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| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells显示文摘人的导致的 pluripotent 茎(iPS ) 房间类似于胚胎的茎(ES ) 房间,和罐头强烈地增殖并且区分进许多房间类型。然而,人的 iPS 房间的肝的区别还没被报导了。在这份报告,人的 iPS 房间被导致由一个逐步的协议区分进肝的房间。肝房间标记的表达式和人的 iPS 的肝相关的函数导出房间的房间被监视并且与区分的人的 ES 房间和主要人的 hepatocytes 的相比。在白天 7 点的约 60% 区分的人的 iPS 房间表示了肝的标记 alpha fetoprotein 和白长袍的。在白天 21 点的区分的房间包括白朊 Asecretion,肝糖合成,脲生产和可诱导的细胞色素 P450 活动展出了肝房间功能。肝的标记的表示和 iPS 的肝相关的功能导出房间的肝的房间比得上人的 ES 导出房间的肝的房间的。这些结果证明人的 iPS 房间,类似于人的 ES 房间,能高效地被导致区分房间进象 hepatocyte 一样。 | Zhihua Song Jun Cai Yanxia Liu Dongxin Zhao Jun Yong Shuguang Duo Xijun Song Yushan Guo Yang Zhao Han Qin Xiaolei Yin Chen Wu Jie Che Shichun Lu Mingxiao Ding Hongkui Deng | 2009 | Cell Research2009，19，11： | 63 |
| 3 | Noether symmetries of the nonconservative and nonholonomic systems on time scales显示文摘In this paper we give a new method to investigate Noether symmetries and conservation laws of nonconservative and nonholonomic mechanical systems on time scales , which unifies the Noether's theories of the two cases for the continuous and the discrete nonconservative and nonholonomic systems. Firstly, the exchanging relationships between the isochronous variation and the delta derivatives as well as the relationships between the isochronous variation and the total variation on time scales are obtained. Secondly, using the exchanging relationships, the Hamilton's principle is presented for nonconservative systems with delta derivatives and then the Lagrange equations of the systems are obtained. Thirdly, based on the quasi-invariance of Hamiltonian action of the systems under the infinitesimal transformations with respect to the time and generalized coordinates, the Noether's theorem and the conservation laws for nonconservative systems on time scales are given. Fourthly, the d'Alembert-Lagrange principle with delta derivatives is presented, and the Lagrange equations of nonholonomic systems with delta derivatives are obtained. In addition, the Noether's theorems and the conservation laws for nonholonomic systems on time scales are also obtained. Lastly, we present a new version of Noether's theorems for discrete systems. Several examples are given to illustrate the application of our results. | CAI PingPing FU JingLi GUO YongXin | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，5： | 52 |
| 4 | PCT:Point cloud transformer显示文摘The irregular domain and lack of ordering make it challenging to design deep neural networks for point cloud processing.This paper presents a novel framework named Point Cloud Transformer(PCT)for point cloud learning.PCT is based on Transformer,which achieves huge success in natural language processing and displays great potential in image processing.It is inherently permutation invariant for processing a sequence of points,making it well-suited for point cloud learning.To better capture local context within the point cloud,we enhance input embedding with the support of farthest point sampling and nearest neighbor search.Extensive experiments demonstrate that the PCT achieves the state-of-the-art performance on shape classification,part segmentation,semantic segmentation,and normal estimation tasks. | Meng-Hao Guo Jun-Xiong Cai Zheng-Ning Liu Tai-Jiang Mu Ralph R.Martin Shi-Min Hu | 2021 | Computational Visual Media2021，7，2： | 55 |
| 5 | Immunohistochemical study on p53,H-rasp21,c-erbB-2 protein and PCNA expression in HCC tissues of Hart and minority ethnic patients显示文摘AIM To find out the difference of humanprimary liver carcinogenesis between Han andminority ethnic patients in Xinjiang.METHODS Expression of p53,c-erbB-2,H-rasp21 protein and proliferating cell nuclearantigen(PCNA)in tumor tissues of 50 patients(Han 38,minority 12)with primary hepaticcarcinoma was detected byimmunohistochemistry(LSAB).RESULTS The positive frequency of p53,c-erbB-2,H-rasp21 and PCNA expression was46.0%(23/50),70.0%(35/50),68.0%(34/50)and 82.0%(41/50)in tumor tissues;4.0%(2/50),22.0%(11/50),64.0%(32/50)and 52.0%(26/ 50)in peritumors respectively and asignificant difference,except for H-rasp21,ofoncogene alteration was found(P<0.05)between tumor and non-tumorous tissues.Combined the three oncogenes alteration,26%(13/50)tumor tissues had positiveimmunoreactivity,but in peritumor and normallivers it was negative.The positive rate of p53,c-erbB-2 and H-rasp21 protein expression was39.5%(15/38),60.5%(23/38)and 39.5%(15/38)in tumors of Han patients;66.7%(8/12),100%(12/12)and 75.0%(9/12)in minoritiesrespectively,with statistical difference (P<0.05).CONCLUSION Overexpression of p53,c-erbB-2and H-rasp21 in human primary liver carcinoma isan important biomarker of genetic alteration.The different frequency of these oncogeneticchanges may reflect some environmental or/andethnic hereditary factors affecting the livercarcinogenesis.The special life style of Han,Uygur,Kazak and Mongolia nationalities inXinjiang may also be related to theetiopathogenesis of this disease. | Guo Yue Lin Zhao Lun Chen Cai Mo Lu Ying Li Xiao Jia Ping Rong Huang Department of Laboratory Medicine,Chinese PLA 474 Hospital,Urumqi 830011,Xinjiang Uygur Autonomic Region,China Department of Pathology,the 1st Teaching Hospital,Xinjiang Medical University,Urumqi 830054,Xinjiang Uygur Autonomic Region,China | 2000 | World Journal of Gastroenterology2000，6，2： | 40 |
| 6 | A Positioning System based on Communication Satellites and the Chinese Area Positioning System(CAPS)显示文摘The Chinese Area Positioning System(CAPS) is a positioning system based on satellite communication that is fundamentally different from the 3'G'(GPS,GLONASS and GALILEO) systems.The latter use special-purpose navigation satellites to broadcast navi-gation information generated on-board to users,while the CAPS transfers ground-generated navigation information to users via the communication satellite.In order to achieve accurate Positioning,Velocity and Time(PVT),the CAPS employs the following strategies to over-come the three main obstacles caused by using the communication satellite:(a) by real-time following-up frequency stabilization to achieve stable frequency;(b) by using a single carrier in the transponder with 36 MHz band-width to gain sufficient power;(c) by incorporating Decommissioned Geostationary Orbit communication satellite(DGEO),barometric pressure and Inclined Geostationary Orbit communication satellite(IGSO) to achieve the 3-D posi-tioning.Furthermore,the abundant transponders available on DGEO can be used to realize the large capacity of communication as well as the integrated navigation and communication.With the communication functions incorporated,five new functions appear in the CAPS:(1) combination of navigation and communication;(2) combination of navigation and high accu-racy orbit measurement;(3) combination of navigation message and wide/local area differen-tial processing;(4) combination of the switching of satellites,frequencies and codes;and(5) combination of the navigation message and the barometric altimetry.The CAPS is thereby labelled a PVT5C system of high accuracy.In order to validate the working principle and the performance of the CAPS,a trial system was established in the course of two years at a cost of about 20 million dollars.The trial constellation consists of two GEO satellites located at E87.5° and E110.5°,two DGEOs located at E130° and E142°,as well as barometric altimetry as a virtual satellite.Static and dynamic performance tests were completed for the Eastern,the Western,the Northern,the Southern and the Middle regions of China.The evaluation results are as follows:(1) land static test,plane accuracy range:C/A code,15~25m;P code,5~10 meters;altitude accuracy range,1~3 m;(2) land dynamic test,plane accuracy range,C/A code,15~25m;P code,8~10m;(3) velocity accuracy,C/A code,0.13~0.3ms-1,P code,0.15~0.17ms-1;(4) timing accuracy,C/A code,160ns,P code,13 ns;(5) timing compared accuracy of Two Way Satellite Time and Frequency Transfer(TWSTFT),average accuracy,0.068ns;(6) random error of the satellite ranging,10.7 mm;(7) orbit determination accuracy,better than 2 m.The above stated random error is 1σ error.At present,this system is used as a preliminary operational system and a complete system with 3 GEO,3 DGEO and 3 IGSO is being established. | Guo-Xiang Ai Hu-Li Shi Hai-Tao Wu Yi-Hua Yan Yu-Jing Bian Yong-Hui Hu Zhi-Gang Li Ji Guo Xian-De Cai | 2008 | Chinese Journal of Astronomy and Astrophysics2008，8，6： | 33 |
| 7 | Effect of Nitrogen Management on Yield and Water Use Efficiency of Rainfed Wheat and Maize in Northwest China显示文摘A field experiment with four treatments and four replicates in a randomized complete block design was conducted at the Changwu Experimental Station in Changwu County, Shaanxi Province, of Northwest China from 1998 to 2002. The local cropping sequence of wheat, wheat-beans, maize, and wheat over the 4-year period was adopted. A micro-plot study using 15N-labelled fertilizer was carried out to determine the fate of applied N fertilizer in the first year. When N fertilizer was applied wheat (years 1, 2 and 4) and maize (year 3) grain yield increased significantly (P<0.05) (>30%), with no significant yield differences in normal rainfall years (Years 1, 2 and 3) for N application at the commonly application rate and at 2/3 of this rate. Grain yield of wheat varied greatly between years, mainly due to variation in annual rainfall. Results of 15N studies on wheat showed that plants recovered 36.6%-38.4% of the N applied, the N remained in soil (0-40 cm) ranged from 29.2% to 33.6%, and unaccounted-for N was 29.5%-34.2%. The following crop (wheat) recovered 2.1%-2.8% of the residual N from N applied to the previous wheat crop with recovery generally decreasing in the subsequent three crops (beans, maize and wheat). | DANG Ting-Hui CAI Gui-Xin GUO Sheng-Li HAO Ming-De L. K. HENG | 2006 | Pedosphere2006，16，4： | 25 |
| 8 | Lubricating a bright future:Lubrication contribution to energy saving and low carbon emission显示文摘Both the academic society and the industry are hunting for new energy forms for the future.However,the world should not forget the conventional technologies that contribute to the sustainable society by technical innovations.Among them,lubrication plays a significant role in energy saving and in low CO2emission by increasing the fuel efficiency and by prolonging the service life of machines.With the advance of novel synthetic approaches,and nanoscience and technologies,novel lubrication oils and additives and their formulations are being developed to reduce friction and wear,and novel surface treatment routes and surface coatings are invented and provide more efficient lubrication.These technologies create tremendous chances for machines to work more efficiently with low energy consumption.Here we review the recent progresses and challenges associated with some novel lubrication techniques that include novel surface treatment(such as texturing,high-performance nanocomposite coatings,adapting coating),tribology design(solid and liquid lubrication),energy-conserving engine oil and novel lubricants and formula(such as ionic liquids,low S,P content additives)which are to be adopted to enhance the fuel efficiency to achieve energy saving and low carbon emission.There is increased demand to replace fossil lubricants by degradable green lubricants.Specially designed coatings can reduce drag significantly during navigation of both airplanes and ships.All these aspects will be also reviewed in the paper. | CAI MeiRong GUO RuiSheng ZHOU Feng LIU WeiMin | 2013 | Science China(Technological Sciences)2013，56，12： | 22 |
| 9 | Genome-wide analysis of the WRKY transcription factor gene family in Gossypium raimondii and the expression of orthologs in cultivated tetraploid cotton显示文摘WRKY proteins are members of a family of transcription factors in higher plants that function in plant responses to various physiological processes.We identified 120 candidate WRKY genes from Gossypium raimondii with corresponding expressed sequence tags in at least one of four cotton species,Gossypium hirsutum,Gossypium barbadense,Gossypium arboreum,and G.raimondii.These WRKY members were anchored on 13 chromosomes in G.raimondii with uneven distribution.Phylogenetic analysis showed that WRKY candidate genes can be classified into three groups,with 20 members in group I,88 in group II,and 12 in group III.The88 genes in group II were further classified into five subgroups,groups IIa–e,containing 7,16,37,15,and 13 members,respectively.We characterized diversity in amino acid residues in the WRKY domain and/or other zinc finger motif regions in the WRKY proteins.The expression patterns of WRKY genes revealed their important roles in diverse functions in cotton developmental stages of vegetative and reproductive growth and stress response.Structural and expression analyses show that WRKY proteins are a class of important regulators of growth and development and play key roles in response to stresses in cotton. | Caiping Cai Erli Niu Hao Du Liang Zhao Yue Feng Wangzhen Guo | 2014 | The Crop Journal2014，2，Z1： | 23 |
| 10 | Gut microbial diversity analysis using Illumina sequencing for functional dyspepsia with liver depression-spleen deficiency syndrome and the interventional Xiaoyaosan in a rat model显示文摘AIM To investigate gut microbial diversity and the interventional effect of Xiaoyaosan(XYS) in a rat model of functional dyspepsia(FD) with liver depression-spleen deficiency syndrome. METHODS The FD with liver depression-spleen deficiency syndrome rat model was established through classic chronic mild unpredictable stimulation every day. XYS group rats received XYS 1 h before the stimulation. The models were assessed by parameters including state ofthe rat, weight, sucrose test result and open-field test result. After 3 wk, the stools of rats were collected and genomic DNA was extracted. PCR products of the V4 region of 16 S rD NA were sequenced using a barcoded Illumina paired-end sequencing technique. The primary composition of the microbiome in the stool samples was determined and analyzed by cluster analysis.RESULTS Rat models were successfully established, per data from rat state, weight and open-field test. The microbiomes contained 20 phyla from all samples. Firmicutes, Bacteroidetes, Proteobacteria, Cyanobacteria and Tenericutes were the most abundant taxonomic groups. The relative abundance of Firmicutes, Proteobacteria and Cyanobacteria in the model group was higher than that in the normal group. On the contrary, the relative abundance of Bacteroidetes in the model group was lower than that in the normal group. Upon XYS treatment, the relative abundance of all dysregulated phyla was restored to levels similar to those observed in the normal group. Abundance clustering heat map of phyla corroborated the taxonomic distribution. CONCLUSION The microbiome relative abundance of FD rats with liver depression-spleen deficiency syndrome was significantly different from the normal cohort. XYS intervention may effectively adjust the gut dysbacteriosis in FD. | Juan-Juan Qiu Zhe Liu Peng Zhao Xue-Jun Wang Yu-Chun Li Hua Sui Lawrence Owusu Hui-Shu Guo Zheng-Xu Cai | 2017 | World Journal of Gastroenterology2017，23，5： | 23 |
| 11 | Characterizati0n,development and exploitation of EST-derived microsatellites in Gossypium raimondii Ulbrich显示文摘Microsatellite DNA or simple sequence repeats (SSRs) can be derived from expressed se- quence tags (ESTs). These markers are important for gene mapping as well as marker-assisted selection (MAS). To develop EST-SSRs for cotton gene map- ping, we selected and characterized functional markers in Gossypium raimondii, which consisted of 58906 non-redundant EST sequences from NCBI. Among them there were 2620 microsatellite se- quences containing 2818 EST-SSRs, which amoun- ted to 4.45% of the non-redundant starting sequence population. This incidence was equivalent to one EST-SSR in every 14.8 kb of G. raimondii genetic material. Among the different motifs ranging from 1 to 6 bp, trinucleotide repeats were most abundant (38.31%), followed by dinucleotide repeats (24.09%) and mononucleotide repeats (23.35%). Among all identified motif types, A/T had the highest frequency (18.67%), followed by AT/TA (14.83%). Among the compound motifs, tandem trinucleotides occurred with the highest frequency (48.65%). In all, we identi- fied 1554 EST-SSRs primer pair sequences. 300 of them were randomly selected to screen the poly- morphisms between the mapping parents G· hirsutum acc. TM-1 and G· barbadense cv. Hai7124, to con- struct linkage groups in cultivated allotetraploid cot- ton. Among them, 129 (43%) primer pairs were found to have polymorphisms. Using these EST-SSRs we can compare EST-SSR distributions among different cotton species and various chromosomal locations. | WANG Changbiao GUO Wangzhen CAI Caiping ZHANG Tianzhen | 2006 | Chinese Science Bulletin2006，51，5： | 21 |
| 12 | Relationship between tumor necrosis factor-α and liver fibrosis显示文摘RelationshipbetweentumornecrosisfactorαandliverfibrosisWANGXin,CHENYueXiang,XUCaiFu,ZHAOGuoNing,HUANGYuXinandWANGQinLiD... | WANG Xin, CHEN Yue Xiang, XU Cai Fu, ZHAO Guo Ning, HUANG Yu Xin and WANG Qin Li Department of Gastroenterology, Tangdu Hospital, The Fourth Military Medical University, Xi′an 710038, Shaanxi Province, China | 1998 | World Journal of Gastroenterology1998，4，1： | 21 |
| 13 | Efficacy and Safety of Niaoduqing Particles for Delaying Moderate-to-severe Renal Dysfunction: A Randomized, Double-blind, Placebo-controlled, Multicenter Clinical Study显示文摘 | Ying Zheng Guang-Yan Cai Li-Qun He Hong-Li Lin Xiao-Hong Cheng Nian-Song Wang Gui-Hua Jian Xu-Sheng Liu Yu-Ning Liu Zhao-Hui Ni Jing-Ai Fang Han-Lu Ding Wang Guo Ya-Ni He Li-Hua Wang Ya-Ping Wang Hong-Tao Yang Zhi-Ming Ye Ren-Huan YU Li-Juan Zhao Wen-Hua Zhou Wen-Ge Li Hui-Juan Mao Yong-Li Zhan Zhao Hu Chen Yao Ri-Bao Wei Xiang-Mei Chen | 2017 | Chinese Medical Journal2017，，20： | 21 |
| 14 | Secukinumab demonstrates high efficacy and a favorable safety profile over 52 weeks in Chinese patients with moderate to severe plaque psoriasis显示文摘Background:Psoriasis is a chronic inflammatory skin disease,affecting about 0.6%of the Chinese population.Many patients are not well controlled by conventional treatments,thus there is need for new treatment regimens.In this study,we assessed the efficacy and safety of secukinumab in Chinese patients with moderate to severe plaque psoriasis.Methods:This study was a 52-week,multicentre,randomized,double-blind,placebo-controlled,parallel-group,Phase 3 trial.A sub-population of study participants(≥18 years)of Chinese ethnicity were randomized to receive subcutaneous injections of 300 or 150 mg secukinumab,or placebo.The co-primary endpoints were psoriasis area severity index(PASI)75 and Investigator’s Global Assessment(IGA)0/1 at Week 12.Results:A total of 441 Chinese patients were enrolled in this study.Co-primary outcomes were achieved;300 and 150 mg secukinumab were superior to placebo as shown in the proportion of patients that achieved PASI 75(97.7%and 87.2%vs.3.7%,respectively;P<0.001),and IGA 0/1(82.3%and 69.7%vs.2.7%;P<0.001)at Week 12.Treatment efficacy was maintained until Week 52.There was no increase in overall adverse events with secukinumab relative to placebo throughout the 52-week period.Conclusion:Secukinumab is highly effective and well tolerated in Chinese patients with moderate to severe plaque psoriasis. | Lin Cai Jian-Zhong Zhang Xu Yao Jun Gu Quan-Zhong Liu Min Zheng Shi-Fa Zhang Jin-Hua Xu Cheng-Xin Li Hao Cheng Qing Guo Wei-Li Pan Shen-Qiu Li Ruo-Yu Li Zai-Pei Guo Zhi-Qi Song Shan-Shan Li Xiu-Qin Dong Linda Wang Rong Fu Pascaline Regnault Pascal Charef Ratal Mazur Manmath Patekar | 2020 | Chinese Medical Journal2020，，22： | 21 |
| 15 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 16 | The formation mechanism of high-quality dolomite reservoir in the deep of Puguang Gas Field显示文摘The discovery of Puguang Gas Field provides the exploration of China deep marine carbonate rock with important references.In Puguang Gas Field,the dolomite reservoirs discovered in the deep are the best in the present of China,which present big thickness and wide-range distribution,and develop abundant secondary porosity.The researches show that Puguang Gas Field bears the characteristics of early gas-filling time,deep burial,high matured organic matter and long-term interaction of hydrocarbon(oil and gas)-water-rock(carbonate reservoir).The developments of secondary pores in this area are affected by multiple diagenesis and their formation mechanisms are complicated.Through the research on depositional environment,sedimentary facies and reservoir porosity characters of Changxing and Feixianguan Formations,it is thought that high-quality dolomite reservoirs of Puguang Gas Field form on the favorable sedimentary facies belts,which are the integrate result affected by several factors including superficial corrosion,burial corrosion,overpressure and tectonic movement,among which burial corrosion of TSR to reservoir and overpressure formed by thermal evolution of organic matter have great effect on the formation of secondary porosity of Changxing and Feixianguan Formations. | MA YongSheng 1 ,GUO TongLou 1 ,ZHAO XueFeng 2 &CAI XunYu 1 1 Southern Exploration&Production Company,Sinopec,Kunming 650200,China 2 China University of Mining and Technology,Beijing 100083,China | 2008 | Science China Earth Sciences2008，51，S1： | 19 |
| 17 | ALDH2 protects against stroke by clearing 4-HNE显示文摘(ALDH2 ) 醛脱氢酶 2 是使象 4-hydroxy-2-nonenal (4-HNE ) 那样的乙醇和有毒的醛产生代射变化的 mitochondrial 酶。用不偏的 proteomic 搜索,我们作为与自发地高血压的老鼠(SHR ) 相比在击容易的自发地高血压的老鼠(SHR-SP ) 识别了 ALDH2 缺乏。我们作为 overexpression 在 neuronal 损害结束了 ALDH2 缺乏的原因的角色或 ALDH2 的激活由清除 4-HNE 在授与 neuroprotection 在 vitro 研究。进一步, ALDH2 击倒的老鼠揭示了 PKCε 的 neuroprotective 效果的缺席;。被知道对击施加保护的中等乙醇管理被显示提高 4-HNE 的 detoxification,并且免于 ischemic 通过 PKCε 的服的损害; -ALDH2 小径。在 SHR-SP,浆液 4-HNE 水平固执地与 lifespan 相反地被提高并且相关。在在人的击的 4-HNE 的角色被它的血浆层次的坚持的举起也在击以后建议至少 6 个月。最后,我们观察到发展了的跟随 8 年的 1 242 个题目中的 21 个比没得中风的那些摸有的更高起始的血浆 4-HNE 层次。这些调查结果建议 ALDH2 小径的激活可以在击容易的题目的鉴定用作一个有用索引,并且 ALDH2 小径可以是在击的治疗学的干预的一个潜在的目标。 | Jin-Min Guo Ai-Jun Liu Pu Zang Wen-Zhe Dong Li Ying Wei W ang Pu Xu Xu-Rui Song Jun Cai She-Qing Zhang Jun-Li Duan Jawahar L Mehta Ding-Feng Su | 2013 | Cell Research2013，23，7： | 19 |
| 18 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 19 | Association analysis of fiber quality traits and exploration of elite alleles in Upland cotton cultivars/accessions(Gossypium hirsutum L.)显示文摘Exploring the elite alleles and germplasm accessions related to fiber quality traits will accelerate the breeding of cotton for fiber quality improvement. In this study, 99 Gossypium hirsutum L. accessions with diverse origins were used to perform association analysis of fiber quality traits using 97 polymorphic microsatellite marker primer pairs. A total of 107 significant marker-trait associations were detected for three fiber quality traits under three different environments, with 70 detected in two or three environments and 37 detected in only one environment. Among the 70 significant marker-trait associations, 52.86% were reported previously, implying that these are stable loci for target traits. Furthermore, we detected a large number of elite alleles associated simultaneously with two or three traits. These elite alleles were mainly from accessions collected in China, introduced to China from the United States, or rare alleles with a frequency of less than5%. No one cultivar contained more than half of the elite alleles, but 10 accessions were collected from China and the two introduced from the United States did contain more than half of these alleles. Therefore, there is great potential for mining elite alleles from germplasm accessions for use in fiber quality improvement in modern cotton breeding. | Caiping Cai Wenxue Ye Tianzhen Zhang Wangzhen Guo | 2014 | Journal of Integrative Plant Biology2014，56，1： | 18 |
| 20 | The controlling factors of oil and gas charging and accumulation of Puguang gas field in the Sichuan Basin显示文摘Combined with oil and gas transport and accumulation, structure-lithology evolution history, and with geochemistry and synthesizing geology methods, this paper studies the oil and gas discharge history of Puguang large scale gas field and the main controlling factors of oil accumulation. The natural gas in Puguang gas field is mainly coal-derived gas and oil-racked gas. The main hydrocarbon is Upper Permian coal mudstone and Lower Silurian mud shale with organic material. Puguang gas field has gone through discharge and adjustment 3 times, and it has favorable palaeostructure location, high quality dredge and effectively conserving conditions. | MA YongSheng CAI XunYu GUO TongLou | 2007 | Chinese Science Bulletin2007，52，A01： | 18 |
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