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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | Spatial and temporal variations of vegetation cover and the relationships with climate factors in Inner Mongolia based on GIMMS NDVI3g data显示文摘Variation in vegetation cover in Inner Mongolia has been previously studied by the remote sensing data spanning only one decade. However, spatial and temporal variations in vegetation cover based on the newly released GIMMS NDVI3g data spanning nearly thirty years have yet to be analyzed. In this study, we applied the methods of the maximum value composite(MVC) and Pearson's correlation coefficient to analyze the variations of vegetation cover in Inner Mongolia based on GIMMS NDVI3g data spanning from 1982 to 2013. Our results indicate that the normalized difference vegetation index(NDVI) increased at a rate of 0.0003/a during the growing seasons despite of the drier and hotter climate in Inner Mongolia during the past three decades. We also found that vegetation cover in the southern agro-pastoral zone significantly increased, while it significantly decreased in the central Alxa. The variations in vegetation cover were not significant in the eastern and central regions. NDVI is positively correlated with precipitation(r=0.617, P=0.000) and also with air temperature(r=0.425, P=0.015), but the precipitation had a greater effect than the air temperature on the vegetation variations in Inner Mongolia. | TONG Siqin ZHANG Jiquan BAO Yuhai Wurina Terigele Weilisi Lianxiao | 2017 | Journal of Arid Land2017，9，3： | 10 |
| 3 | Matrix stiffness modulates tip cell formation through the p-PXN-Rac1-YAP signaling axis显示文摘Endothelial tip cell outgrowth of blood-vessel sprouts marks the initiation of angiogenesis which is critical in physiological and pathophysiological procedures.However,how mechanical characteristics of extracellular matrix(ECM)modulates tip cell formation has been largely neglected.In this study,we found enhanced CD31 expression in the stiffening outer layer of hepatocellular carcinoma than in surrounding soft tissues.Stiffened matrix promoted sprouting from endothelial cell(EC)spheroids and upregulated expressions of tip cell-enriched genes in vitro.Moreover,tip cells showed increased cellular stiffness,more actin cytoskeleton organization and enhanced YAP nuclear transfer than stalk and phalanx ECs.We further uncovered that substrate stiffness regulates FAK and Paxillin phosphorylation in focal adhesion of ECs promoting Rac1 transition from inactive to active state.YAP is subsequently activated and translocated into nucleus,leading to increased tip cell specification.p-Paxillin can also loosen the intercellular connection which also facilitates tip cell specification.Collectively our present study shows that matrix stiffness modulates tip cell formation through p-PXN-Rac1-YAP signaling axis,shedding light on the role of mechanotransduction in tip cell formation.This is of special significance in biomaterial design and treatment of some pathological situations. | Yaru Guo Feng Mei Ying Huang Siqin Ma Yan Wei Xuehui Zhang Mingming Xu Ying He Boon Chin Heng Lili Chen Xuliang Deng | 2022 | Bioactive Materials2022，7，1： | 4 |
| 4 | Microbial diversity and functionally distinct groups in produced water from the Daqing Oilfield,China显示文摘The microbial community structure and functionally distinct groups in three kinds of produced water samples from the shallow,mesothermic and low-salinity Daqing oil reservoir were systematically evaluated using both culture-dependent and culture-independent methods.Sequence analysis of the 16S rRNA genes indicated that the bacterial library was dominated by Acinetobacter and Arcobacter and the archaeal community was dominated by Methanosaeta and Methanolinea.Two isolated methanogens were closely related with Methanothermobacter thermautotrophicus and Methanoculleus receptaculi.The fermentative bacteria were identified as Pseudomonas,Haloanaerobium,Alcalibacter,Arcobacter,and Pannonibacter.The predominant nitrate-reducing bacteria fell within the genus Pseudomonas.The dominant members of the cultured hydrocarbon-oxidizing bacteria were phylogenetically associated with Micrococcus,Pseudomonas,and Bacillus.Enrichments of biosurfactants and biopolymer producing groups mainly yielded Pseudomonas,Bacillus,and Acenitobacter-related members.The functional groups related to polymer degradation were also affiliated with Pseudomonas and Bacillus.Results from this study provide the fresh insight into the diversity of microbial communities in Daqing petroleum reservoirs.The vast pool of functional strains retrieved in this study was presumed to include the promising strains that could be applied in microbial-enhanced oil recovery in future. | Li Hui Ai Mingqiang Han Siqin Guo Yanling Li Nana Shi Rongjiu Zeng Xiangling Leng Shengbing Zhao Jinyi Liu Xiaobo Zhang Ying | 2012 | Petroleum Science2012，9，4： | 3 |
| 5 | The role of intraoperative electron radiotherapy in centrally located hepatocellular carcinomas treated with narrow-margin (<1 cm) hepatectomy: a prospective, phase 2 study显示文摘Background: Postoperative radiotherapy (RT) is known to play an important role in the treatment of hepatocellular carcinomas (HCCs), but the specific role of intraoperative electron radiotherapy (IOERT) in HCCs remains unclear. The aim of this study was to investigate the safety and efficacy of IOERT in centrally located HCCs treated with narrow-margin (<1 cm) hepatectomy. Methods: This was a single-center, phase 2, prospective non-randomized controlled study, including 268 patients with centrally located HCCs who underwent narrow-margin hepatectomy. The patients were subsequently allocated to the IOERT group (n=59) or to the control group (n=65). The primary outcome of the study was to compare recurrence-free survival (RFS) between the IOERT group and the control group, and the secondary outcome was to compare overall survival (OS) rate between the two groups. Results: Of 268 patients enrolled, a total of 124 were included in the study: 59 in IOERT group, 65 in control group. The 1-, 2-, 3-year RFS rates were 79.3%, 62.1% and 45.8% for patients in the IOERT group, and 47.6%, 28.6%, and 22.9% for patients in the control group, respectively (P=0.025). The 1-, 2-, and 3-year OS rates were 100.0%, 94.9%, and 83.7% for patients in the IOERT group, and 92.3%, 87.5%, and 79.4% for patients in the control group, respectively (P=0.314). Subgroup analysis of MVI (+) patients revealed that RFS and OS are significantly prolonged in the IOERT subgroup as compared to the control, whereas there was no significant difference of RFS and OS between the two groups in MVI (−) patients. Conclusions: IOERT for centrally located HCCs with concurrent narrow-margin hepatectomy was feasible and safe. Statistically better RFS rate was observed in the IOERT group compared to the control group. Subgroup analysis revealed that IOERT was more beneficial for postoperative survival of HCC patients with MVI. Trial Registration: ChiCTR-TRC-12002802;www.who.int/ictrp. | Liming Wang Yunhe Liu Weiqi Rong Fan Wu Weibo Yu Kan Liu Shengtao Lin Yiling Zheng Kai Zhang Tana Siqin Changcheng Tao Mei Liu Bo Chen Qinfu Feng Jianxiong Wu | 2022 | Hepatobiliary Surgery and Nutrition2022，11，4： | 2 |
| 6 | Dy3+ and Nd3+in- duced genetic mutation of bacillus alpha-amylase 显示文摘 | Zhang DY Hu JH Siqin B | 2009 | Journal of Inorganic Biochemistry2009，103，7： | 1 |
| 7 | A joint call for actions to advance taxonomy in China显示文摘Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China. | Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu | 2022 | Zoological Systematics2022，47，3： | 1 |
| 8 | Human mobility data in the COVID-19 pandemic:characteristics,applications,and challenges显示文摘The COVID-19 pandemic poses unprecedented challenges around the world.Many studies have applied mobility data to explore spatiotemporal trends over time,investigate associations with other variables,and predict or simulate the spread of COVID-19.Our objective was to provide a comprehensive overview of human mobility open data to guide researchers and policymakers in conducting data-driven evaluations and decision-making for the COVID-19 pandemic and other infectious disease outbreaks.We summarized the mobility data usage in COVID-19 studies by reviewing recent publications on COVID-19 and human mobility from a data-oriented perspective.We identified three major sources of mobility data:public transit systems,mobile operators,and mobile phone applications.Four approaches have been commonly used to estimate human mobility:public transit-based flow,social activity patterns,index-based mobility data,and social media-derived mobility data.We compared mobility datasets’characteristics by assessing data privacy,quality,space–time coverage,high-performance data storage and processing,and accessibility.We also present challenges and future directions of using mobility data.This review makes a pivotal contribution to understanding the use of and access to human mobility data in the COVID-19 pandemic and future disease outbreaks. | Tao Hu Siqin Wang Bing She Mengxi Zhang Xiao Huang Yunhe Cui Jacob Khuri Yaxin Hu Xiaokang Fu Xiaoyue Wang Peixiao Wang Xinyan Zhu Shuming Bao Wendy Guan Zhenlong Li | 2021 | International Journal of Digital Earth2021，14，9： | 1 |
| 9 | Anti-Lung-Cancer Activity and Liposome-Based Delivery Systems of β -Elemene显示文摘 | Meiwan Chen Jinming Zhang Siqin Yu Shengpeng Wang Zaijun Zhang Jianqiang Chen Jian Xiao Yitao Wang Yoshiyuki Kimura | 2012 | Evidence-Based Complementary and Alternative Medicine2012，，： | 1 |
| 10 | Magnetic and electrical properties of Z-type hexaferrites sintered in different atmospheres显示文摘 | Xiaozhi Zhang Zhenxing Yue Siqin Meng Bin Peng Lixin Yuan | 2015 | Materials Research Bulletin2015，，： | 1 |
| 11 | High corn oil dietary intake improves health and longevity of aging mice显示文摘 | Hongwei Si Longyun Zhang Siqin Liu | 2014 | Experimental Gerontology2014，58，10： | 1 |
| 12 | A new species of Chresmodidae from Mid-Cretaceous amber discovered in Myanmar显示文摘The extinct new species,Chresmoda chikuni Zhang & Ge,sp. nov. is described from the Mid-Cretaceous amber from northern Myanmar. This amber insect exhibits a very peculiar combination of derived characters like strongly elongated,free coxa,non-clawed pretarsus. The type specimens are deposited in the Three Gorges Entomological Museum,Chongqing,China. | Weiwei Zhang Wanzhi Cai Wenzhu Li Xingke Yang Siqin Ge | 2017 | Zoological Systematics2017，42，2： | 0 |
| 13 | The structure of the compound eyes and phototaxis in two phenotypes of the bean pest Callosobruchus maculatus(Coleoptera:Bruchinae)显示文摘Callosobruchus maculatus(Fabricius,1775)(Coleoptera:Bruchinae)is a destructive agricultural pest that is harmful to beans worldwide and an important quarantine pest in China.It was divided into two phenotypes based on polyphenism:normal and flight forms.In this study,we first compared the morphological structures of the compound eyes of the two forms.According to the results of scanning electron microscopy(SEM),transmission electron microscopy(TEM),microcomputed tomography(micro-CT),and computer three-dimensional reconstruction,there are no differences in the structures of the compound eyes between the normal and flight forms except for the number of ommatidia.From the internal structure,the compound eyes have a biconvex cornea with open rhabdom and acone eye,crystalline cone directly connected with rhabdom,and no clear zone.It is a kind of apposition eye.Ommatidia facets range in shape from quadrilateral to hexagonal and some irregular shapes.On electroretinograms(ERGs),the normal and flight forms showed different spectral sensitivities:the normal form had the strongest response to ultraviolet light,whereas the flight form had the strongest response to white light.Behavioral assays revealed that the normal and flight forms showed completely opposite phototaxis behaviors;the flight form exhibited positive phototaxis,whereas the normal form exhibited negative phototaxis.This study not only enriches our knowledge on coleopteran compound eyes but also provides a foundation for in-depth research on the photoreceptor mechanisms of compound eyes,which may be useful in pest control management. | Zhong Du Tianhao Zhang Fengming Wu Zulong Liang Xiaokun Liu Muinde Jacob Weili Fan Lei Jiang Lijie Zhang Siqin Ge Guohong Wang | 2023 | Zoological Systematics2023，48，3： | 0 |
| 14 | The gross α and β radioactivity levels of drinking water source in one oil industrial city in northeast China显示文摘Objective:To investigate the grossαandβradioactivity levels of drinking water source in the city,the largest oil field production base in northeast China,in order to ensure the safety of drinking water and public health.Methods:The water samples from three drinking water sources were collected and tested in the dry and wet season,respectively.The grossαradioactivity was measured by standard curve method,grossβwas measured by thin sample method.Results:Totally 184 samples were collected from the three sampling areas in dry and wet season respectively.The average values of grossαandβradioactivity levels in the drinking water source area were(0.24±0.09)and(0.30±0.17)Bq/L respectively.The average activity concentration of grossαand grossβin the dry season was(0.23±0.09)and(0.29±0.18)Bq/L,respectively.The grossαandβradioactivity levels gradually decreased from the intake to the end of the reservoir of drinking water source areas.Conclusions:The grossαandβradioactivity levels and distribution of drinking water source areas in this city were all lower than the drinking water limit issued by China and the reference level recommended by the World Health Organization.The radioactivity of water body of the drinking water source was within the normal background level. | Yan Shi Wa Gao Tuya Siqin Zhigang Li Jianwei Zhang Rongshu Guan Jinfeng Li Peilin Sun Hongtao Zhao | 2021 | Radiation Medicine and Protection2021，2，2： | 0 |
| 15 | Integrated risk assessment framework for transformation products of emerging contaminants:what we know and what we should know显示文摘The continuous input of various emerging contaminants(ECs)has inevitably introduced large amounts of transformation products(TPs)in natural and engineering water scenarios.Structurally similar to the precursor species,the TPs are expected to possess comparative,if not more serious,environmental properties and risks.This review summarizes the state-of-the-art knowledge regarding the integrated risk assessment frameworks of TPs of ECs,mainly involving the exposure-and effectdriven analysis.The inadequate information within existing frameworks that was essential and critical for developing a better risk assessment framework was discussed.The main strategic improvements include(1)non-targeted product analysis in both laboratory and field samples,(2)omics-based highthroughput toxicity assessment,(3)multichannel-driven mode of action in conjugation with effectdirected analysis,and(4)machine learning technology.Overall,this review provides a concise but comprehensive insight into the optimized strategy for evaluating the environmental risks and screening the key toxic products from the cocktail mixtures of ECs and their TPs in the global water cycle.This facilitates deciphering the mode of toxicity in complex chemical mixtures and prioritizing the regulated TPs among the unknown products,which have the potential to be considered a class of novel'ECs'ofgreatconcern. | Shengqi Zhang Qian Yin Siqin Wang Xin Yu Mingbao Feng | 2023 | Frontiers of Environmental Science & Engineering2023，17，7： | 0 |
| 16 | Studies on the Inversion Phenomenon of Physical Properties Observed in the Huagang Formation Reservoir in the Xihu Sag Based on the Water-Rock Reaction Experiments显示文摘In the Xihu Sag,the reservoirs of the Paleogene Huagang formation have entered the middle diagenetic stage A and the rock physical properties of the water layer are considerably more suitable for the gas migration and storage than those of the present gas layer,indicating the inversion of the physical properties.In this study,core samples were collected from the corresponding reservoir to conduct water-rock reaction experiments in acidic,alkaline,and neutral systems under the specific temperature and pressure.The reasons for the inversion of physical properties were investigated based on the experiment results in reservoir diagenetic environments.The inversion of physical properties can be attributed to the fact that the diagenetic environment around the gas-water interface controls the water-rock reaction effect.With different types of acidic substances,two different situations corresponding to inverted physical properties were analyzed along with the corresponding mechanisms.When the pore fluid is acidic,the physical properties make the overall water layer a better reservoir space than the gas layer,which can be referred to as the overall inversion of physical properties.When the fluid were generally neutral or weakly alkaline and the gas layer was rich in CO2,only the physical properties of the water layer adjacent to the gas-water interface were more favorable for the gas migration than those of the gas layer.This phenomenon can be referred to as the near-interface inversion of physical properties. | HUANG Siqin XU Fanghao XU Guosheng CUI Hengyuan ZHANG Wu | 2021 | Journal of Ocean University of China2021，20，4： | 0 |
| 17 | Biomaterial-induced macrophage polarization for bone regeneration显示文摘As the main target cells of immune regulation,macrophages play an important role in the bone regeneration process.Macrophages can be polarized into the M1 and M2 types under the stimulation of different factors.They have proinflammatory and anti-inflammatory effects,respectively,and play key roles in different stages of bone regeneration.The ratio of M1 to M2 macrophages can be regulated by immunomodulatory biomaterials to promote bone repair and regeneration.In this paper,we review the recent literature on the chemical,physical and biological properties of biomaterials and the regulation of macrophage polarization under the influence of other factors.We also cover new methods for preparing immunomodulatory biomaterials for bone regeneration.This paper will provide new design ideas for the development of biomaterials with immunological properties and will support the clinical translation of bone-related medical biomaterials. | Long Chen Zhicheng Yao Siqin Zhang Kuihan Tang Qiming Yang Yuanzheng Wang Bohan Li Yingjie Nie Xiaobin Tian Li Sun | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
| 18 | Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome显示文摘Intelligent responsive drug delivery system opens up new avenues for realizing safer and more effective combination immunotherapy.Herein,a kind of tumor cascade-targeted responsive liposome(NLG919@Lip-pep1)is developed by conjugating polypeptide inhibitor of PD-1 signal pathway(AUNP-12),which is also a targeted peptide that conjugated with liposome carrier through matrix metalloproteinase-2(MMP-2)cleavable peptide(GPLGVRGD).This targeted liposome is prepared through a mature preparation process,and indoleamine-2,3-dioxygenase(IDO)inhibitor NLG919 was encapsulated into it.Moreover,mediated by the enhanced permeability and retention effect(EPR effect)and AUNP-12,NLG919@Lip-pep1 first targets the cells that highly express PD-L1 in tumor tissues.At the same time,the over-expressed MMP-2 in the tumor site triggers the dissociation of AUNP-12,thus realizing the precise block of PD-1 signal pathway,and restoring the activity of T cells.The exposure of secondary targeting moduleⅡVRGDC-NLG919@Lip mediated tumor cells targeting,and further relieved the immunosuppressive microenvironment.Overall,this study offers a potentially appealing paradigm of a high efficiency,low toxicity,and simple intelligent responsive drug delivery system for targeted drug delivery in breast cancer,which can effectively rescue and activate the body's anti-tumor immune response and furthermore achieve effective treatment of metastatic breast cancer. | Chuan Hu Yujun Song Yiwei Zhang Siqin He Xueying Liu Xiaotong Yang Tao Gong Yuan Huang Huile Gao | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 0 |
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