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| 1 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 2 | Evolution of Jobs-housing Spatial Relationship in Beijing Metropolitan Area:A Job Accessibility Perspective显示文摘With the urban expansion and economic restructuring, the jobs-housing relationship has become an important issue in studies on urban spatial structure. This paper employed a job accessibility model, which is an evaluation instrument to measure the jobs-housing relationship in Beijing Metropolitan Area from a job accessibility perspective. The results indicate that the population in the central city is declining, whereas the population in the suburbs is consistently growing and forming new population centers. However, the distribution pattern of employment is still highly centralized. Job accessibility varies in different locations, but the inner-city areas(within the Third Ring road) have seen improved job accessibility over time while job accessibility in the suburbs(especially outside the Fourth Ring road) has decreased, and this has led it to become a primary area of residential and employment mismatch. At the same time, the new towns in the outer suburbs have not yet demonstrated great potential to attract more jobs. In addition we find that, to some extent, urban planning changes the jobs-housing relationship, but a polycentric urban spatial structure is not yet evident. The floating population and related housing policy also affect the jobs-housing relationship. We propose some measures to resolve the spatial mismatch as well as some future research directions. | HAN Huiran YANG Chengfeng WANG Enru SONG Jinping ZHANG Meng | 2015 | Chinese Geographical Science2015，25，3： | 9 |
| 3 | Phylogenetic and genetic characterization of a 2017 clinical isolate of H7N9 virus in Guangzhou,China during the fifth epidemic wave显示文摘Pathogenic H7N9 influenza viruses continue to pose a public health concern. The H7N9 virus has caused five outbreak waves of human infections in China since 2013. In the present study, a novel H7N9 strain(A/Guangdong/8 H324/2017) was isolated from a female patient with severe respiratory illness during the fifth wave of the 2017 H7N9 epidemic. Phylogenetic analysis showed that the H7N9 viruses collected during the fifth wave belong to two different lineages: the Pearl River Delta lineage and the Yangtze River Delta lineage. The novel isolate is closely related to the Pearl River Delta H7N9 viruses, which were isolated from patients in Guangdong Province. The novel H7N9 isolate has an insertion of three basic amino acids in the cleavage site of hemagglutinin(HA), which may enhance virulence in poultry. The 2017 isolate also possesses an R292 K substitution in the neuraminidase(NA)protein, which confers oseltamivir resistance. This study highlights the pandemic potential of the novel H7N9 virus in mammals;thus, future characterization and surveillance is warranted. | Yongqiang Deng Chunlin Li Jianfeng Han Yingfen Wen Jian Wang Wenxing Hong Xiaofeng Li Zhongyu Liu Qing Ye Jing Li Changshuai Zhou Lei Yu Chengfeng Qin Fuchun Zhang Tao Jiang | 2017 | Science China(Life Sciences)2017，60，12： | 9 |
| 4 | Study of the Surface Morphology of Gas Hydrate显示文摘Study of the surface morphology of gas hydrate is of great importance in understanding its physical properties and occurrence.In order to investigate the surface morphology of different types(sI and sII)and occurrences(pore-filling and fracture-filling)of gas hydrate,both lab-synthesized and drilled-gas hydrate samples were measured using cryo-scanning electron microscopy(cryo-SEM).Results showed that the surface of s I hydrate was relatively smooth,and spongy nano-pores(200–400 nm)gradually occurred at the surface during continuous observation.The surface of sII hydrate was more compact,showing a tier-like structure.Hydrate occurred in quartz sand and usually filled the pores of the sediments and both hydrate and sediments were cemented with each other.SEM observation of the gas hydrates collected from the South China Sea showed that the surface morphology and contact relation with sediments varied with hydrate occurrence.For instance,hydrates dispersed in sediments mainly filled the pores of the sediments.The existence of microorganism shells,such as foraminifera,was beneficial to the formation of gas hydrate.When hydrate occurred as a massive or vein structure,it was easily distinguished from the surrounding sediments.The surface of hydrate with massive or vein structure showed two distinct characters:one was dense and smooth,the other is porous(several to tens of micrometers in diameter).The occurrence of different hydrate morphologies was probably caused by the supplement rates of methane gas. | SUN Jianye LI Chengfeng HAO Xiluo LIU Changling CHEN Qiang WANG Daigang | 2020 | Journal of Ocean University of China2020，19，2： | 9 |
| 5 | 寨卡病毒引起小鼠睾丸损伤并导致雄性不育显示文摘虽然寨卡病毒与其他黄病毒属成员,如登革热病毒、乙型脑炎病毒和两尼罗病毒都是通过蚊媒传播,但是前人的研究发现寨卡病毒在精液中存在数月之久,暗示其性接触传播的可能性。本研究表明寨卡病毒影响雄性生殖系统,提示了其对男性健康的潜在危害。 | Wenqiang Ma Shihua Li Shuoqian Ma Lina Jia Fuchun Zhang Yong Zhang Jingyuan Zhang Gary Wong Shanshan Zhang Xuancheng Lu Mei Liu Jinghua Yan Wei Li Chuan Qin Daishu Han Chengfeng Qin Na Wang 李向东 高福 | 2017 | 科学新闻2017，19，4： | 5 |
| 6 | Crystalline behaviors and phase transition during the manufacture of fine denier PA6 fibers显示文摘Recently we have successfully produced fine denier PA6 fibers by using additives containing lanthanide compounds.Meanwhile,crystallization and phase transition of PA6 fibers during spinning and drawing processes were investigated.During the spinning process,β phase crystal could be obtained in as-spun PA6 fibers which were produced with relatively high melt draw ratio,while γ phase crystal predominated when the melt draw ratio was relatively low.β phase crystal,whose behaviors are similar with those of γ phase by FT-IR and XRD characterization,could be transformed to α form easily when PA6 fibers are immersed in boiling water.However,γ phase crystal of PA6 remains unchanged in boiling water.Thus,β and γ phase crystals of PA6 can be differentiated by the crystalline behaviors of PA6 fibers after treatment in boiling water.Further experiments demonstrate that the β phase can also be produced during a drawing process where a phase transformation from γ to α occurs.In other words,β phase may act as an intermediate state during the phase transformation. | ZHANG ChengFeng LIU YuHai LIU ShaoXuan LI HuiZhen HUANG Kun PAN QingHua HUA XiaoHui HAO ChaoWei MA QingFang LV ChangYou LI WeiHong YANG ZhanLan ZHAO Ying WANG DuJin LAI GuoQiao JIANG JianXiong XU YiZhuang WU JinGuang | 2009 | Science China Chemistry2009，52，11： | 4 |
| 7 | Targeting EZH1/2 induces cell cycle arrest and inhibits cell proliferation through reactivation of p57CDKN1C and TP53INP1 in mantle cell lymphoma显示文摘Objective: To explore the effect of dysregulation of epigenetic regulator EZH1 and EZH2 on the proliferation in MCL and the underlying mechanisms.Methods: In this study, we elucidated the role of EZH1 and EZH2 overexpression by immunohistochemistry and correlated them to clinical outcome in 41 MCL patients.Quantitative real-time PCR and Western blot were applied to confirm the level of EZH1 and EZH2 in well-characterized MCL cell lines which were compared to those of na?ve B cells.Then we manipulated the expression of EZH1 and EZH2 in MCL cells using CRISPR/Cas9 system to directly investigate their functional roles in MCL.We also evaluated the effect of two small molecule selective inhibitors, EPZ005687 and UNC1999, on MCL cell proliferation, cell cycle distribution and apoptosis in vitro.Finally, we performed RNA-sequencing(RNA-Seq) and Chromatin immunoprecipitation(ChIP) assay to further gain insight into the underlying molecular mechanisms.Results: We found that EZH2 protein is overexpressed in approximately half of this cohort of MCL cases.More importantly, the overexpression of EZH2 is associated with poor OS in the patients.Nevertheless, simple EZH2 depletion in vitro has little impact on the viability of MCL cells, predominantly because of the consequent up-regulation of EZH1.Consistently, UNC1999, a dual EZH1/2 inhibitor, unlike the EZH2 selective inhibitor EPZ005687, exerts a potent inhibitory effect on MCL cells.Furthermore, we discover CDKN1C and TP53 INP1 as the two important cell cycle regulators, the expression of which are repressed by EZH1/2 mediated epigenetic regulation and are restored by EZH1/2 dual inhibition.Conclusions: Our study suggests that EZH2 participates in the pathogenesis of MCL which may serve as a potential biomarker for prognosis prediction.The dual inhibition of EZH1/2 is a promising therapeutic strategy for MCL. | Wei Li Chengfeng Bi Yating Han Tian Tian Xianhuo Wang Huijing Bao Xiaoying Xu Xuhan Zhang Lu Liu Weiwei Zhang Hai Gao Huaqing Wang Huilai Zhang Bin Meng Xi Wang Kai Fu | 2019 | Cancer Biology & Medicine2019，16，3： | 2 |
| 8 | Room temperature ionic liquid 1-ethyl-3-hexylimidazolium-bis (tri- fluoromethylsulfonyl)-imide as lubricant for steel-steel con- tact显示文摘 | Lu Qimlng Wang Haizhong Ye Chengfeng | 2004 | Tribology International2004，37，7： | 1 |
| 9 | Tribological Performance of Room-Temperature Ionic Liquids as Lubricant显示文摘 | Weimin Liu Chengfeng Ye Qingye Gong Haizhong Wang Peng Wang | 2002 | Tribology Letters2002，，2： | 1 |
| 10 | Hydrothermal synthesis of large-sized hydroxyapatite whiskers regulated by glutamic acid in solutions with low supersaturation of precipitation显示文摘 | Chengfeng Li Shuguang Liu Guochang Li Jiahai bai Weiwei Wang Qingyang Du | 2010 | Advanced Powder Technology2010，，4： | 1 |
| 11 | Prognostic Factors of Ampulla of Vater Carcinoma after Radical Surgery显示文摘OBJECTIVE Ampullary carcinoma is a rare disease with betterprognosis than other periampullary neoplasms. This studyinvestigated the association between clinicopathologic factors andprognosis after radical resection of ampulla of Vater carcinoma.METHODS Clinical data from 105 patients who underwentradical pancreaticoduodenectomy from January 1990 to December2005 were retrospectively analyzed by the Kaplan-Meier method,log-rank test, and the Cox proportional hazard model.RESULTS The in-hospital mortality rate was 8.6%, the lymphnode metastasis rate was 37.1%, and the five-year survival ratewas 42.8%. Pancreatic involvement (P = 0.027), tumor diameter (P= 0.008), T stage (P = 0.003), TNM stage (P < 0.001), and number ofmetastatic lymph nodes (P < 0.001) were associated with prognosiswhen the univariate analysis was used. Multivariate analysisshowed that the number of lymph node metastases (P < 0.001;OR: 1.923; CI: 1.367-2.705) and tumor diameter (P = 0.03; OR: 1.432;CI: 1.035-1.981) were the independent prognostic factors.CONCLUSION The number of metastatic lymph nodes andtumor diameter are important pathologic factors predictingprognosis of ampulla of Vater carcinoma after radical resection,and lymph node dissection during the radical surgery effectivelyimproves the survival rate. | Dongbing Zhao Yongkai Wu Yi Shan Chengfeng Wang Ping Zhao | 2009 | Chinese Journal of Clinical Oncology2009，6，2： | 1 |
| 12 | Bone Marrow Transplantation Combined with Mesenchymal Stem Cells Induces Immune Tolerance without Cytotoxic Conditioning显示文摘 | Yunchuan Wang Jiaqi Liu Chengfeng Xu Wanfu Zhang Li Bai Na Li Yang Liu Yaojun Wang Yingjun Su Dahai Hu | 2011 | Journal of Surgical Research2011，，1： | 1 |
| 13 | Tribological Performance of Room-Temperature Ionic Liquids as Lubricant显示文摘 | Weimin Liu Chengfeng Ye Qingye Gong Haizhong Wang Peng Wang | 2002 | Tribology Letters2002，，2： | 1 |
| 14 | Parameterization of water component absorption in an inland eutrophic lake and its seasonal variability: a case study in Lake Taihu显示文摘 | Deyong Sun Yunmei Li Qiao Wang Chengfeng Le Changchun Huang Lizhen Wang | 2009 | International Journal of Remote Sensing2009，，13： | 1 |
| 15 | Estimation of exhaust emission from ocean-going vessels in Hong Kong显示文摘 | P.S. Yau S.C. Lee James J. Corbett Chengfeng Wang Y. Cheng K.F. Ho | 2012 | Science of the Total Environment2012，，： | 1 |
| 16 | Integrating genetic algorithm method with neural network for land use classification using SZ-3 CMODIS data显示文摘This paper presents a methodology on land use mapping using CMODIS (Chinese Moderate Resolution Imaging Spectroradiometer ) data on-board SZ-3 (Shenzhou 3) spacecraft. The integrated method is composed of genetic algorithm (GA) for feature extraction and neural network classifier for land use classification. In the data preprocessing, a moment matching method was adopted to reuse classification was obtained. To generate a land use map, the three layers back propagation neural network classifier is used for training the samples and classification. Compared with the Maximum Likelihood classification algorithm, the results show that the accuracy of land use classification is obviously improved by using our proposed method, the selected band number in the classification process is reduced,and the computational performance for training and classification is improved. The result also shows that the CMODIS data can be effectively used for land use/land cover classification and change monitoring at regional and global scale. | WANG Changyao LUO Chengfeng LIU Zhengjun | 2005 | Progress in Natural Science:Materials International2005，15，10： | 1 |
| 17 | Partitioning particulate scattering and absorption into contributions of phytoplankton and non-algal particles in winter in Lake Taihu (China)显示文摘 | Deyong Sun Yunmei Li Qiao Wang Heng Lv Chengfeng Le Changchun Huang Shaoqi Gong | 2010 | Hydrobiologia2010，，1： | 1 |
| 18 | Real-timecontrol of 3D virtual human motion using adepth-sensing camera for agricultural machinery training显示文摘 | Wang Chengfeng Ma Qin Zhu Dehai | 2013 | Mathematical and Computer Modelling (S0895-7177)2013，58，： | 1 |
| 19 | Structures and Receptor Binding of Hemagglutinins from Human-Infecting H7N9 Influenza Viruses显示文摘 | Yi Shi Wei Zhang Fei Wang Jianxun Qi Ying Wu Hao Song Feng Gao Yuhai Bi Yanfang Zhang Zheng Fan Chengfeng Qin Honglei Sun Jinhua Liu Joel Haywood Wenjun Liu Weimin Gong Dayan Wang Yuelong Shu Yu Wang Jinghua Yan George F. Gao | 2013 | Science2013，，6155： | 1 |
| 20 | Guidelines for the Diagnosis and Treatment of Dengue in China显示文摘Dengue is the most prevalent and rapidly spreading mosquito-borne viral disease.As a dengue non-endemic country,China has experienced several dengue outbreaks in recent years.However,dengue patients in China display clinical characteristics that are distinct from those of patients in dengue-endemic countries.To standardize the diagnosis and treatment of dengue fever,the experts at the Society of Infectious Diseases,Society of Tropical Medicine and Parasitology of the Chinese Medical Association,and the Society of Emergency Medicine of China Association of Chinese Medicine have developed a guideline after reviewing the following guidelines and data:guidelines for diagnosis,treatment,prevention,and control of dengue(World Health Organization,2009);the guidelines for diagnosis and treatment of dengue(National Health and Family Planning Commission of the People’s Republic of China,2014,Edition 2);health industry standard of the People’s Republic of China“diagnosis for dengue fever(WS216-2018)”;and systemic reports on dengue.The new guideline includes eight aspects:introduction,terminology,epidemiology and prevention,etiology and pathogenesis,clinical features,diagnosis,treatment,and problems to be solved. | Fuchun Zhang Jianfeng He Jie Peng Xiaoping Tang Chengfeng Qin Hongzhou Lu Xingwang Li Qingquan Liu Hong Zhao Jifang Sheng Guiqiang Wang Society of Infectious Diseases,Society of Tropical Medicine and Parasitology,Chinese Medical Association Society of Emergency Medicine,China Association of Chinese Medicine | 2021 | Infectious Diseases & Immunity2021，1，3： | 1 |
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