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| 1 | Myocardial infarction secondary prevention study (MISPS)显示文摘Background Traditional Chinese medicine (TCM), especially herbal medicine, has been widely used in China and now is also being increasingly used in other countries for the treatment of cardiovascular diseases. Although many studies have demonstrated that certain Chinese herbal products are effective and safe for the treatment of cardiovascular diseases, most of these lack sufficient quality. Therefore, large randomized clinical trials and further scientific research to determine its safety, effectiveness are necessary.QiShen YiQi Dripping Pills (QSYQDP) is a herbal preparation clinically used in the treatment and prevention of coronary artery disease. Preliminary observations have shown its safety and effectiveness. Methods/Design This randomized, controlled trial will recruit 3600 patients with a history of myocardial infarction. Patients will be randomized into two groups by a Centr-Randomized System. One group receives QSYQDP, the other group receive aspirin. This trial protocol will describe eligibility criteria, detailed information on the treatment definition, blinding, endpoints, statistical methods, sample size determination, data management, legal aspects, and the current status of the trial. Discussion This trial is one of the first randomized, controlled clinical trial to evaluate the efficacy and safety of traditional Chinese herbal medicine in the treatment and secondary prevention of coronary artery disease. The results of this study should help to define the role of TCM in modern medical care, as well as to provide the management strategy for CAD patients in China and other countries. | Hongcai SHANG Guohua DAI Junhua HANG Yaozu XIANG Yang WANG Junping ZHANG Wuxun DU Jingyuan MAO Chen YAO Weiliang WENG Tiancai WEN Boli ZHANG | 2006 | Journal of Geriatric Cardiology2006，3，2： | 14 |
| 2 | Assessment of Two Turbulence Models and Some Compressibility Corrections for Hypersonic Compression Corners by High-order Difference Schemes显示文摘Spalart-Allmaras (S-A ) 骚乱模型,砍压力运输(SST ) 骚乱模型和他们的压缩的可能性修正是为由使用高顺序的差别计划的极超音速的压缩角落流动的 revaluated。密度坡度,压力膨胀和狂暴的马赫数字的压缩的可能性效果被说明。以便减少在模型无常和 discretization 错误之间的混乱,正式第五顺序的明确的加权的紧缩的非线性的计划(WCNS-E-5 ) 被采用因为传送对流术语,和一个第四顺序的蹒跚的中央差别计划被申请粘滞术语。 | TU Guohua DENG Xiaogang MAO Meiliang | 2012 | Chinese Journal of Aeronautics2012，25，1： | 11 |
| 3 | Developing Hybrid cell-edge and cell-node Dissipative Compact Scheme for Complex Geometry Flows显示文摘Developing high resolution finite difference scheme and enabling the use of this scheme on complex geometry are the aims of this study.High resolution has been achieved by Dissipative Compact Schemes(DCS),however,according to the recent research,applications of DCS on complex geometry may have serious problem for that the Geometric Conservation Law(GCL)is not satisfied,and this may cause numerical instability.To cope with this problem,a new scheme named Hybrid cell-edge and cell-node Dissipative Compact Scheme(HDCS)has been formulated.The formulation of the HDCS contains two steps.First,a new central compact scheme is formulated for the purpose of conveniently fulfilling the GCL,and then dissipation is added on the central scheme by high-order dissipative interpolation of cell-edge variables.The solutions of Euler and Navier-Stokes equations show that the HDCS can be applied successfully on complex geometry,while the DCS may suffer numerical instabilities.Moreover,high resolution of the HDCS may be observed in the test of scattering of acoustic waves by multiple cylinders. | DENG XiaoGang JIANG Yi MAO MeiLiang LIU HuaYong TU GuoHua | 2013 | Science China(Technological Sciences)2013，56，10： | 10 |
| 4 | Validation of a RANS transition model using a high-order weighted compact nonlinear scheme显示文摘A modified transition model is given based on the shear stress transport (SST) turbulence model and an intermittency transport equation. The energy gradient term in the original model is replaced by flow strain rate to saving computational costs. The model employs local variables only, and then it can be conveniently implemented in modern computational fluid dynamics codes. The fifth-order weighted compact nonlinear scheme and the fourth-order staggered scheme are applied to discrete the governing equations for the purpose of minimizing discretization errors, so as to mitigate the confusion between numerical errors and transition model errors. The high-order package is compared with a second-order TVD method on simulating the transitional flow of a flat plate. Numerical results indicate that the high-order package give better grid convergence property than that of the second-order method. Validation of the transition model is performed for transitional flows ranging from low speed to hypersonic speed. | TU GuoHua DENG XiaoGang MAO MeiLiang | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，4： | 8 |
| 5 | High-Order and High Accurate CFD Methods and Their Applications for Complex Grid Problems显示文摘The purpose of this article is to summarize our recent progress in high-order and high accurate CFD methods for flow problems with complex grids as well as to discuss the engineering prospects in using these methods.Despite the rapid development of high-order algorithms in CFD,the applications of high-order and high accurate methods on complex configurations are still limited.One of the main reasons which hinder the widely applications of thesemethods is the complexity of grids.Many aspects which can be neglected for low-order schemes must be treated carefully for high-order ones when the configurations are complex.In order to implement highorder finite difference schemes on complex multi-block grids,the geometric conservation lawand block-interface conditions are discussed.A conservativemetricmethod is applied to calculate the grid derivatives,and a characteristic-based interface condition is employed to fulfil high-order multi-block computing.The fifth-order WCNS-E-5 proposed by Deng[9,10]is applied to simulate flows with complex grids,including a double-delta wing,a transonic airplane configuration,and a hypersonic X-38 configuration.The results in this paper and the references show pleasant prospects in engineering-oriented applications of high-order schemes. | Xiaogang Deng Meiliang Mao Guohua Tu Hanxin Zhang Yifeng Zhang | 2012 | Communications in Computational Physics2012，11，4： | 6 |
| 6 | A novel vector of topological and structural information for amino acids and its QSAR applications for peptides and analogues显示文摘A new descriptor, called vector of topological and structural information for coded and noncoded amino acids (VTSA), was derived by principal component analysis (PCA) from a matrix of 66 topological and structural variables of 134 amino acids. The VTSA vector was then applied into two sets of peptide quantitative structure-activity relationships or quantitative sequence-activity modelings (QSARs/ QSAMs). Molded by genetic partial least squares (GPLS), support vector machine (SVM), and immune neural network (INN), good results were obtained. For the datasets of 58 angiotensin converting en-zyme inhibitors (ACEI) and 89 elastase substrate catalyzed kinetics (ESCK) , the R2, cross-validation R2, and root mean square error of estimation (RMSEE) were as follows: ACEI, R2cu≥0.82, Q2cu≥0.77, Ermse≤0.44 (GPLS+SVM); ESCK, R2cu≥0.84, Q2cu≥0.82, Ermse≤0.20 (GPLS+INN), respectively. | LI ZhiLiang LI GenRong SHU Mao SUN JiaYing YANG ShanBin MEI Hu ZHANG MengJun ZHOU Ping WU ShiRong CHEN GuoHua LU FengLin LU TingTing | 2008 | Science China Chemistry2008，51，10： | 2 |
| 7 | Range walk and array rotation in space-time adaptive processing:effects and compensations显示文摘This paper proposes a unified clutter model incorporating the effects of range walk and array rotation for space-time adaptive processing(STAP) in airborne multi-channel early-warning radar.Based on this clutter model,STAP performance is then analyzed from the perspective of covariance matrix tapering(CMT).For STAP performance degradation due to array rotation,a determinate compensation method is proposed based on the CMT method.Numerical examples are provided to verify the analysis and the proposed compensation method. | Jinping Sun Guohua Wang Shiyi Mao | 2010 | Journal of Systems Engineering and Electronics2010，21，4： | 2 |
| 8 | Analysis of multicomponent LMF signals using time-frequency and the gray-scale inverse hough transform显示文摘 | Wei Guohua Wu Siliang Mao E | 2003 | Statistical Signal Processing2003，10，： | 1 |
| 9 | Geometric conservation law and applications to high-order finite difference schemes with stationary grids 显示文摘 | Deng Xiaogang Mao Meiliang Tu Guohua | 2011 | Journal of Computational Physics2011，230，4： | 1 |
| 10 | Extending weighted compact nonlinear schemes to complex grids with character based interface condition显示文摘 | XIAOGANG DENG MEILIANG MAO GUOHUA TU | | 0，，12： | 1 |
| 11 | Geometric conservation law and applications to high-or der finite difference schemes with stationary grids显示文摘 | XIAOGANG DENG MEILIANG MAO GUOHUA TU | | 0，，04： | 1 |
| 12 | Further studies on geometric conservation law and applications to high order finite difference schemes with stationary grids 显示文摘 | Deng Xiaogang Yaobing Min Meiliang Mao Huayong Liu Guohua Tu Hanxin Zhang | 2013 | Journal of Computational Physics2013，239，90： | 1 |
| 13 | Comparison of the Pipeline embolisation device alone or combined with coiling for treatment of different sizes of intracranial aneurysms显示文摘Objectives The aim of this study was to compare complications and outcomes between intracranial aneurysms treated with the Pipeline embolisation device(PED)alone or with PED combined with coiling for different-sized aneurysms.Method Patients with aneurysms treated by PED were collected from the PED in China postmarket multicentre registry study.We performed a propensity match analysis to compare the efficacy and safety between PED alone and PED combined with coiling treatment,and then aneurysms were organised into three groups based on their size:small(≤7 mm),medium(≤15 mm to>7 mm)and large/giant(>15 mm).Complications and aneurysm occlusion rates in the aneurysm size groups were compared between PED alone and PED combined with coiling patients.Result A total of 1171 patients with 1322 aneurysms were included.All patients received clinical follow-up,while angiographic follow-up was available in 967 aneurysms.For small aneurysms,there was no difference in the aneurysm occlusion rate between two groups(79.1%vs 88.4%,respectively),while there was a significant increase in the ischaemic complication rate(8.3%vs 19.3%,respectively,p=0.0001).For medium and large/giant saccular aneurysms,PED combined with coiling significantly improved the occlusion rate(medium aneurysms:74.7%vs 88.8%,respectively,p<0.0001;large/giant saccular aneurysms:72.9%vs 86.9%,respectively,p=0.018),while there were no differences in the total complication rate.For large/giant non-saccular aneurysms,two groups showed no differences.Conclusion Use of the PED with adjunctive coils can significantly improve the occlusion rate of medium aneurysms,without increasing the total complication rate. | Chao Wang Bin Luo Tianxiao Li Aisha Maimaitili Guohua Mao Donglei Song Yunyan Wang Wenfeng Feng Yang Wang Huaizhang Shi Jieqing Wan Jianmin Liu Sheng Guan Yuanli Zhao Hongqi Zhang | 2022 | Stroke & Vascular Neurology2022，7，4： | 1 |
| 14 | Extending the fifth-order weighted compact nonlinear scheme to complex grids with characteristic-based interface conditions显示文摘 | Deng Xiaogang Mao Meiliang Tu Guohua | 2010 | AIAA Journal2010，48，12： | 1 |
| 15 | Laboratory study on high-temperature adsorption of HCI by dry-injection of Ca(OH)2 in a dual-layer granular bed filter显示文摘 | Junjun TAN Guohua YANG Jingqiao MAO Huichao DAI | 2014 | Frontiers of Environmental Science & Engineering2014，8，6： | 0 |
| 16 | Quantitatively mapping local quality of super-resolution microscopy by rolling Fourier ring correlation显示文摘In fluorescence microscopy,computational algorithms have been developed to suppress noise,enhance contrast,and even enable super-resolution(SR).However,the local quality of the images may vary on multiple scales,and these differences can lead to misconceptions.Current mapping methods fail to finely estimate the local quality,challenging to associate the SR scale content.Here,we develop a rolling Fourier ring correlation(rFRC)method to evaluate the reconstruction uncertainties down to SR scale.To visually pinpoint regions with low reliability,a filtered rFRC is combined with a modified resolution-scaled error map(RSM),offering a comprehensive and concise map for further examination.We demonstrate their performances on various SR imaging modalities,and the resulting quantitative maps enable better SR images integrated from different reconstructions.Overall,we expect that our framework can become a routinely used tool for biologists in assessing their image datasets in general and inspire further advances in the rapidly developing field of computational imaging. | Weisong Zhao Xiaoshuai Huang Jianyu Yang Liying Qu Guohua Qiu Yue Zhao Xinwei Wang Deer Su Xumin Ding Heng Mao Yaming Jiu Ying Hu Jiubin Tan Shiqun Zhao Leiting Pan Liangyi Chen Haoyu Li | 2023 | Light(Science & Applications)2023，12，12： | 0 |
| 17 | Ni_(3)Fe/Ni_(4)S_(3)/Ni/C Mixed Crystal Composite Nanofibers Prepared by Electrospinning and Heat Treatment Methods for Oxygen Evolution Reaction显示文摘OER catalyst of Ni_(3)Fe/Ni_(4)S_(3)/Ni/C(NiFeSC series)mixed crystal composite nanofibers was prepared by electrospinning and atmospheric heat treatment process.The testing results indicate that the diameters of Ni_(3)Fe/Ni_(4)S_(3)/Ni/C composite nanofibers is about 200 nm,the grains size is about 1-3 nm,and the fiber surface is rough.The electrochemical test results show that the heterojunction of the prepared Ni_(3)Fe/Ni_(4)S_(3)/Ni/C hybrid crystal composite nanofiber has synergistic effect with sulfide,and exhibits good electrocatalytic activity of water decomposition and OER in alkaline system.The OER electrocatalytic performance of Ni_(3)Fe/Ni_(4)S_(3)/Ni/C composite electrode prepared via a heat treatment at 1000℃process was tested in 1 mol/L KOH electrolytes.The results show that the overpotential is about 298 mV,the Tafel slope is about 74 mV?dec-1,and the surface resistance is about 1.69Ω·cm^(2),at the current density of 10 mA·cm^(-2). | LI Tao ZHONG Shujie LOU Qiongyue LING Shuai CHEN Jian MA Guohua YANG Mao WU Xiaoqiang | 2023 | Journal of Wuhan University of Technology(Materials Science)2023，38，2： | 0 |
| 18 | Genetic Architecture of Childhood Kidney and Urological Diseases in China显示文摘Kidney disease is manifested in a wide variety of phenotypes,many of which have an important hereditary component.To delineate the genotypic and phenotypic spectrum of pediatric nephropathy,a multicenter registration system is being imple-mented based on the Chinese Children Genetic Kidney Disease Database(CCGKDD).In this study,all the patients with kidney and urological diseases were recruited from 2014 to 2020.Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features.The genetic diagnosis was confirmed in 883 of 2256(39.1%)patients from 23 provinces in China.Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome(SRNS,23.5%),glomerulonephritis(GN,32.2%),congenital anomalies of the kidney and urinary tract(CAKUT,21.2%),cystic renal disease(3.9%),renal calcinosis/stone(3.6%),tubulopathy(9.7%),and chronic kidney disease of unknown etiology(CKDu,5.8%).The pathogenic variants of 105 monogenetic disorders were identified.Ten distinct genomic disorders were identified as pathogenic copy number variants(CNVs)in 11 patients.The diagnostic yield differed by subgroups,and was highest in those with cystic renal disease(66.3%),followed by tubulopathy(58.4%),GN(57.7%),CKDu(43.5%),SRNS(29.2%),renal calcinosis/stone(29.3%)and CAKUT(8.6%).Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions.We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed.Our data demonstrate the utility of family-based exome sequencing,and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease. | Ye Fang Hua Shi Tianchao Xiang Jiaojiao Liu Jialu Liu Xiaoshan Tang Xiaoyan Fang Jing Chen Yihui Zhai Qian Shen Guomin Li Li Sun Yunli Bi Xiang Wang Yanyan Qian Bingbing Wu Huijun Wang Wenhao Zhou Duan Ma Jianhua Mao Xiaoyun Jiang Shuzhen Sun Ying Shen Xiaorong Liu Aihua Zhang Xiaowen Wang Wenyan Huang Qiu Li Mo Wang Xiaojie Gao Yubin Wu Fang Deng Ruifeng Zhang Cuihua Liu Li Yu Jieqiu Zhuang Qing Sun Xiqiang Dang Haitao Bai Ying Zhu Siguang Lu Bili Zhang Xiaoshan Shao Xuemei Liu Mei Han Lijun Zhao Yuling Liu Jian Gao Ying Bao Dongfeng Zhang Qingshan Ma Liping Zhao Zhengkun Xia Biao Lu Yulong Wang Mengzhun Zhao Jianjiang Zhang Shan Jian Guohua He Huifeng Zhang Bo Zhao Xiaohua LI Feiyan Wang Yufeng Li Hongtao Zhu Xinhui Luo Jinghai Li Jia Rao Hong Xu | 2021 | Phenomics2021，1，3： | 0 |
| 19 | Microenvironment components and spatially resolved single-cell transcriptome atlas of breast cancer metastatic axillary lymph nodes显示文摘As an indicator of clinical prognosis,lymph node metastasis of breast cancer has drawn great attention.Many reports have revealed the characteristics of metastatic breast cancer cells,however,the effect of breast cancer cells on the microenvironment components of lymph nodes and spatial transcriptome atlas remains unclear.In this study,by integrating single-cell RNA sequencing(scRNA-seq)and spatial transcriptomics,we investigate the transcriptional profiling of six surgically excised lymph node samples and the spatial organization of one positive lymph node.We identify the existence of osteoclast-like giant cells(OGC)which have high expressions of CD68 and CD163,the biomarkers of tumor-associated macrophages(TAMs).Through a spatially resolved transcriptomic method,we find that OGCs are scattered among metastatic breast cancer cells.In the lymph node microenvironment with breast cancer cell infiltration,TAMs are enriched in protumoral pathways including NF-kB signaling pathways and NoD-like receptor signaling pathways.Further subclustering demonstrates the potential differentiation trajectory in which macrophages develop from a state of active chemokine production to a state of active lymphocyte activation.This study is the first to integrate scRNA-seq and spatial transcriptomics in the tumor microenvironment of axillary lymph nodes,offering a systematic approach to delve into breast cancer lymph node metastasis. | Kun Xu Runtian Wang Qin Chen Yiqiu Liu Xintong Li Ling Mao Cenzhu Wang Fangyan Gao Longfei Hu Hui Xie Cong Wang Guohua Zhou Xiaoxiang Guan | 2022 | Acta Biochimica et Biophysica Sinica2022，54，9： | 0 |
| 20 | Recognition for avian influenza virus proteins based on support vector machine and linear discriminant analysis显示文摘Total 200 properties related to structural characteristics were employed to represent structures of 400 HA coded proteins of influenza virus as training samples. Some recognition models for HA proteins of avian influenza virus (AIV) were developed using support vector machine (SVM) and linear discriminant analysis (LDA). The results obtained from LDA are as follows: the identification accuracy (Ria) for training samples is 99.8% and Ria by leave one out cross validation is 99.5%. Both Ria of 99.8% for training samples and Ria of 99.3% by leave one out cross validation are obtained using SVM model, respectively. External 200 HA proteins of influenza virus were used to validate the external predictive power of the resulting model. The external Ria for them is 95.5% by LDA and 96.5% by SVM, respectively, which shows that HA proteins of AIVs are preferably recognized by SVM and LDA, and the performances by SVM are superior to those by LDA. | LIANG GuiZhao CHEN ZeCong YANG ShanBin MEI Hu ZHOU Yuan YANG Li ZHOU Peng YANG ShengXi SHU Mao LIAO ChunYang WU ShiRong LI GenRong HE Liu GAO JianKun Gan MengYu LI DeJing CHEN GuoPing WANG GuiXue LONG Sha JING JuHua ZHENG XiaoLin ZENG Hui ZHANG QiaoXia ZHANG MengJun YANG Qi TIAN FeiFei TONG JianBo WANG JiaoNa LIU YongHong LI Bo QIU LiangJia CAI ShaoXi ZHAO Na YANG Yan SU XiaLi SONG Jian CHEN MeiXia ZHANG XueJiao SUN JiaYing LI JingWei CHEN GuoHua CHEN Gang DENG Jie PENG ChuanYou ZHU WanPing XU LuoNan WU YuQuan LIAO LiMin LI Zhi LI Jun LU DaJun SU QinLiang HUANG ZhengHu ZHOU Ping LI ZhiLiang | 2008 | Science China Chemistry2008，51，2： | 0 |
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