successful production test further indicates that safe and effective NGH exploitation is feasible in clayey silt NGH reservoirs.The industrialization of hydrates consists of five stages in general,namely theoretical research and simulation experiments,exploratory production test,experimental production test,productive production test,and commercial production.The second production test serves as an important step from the exploratory production test to experimental production test. | Jian-liang Ye Xu-wen Qin Wen-wei Xie Hai-long Lu Bao-jin Ma Hai-jun Qiu Jin-qiang Liang Jing-an Lu Zeng-gui Kuang Cheng Lu Qian-yong Liang Shi-peng Wei Yan-jiang Yu Chunsheng Liu Bin Li Kai-xiang Shen Hao-xian Shi Qiu-ping Lu Jing Li Bei-bei Kou Gang Song Bo Li He-en Zhang Hong-feng Lu Chao Ma Yi-fei Dong Hang Bian | 2020 | China Geology2020，3，2： | 22 |
| 17 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 18 | Regeneration of 2-amino-2-methyl-1-propanol used for carbon dioxide absorption显示文摘为了改进二氧化碳的效率骑车,处理并且减少新生能量消耗,一个位的联盟者妨碍了 2-amino-2-methyl-1-propranol (安培) 的胺被调查作为 CO2 吸收剂决定它的新生行为。CO2 吸收和胺新生特征试验性地在各种各样的操作条件下面被检验。新生效率在 358 ~ 403 K 的温度范围期间从 86.2% ~ 98.3% 增加了。为安培的最合适的新生温度是 383 K,处于这个实验条件,并且吸收 / 新生的新生效率变从 98.3% ~ 94.0% 下降了。很多热马厩盐(HSS ) 能在 CO2 吸收容量和新生效率引起减小。结果显示水的安培更容易比另外的胺与吸收容量的更少的损失再生,例如,单音的乙醇胺(MEA ) , diethanolamine (DEA ) , diethylenetriamine (DETA ) ,和 N-methyldiethanolamine (MDEA ) 。 | ZHANG Pei SHI Yao WEI Jianwen ZHAO Wei YE Qing | 2008 | Journal of Environmental Sciences2008，20，1： | 21 |
| 19 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 20 | Clinical trial with traditional Chinese medicine intervention ''tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'' for chronic hepatitis B-associated liver failure显示文摘AIM:To study the clinical efficacy of traditional Chinese medicine(TCM)intervention'tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK')for treating liver failure due to chronic hepatitis B.METHODS:We designed the study as a randomized controlled clinical trial.Registration number of Chinese Clinical Trial Registry is Chi CTR-TRC-12002961.A total of 144 patients with liver failure due to infection with chronic hepatitis B virus were enrolled in this randomized controlled clinical study.Participants were randomly assigned to the following three groups:(1)a modern medicine control group(MMC group,36patients);(2)a'tonifying qi and detoxification'('TQD')group(72 patients);and(3)a'tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK')group(36patients).Patients in the MMC group received general internal medicine treatment;patients in the'TQD'group were given a TCM formula'tonifying qi and detoxification'and general internal medicine treatment;patients in the'TTK'group were given a TCM formula of'TTK'and general internal medicine treatment.All participants were treated for 8 wk and then followed at 48 wk following their final treatment.The primaryefficacy end point was the patient fatality rate in each group.Measurements of various virological and biochemical indicators served as secondary endpoints.The one-way analysis of variance and the t-test were used to compare patient outcomes in the different treatment groups.RESULTS:At the 48-wk post-treatment time point,the patient fatality rates in the MMC,'TQD',and'TTK'groups were 51.61%,35.38%,and 16.67%,respectively,and the differences between groups were statistically significant(P<0.05).However,there were no significant differences in the levels of hepatitis B virus DNA or prothrombin activity among the three groups(P>0.05).Patients in the'TTK'group had significantly higher levels of serum total bilirubin compared to MMC subjects(339.40μmol/L±270.09μmol/L vs 176.13μmol/L±185.70μmol/L,P=0.014).Serum albumin levels were significantly increased in both the'TQD'group and'TTK'group as compared with the MMC group(31.30 g/L±4.77g/L,30.72 g/L±2.89 g/L vs 28.57 g/L±4.56 g/L,P<0.05).There were no significant differences in levels of alanine transaminase among the three groups(P>0.05).Safety data showed that there was one case of stomachache in the'TQD'group and one case of gastrointestinal side effect in the'TTK'group.CONCLUSION:Treatment with'TTK'improved the survival rates of patients with liver failure due to chronic hepatitis B.Additionally,liver tissue was regenerated and liver function was restored. | Han-Min Li Zhi-Hua Ye Jun Zhang Xiang Gao Yan-Ming Chen Xin Yao Jian-Xun Gu Lei Zhan Yang Ji Jian-Liang Xu Ying-He Zeng Fan Yang Lin Xiao Guo-Guang Sheng Wei Xin Qi Long Qing-Jing Zhu Zhao-Hong Shi Lian-Guo Ruan Jia-Yao Yang Chang-Chun Li Hong-Bin Wu Sheng-Duo Chen Xin-La Luo | 2014 | World Journal of Gastroenterology2014，20，48： | 20 |
您所在的机构暂未开通此部分的功能，请联系管理员