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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | The linkage maps of Dendrobium species based on RAPD and SRAP markers显示文摘Dendrobium plants are used commonly as tonic herbs and health food in many Asian countries,especially in China.Here we report the genetic map construction of two Dendrobium species with a double pseudo-testcross strategy using random amplified polymorphic DNA(RAPD) and sequence-related amplified polymorphism(SRAP) markers.A F1 mapping population of 90 individuals was developed from a cross between D.officinale and D.hercoglossum.A total of 307 markers,including 209 RAPD and 98 SRAP,were identified and used for genetic linkage group(LG) analysis.The D.officinale linkage map consisted of 11 major linkage groups and 3 doublets,which covered 629.4 cM by a total of 62 markers with an average locus distance of 11.2 cM between two adjacent markers.The D.hercoglossum linkage map contained 112 markers mapped on 15 major and 4 minor linkage groups,spanning a total length of 1,304.6 cM with an average distance of 11.6 cM between two adjacent markers.The maps constructed in this study covered 92.7% and 82.7% of the D.hercoglossum and D.officinale genomes respectively,providing an important basis for the mapping of horticultural and medicinal traits and for the application of marker-assisted selection in Dendrobium breeding program. | Dawei Xue Shangguo Feng Hongyan Zhao Hua Jiang Bo Shen Nongnong Shi Jiangjie Lu Junjun Liu Huizhong Wang | 2010 | Journal of Genetics and Genomics2010，37，3： | 26 |
| 3 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 4 | Response of runoff to climate change and its future tendency in the source region of Yellow River显示文摘这研究检验水文学和来源区域的气象学的数据从 1956 ~ 2010 的黄河和从地区性的气候的未来气候情形当模特儿(摘要) 在 20102020 期间。通过分析流动变化并且揭示气候原因,它为未来流动预言变化趋势。年度吝啬的流动显示出一个减少的趋势在,这被发现最近在有 5a, 8a, 15a, 22a 和 42a 的伪时期的黄河的来源区域的 50 年;削弱的华南海夏天季风导致了降水减少,以及蒸发增加并且在全球温暖的情形冻结土壤退化是气候因素,它引起了流动减少。基于地区性的气候模型摘要预言,在黄河的来源区域的流动是可能的在下一 20 年里通常减少。 | Li Lin Shen Hongyan Dai Sheng Xiao Jianshe Shi Xinghe | 2012 | Journal of Geographical Sciences2012，22，3： | 11 |
| 5 | BRAF^(V600E) vs. TIRADS in predicting papillary thyroid cancers in Bethesda system Ⅰ, Ⅲ, and Ⅴ nodules显示文摘Objective: Bethesda System for Reporting Thyroid Cytopathology(BSRTC) categories Ⅰ, Ⅲ, and Ⅴaccount for a significant proportion of fine needle aspiration cytology(FNAC) diagnoses. This study aimed to compare the diagnostic efficacy of BRAF^(V600E) mutation and the Thyroid Imaging Reporting and Data System(TIRADS) classification in differentiating papillary thyroid cancers(PTCs) from benign lesions among BSRTC I, III, and V nodules.Methods: A total of 472 patients with 479 nodules were enrolled in this prospective study. Ultrasound, BRAF^(V600E) mutation testing, and FNAC were performed in each nodule, followed by surgery or regular ultrasound examination.Results: In the BSRTC I category, BRAF^(V600E) showed similar sensitivity, higher specificity, and lower accuracy when compared with TIRADS. In the BSRTC III/V category, the sensitivity, specificity, and accuracy of BRAF^(V600E) were similar to those of TIRADS. In comparison to BRAF^(V600E) alone, the combination of the two methods significantly improved sensitivity(BSRTC Ⅰ:93.6% vs. 67.7%, P < 0.01; BSRTC Ⅲ: 93.8% vs. 75.0%, P < 0.01; BSRTC V: 96.0% vs. 85.3%, P < 0.001). When compared with TIRADS alone, the combination improved sensitivity in BSRTC Ⅰ nodules(93.6% vs. 74.2%, P < 0.05), increased sensitivity and decreased accuracy in BSRTC III nodules(93.8% vs. 75.0%, P < 0.01, 91.0% vs. 93.6%, P < 0.01), and improved both sensitivity and accuracy in BSRTC V nodules(96.0% vs. 82.0%, P < 0.001; 94.2% vs. 81.3%, P < 0.001).Conclusions: BRAF^(V600E) exhibited higher specificity and lower accuracy compared with TIRADS in BSRTC Ⅰ nodules, while the two methods showed similar diagnostic value in BSRTC Ⅲ/Ⅴ nodules. The combination of the two methods distinctly improved sensitivity in the diagnosis of PTCs in BSRTC Ⅰ, Ⅲ, and Ⅴ nodules. | Ya Wu Ting Xu Xingyue Cao Xin Zhao Hongyan Deng Jianxiang Wang Xiao Li Qing Yao Xinhua Ye Meiping Shen Xiaohong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 9 |
| 6 | One-step synthesis of hydrophobic magnesium hydroxide nanoparticles and their application in flame-retardant polypropylene composites显示文摘Hydrophobic magnesium hydroxide(MH) nanoparticles were prepared by a one-step synthesis method in a high-gravity environment generated by a novel impinging stream–rotating packed bed(IS-RPB) reactor. The reactant solutions were simultaneously and continuously pumped into the IS-RPB reactor, and then Tween80 was added as a surface modifier. The morphology, structure, and properties of blank and hydrophobic MH were characterized. The effects of MH nanoparticles on the flame retardancy, thermal stability, and mechanical properties of PP/MH composites were also studied. We found that the obtained MH nanoparticles exhibited hexagonal lamella with a mean size of 30 nm, excellent hydrophobic properties(e.g., high water contact angle of 112°), and improved thermal stability of MH. The limiting oxygen index(LOI) further showed that increased MH loading can significantly improve flame-retardant performance, which reached 29.3% for PP/MH composites with 30 wt% hydrophobic samples. The thermal stability and mechanical properties of the PP/MH composites with hydrophobic samples were also much higher than those of PP/MH composites with blank MH. Results showed that the one-step synthesis had high potential application in the large-scale production of hydrophobic MH nanoparticles. | Hongyan Shen Youzhi Liu | 2018 | Chinese Journal of Chemical Engineering2018，26，10： | 9 |
| 7 | Response of water resources to climate change and its future trend in the source region of the Yangtze River显示文摘在这份报纸,在中国的表面水流动和它的气候的原因的变化用水文学被分析,气象学的观察数据,以及影响数据设定(版本 2.0 ) 在 2009 年 11 月由国家气候中心出版了。结果显示表面水资源在过去的 51 年在长江的来源区域显示出一个增加的趋势,特别在 2004 以后。趋势很清楚地被显示出,并且在加热地的西藏的高原提高了效果,和进入的高原季风的地方,有 9 年和 22 年的伪时期一个强壮的时期。显著地增加的降水,和冰河融化由于气候变化增加的水,所有哪个是为来源区域的水资源的增加的主要气候的原因。基于全球气候模型预言,在 SRESA1B 气候变化情形,水资源是可能的在这个区域增加下一 20 年。 | LlLin SHEN Hongyan DAI Sheng LI Hongmei XIAO Jianshe | 2013 | Journal of Geographical Sciences2013，23，2： | 8 |
| 8 | In situ synthesis of hydrophobic magnesium hydroxide nanoparticles in a novel impinging stream-rotating packed bed reactor显示文摘Hydrophobic Mg(OH)_2nanoparticles were successfully synthesized via an in situ surface modification method in a novel impinging stream-rotating packed bed(IS-RPB) reactor using oleic acid(C_(17)H_(33)COOH, OA) as a surface modifier, magnesium chloride hexahydrate in the presence of ethanol as a precursor, and sodium hydroxide as a precipitant. The products were characterized by Fourier transform infrared spectroscopy(FTIR), Field emission scanning electron microscopy(FESEM), X-ray diffraction(XRD), and thermogravimetry-differential scanning calorimetry(TG-DSC). Compatibility with organic solutions was determined by sedimentation tests. The prepared nanoparticles exhibited regular hexagonal lamella with an average diameter of 30 nm when OA is added to the reaction system; this result indicates that OA regulates the morphology of the Mg(OH)_2nanoparticles.XRD revealed that the high-purity Mg(OH)_2product presents a brucite structure, and the I_(001)/I_(101) of hydrophobic Mg(OH)_2(0.86) was higher than that of the blank Mg(OH)_2(0.63). FTIR analysis showed that OA bonded to the surface of the Mg(OH)_2. Compared with the blank Mg(OH)_2product, the product obtained through the proposed method possesses excellent hydrophobic properties, including a high water contact angle of 101.4° and good compatibility with liquid paraffin. TG-DSC analysis indicated that the total percentage of mass loss of hydrophobic Mg(OH)_2(40.88%) was higher than that of the blank Mg(OH)_2product(33.18%). The in situ surface modification method proposed in this work presents potential use in the large-scale production of Mg(OH)_2nanoparticles. | Hongyan Shen Youzhi Liu | 2016 | Chinese Journal of Chemical Engineering2016，24，9： | 5 |
| 9 | Atacamite and Nantokite in Kaerqueka Copper Deposit of Qimantag Area:Evidence for Cenozoic Climate Evolution of the Qaidam Basin显示文摘Using a mineralogy method to reflect climate evolution is a new approach to research Cenozoic environmental progression of the Qaidam Basin. In this paper, we present the chemical composition and crystallographic parameter of atacamite, nantokite, and tenorite in cryptocrystalline aggregates from the Kaerqueka copper deposit of Qimantag metallogenic belt by means of electron microprobe and in-situ X-ray diffraction analyses. Atacamite and nantokite occur in an intimate intergrowth as the secondary precipitation of chalcopyrite and bornite filling in the interstitial space of andradite in the Kaerqueka copper deposit, with an average composition of Cl: 12.38 wt.%, Cu: 63.76 wt.%, O: 21.46 wt.%. X-ray microdiffraction shows that the intergrowth contains nantokite with a cubic unit cell a=5.403(2) ? and atacamite with an orthorhombic unit cell a=6.030(3), b=6.883(2), c=9.114(1) ?. XRD quantitative calculation shows that the nanometric aggregate contains 36.07 wt.% tenorite, 18.41 wt.% atacamite, and 45.52 wt.% nantokite. The presence of nantokite and atacamite requires saline solutions for their formation and hyper-arid climate conditions for their preservation. Combined with the data of salt lakes and the pollen sequence of western China, we suggest that during the uplift of the Tibetan Plateau and the retreat of the Paratethys, saline water was forced to the surface through a basal fracture zone. In the hyper-arid climate of the Qaidam Basin, the recharge of groundwater by direct precipitation is negligible, and groundwater is derived from inflow from the salt lakes. Thus, atacamite is preserved. In addition, spertiniite in the edge and fractures of atacamite and nantokite may represent wetter climate after the formation of atacamite and nantokite. | Liwen Yi Xiangping Gu Anhuai Lu Xiangyu Li Dexian Zhang Zhiling Wang Jianping Liu Shuai Li Zhengxiang Shu Cui Yu Hongyan Zuo Can Shen | 2017 | Journal of Earth Science2017，28，3： | 3 |
| 10 | Major and Trace Elements of Magnetite from the Qimantag Metallogenic Belt: Insights into Evolution of Ore–forming Fluids显示文摘Magnetite, as a genetic indicator of ores, has been studied in various deposits in the world. In this paper, we present textural and compositional data of magnetite from the Qimantag metallogenic belt of the Kunlun Orogenic Belt in China, to provide a better understanding of the formation mechanism and genesis of the metallogenic belt and to shed light on analytical protocols for the in situ chemical analysis of magnetite. Magnetite samples from various occurrences, including the ore–related granitoid pluton, mineralised endoskarn and vein–type iron ores hosted in marine carbonate intruded by the pluton, were examined using scanning electron microscopy and analysed for major and trace elements using electron microprobe and laser ablation–inductively coupled plasma–mass spectrometry. The field and microscope observation reveals that early–stage magnetite from the Hutouya and Kendekeke deposits occurs as massive or banded assemblages, whereas late–stage magnetite is disseminated or scattered in the ores. Early–stage magnetite contains high contents of Ti, V, Ga, Al and low in Mg and Mn. In contrast, late–stage magnetite is high in Mg, Mn and low in Ti, V, Ga, Al. Most magnetite grains from the Qimantag metallogenic belt deposits except the Kendekeke deposit plot in the ' Skarn ' field in the Ca+Al+Mn vs Ti+V diagram, far from typical magmatic Fe deposits such as the Damiao and Panzhihua deposits. According to the(Mg O+Mn O)–Ti O2–Al2O3 diagram, magnetite grains from the Kaerqueka and Galingge deposits and the No.7 ore body of the Hutouya deposit show typical characteristics of skarn magnetite, whereas magnetite grains from the Kendekeke deposit and the No.2 ore body of the Hutouya deposit show continuous elemental variation from magmatic type to skarn type. This compositional contrast indicates that chemical composition of magnetite is largely controlled by the compositions of magmatic fluids and host rocks of the ores that have reacted with the fluids. Moreover, a combination of petrography and magnetite geochemistry indicates that the formation of those ore deposits in the Qimantag metallogenic belt involved a magmatic–hydrothermal process. | YI Liwen GU Xiangping LU Anhuai LIU Jianping LEI Hao WANG Zhiling CUI Yu ZUO Hongyan SHEN Can | 2015 | Acta Geologica Sinica(English Edition)2015，89，4： | 2 |
| 11 | Extraction Optimization of Polysaccharides from Rhizoma Polygonati by Response Surface Methodology and Content Determination显示文摘[Objectives]This study aimed to investigate the water extraction-alcohol precipitation technology and content determination method of polysaccharides in Rhizoma Polygonati.[Methods]Taking the content of polysaccharides in the extract as the indicator,the extraction process was optimized using single-factor tests and Box-Behnken Design.The content of polysaccharides extracted was determined by the anthrone-sulfuric acid method.Among the three factors in the test design,the solid/liquid ratio and extraction time had a significant effect(P<0.05,P<0.01),while the extraction temperature had no effect on the content of polysaccharides extracted(P>0.05).[Results]The optimal extraction process for polysaccharides in Rhizoma Polygonati was as follows:liquid/solid ratio 20∶1(mL/g),extraction time 2 h,and extraction temperature 85℃.Under the optimal extraction process,the content of polysaccharides in the extract reached 12.50%.[Conclusions]The extraction process optimized by response surface methodology for polysaccharides in Rhizoma Polygonati is reliable and has practical value,and can be used to guide production practices. | Qianru SHEN Lian LIAN Hongyan YU Cheng YANG | 2020 | Medicinal Plant2020，11，6： | 2 |
| 12 | A Repressor Complex Governs the Integration of Flowering Signals in Arabidopsis显示文摘 | Dan Li Chang Liu Lisha Shen Yang Wu Hongyan Chen Masumi Robertson Chris A. Helliwell Toshiro Ito Elliot Meyerowitz Hao Yu | 2008 | Developmental Cell2008，，1： | 1 |
| 13 | Tile genetic epidemiology research of pri- mary liver cancer 显示文摘 | Meng Hui Liu Hongyan Cai Rulin Jiang Feng Jiang Qing five Lin Wenyao Shen Fumin | 2002 | Chinese journal of epidemiology2002，，6： | 1 |
| 14 | Adsorption of Acid Red G dye on octadecyl trimethylammonium montmorillonite显示文摘 | Dong Shen Tong Chun Hui (Clayton) Zhou Yan Lu Hongyan Yu Guo Fei Zhang Wei Hua Yu | 2010 | Applied Clay Science2010，，3： | 1 |
| 15 | Advances in new antivirals for chronic hepatitis B显示文摘Chronic hepatitis B virus(HBV)infection remains a global health burden.Timely and effective antiviral therapy is beneficial for patients with HBV infection.With existing antiviral drugs,including nucleos(t)ide analogs and interferon-alfa,patients can achieve viral suppression with improved prognosis.However,the rate of hepatitis B surface antigen loss is low.To achieve a functional cure and even complete cure in chronic hepatitis B patients,new antivirals need to be developed.In this review,we summarized the advantages and disadvantages of existing antiviral drugs and focused on new antivirals including direct-acting antiviral drugs and immunotherapeutic approaches. | Yanhua Tang Hongyan Liang Ge Zeng Sheng Shen Jian Sun | 2022 | Chinese Medical Journal2022，，5： | 1 |
| 16 | Germ cell sex prior to meiosis in the rainbow trout显示文摘Germ cells make two major decisions when they move from an indeterminate state to their final stage of gamete production.One decision is sexual commitment for sperm or egg production,and the other is to maintain mitotic division or entry into meiosis.It is unclear whether the two decisions are made as a single event or separate events,because there has been no evidence for the presence of germ cell sex prior to meiosis.Here we report direct evidence in the fish rainbow trout that gonia have distinct sexuality.We show that dazl expression occurs in both male and female gonia but exhibits differential intracellular distribution.More strikingly,we show that boule is highly expressed in male gonia but absent in female gonia.Therefore,mitotic gonia possess sex,sperm/egg decision and mitosis/meiosis decision are two independent events,and sperm/egg decision precedes mitosis/meiosis decision in rainbow trout,making this organism a unique vertebrate model for mechanistic understanding of germ cell sex differentiation and relationship between the two decisions. | Mingyou Li Qian Shen Foong Mei Wong Hongyan Xu Ni Hong Lingbing Zeng Lin Liu Qiwei Wei Yunhan Hong | 2011 | Protein & Cell2011，2，1： | 1 |
| 17 | Proteome-Wide Profiling of the Covalent-Druggable Cysteines with a Structure-Based Deep Graph Learning Network显示文摘Covalent ligands have attracted increasing attention due to their unique advantages,such as long residence time,high selectivity,and strong binding affinity.They also show promise for targets where previous efforts to identify noncovalent small molecule inhibitors have failed.However,our limited knowledge of covalent binding sites has hindered the discovery of novel ligands.Therefore,developing in silico methods to identify covalent binding sites is highly desirable.Here,we propose DeepCoSI,the first structure-based deep graph learning model to identify ligandable covalent sites in the protein.By integrating the characterization of the binding pocket and the interactions between each cysteine and the surrounding environment,DeepCoSI achieves state-of-the-art predictive performances.The validation on two external test sets which mimic the real application scenarios shows that DeepCosI has strong ability to distinguish ligandable sites from the others.Finally,we profiled the entire set of protein structures in the RCSB Protein Data Bank(PDB)with DeepCoSI to evaluate the ligandability of each cysteine for covalent ligand design,and made the predicted data publicly available on website. | Hongyan Du Dejun Jiang Junbo Gao Xujun Zhang Lingxiao Jiang Yundian Zeng Zhenxing Wu Chao Shen Lei Xu Dongsheng Cao Tingjun Hou Peichen Pan | 2022 | Research2022，，4： | 1 |
| 18 | A Super-resolution Reconstruction Algorithm for Hyperspectral Images显示文摘 | Zhang Hongyan Zhang Liangpei Shen Huanfeng | 2012 | Signal Processing2012，92，9： | 1 |
| 19 | A novel mitochondria-targeting tetrapeptide for subcellular delivery of nanoparticles显示文摘Mitochondrial dysfunction is associated with the emergence of several neurological and cardiovascular diseases. Hence, mitochondria-targeting delivery strategies are highly significant and critically needed. In this study, we developed a small library of peptides simulating the mitochondria-targeting peptide SS-31, a promising tetra-peptide with antioxidant character, and subsequently evaluated the toxicity, antioxidant ability and mitochondrial delivery of nanoparticles. Among the designed peptides, RF-2 (DArg-Dmt-Arg-Phe-NH2) showed controlled toxicity and excellent protection against gentamicin-induced hair cell damage, as compared with SS-31. More importantly, RF-2-modified PLGA nanoparticles demonstrated high colocalization with mitochondria and comparable specific subcellular accumulation, when compared with SS-31. Taken together, the obtained results supported RF-2 as a mitochondriatargeting peptide with high potential as a targeted carrier. | Yanhui Sun Aiyan Zhan Shuang Zhou Xiao Kuang Hongyan Shen Hongzhuo Liu Youjun Xu | 2019 | Chinese Chemical Letters2019，30，7： | 1 |
| 20 | Two-step Sparse Coding for the Pan-sharpening of Remote Sensing Images显示文摘 | JIANG Cheng ZHANG Hongyan SHEN Huanfeng | 2014 | IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing2014，7，5： | 1 |
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