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| 1 | Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society显示文摘 | Elizabeth R. Seaquist John Anderson Belinda Childs Philip Cryer Samuel Dagogo-Jack Lisa Fish Simon R. Heller Henry Rodriguez James Rosenzweig Robert Vigersky | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，5： | 2 |
| 2 | Vascular-confined multi-passage discoidal nanoconstructs for the low-dose docetaxel inhibition of triple-negative breast cancer growth显示文摘Taxane efficacy in triple negative breast cancer(TNBC)is limited by insufficient tumor accumulation and severe off-target effects.Nanomedicines offer a unique opportunity to enhance the anti-cancer potency of this drug.Here,1,000 nm×400 nm discoidal polymeric nanoconstructs(DPN)encapsulating docetaxel(DTXL)and the near infrared compound Iipid-Cy5 were engineered.DPN were obtained by filling multiple times cylindrical wells in a poly(vinyl alcohol)template with a polymer mixture comprising poly(lactic-co-glycolic acid)(PLGA)and poly(ethylene glycol)diacrylate(PEG-DA)chains together with therapeutic and imaging agents.The resulting“multi-passage”DPN exhibited higher DTXL loading,Iipid-Cy5 stability,and stiffness as compared to the conventional'single-passage'approach.Confocal microscopy confirmed that DTXL-DPN were not taken up by MDA-MB-231 cells but would rather sit next to the cell membrane and slowly release DTXL thereof.Empty DPN had no toxicity on TNBC cells,whereas DTXL-DPN presented a cytotoxic potential comparable to free DTXL(IC_(50)=2.6 nM±1.0 nM vs.7.0 nM±1.09 nM at 72 h).In orthotopic murine models,DPN accumulated in TNBC more efficiently than free-DTXL.With only 2 mg/kg DTXL,intravenously administered every 2 days for a total of 13 treatments,DTXL-DPN induced tumor regression and were associated to an overall 80%survival rate as opposed to a 30%survival rate for free-DTXL,at 120 days.All untreated mice succumbed before 90 days.Collectively,this data demonstrates that vascular confined multi-passage DPN,biomimicking the behavior of circulating platelets,can efficiently deliver chemotherapeutic molecules to malignant tissues and effectively treat orthotopic TNBC at minimal taxane doses. | Alessia Felici Daniele Di Mascolo Miguel Ferreira Simone Lauciello Luca Bono Andrea Armirotti Arunkumar Pitchaimani Anna Lisa Palange Paolo Decuzzi | 2022 | Nano Research2022，15，1： | 2 |
| 3 | Software-Related Recalls: An Analysis of Records显示文摘 | Simone Lisa K | 2013 | Biomedical Instrumentation & Technology2013，，6： | 1 |
| 4 | FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis显示文摘 | Pauline Andreu Magnus Johansson Nesrine I. Affara Ferdinando Pucci Tingting Tan Simon Junankar Lidiya Korets Julia Lam David Tawfik David G. DeNardo Luigi Naldini Karin E. de Visser Michele De Palma Lisa M. Coussens | 2010 | Cancer Cell2010，，2： | 1 |
| 5 | Blood and plasma- based proteomic biomarker research in Alzheimer's disease 显示文摘 | Simone Lisa Frank Fahraco David Prvulovic | 2013 | Pro- gress in Neurobiology2013，101，： | 1 |
| 6 | Phase II Study of Biweekly Pemetrexed and Gemcitabine in Patients with Previously Untreated Advanced Non-small Cell Lung Cancer显示文摘 | David R. Spigel John D. Hainsworth John H. Barton Jeffrey F. Patton John D. Zubkus Lisa Simons Paula Griner Howard A. Burris F. Anthony Greco | 2010 | Journal of Thoracic Oncology2010，，6： | 1 |
| 7 | Biomarkers and Mechanisms of FANCD2 Function显示文摘 | Henning Willers Lisa A. Kachnic Chen-Mei Luo Li Li Martin Purschke Kerstin Borgmann Kathryn D. Held Simon N. Powell Lisa Wiesmuller | 2008 | Journal of Biomedicine and Biotechnology2008，，： | 1 |
| 8 | Relationship Between Level of Hepatitis B Virus DNA and Liver Disease: A Population-based Study of Hepatitis B e Antigen–Negative Persons With Hepatitis B显示文摘 | Brian J. McMahon Lisa Bulkow Brenna Simons Yuhong Zhang Susan Negus Chriss Homan Philip Spradling Eyasu Teshale Daryl Lau Mary Snowball Stephen E. Livingston | 2014 | Clinical Gastroenterology and Hepatology2014，，4： | 1 |
| 9 | “Bulletproof skeptics in life’s jungle”: which self-exempting beliefs about smoking most predict lack of progression towards quitting?显示文摘 | Wendy Oakes Simon Chapman Ron Borland James Balmford Lisa Trotter | 2004 | Preventive Medicine2004，，： | 1 |
| 10 | Palliative Radiotherapy for Bone Metastases: An ASTRO Evidence-Based Guideline显示文摘 | Stephen Lutz Lawrence Berk Eric Chang Edward Chow Carol Hahn Peter Hoskin David Howell Andre Konski Lisa Kachnic Simon Lo Arjun Sahgal Larry Silverman Charles von Gunten Ehud Mendel Andrew Vassil Deborah Watkins Bruner William Hartsell | 2011 | International Journal of Radiation Oncology Biology Physics2011，，4： | 1 |
| 11 | Aortic Pulse-Wave Velocity and Its Relationship to Mortality in Diabetes and Glucose Intolerance: An Integrated Index of Vascular Function?显示文摘 | Kennedy Cruickshank Lisa Riste Simon G. Anderson John S. Wright Graham Dunn Ray G. Gosling | 2002 | Circulation: Journal of the American Heart Association2002，，16： | 1 |
| 12 | Genomic correlates of response to CTLA-4 blockade in metastatic melanoma显示文摘 | Van Allen Eliezer M. Miao Diana Schilling Bastian Shukla Sachet A. Blank Christian Zimmer Lisa Sucker Antje Hillen Uwe Geukes Foppen Marnix H. Goldinger Simone M. Utikal Jochen Hassel Jessica C. Weide Benjamin Kaehler Katharina C. Loquai Carmen Mohr Peter | 2015 | Science . 2015 (6257)2015，，6257： | 1 |
| 13 | Effective suppression of multiply scattering light in static and dynamic light scattering显示文摘 | Peter Hulstede Simone Wiegand | 1998 | Applied Optics1998，37，27： | 1 |
| 14 | Cardiac Magnetic Resonance (CMR) for the Differentiation of AL and ATTR Cardiac Amyloidosis显示文摘 | Jason N. Dungu Oswaldo Valencia Jennifer H. Pinney Simon D.J. Gibbs Dorota Rowczenio Janet A. Gilbertson Helen J. Lachmann Ashutosh Wechalekar Julian D. Gillmore Carol J. Whelan Philip N. Hawkins Lisa J. Anderson | 2013 | JACC: Cardiovascular Imaging2013，，： | 1 |
| 15 | IL -25 drives remodelling in allergic airways disease induced by house dust mite显示文摘 | Lisa G Gregory Carla P Jones Simone A Walker | 2013 | Respiratory research2013，68，： | 1 |
| 16 | Chemical solutions for greywater recycling显示文摘 | Marc Pidou Lisa Avery Tom Stephenson Paul Jeffrey Simon A. Parsons Shuming Liu Fayyaz A. Memon Bruce Jefferson | 2007 | Chemosphere2007，，1： | 1 |
| 17 | Cerebral microbleeds and vascular cognitive impairment显示文摘 | David JW Simone MG Lisa C | 2010 | J Neurotog Sci2010，299，1： | 1 |
| 18 | Thermal evolution of an ancient subduction interface revealed by Lue Hf garnet geochronology, Halilba■? Complex(Anatolia)显示文摘The thermal structure of subduction zones exerts a major influence on deep-seated mechanical and chemical processes controlling arc magmatism, seismicity, and global element cycles. Accretionary complexes exposed inland may comprise tectonic blocks with contrasting pressureetemperature(Pe T)histories, making it possible to investigate the dynamics and thermal evolution of former subduction interfaces. With this aim, we present new Lue Hf geochronological results for mafic rocks of the Halilbag?Complex(Anatolia) that evolved along different thermal gradients. Samples include a lawsoniteeepidote blueschist, a lawsoniteeepidote eclogite, and an epidote eclogite(all with counter-clockwise Pe T paths),a prograde lawsonite blueschist with a 'hairpin'-type Pe T path, and a garnet amphibolite from the overlying sub-ophiolitic metamorphic sole. Equilibrium phase diagrams suggest that the garnet amphibolite formed at w0.6 -0.7 GPa and 800 -850℃, whereas the prograde lawsonite blueschist records burial from 2.1 GPa and 420℃ to 2.6 GPa and 520℃. Well-defined Lue Hf isochrons were obtained for the epidote eclogite(92.38 ± 0.22 Ma) and the lawsoniteeepidote blueschist(90.19 ± 0.54 Ma),suggesting rapid garnet growth. The lawsoniteeepidote eclogite(87.30 ± 0.39 Ma) and the prograde lawsonite blueschist(ca. 86 Ma) are younger, whereas the garnet amphibolite(104.5 ± 3.5 Ma) is older.Our data reveal a consistent trend of progressively decreasing geothermal gradient from granulite-facies conditions at ~104 Ma to the epidote-eclogite facies around 92 Ma, and the lawsonite blueschist-facies between 90 Ma and 86 Ma. Three Lue Hf garnet dates(between 92 Ma and 87 Ma) weighted toward the growth of post-peak rims(as indicated by Lu distribution in garnet) suggest that the HP/LT rocks were exhumed continuously and not episodically. We infer that HP/LT metamorphic rocks within the Halilbag?Complex were subjected to continuous return flow, with 'warm' rocks being exhumed during the tectonic burial of 'cold' ones. Our results, combined with regional geological constraints, allow us to speculate that subduction started at a transform fault near a mid-oceanic spreading centre. Following its formation, this ancient subduction interface evolved thermally over more than 15 Myr, most likely as a result of heat dissipation rather than crustal underplating. | Amaury Pourteau Erik E.Scherer Simon Schorn Rebecca Bast Alexander Schmidt Lisa Ebert | 2019 | Geoscience Frontiers2019，10，1： | 1 |
| 19 | Palliative Radiotherapy for Bone Metastases: An ASTRO Evidence-Based Guideline显示文摘 | Stephen Lutz Lawrence Berk Eric Chang Edward Chow Carol Hahn Peter Hoskin David Howell Andre Konski Lisa Kachnic Simon Lo Arjun Sahgal Larry Silverman Charles von Gunten Ehud Mendel Andrew Vassil Deborah Watkins Bruner William Hartsell | 2011 | International Journal of Radiation Oncology, Biology, Physics2011，，4： | 1 |
| 20 | The human melanocortin-1 receptor locus: analysis of transcription unit, locus polymorphism and haplotype evolution显示文摘 | Aaron G. Smith Neil F. Box Lisa H. Marks Wei Chen Darren J. Smit Jason R. Wyeth Gavin A. Huttley Simon Easteal Richard A. Sturm | 2001 | Gene2001，，1： | 1 |
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