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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Physics-informed neural networks(PINNs)for fluidmechanics:a review显示文摘Despite the significant progress over the last 50 years in simulating flow problems using numerical discretization of the Navier–Stokes equations(NSE),we still cannot incorporate seamlessly noisy data into existing algorithms,mesh-generation is complex,and we cannot tackle high-dimensional problems governed by parametrized NSE.Moreover,solving inverse flow problems is often prohibitively expensive and requires complex and expensive formulations and new computer codes.Here,we review flow physics-informed learning,integrating seamlessly data and mathematical models,and implement them using physics-informed neural networks(PINNs).We demonstrate the effectiveness of PINNs for inverse problems related to three-dimensional wake flows,supersonic flows,and biomedical flows. | Shengze Cai Zhiping Mao Zhicheng Wang Minglang Yin George Em Karniadakis | 2021 | Acta Mechanica Sinica2021，37，12： | 7 |
| 3 | Highly diversified Zika viruses imported to China, 2016显示文摘 | Yanjun Zhang Wenxian Chen Gary Wong Yuhai Bi Juying Yan Yi Sun Enfu Chen Hao Yan Xiuyu Lou Haiyan Mao Shichang Xia George F.Gao Weifeng Shi Zhiping Chen | 2016 | Protein & Cell2016，7，6： | 7 |
| 4 | Skeletochronological Study of Age,Longevity and Growth in a Population of Rana nigromaculata(Amphibia:Anura) in Sichuan,China显示文摘A skeletochronological study was conducted for the age, longevity and growth of a Rana nigromaculata population in northeastern Sichuan, China. Of 139 specimens, 119(68 males and 51 females) exhibited distinct arrested growth lines in phalanges. Age at first reproduction was found to be two years of age for males and three for females. Maximum longevity was estimated to be at least six years in males and seven years in females. Average age did not differ between males and females. Breeding females were significantly older than breeding males. Females were larger in body size and heavier in body mass than males. Age was not correlated with body size and body mass in males, but a significant correlation was found among age, body size and body mass in females. The growth curve appeared significantly different between the sexes, with a higher growth rate throughout life and a larger asymptotic size in females. Moreover, analysis of the growth model indicated that the population studied was relatively stable. | Min MAO Yan HUANG Zhiping MI Yanhong LIU Caiquan ZHOU | 2012 | Asian Herpetological Research2012，3，3： | 3 |
| 5 | Asymmetry of Testes in Guenther's Frog,Hylarana guentheri(Anuar:Ranidae)显示文摘Testes size in most animals commonly shows directional asymmetry.In birds,the left testis mass is usually larger than the right one,but the reports on the testes asymmetry in anurans are very few.M?ller(1994)hypothesized that the right testis serves a compensatory role and increases in size when the left one is defective,and further suggested that testes asymmetry may be a reliable indicator of individual body condition.In this paper,we tested the compensation hypothesis in the Guenther's frog,Hylarana guentheri.From 60 sampled males,we found that there was a signifi cant directional asymmetry in testes mass,with the left testis size being significantly correlated with relative testes asymmetry,providing evidence that the right testis had a compensatory function.However,testes mass and asymmetry were not correlated with body condition.Hence,we found no evidence that testes asymmetry in the Guenther's frog ref lected male condition,and male age was also not related to testes mass or asymmetry. | Yanhong LIU Wenbo LIAO Caiquan ZHOU Zhiping MI Min MAO | 2011 | Asian Herpetological Research2011，2，4： | 3 |
| 6 | Physics-informed neural networks with residual/gradient-based adaptive sampling methods for solving partial differential equations with sharp solutions显示文摘We consider solving the forward and inverse partial differential equations(PDEs)which have sharp solutions with physics-informed neural networks(PINNs)in this work.In particular,to better capture the sharpness of the solution,we propose the adaptive sampling methods(ASMs)based on the residual and the gradient of the solution.We first present a residual only-based ASM denoted by ASMⅠ.In this approach,we first train the neural network using a small number of residual points and divide the computational domain into a certain number of sub-domains,then we add new residual points in the sub-domain which has the largest mean absolute value of the residual,and those points which have the largest absolute values of the residual in this sub-domain as new residual points.We further develop a second type of ASM(denoted by ASMⅡ)based on both the residual and the gradient of the solution due to the fact that only the residual may not be able to efficiently capture the sharpness of the solution.The procedure of ASMⅡis almost the same as that of ASMⅠ,and we add new residual points which have not only large residuals but also large gradients.To demonstrate the effectiveness of the present methods,we use both ASMⅠand ASMⅡto solve a number of PDEs,including the Burger equation,the compressible Euler equation,the Poisson equation over an Lshape domain as well as the high-dimensional Poisson equation.It has been shown from the numerical results that the sharp solutions can be well approximated by using either ASMⅠor ASMⅡ,and both methods deliver much more accurate solutions than the original PINNs with the same number of residual points.Moreover,the ASMⅡalgorithm has better performance in terms of accuracy,efficiency,and stability compared with the ASMⅠalgorithm.This means that the gradient of the solution improves the stability and efficiency of the adaptive sampling procedure as well as the accuracy of the solution.Furthermore,we also employ the similar adaptive sampling technique for the data points of boundary conditions(BCs)if the sharpness of the solution is near the boundary.The result of the L-shape Poisson problem indicates that the present method can significantly improve the efficiency,stability,and accuracy. | Zhiping MAO Xuhui MENG | 2023 | Applied Mathematics and Mechanics(English Edition)2023，44，7： | 1 |
| 7 | Controlled growth of magnesium hydroxide crystals and its effect on the high- temperature properties of cotton/ magnesium hydroxide composites显示文摘 | Hui Ma Zhixiang Chen Zhiping Mao | 2013 | Vacuum2013，，95： | 1 |
| 8 | A method for repairing the inconsistency of fuzzy preference rela tions显示文摘 | Ma Jian Fan Zhiping Jiang Yanping Mao Jiye Ma Louis | 2006 | Fuzzy Sets and Systems2006，，157： | 1 |
| 9 | The flame retardancy and thermal stability properties of poly (ethylene tereph- thalate)/hexakis (4-nitrophenoxy) cyclotriphosphazene sys- tems显示文摘 | Zhang Xuan Zhong Yi Mao Zhiping | 2012 | Poiym Degrad Stab2012，97，： | 1 |
| 10 | Ester cross linking of cotton cellulose by polycarboxylic acids:the pH-dependecy显示文摘 | Yang Charles Q Mao Zhiping Gray Lickfield | 2000 | Textile Chemiset and Colorist2000，32，11： | 1 |
| 11 | Thermally conductive poly(lactic acid)/boron nitride composites via regenerated cellulose assisted Pickering emulsion approach显示文摘Polymer-based thermally conductive composites have attracted tremendous interest in thermal management of electronics.However,it remains challenging to achieve high thermal conductivity partly because the difficulty to obtain favorable distribution and orientation of conductive fillers within the polymer matrix.Herein,networked boron nitride(BN)conductive pathway was realized within the poly(lactic acid)(PLA)matrix,via regenerated cellulose(RC)-assisted assembly of BN on Pickering emulsion interface based on the noncovalent interaction,followed by solvent evaporation and hot-compressing.The strong noncovalent interactions between BN and RC were found critical to enhance the wettability and stability of BN in aqueous media with a lowest mass ratio of 1:40 of RC and BN.The obtained PLA/BN composites feature a thermal conductivity of 1.06 W/(m K)at 28.4 wt%BN loading,representing an enhancement of 430%comparing to neat PLA,and the crystallinity of the composites could increase significantly from11.7%(neat PLA)to 43.7%.This simple,environmentally friendly and effective strategy could be easily extended for effective construction of thermally conductive composites. | Yating Wang Hong Jin Jiajun Shen Bijia Wang Xueling Feng Zhiping Mao Yumei Zhang Xiaofeng Sui | 2022 | Journal of Materials Science & Technology2022，，6： | 1 |
| 12 | Nonlocal Flocking Dynamics: Learning the Fractional Order of PDEs from Particle Simulations显示文摘Flocking refers to collective behavior of a large number of interacting entities,where the interactions between discrete individuals produce collective motion on the large scale.We employ an agent-based model to describe the microscopic dynamics of each individual in a flock,and use a fractional partial differential equation(fPDE)to model the evolution of macroscopic quantities of interest.The macroscopic models with phenomenological interaction functions are derived by applying the continuum hypothesis to the microscopic model.Instead of specifying the fPDEs with an ad hoc fractional order for nonlocal flocking dynamics,we learn the effective nonlocal influence function in fPDEs directly from particle trajectories generated by the agent-based simulations.We demonstrate how the learning framework is used to connect the discrete agent-based model to the continuum fPDEs in one-and two-dimensional nonlocal flocking dynamics.In particular,a Cucker-Smale particle model is employed to describe the microscale dynamics of each individual,while Euler equations with nonlocal interaction terms are used to compute the evolution of macroscale quantities.The trajectories generated by the particle simulations mimic the field data of tracking logs that can be obtained experimentally.They can be used to learn the fractional order of the influence function using a Gaussian process regression model implemented with the Bayesian optimization.We show in one-and two-dimensional benchmarks that the numerical solution of the learned Euler equations solved by the finite volume scheme can yield correct density distributions consistent with the collective behavior of the agent-based system solved by the particle method.The proposed method offers new insights into how to scale the discrete agent-based models to the continuum-based PDE models,and could serve as a paradigm on extracting effective governing equations for nonlocal flocking dynamics directly from particle trajectories. | Zhiping Mao Zhen Li George Em Karniadakis | 2019 | Communications on Applied Mathematics and Computation2019，1，4： | 0 |
| 13 | Preparation Technology and Property Research of Ultra-Concentrated Liquid Detergent显示文摘 | Xiumei Tai Xiaoying Liu Guoyong Wang Xuebin Mao Zhiping Du | 2016 | China Detergent & Cosmetics2016，1，4： | 0 |
| 14 | Polyoxometalate-loaded Nanocellulose Sponge as a Novel Catalyst for the Regioselective Hydroboration of Phenylacetylene显示文摘In this work,an amino-modified cellulose nanofiber sponge was prepared and used as a support for polyoxometalate(POM)catalysts with a high loading efficiency.Fourier transform infrared spectroscopy,thermogravimetric analysis,and energy-dispersive X-ray spectroscopy revealed that an Anderson-type POM,(NH4)4[CuMo6O18(OH)6]·5H2O was successfully immobilized on the sponge based on electrostatic interactions.Morphological analysis indicated that the POM-loaded sponge retained its porous structure and that the POM was homogeneously distributed on the sponge walls.The POM-loaded sponge exhibited excellent mechanical properties by recovering 79.9%of its original thickness following a 60%compression strain.The POM-loaded sponge was found to effectively catalyze the hydroboration of phenylacetylenes,yielding excellent conversion and regioselectivity of up to 96%and 99%,respectively.Its catalytic activity remained unchanged after five reuse cycles.These findings represent a scalable strategy for immobilizing POMs on porous supports. | GuoQing Yang CongCong Zhang BiJia Wang ZhiPing Mao Hong Xu Yi Zhong XueLing Feng XiaoFeng Sui | 2019 | Paper And Biomaterials2019，4，2： | 0 |
| 15 | Schisandrin B protects PC12 cells by decreasing the expression of amyloid precursor protein and vacuolar protein sorting 35显示文摘PC12 cell injury was induced using 20 μM amyloid β-protein 25-35 to establish a model of Alzheimer's disease. The cells were then treated with 5, 10, and 25 μM Schisandrin B. Methylthiazolyldiphenyl-tetrazolium bromide assays and Hoechst 33342 staining results showed that with increasing Schisandrin B concentration, the survival rate of PC12 cells injured by amyloid β-protein 25-35 gradually increased and the rate of apoptosis gradually decreased. Reverse transcription-PCR, immunocytochemical staining and western blot results showed that with increasing Schisandrin B concentration, the mRNA and protein expression of vacuolar protein sorting 35 and amyloid precursor protein were gradually decreased. Vacuolar protein sorting 35 and amyloid precursor protein showed a consistent trend for change. These findings suggest that 5, 10, and 25 μM Schisandrin B antagonizes the cellular injury induced by amyloid β-protein 25-35 in a dose-dependent manner. This may be caused by decreasing the expression of vacuolar protein sorting 35 and amyloid precursor protein. | Mingmin Yan Shanping Mao Huimin Dong Baohui Liu Qian Zhang Gaofeng Pan Zhiping Fu | 2012 | Neural Regeneration Research2012，7，9： | 0 |
| 16 | Analysis and Approximation of Gradient Flows Associated with a Fractional Order Gross-Pitaevskii Free Energy显示文摘We establish the well-posedness of the fractional PDE which arises by considering the gradient flow associated with a fractional Gross-Pitaevskii free energy functional and some basic properties of the solution.The equation reduces to the Allen-Cahn or Cahn-Hilliard equations in the case where the mass tends to zero and an integer order derivative is used in the energy.We study how the presence of a non-zero mass affects the nature of the solutions compared with the Cahn-Hilliard case.In particular,we show that,analogous to the Cahn-Hilliard case,the solutions consist of regions in which the solution is a piecewise constant(whose value depends on the mass and the fractional order)separated by an interface whose width is independent of the mass and the fractional derivative.However,if the average value of the initial data exceeds some threshold(which we determine explic让ly),then the solution will tend to a single constant steady state. | Mark Ainsworth Zhiping Mao | 2019 | Communications on Applied Mathematics and Computation2019，1，1： | 0 |
| 17 | Efficient and Accurate Numerical Methods Using the Accelerated Spectral Deferred Correction for Solving Fractional Differential Equations显示文摘We develop an efficient and accurate spectral deferred correction(SDC)method for fractional differential equations(FDEs)by extending the algorithm in[14]for classical ordinary differential equations(ODEs).Specifically,we discretize the resulted Picard integral equation by the SDC method and accelerate the convergence of the SDC iteration by using the generalized minimal residual algorithm(GMRES).We first derive the correction matrix of the SDC method for FDEs and analyze the convergence region of the SDC method.We then present several numerical examples for stiff and non-stiff FDEs including fractional linear and nonlinear ODEs as well as fractional phase field models,demonstrating that the accelerated SDC method is much more efficient than the original SDC method,especially for stiff problems.Furthermore,we resolve the issue of low accuracy arising from the singularity of the solutions by using a geometric mesh,leading to highly accurate solutions compared to uniform mesh solutions at almost the same computational cost.Moreover,for long-time integration of FDEs,using the geometric mesh leads to great computational savings as the total number of degrees of freedom required is relatively small. | Xuejuan Chen Zhiping Mao George Em Karniadakis | 2022 | Numerical Mathematics(Theory,Methods and Applications)2022，15，4： | 0 |
| 18 | An integrated genome-wide analysis identifies HUR/ELAVL1 as a positive regulator of osteogenesis through enhancing theβ-catenin signaling activity显示文摘Osteoporosis is a prevalent multifactorial bone disease with a strong genetic contribution.The heritability of traits that contribute to osteoporosis(bone mass,bone mineral density(BMD),bone size,bone loss and fractures)ranges from 50 to 85%,suggesting that a comprehensive understanding of the genetic basis may help identify new therapeutic targets.1 However,the genetic characteristics remain obscure,and the existing drug targets are associated with various challenges.Numerous studies have demonstrated that high-throughput sequencing data analysis is fruitful for identifying novel targets of human diseases.2 We therefore integrated GWAS and transcriptome analyses through Multi-marker Analysis of GenoMic Annotation(MAGMA)and weighted gene co-expression network analysis3(WGCNA)to identify new network modules and potential therapeutic genes for osteoporosis.As an illustration,the flow chart presenting the process of the present study was shown in Figure S1. | Ying Huai Zhihao Chen Xiaoni Deng Xue Wang Wenjing Mao Zhiping Miao Yu Li Hui Li Xiao Lin Airong Qian | 2023 | Genes & Diseases2023，10，2： | 0 |
| 19 | High Order Conservative Finite Difference/Fourier Spectral Methods for Inviscid Surface Quasi-Geostrophic Flows显示文摘In this paper,we develop an effective conservative high order finite difference scheme with a Fourier spectral method for solving the inviscid surface quasigeostrophic equations,which include a spectral fractional Laplacian determining the vorticity for the transport velocity of the potential temperature.The fractional Laplacian is approximated by a Fourier-Galerkin spectral method,while the time evolution of the potential temperature is discretized by a high order conservative finite difference scheme.Weighted essentially non-oscillatory(WENO)reconstructions are also considered for comparison.Due to a low regularity of problems involving such a fractional Laplacian,especially in the critical or supercritical regime,directly applying the Fourier spectral method leads to a very oscillatory transport velocity associated with the gradient of the vorticity,e.g.around smooth extrema.Instead of using an artificial filter,we propose to reconstruct the velocity from the vorticity with central difference discretizations.Numerical results are performed to demonstrate the good performance of our proposed approach. | Nan Zhang Zhiping Mao Tao Xiong | 2022 | Communications in Computational Physics2022，32，10： | 0 |
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