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| 1 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 2 | Towards 6G wireless communication networks:vision,enabling technologies,and new paradigm shifts显示文摘The fifth generation(5G)wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized,such as mass connectivity,ultra-reliability,and guaranteed low latency.However,5G will not meet all requirements of the future in 2030 and beyond,and sixth generation(6G)wireless communication networks are expected to provide global coverage,enhanced spectral/energy/cost efficiency,better intelligence level and security,etc.To meet these requirements,6G networks will rely on new enabling technologies,i.e.,air interface and transmission technologies and novel network architecture,such as waveform design,multiple access,channel coding schemes,multi-antenna technologies,network slicing,cell-free architecture,and cloud/fog/edge computing.Our vision on 6G is that it will have four new paradigm shifts.First,to satisfy the requirement of global coverage,6G will not be limited to terrestrial communication networks,which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle(UAV)communication networks,thus achieving a space-airground-sea integrated communication network.Second,all spectra will be fully explored to further increase data rates and connection density,including the sub-6GHz,millimeter wave(mmWave),terahertz(THz),and optical frequency bands.Third,facing the big datasets generated by the use of extremely heterogeneous networks,diverse communication scenarios,large numbers of antennas,wide bandwidths,and new service requirements,6G networks will enable a new range of smart applications with the aid of artificial intelligence(AI)and big data technologies.Fourth,network security will have to be strengthened when developing 6G networks.This article provides a comprehensive survey of recent advances and future trends in these four aspects.Clearly,6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears. | Xiaohu YOU Cheng-Xiang WANG Jie HUANG Xiqi GAO Zaichen ZHANG Mao WANG Yongming HUANG Chuan ZHANG Yanxiang JIANG Jiaheng WANG Min ZHU Bin SHENG Dongming WANG Zhiwen PAN Pengcheng ZHU Yang YANG Zening LIU Ping ZHANG Xiaofeng TAO Shaoqian LI Zhi CHEN Xinying MA Chih-Lin I Shuangfeng HAN Ke LI Chengkang PAN Zhimin ZHENG Lajos HANZO Xuemin(Sherman)SHEN Yingjie Jay GUO Zhiguo DING Harald HAAS Wen TONG Peiying ZHU Ganghua YANG Jun WANG Erik GLARSSON Hien Quoc NGO Wei HONG Haiming WANG Debin HOU Jixin CHEN Zhe CHEN Zhangcheng HAO Geoffrey Ye LI Rahim TAFAZOLLI Yue GAO HVincent POOR Gerhard P.FETTWEIS Ying-Chang LIANG | 2021 | Science China(Information Sciences)2021，64，1： | 122 |
| 3 | Inhibitory effect of IGF-Ⅱ antisense RNA on malignant phenotype of hepatocellular carcinoma显示文摘INIRODUCTIONAccording to the therapeutic effect and strategy ofantisense RNA for hepatoccllular carcinoma(HCC),we have specifically synthesized partialcDNA of human insulin-like growth factor Ⅱ(IGF-Ⅱ)and constructed IGF-Ⅱ cDNA antisenseeukaryotic expression vector.The constructedvector was introduced into hepatoma cell lineSMMC-7721 to block the intrinsic IGF-Ⅱexpression.The biological behavior changes ofhepatoma cells were observed.All these | Dong Hua Yang Ming Qing Zhang Jiang Du Chong Xu Oiao Ming Liang Ji Fang Mao Han Rong Qin Zi Rong Fan Department of Gastroenterology,Zhujiang Hospital,the First Military Medical University,Guangzhou 510282,China Laboratory of Molecular Biology,Zhujiang Hospital,the First Military Medical University,Guangzhou,China Departrnent of Biochemistry,the Second Military Medical University,Shanghai,China | 2000 | World Journal of Gastroenterology2000，6，2： | 54 |
| 4 | COX-2 expression in gastric cancer and its relationship with angiogenesis using tissue microarray显示文摘AIM: To explore the expression and clinicopathological significance of cyclooxygenase-2 (COX-2) and microvessel density (MVD) in gastric carcinogenesis, and to investigate their roles in the invasion and the relationship between biological behaviors and prognosis of gastric cancer. METHODS: Using Envision immunohistochemistry, COX-2 and CD34 expressions in gastric cancer tissue array were examined. MVD was counted and the relationship between the biological behaviors and prognosis was analyzed. RESULTS: The expression of COX-2 in gastric cancer tissue was significantly higher than that in normal mucosa (χ2 = 12.191, P < 0.05). The over-expression of COX-2 in gastric cancer was obviously related to metastasis and depth of invasion (χ2 = 6.315, P < 0.05), but not related to the histological type and Borrmann type (χ2 = 5.391 and χ2 = 2.228, respectively). Moreover, MVD in gastric cancer tissues was significantly higher than that in the normal mucosa (65.49 ± 20.64 vs 36.21 ± 18.47, t/F = 7.53, P < 0. 05). MVD was related to the histologic type and metastasis (t/F = 3.68 and t/F = 4.214, respectively, P < 0. 05), but not related to the depth of invasion and Borrmann type (t/F = 0.583 and t/F = 0.459, respectively). MVD in COX-2-positive tissues was markedly higher compared to COX-2-negative tissues, indicating a positive correlation between COX-2 expression and MVD (t = 13.12, P < 0. 05). CONCLUSION: Tissue microarray (TMA) is a powerful tool for rapid identifi cation of the molecular alterations in gastric cancer. COX-2 expression, via inducingangiogenesis, may play an important role in gastric carcinogenesis. It could be served as a determinant factor for clinical prognosis and curative effect. | Xiao-Yun Mao Xiao-Ge Wang Xiao-Jun Lv Lei Xu Cheng-Bo Han | 2007 | World Journal of Gastroenterology2007，13，25： | 46 |
| 5 | CXCR4/SDF-1 axis is involved in lymph node metastasis of gastric carcinoma显示文摘AIM:To investigate the role of CXC chemokine receptor-4 (CXCR4) and stromal cell-derived factor-1 (SDF-1) in lymph node metastasis of gastric carcinoma.METHODS:In 40 cases of gastric cancer,expression of CXCR4 mRNA in cancer and normal mucous membrane and SDF-1 mRNA in lymph nodes around the stomach was detected using quantitative polymerase chain reaction (PCR) (TaqMan) and immunohistochemistric assay.SGC-7901 and MGC80-3 cancer cells were used to investigate the effect of SDF-1 on cell proliferation and migration.RESULTS:Quantitative reverse transcription PCR and immunohistochemistry revealed that the expression level of CXCR4 in gastric cancer was significantly higher than that in normal mucous membrane (1.6244 ± 1.3801 vs 1.0715 ± 0.5243,P < 0.05).The expression level of CXCR4 mRNA in gastric cancer with lymph node metastasis was also significantly higher than that without lymph node metastasis (0.823 ± 0.551 vs 0.392 ± 0.338,P < 0.05).CXCR4 expression was significantly related to poorly differentiated,high tumor stage and lymph node metastasis.Significant differences in the expression level of SDF-1 mRNA were found between lymph nodes in metastatic gastric cancer and normal nodes (0.5432 ± 0.4907 vs 0.2640 ± 0.2601,P < 0.05).The positive expression of SDF-1 mRNA in lymph nodes of metastatic gastric cancer was consistent with the positive expression of CXCR4 mRNA in gastric cancer (r=0.776,P < 0.01).Additionally,human gastric cancer cell lines expressed CXCR4 and showed vigorous proliferation and migratory responses to SDF-1.AMD3100 (a specific CXCR4 antagonist) was also found to effectively reduce the migration of gastric cancer cells.CONCLUSION:The CXCR4/SDF-1 axis is involved in the lymph node metastasis of gastric cancer.CXCR4 is considered as a potential therapeutic target in the treatment of gastric cancer. | Bao-Cheng Zhao Zhen-Jun Wang Wei-Zheng Mao Hua-Chong Ma Jia-Gang Han Bo Zhao Hui-Min Xu | 2011 | World Journal of Gastroenterology2011，17，19： | 30 |
| 6 | Surveillance, epidemiology, and pathogen spectrum of hand, foot, and mouth disease in mainland of China from 2008 to 2017显示文摘Hand,foot and mouth disease(HFMD)was reported in May 2,2008 to be the 38th legally notifiable disease in China's National Notifiable Disease Reporting and Surveillance System.In order to solve the infection,an extensive three-level HFMD surveillance laboratory network was established.In this study,the framework of that network is assessed and the incidence of HFMD in China from 2008 to 2017 is reported using a descriptive epidemiologic method.During these 10 years,a series of techniques have been widely applied in all the network laboratories.Using information and material obtained from the network,a virus bank and database containing 18,238 viruses were established.Nationally,18,184,834 HFMD cases,including 152,436 severe cases and 3633 fatal cases,were reported in mainland of China.The average annual incidence in the population was 133.99/100,000 people,with a maximum incidence of 205.06/100,000 people in 2014.The incidence and mortality rates of HFMD were the highest in children aged 1–2 years.The numbers of reported cases fluctuated,with a high incidence observed every 2 years.An overall increase in the number of reported cases was also observed throughout the study period.Despite this,the incidence of severe cases and the mortality rate have been decreasing.High-risk regions are located in southern,eastern,and central China.Two peaks of HFMD infection cases were observed annually except for Northeast China.Different proportions of enterovirus serotypes were observed during the studied years.The predominant enterovirus varies from year to year,but the disease severity is always closely related to the specific serotype.EV-A71 is the dominant serotype associated with severe and fatal cases,with constituent ratios of 70.03%and 92.23%,respectively.The studied highly sensitive and efficient surveillance network provides information that is critical for prevention and control of the disease.It is extremely necessary and important to continuously conduct extensive virological surveillance for HFMD. | Tianjiao Ji Taoli Han Xiaojuan Tan Shuangli Zhu Dongmei Yan Qian Yang Yang Song Aili Cui Yan Zhang Naiying Mao Songtao Xu Zhen Zhu Dandan Niu Yong Zhang Wenbo Xu | 2019 | Biosafety and Health2019，1，1： | 26 |
| 7 | Plumbagin suppresses chronic periodontitis in rats via down-regulation of TNF-α, IL-1β and IL-6 expression显示文摘长期的 periodontitis (CP ) 是最普通的口头的疾病之一,它在成年人引起牙槽的骨头吸收和牙齿损失。在我们试图调查 plumbagin (PL ) 的潜力的这研究,广泛地调查的活跃混合物在对待 CP 从繁体中文植物石墨 zeylanica L 提取了。人的牙齿周围的系带干细胞(PDLSC ) 在 vitro 被用于研究,而 CP 的一个动物模型被 ligation+Porphyromonas gingivalis (Pg ) 在 SD 老鼠建立刺激。老鼠与 PL 被注射(2, 4,和 6 mgs。在这研究,我们建立了 biomarkers 的焦点模式描绘 Gegen Qinlian 煎(GQD ) 的剂量效果关系,为对待类型 2 糖尿病 mellitus (2-DM ) 的一个 TCM 公式。2-DM 的一个老鼠模型通过喂的饮食与低剂量的 STZ 注射相结合的高脂肪被建立。有 2-DM 的老鼠是管理高度,中间或低剂量(6.785, 4.071, 1.357 mgl/L ) 在 vitro 引起了 glomerular podocyte apoptosis,它被无毒的 chrysin (1-20 mol/L ) dose-dependently 通过 DNA 的减小稀释破碎。Chrysin 处理 dose-dependently 恢复了增加的 Bax/Bcl-2 比率,并且在高暴露葡萄糖的肾的 podocytes 压制了 Apaf-1 正式就职和提高的细胞色素 c 版本。在糖尿病的 db/db 老鼠, chrysin 的口头的管理(10 mgf 1.84 ??? ?? | Xin-yi ZHENG Chuan-yuan MAO Han QIAO Xi ZHANG Li YU Ting-yu WANG Er-yi LU | 2017 | Acta Pharmacologica Sinica2017，38，8： | 22 |
| 8 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 9 | Thorombolytic therapy with rescue percutaneous coronary intervention versus primary percutaneous coronary intervention in patients with acute myocardial infarction: a multicenter randomized clinical trial显示文摘背景尽管有营救的 thrombolytic 治疗经皮的冠的干预(一种总线标准)是为圣片断举起的普通治疗策略尖锐心肌的梗塞( STEMI ),欠缺的数据在它相对主要一种总线标准,和比较的功效上是可得到的因此是这 study.Methods 的目的这 multicenter ,开标签,使随机化,平行试用与 STEMI 在病人(年龄 70 年)上在 12 所医院里被进行在 12 以内介绍了症状发作的小时(吝啬的间隔> 3 个小时)。病人们被使随机化到三个组:主要一种总线标准组(n=101 ) ;recombinant staphylokinase (r-Sak ) 组(n=104 ) ;并且 recombinant 织物类型 plasminogen 使活跃之物(rt-PA ) 组(n=106 ) 。为分配到 thrombolytic 治疗手臂的所有病人,冠的 angiography 在药治疗以后在 90 分钟被执行证实梗塞相关的动脉(IRA ) 明显;营救一种总线标准与 TIMI 流动等级 2 在情况中被执行。赤裸金属的 stent 培植为所有病人被计划。 113.4 的一般水准纪录开始 thrombolytic 治疗( door-to-needle 时间)和 141.2 分钟在 IRA (到汽球时间的门)执行第一汽球通货膨胀的在它要求了的随机化以后的结果 IRA 明显( TIMI 流动等级 2 或 3 )和 TIMI 流动等级的 .Rates 3 是显著地更低的在在 90 点的 thrombolysis 组在过程的结束比在主要一种总线标准组在药治疗以后纪录(70.5%对98.0%, P < 0.0001 ,和53.0%对85.9%, P < 0.0001 ,分别地)。有 stenting 的营救一种总线标准在 thrombolytic 治疗手臂在 117 个病人(55.7%) 被执行。明显和 3 仍然是的 TIMI 流动等级的率显著地比在主要一种总线标准组在营救一种总线标准降低(88.9% 对 97.9% , P=0.0222,并且 68.4% 对 85.0% , P=0.0190,分别地) 。在 30 天治疗以后,死亡率在比在主要一种总线标准组与营救一种总线标准组相结合的 thrombolysis 是显著地更高的(7.1% 对 0, P=0.0034 ) 。 death/Ml 和流血复杂并发症的率比在主要一种总线标准组在与营救一种总线标准组一起的 thrombolysis 是显著地更高的(10.0%对1.0%, P=0.0380 ,并且28.10%对8.91%, P=0.0001 ,分别地)有营救一种总线标准的 .Conclusions Thrombolytic 治疗与冠的明显和 TIMI 流动等级的显著地更低的率被联系 3 ,但是与在 30 天的死亡, death/Ml 和出血性的复杂并发症的显著地更高的率,作为与在这组中国 S | GAO Run-lin HAN Ya-ling YANG Xin-chun MAO Jie-ming FANG Wei-yi WANG Lei SHEN Wei-feng LI Zhan-quan JIA Guo-liang LU Shu-zheng WEI Meng ZENG Ding-yin CHEN Ji-lin QIN Xue-wen XU Bo DU Chang-hui | 2010 | Chinese Medical Journal2010，，11： | 15 |
| 10 | Long Distance Transmission of SARS-CoV-2 from Contaminated Cold Chain Products to Humans——Qingdao City,Shandong Province,China,September 2020显示文摘Summary What is already known about this topic?Though coronavirus disease 2019(COVID-19)has largely been controlled in China,several outbreaks of COVID-19 have occurred from importation of cases or of suspected virus-contaminated products.Though several outbreaks have been traced to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)isolated on the outer packaging of cold chain products,live virus has not been obtained. | Huilai Ma Zhaoguo Wang Xiang Zhao Jun Han Yong Zhang Hong Wang Cao Chen Ji Wang Fachun Jiang Jie Lei Jingdong Song Shaofeng Jiang Shuangli Zhu Huihui Liu Dongyan Wang Yao Meng Naiying Mao Yanhai Wang Zhen Zhu Zhixiao Chen Bingling Wang Qinqin Song Haijun Du Qun Yuan Dong Xia Zhiqiang Xia Peipei Liu Yuchao Wu Zijian Feng Ruqin Gao George F.Gao Wenbo Xu | 2021 | China CDC weekly2021，3，30： | 13 |
| 11 | De novo mutation in ATP6V1B2 impairs lysosome acidification and causes dominant deafness-onychodystrophy syndrome显示文摘 | Yongyi Yuan Jianguo Zhang Qing Chang Jin Zeng Feng Xin Jianjun Wang Qingyan Zhu Jing Wu Jingqiao Lu Weiwei Guo Xukun Yan Hui Jiang Binfei Zhou Qi Li Xue Gao Huijun Yuan Shiming Yang Dongyi Han Zixu Mao Ping Chen Xi Lin Pu Dai | 2014 | Cell Research2014，24，11： | 13 |
| 12 | Activity of the Lenglongling fault system and seismotectonics of the 2016 MS6.4 Menyuan earthquake显示文摘The MS6.4 Menyuan earthquake occurred on the northern side of the Lenglongling fault(LLLF) in the mid-western of the Qilian-Haiyuan fault zone on January 21, 2016. The earthquake epicenter was distant from the Minle-Damaying and Huangcheng-Shuangta faults, eastern of the Northern Qilian Shan fault zone. A near northwest-striking rupture plane intersects the two faults at a certain angle. The focal mechanism solution shows that this was a thrust-type earthquake, slightly different from the strike-slip movement with a thrust component of the LLLF. Field geological mapping, tectonic geomorphology analysis, trench excavation and 14 C dating reveal that(1) the LLLF has been obviously active since the Holocene, and may behave with characteristic slip behavior and produce M_W7.3–7.5 earthquakes;(2) the LLLF appears as a flower structure in terms of structure style, and dips NNE at a steep angle; and(3) the most recent earthquake event occurred after 1815–1065 a BP. An associated fault, the Northern Lenglongling fault(NLLLF), is located at the northwestern end of the LLLF. Consequently, the NLLLF was continually subject to tectonic pushing effects from the left-lateral shear at the end of the LLLF, and, accordingly, it bent and rotated outward tectonically.Subsequently, the fault deviated from the dominant rupture azimuth and activity weakened. In the late Quaternary, it behaved as a thrust fault with no obvious deformation at the surface. This is indicated by the arc shape, with a micro-protrusion northeastward,and no geologic or geomorphic signs of surface rupturing since the late Quaternary. However, such faults could still rupture at depth, producing moderate-strong earthquakes. The geometric and kinematic properties of the NLLLF are in good agreement with the occurrence and kinematic properties of nodal plane 2, and with the distribution characteristics of the aftershocks and seismic intensity. Therefore, the NLLLF is a more suitable seismogenic structure for the MS 6.4 Menyuan earthquake. In addition, the thrust movement of the NLLLF accommodates subsequent movement of the LLLF. During the historical evolution of the NLLLF,the LLLF and the NLLLF have affected the local topography through tectonic uplift. | GUO Peng HAN ZhuJun AN YanFen JIANG WenLiang MAO ZeBin FENG Wei | 2017 | Science China Earth Sciences2017，60，5： | 13 |
| 13 | Coordinated Transcriptional Regulation by the UVB Photoreceptor and Multiple Transcription Factors for Plant UV-B Responses显示文摘Non-damaging ultraviolet B(UV-B)light promotes photomorphogenic development and stress acclimation through UV-B-specific signal transduction in Arabidopsis.UV-B irradiation induces monomerization and nuclear translocation of the UV-B photoreceptor UV RESISTANCE LOCUS 8(UVR8).However,it is not clear how the nuclear localization of UVR8 leads to changes in global gene expression.Here,we reveal that nuclear UVR8 governs UV-B-responsive transcriptional networks in concert with several previously known transcription factors,including ELONGATED HYPOCOTYL 5(HY5)and PHYTOCHROME INTERACTING FACTOR 4(PIF4).Based on the transcriptomic analysis,we identify MYB13 as a novel positive regulator in UV-B-induced cotyledon expansion and stress acclimation.MYB13 is UV-B inducible and is predominantly expressed in the cotyledons.Our results demonstrate that MYB13 protein functions as a transcription factor to regulate the expression of genes involved in auxin response and flavonoid biosynthesis through direct binding with their promoters.In addition,photoactivated UVR8 interacts with MYB13 in a UV-B-dependent manner and differentially modulates the affinity of MYB13 with its targets.Taken together,our results elucidate the cooperative function of the UV-B photoreceptor UVR8 with various transcription factors in the nucleus to orchestrate the expression of specific sets of downstream genes and,ultimately,mediate plant responses to UV-B light. | Chongzhen Qian Zhiren Chen Qing Liu Weiwei Mao Yanling Chen Wei Tian Yan Liu Jiupan Han Xinhao Ouyang Xi Huang | 2020 | Molecular Plant2020，13，5： | 13 |
| 14 | The coalbed methane production potential method for optimization of wells location selection显示文摘 | Feng-Ke DOU Yong-Shang KANG Shao-Feng QIN De-Lei MAO Jun HAN | 2013 | Journal of Coal Science & Engineering(China)2013，19，2： | 11 |
| 15 | Autoantibodies in Chinese patients with chronic hepatitis B:Prevalence and clinical associations显示文摘AIM: To investigate the prevalence of autoantibodies and their associations with clinical features in Chinesepatients with chronic hepatitis B(CHB).METHODS: A total of 325 Chinese patients with CHB were enrolled in this retrospective,hospitalbased study.Patients with chronic hepatitis C(CHC),autoimmune hepatitis(AIH),or primary biliary cirrhosis(PBC) were included,with healthy donors acting as controls.A panel of autoantibodies that serologically define AIH and PBC was tested by indirect immunofluorescence assay and line immunoassay.The AIH-related autoantibody profile included homogeneous anti-nuclear antibodies(ANA-H),smooth-muscle antibodies,anti-liver kidney microsome type 1,antiliver cytosolic antigen type 1,and anti-soluble liver antigen/liver pancreas; the PBC-related antibodies were characterized by ANA-nuclear dots/membranous rimlike,anti-mitochondrial antibodies-M2(AMA-M2),antiBPO(recombinant antigen targeted by AMA-M2),antiSp100,anti-promyelocytic leukemia protein(anti-PML),and anti-gp210.The dichotomization of clustering was used to unequivocally designate the AIH or PBC profiles for each case.Anti-Ro52 antibodies were also tested.RESULTS: The prevalence of any autoantibody in CHB amounted to 58.2%,which was similar to the 66.2% prevalence in CHC,significantly higher than the 6.7% in the healthy controls(P < 0.001),and lower than the 100% found in AIH and PBC(P = 0.004 and P < 0.001,respectively).There were more anti-PML and anti-gp210 antibodies among the CHB patients than the CHC patients(11.1% vs 0%,P = 0.003; 12.6% vs 0%,P < 0.001,respectively).The prevalence and titer of AMA,anti-BPO,anti-PML,and anti-gp210 were higher in PBC than in those with CHB.Among the CHB patients,the prevalence of ANA,especially ANA-H,was significantly lower in patients with compensated and decompensated cirrhosis compared with patients without cirrhosis.Thirty-eight cases of hepatocellular carcinoma(HCC) in CHB showed a significant differencecompared with non-HCC patients in the prevalence of anti-PML(0% vs 12.5%,P = 0.013).Dichotomization of the autoantibodies revealed that the PBC profile was more prevalent in patients with CHB than in those with CHC,and that it was strongly correlated with both compensated and decompensated cirrhosis.In contrast,the prevalence of the AIH profile was significantly higher in non-cirrhosis patients with CHB than in those with compensated cirrhosis(18.5% vs 8.2%,P = 0.039).Moreover,the AIH profile was also closely associated with hepatitis B e-antigen positivity.CONCLUSION: ANA-H could be an indicator of earlystage CHB.Dichotomizing the autoantibody profiles revealed that the PBC profile is strongly associated with cirrhosis in CHB. | Bo-An Li Jia Liu Jun Hou Jie Tang Jian Zhang Jun Xu Yong-Ji Song Ai-Xia Liu Jing Zhao Jing-Xia Guo Lin Chen Han Wang Li-Hua Yang Jie Lu Yuan-Li Mao | 2015 | World Journal of Gastroenterology2015，21，1： | 11 |
| 16 | Hippo/YAP signaling pathway is involved in osteosarcoma chemoresistance显示文摘Background:Osteosarcoma is the most common bone malignancy in children and adolescents,and 20%-30%of the patients suffer from poor prognosis because of individual chemoresistance.The Hippo/yes-associated protein(YAP) signaling pathway has been shown to play a role in tumor chemoresistance,but no previous report has focused on its involvement in osteosarcoma chemoresistance.This study aimed to investigate the role of the Hippo/YAP signaling pathway in osteosarcoma chemoresistance and to determine potential treatment targets.Methods:Using the Cell Titer-Glo Luminescent cell viability assay and flow cytometry analysis,we determined the proliferation and chemosensitivity of YAP-overexpressing and YAP-knockdown osteosarcoma cells.In addition,using western blotting and the real-time polymerase chain reaction technique,we investigated the alteration of the Hippo/YAP signaling pathway in osteosarcoma cells treated with chemotherapeutic agents.Results:Mammalian sterile 20-like kinase 1(MST1) degradation was increased,and large tumor suppressor kinase1/2(LAT51/2) total protein levels were decreased by methotrexate and doxorubicin,which increased activation and nuclear translocation of YAP.Moreover,YAP increased the proliferation and chemoresistance of MG63 cells.Conclusions:The Hippo/YAP signaling pathway plays a role in osteosarcoma chemoresistance,and YAP is a potential target for reducing chemoresistance. | Dong-Yu Wang Ya-Nan Wu Jun-Qi Huang Wei Wang Meng Xu Jin-Peng Jia Gang Han Bei-Bei Mao Wen-Zhi Bi | 2016 | Chinese Journal of Cancer2016，35，7： | 10 |
| 17 | Polymorphisms of estrogen-metabolizing genes and breast cancer risk: a multigenic study显示文摘Background Endogenous estrogen plays a very important role in the carcinogenesis and progression of breast cancer. The enzymes involved in the biosynthesis and metabolism of estrogen have been proposed to contribute to this effect. To examine this hypothesis, we conducted a case-control study to investigate the relationship between polymorphisms of genes responsible for estrogen biosynthesis (CYP17, cytochrome P450c17a and CYP19, aromatase cytochrome P450) and estrogen sulfation of inactivation (SULT1A1, sulfotransferase1A1) and the risk of breast cancer in Chinese women. Methods This study involved 213 breast cancer patients and 430 matched controls. PCR-based restriction fragment length polymorphism (RFLP) and short tandem repeat polymorphism (STRP) assays were used to detect the mononucleotide transition of CYP17 and SULT1A1 and tandem repeat polymorphism of CYP19. Logistic regression analyses were used to determine OR and 95% CI of each and all three high-risk genotypes, of all three genotypes combined, and of estrogen exposure factors. The relationship between each high-risk genotype and clinicalpathological characteristics were also assessed. Results The frequency of A2 allele of CYP17 was 49.8% in cases and 49.1% in controls (P=0.82). The frequency of His allele of SULT1A1 was significantly higher in cases (13.6%) than in controls (9.5%) (P<0.05). There was also significant difference of the (TTTA) 10 allele of CYP19 which was 12.4% in cases and 8.2% in controls (P<0.05). When the CYP17 A2 allele, CYP19 (TTTA) 10 and SULT1A1 His allele were considered as the “putative high-risk” genotype, there was an increased risk of breast cancer with the number of high-risk genotypes in a dose-response effect (trend, P=0.05). In multivariate analysis, the SULT1A1 genotype remained the most significant determinant for breast cancer, with OR=2.37 (95% CI 1.23–4.74), followed by CYP19, with OR=1.75 (95% CI 1.27–3.56). The (TTTA) 10 allele of CYP19 was associated with tumor size, and the His allele of SULT1A1 associated with status of lymph node metastasis. Conclusions This study supports the hypothesis that breast cancer can be initiated by estrogen exposure and that estrogen metabolizing genes are involved in this mechanism. This multigenic model is useful for identifying individuals who are at higher risks of breast cancer. | HAN Ding-fen ZHOU Xin HU Ming-bai XIE Wei MAO Zong-fu CHEN Dong-e LIU Fang ZHENG Fang | 2005 | Chinese Medical Journal2005，，18： | 9 |
| 18 | A novel HfNbTaTiV high-entropy alloy of superior mechanical properties designed on the principle of maximum lattice distortion显示文摘This paper reports a synergistic design of high-performance BCC high-entropy alloy based on the combined consideration of the principles of intrinsic ductility of elements,maximum atomic size difference for solid solution strengthening and the valence electron concentration criterion for ductility.The single-phase BCC HfNbTaTiV alloy thus designed exhibited a high compressive yield strength of 1350 MPa and a high compressive ductility of>45%at the room temperature.This represents a 50%increase in yield strength relative to a HfNbTaTiZr alloy.This is attributed to the maximized solid solution strengthening effect caused by lattice distortion,which is estimated to be 1094 MPa.The alloy was also able to retain 53%of its yield strength and 77%of its ductility at 700℃.These properties are superior to those of most refractory BCC high-entropy alloys reported in the literature. | Zibing An Shengcheng Mao Yinong Liu Li Wang Hao Zhou Bin Gan Ze Zhang Xiaodong Han | 2021 | Journal of Materials Science & Technology2021，，20： | 9 |
| 19 | Construction of a Normalized Full-Length cDNA Library of Sesame Developing Seed by DSN and SMART^(TM)显示文摘Sesame (Sesamue indicum L.) is one of the most important oilseed crops with high oil yield. Here, we described a simple and efficient method for constructing a normalized cDNA library from a high oil content cultivar of sesame Zhongzhi 14, during its oil accumulation stages. It combined switching mechanism at 5?end of RNA transcript (SMART) technique and duplex-specific nuclease (DSN) normalization methods. Double-stranded cDNAs were synthesized from mRNAs, processed by normalization and Sfi I restriction endonuclease, and finally the cDNAs were ligated to pDNR-LIB vector. The ligation mixture was transformed into Escherichia coli DH10B by electroporation. The capacity of the library was 1.0?06 clones in this library. Gel electrophoresis results indicated the fragments ranged from 700 to 2 000 bp, with the average size of 1 800 bp. Random picking clones showed that the recombination rate was 100%. The results showed that the cDNA library constructed successfully was a full-length library with high quality, and could be used to screen the genes related to development of oil synthesis. | KE Tao DONG Cai-hua MAO Han ZHAO Ying-zhong LIU Hong-yan LIU Sheng-yi | 2011 | Agricultural Sciences in China2011，10，7： | 8 |
| 20 | Extreme precipitation events in East China and associated moisture transport pathways显示文摘Interannual variation of summer precipitation in East China, and frequency of rainstorms during the monsoon season from 1961 to 2010, are analyzed in this study. It is found that the two variables show opposite trends on a decadal time scale: frequency of rainstorms increases significantly after the 1990 s, while summer precipitation in East China decreases during the same period. Analysis of the spatial distribution of summer rainstorm frequency from 1961 to 2010 indicates that it decreases from the southeast to the northwest at the east edge of the large-scale topography associated with the plateaus. Spatial distribution of rainstorms with daily rainfall greater than 50 mm is characterized by a 'high in the southeast and low in the northwest' pattern, similar to the staircase distribution of the topography. However, the spatial distribution of variation in both summer precipitation and frequency of extreme rainstorms under global warming differs significantly from the three-step staircase topography. It is shown that moisture characteristics of summer precipitation and extreme rainstorms during the monsoon season in East China, including moisture transport pathways, moist flow pattern, and spatial structure of the merging area of moist flows, differ significantly. Areas of frequent rainstorms include the Yangtze River Valley and South China. Column-integrated moisture transport and its spatial structure could be summarized as a 'merging' of three branches of intense moist flows from low and middle latitude oceans, and 'convergence' of column-integrated moisture fluxes. The merging area for moist flow associated with rainstorms in the high frequency region is located slightly to the south of the monsoonal precipitation or non-rainstorm precipitation, with significantly strong moisture convergence. In addition, the summer moist flow pattern in East China has a great influence on the frequency of extreme rainstorms. Moisture flux vectors in the region of frequent rainstorms correspond to vortical flow pattern. A comparison of moisture flux vectors associated with non-rainstorms and rainstorms indicates that the moist vortex associated with rainstorms is smaller in size and located to the south of the precipitation maximum, while the moist vortex associated with non-rainstorms is larger and located to the north. It is shown that column-integrated moist transport vortices and the structure of moist flux convergence have significant impacts on the north-south oscillation of frequent rainstorm areas in East China, which is synchronized with the maximum vorticity of moisture transport and the minimum of convergence on the decadal time scale. Synthesis of moisture transport pathways and related circulation impacts leads to a conceptual model of moisture flow associated with rainstorms. | ZHAO Yang XU XiangDe ZHAO TianLiang XU HongXiong MAO Fei SUN Han WANG YuHong | 2016 | Science China Earth Sciences2016，59，9： | 8 |
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