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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Bottom water temperature measurements in the South China Sea,eastern Indian Ocean and western Pacific Ocean显示文摘文章报道了一批新的海底底水温度(BWT)数据,其中南海(SCS)158个站位、东印度洋(EIO)30个站位及西太平洋(WPO)37个站位。基于这批新的BWT数据,获得南海和西太平洋海域底水温度与水深经验关系,可为地球物理和物理海洋提供准确、可靠的海底温度边界。这将有助于海底油气资源调查与评估。同时,这批实测数据表明:1)水深超过3500m的海域,其底水温度在南海约为2.47℃,比东印度洋(~1.34℃)和西太平洋(~1.60℃)稍微偏高。这与大洋传送带模式所预测的情况比较吻合。该模式认为:低温高盐的海水,从北大西洋格陵兰岛和冰岛附近海域下沉到深层,然后向南流动,再与南极洲周围海域的低温高盐海水一同向北进入印度洋和太平洋。而南海是一个相对比较封闭的热带边缘海,其内部海水与印度洋和菲律宾海交换有限,导致海水温度整体高于印度洋和太平洋。2)台西南盆地水深在2700~3000m的部分站位,其底水温高达约3.00℃,明显高于其周边同水深海域底水温度(平均值约为2.33℃)。这可能是台西南盆地海底水热活动导致的结果。3)在东印度洋和西太平洋水深超过4800m海域,底水温度随着水压增大稍有升高,其升高率分别为10.6mK·MPa^(-1)和12.0mK·MPa^(-1)。这与理论估算的深层底水绝热压力温度梯度范围较为吻合。这也意味着东印度洋和西太平洋深层底水,主要由绝热自压作用导致其温度随着深度的增大而升高。 | YANG Xiaoqiu SHI Xiaobin ZHAO Junfeng YU Chuanhai GAO Hongfang CHEN Aihua LU Yuanzheng CEN Xianrong LIN Weiren ZENG Xin XU Hehua REN Ziqiang ZHOU Shengqi XU Ziying SUN Jinlong KAMIYA Nana LIN Jian | 2018 | 热带海洋学报2018，37，5： | 8 |
| 3 | Optical dynamic imaging of the regional blood flow in the rat mesentery under the effect of noradrenalin显示文摘The regional blood flow in the rat mesentery under the effect of noradrenalin is monitored using the laser speckle imaging method. The results show that at the third minute of application of noradrenalin, the blood flow begins to decrease, and the venule blood flow decreases more rapidly than that in the arteriole. Five minutes later blood flow in part of blood vessels begins to resume and the blood flow in the arteriole recovers more quickly than that in the venule. These suggest that laser speckle imaging can obtain the temporal-spatial characteristic of blood flow in mesentery without the need of scanning. It provides a new approach for investigating the change of regional blood flow in the mesentery in microcirculation studies. | CHENG Haiying, LUO Qingming, ZENG Shaoqun, CEN Jian and LIANG Wenxi(The Key Laboratory of Biomedical Photonics of Ministry of Education of China, Huazhong University of Science and Technology, Wuhan 430074, China) | 2003 | Progress in Natural Science:Materials International2003，13，5： | 3 |
| 4 | Scaffolding protein Gab1 regulates myeloid dendritic cell migration in allergic asthma显示文摘气喘是在多重基因、环境的因素之中包含复杂相互影响的普通过敏混乱。最近的研究作为一个新奇气喘危险性因素识别了人的 GAB1 的基因变体。然而,在肺的 Gab1 的功能仍然保持大部分未经勘探。在这研究,我们首先在尖锐恶化期间从气喘的病人在外部血 mononuclear 房间观察了 Gab1 水平的举起与康复相比。有在 myeloid 的有选择地破坏的 Gab1 的老鼠树枝状的房间(mDCs ) 更加在气喘的试验性的模型稀释了过敏发炎。进一步的调查在 Gab1 缺乏的 mDCs 的调停 CCL19 的移植揭示了突出的减小到排干淋巴节点和驾驶 Th2 的适应激活的随后的缺陷。机械学地, Gab1 是在气喘的回答期间调整 mDC 移植的 CCL19/CCR7 chemokine 轴的一个必要部件。一起,这些调查结果在肺为 Gab1 的角色提供第一条证据,给我们气喘的致病的更深的理解。 | Yun Zhang Yun Xu Shuwan Liu Xiaohong Guo Dong Cen Jiaqi Xu Heyuan Li Kaijun Li Chunlai Zeng Linrong LU Yiting Zhou Huahao Shen Hongqiang Cheng Xue Zhang Yuehai Ke | 2016 | Cell Research2016，26，11： | 3 |
| 5 | Lupeol protects against cardiac hypertrophy via TLR4-PI3K-Akt-NF-κB pathways显示文摘Inflammation and apoptosis are main pathological processes that lead to the development of cardiac hypertrophy.Lupeol,a natural triterpenoid,has shown anti-inflammatory and anti-apoptotic activities as well as potential protective effects on cardiovascular diseases.In this study we investigated whether lupeol attenuated cardiac hypertrophy and fibrosis induced by pressure overload in vivo and in vitro,and explored the underlying mechanisms.Cardiac hypertrophy was induced in mice by transverse aortic constriction(TAC)surgery,and in neonatal rat cardiomyocytes(NRCMs)by stimulation with phenylephrine(PE)in vitro.We showed that administration of lupeol(50 mg·kg^(-1)·d^(-1),i.g.,for 4 weeks)prevented the morphological changes and cardiac dysfunction and remodeling in TAC mice,and treatment with lupeol(50μg/mL)significantly attenuated the hypertrophy of PE-stimulated NRCMs,and blunted the upregulated hypertrophic markers ANP,BNP,andβ-MHC.Furthermore,lupeol treatment attenuated the apoptotic and inflammatory responses in the heart tissue.We revealed that lupeol attenuated the inflammatory responses including the reduction of inflammatory cytokines and inhibition of NF-κB p65 nuclear translocation,which was mediated by the TLR4-PI3K-Akt signaling.Administration of a PI3K/Akt agonist 740 Y-P reversed the protective effects of lupeol in TAC mice as well as in PE-stimulated NRCMs.Moreover,pre-treatment with a TLR4 agonist RS 09 abolished the protective effects of lupeol and restored the inhibition of PI3K-Akt-NF-κB signaling by lupeol in PE-stimulated NRCMs.Collectively,our results demonstrate that the lupeol protects against cardiac hypertrophy via anti-inflammatory mechanisms,which results from inhibiting the TLR4-PI3K-Akt-NF-κB signaling. | Dan Li Ying-ying Guo Xian-feng Cen Hong-liang Qiu Si Chen Xiao-feng Zeng Qian Zeng Man Xu Qi-zhu Tang | 2022 | Acta Pharmacologica Sinica2022，43，8： | 3 |
| 6 | Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening显示文摘由系特定的抄写因素的表示的系变换是改变那的 epigenetic 的进程有低效率。一个房间由抵抗系变换的机制大部分是未知的。使用肝特定的抄写因素 Foxa3, Hnf1 和 Gata4 (3TF ) 在老鼠成纤维细胞导致肝的变换,我们证明 3TF 导致了 ATM-p53 小径的强壮的激活,它导致了增长拘捕和房间死亡,和它进一步阻止了肝的变换。尤其是, ATM 激活,独立于 DNA 损坏,对染色质在肝的变换期间开作出回应。由在肝的变换期间描绘早分子的事件,我们发现了那 Baf60b,改变建筑群的 SWI/SNF 染色质的一个成员,连接染色质洞到由便于 ATM 招募到肝的基因 loci 的一块面板的开的染色质区域的 ATM 激活。这些调查结果由在察觉到揭示 ATM-p53 小径的功能使细胞的回答清楚些到系变换染色质洞。 | Shuyi Ji Linying Zhu Yimeng Gao Xiaoran Zhang Yupeng Yan Jin Cen Rongxia Li Rong Zeng Lujian Liao Chunhui Hou Yawei Gao Shaorong Gao Gang Wei Lijian Hui | 2017 | Cell Research2017，27，5： | 2 |
| 7 | Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase显示文摘Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2) has become one major threat to human population health.The RNA-dependent RNA polymerase(RdRp) presents an ideal target of antivirals,whereas nucleoside analogs inhibitor is hindered by the proofreading activity of coronavirus.Herein,we report that corilagin(RAI-S-37) as a non-nucleoside inhibitor of SARS-CoV-2 RdRp,binds directly to RdRp,effectively inhibits the polymerase activity in both cell-free and cell-based assays,fully resists the proofreading activity and potently inhibits SARS-CoV-2 infection with a low 50% effective concentration(EC50) value of 0.13 μmol/L.Computation modeling predicts that RAI-S-37 lands at the palm domain of RdRp and prevents conformational changes required for nucleotide incorporation by RdRp.In addition,combination of RAI-S-37 with remdesivir exhibits additive activity against antiSARS-CoV-2 RdRp.Together with the current data available on the safety and pharmacokinetics of corilagin as a medicinal herbal agent,these results demonstrate the potential of being developed into one of the much-needed SARS-CoV-2 therapeutics. | Quanjie Li Dongrong Yi Xiaobo Lei Jianyuan Zhao Yongxin Zhang Xiangling Cui Xia Xiao Tao Jiao Xiaojing Dong Xuesen Zhao Hui Zeng Chen Liang Lili Ren Fei Guo Xiaoyu Li Jianwei Wang Shan Cen | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 2 |
| 8 | Synthesis and characterization of a sensitive and selective Fe^(3+) fluorescent sensor based on novel sulfonated calix[4]arene-based host-guest complex显示文摘A novel fluorescent sensor was prepared from sulfonated calix[4]arene(SC4A)by the host-guest com-plexation method using the fluorescent dye rhodamine B(RB)as a structure-directing agent.The crystal structure of the host-guest complex(RB@(SC4A)_(3))was confirmed by X-ray diffraction studies while its performance and sensing mechanism for metal ion pollutants were characterized using fluorescence and nuclear magnetic resonance spectroscopies.The results showed that RB@(SC4A)_(3) had a triangular branch structure resulting from host-guest mediation of the interactions between the three SC4A host molecules and the three terminal groups of the guest molecule RB.The host-guest complex exhibited sensitive and selective sensing towards Fe^(3+)ions via a fluorescence quenching mechanism.The results indicated that RB@(SC4A)_(3) could be a promising sensitive and selective fluorescent sensor for metal ion pollutants mon-itoring.It also provided new insights into the synthesis of calixarene-based host-guest complex. | Ran Cen Ming Liu Jihong Lu Weifang Zhang Jingjing Dai Xi Zeng Zhu Tao Xin Xiao | 2022 | Chinese Chemical Letters2022，33，5： | 2 |
| 9 | Etiology of newborn hearing impairment in Guangdong province: 10-year experience with screening, diagnosis, and follow-up显示文摘Background Hearing impairment is one of the most common birth defects in children.Universal newborn hearing screenings have been performed for 19 years in Guangdong province,China.A screening/diagnosis/intervention system has gradually been put in place.Over the past 10 years,a relatively complete data management system had been established.In the present study,an etiological analysis of newborn cases that failed the initial and follow-up screenings was performed.Methods The nature and degree of hearing impairment in newborns were confirmed by a set of procedures performed at the time of initial hearing screening,rescreening and final hearing diagnosis.Then,multiple examinations were performed to explore the associated etiology.Results Over a period of 10 years,720 children were diagnosed with newborn hearing loss.Among these children,445 (61.81%) children had a clearly identified cause,which included genetic factor(s) (30.56%),secretory otitis media (13.30%),maternal rubella virus infection during pregnancy (5.83%),inner ear malformations (4.86%),maternal human cytomegalovirus infection during pregnancy (2.92%),malformation of the middle ear ossicular chain (2.50%) and auditory neuropathy (1.81%).In addition,275 cases of sensorineural hearing loss of unknown etiology accounted for 38.19% of the children surveyed.Conclusions Long-term follow-up is needed to detect delayed hearing impairment and auditory development in children.The need for long-term follow-up should be taken into account when designing an intervention strategy.Furthermore,the use of the deafness gene chip should further elucidate the etiology of neonatal hearing impairment. | Bi-Xing Fang Jin-Tian Cen Tao Yuan Gen-Di Yin Jing Gu Shu-Qi Zhang Zhi-Cheng Li Yin-Fei Liang Xiang-Li Zeng | 2020 | World Journal of Pediatrics2020，16，3： | 2 |
| 10 | CYP4F2rs2108622:a minor significant genetic factor of warfarin dose in Han-Chinese patients with mechanical heart valve replacement显示文摘 | Cen HJ Zeng WT Leng XY | 2010 | Br J Clin Pharmacol2010，70，2： | 1 |
| 11 | Multiple roles of the p75 neurotrophin re- ceptor in the nervous system显示文摘 | Chen Y Zeng J Cen L | 2009 | The journal of International Medical Research2009，37，： | 1 |
| 12 | CYP4F2 rs2108622: a minor significant genetic factor of warfarin dose in Han Chinese patients with mechanical heart valve replacement 显示文摘 | Cen HJ Zeng WT Leng XY | 2010 | Br J Clin Pharmacol2010，70，： | 1 |
| 13 | Enhanced thermal and mechanical properties of epoxy composites by mixing noncovalently functionalized graphene sheets 显示文摘 | ZENG Cen LU Shaomng XIAO Xiane | 2015 | Polymer Bulletin2015，72，3： | 1 |
| 14 | CYP4F2 rs2108622: a minor significant genetic factor of warfarin dose in Han Chinese patients with mechanical heart valve replacement显示文摘 | Cen HJ Zeng WT Leng XY | 2010 | Br J Clin Pharmacol2010，70，2： | 1 |
| 15 | CYP4F2 rs2108622: a minor significant genetic factor of warfarin dose in Han Chinese patients with mechanical heart valve replacement显示文摘 | Cen HJ Zeng WT Leng XY | 2010 | Br J Clin Pharmacol2010，70，2： | 1 |
| 16 | Result analysis of tinnitus handicap inventory in 60 patients with chronic tinnitus显示文摘 | Zeng XL Cen JT Li ZC | 2010 | J Int Adv Otol2010，6，2： | 1 |
| 17 | CYP4F2 rs2108622 :a minor signifi- cant genetic factor of warfarin dose in Han Chinese patients with mechanical heart valve replacement显示文摘 | Cen HJ Zeng WT Leng XY | 2010 | Br J Clin Pharmacol2010，70，2： | 1 |
| 18 | Study of immortalization and malignant transformation of human embryonic esophageal epithelial cells induced by HPV18 E6E7显示文摘 | Shen Z Y Cen S Zeng Y | 2000 | J Cancer Res Clin Oncol2000，126，10： | 1 |
| 19 | Multiple roles of the p75 neurotrophin receptor in the nervous system 显示文摘 | Chen Y Zeng J Cen Y | 2009 | J Int Med Res2009，37，2： | 1 |
| 20 | CYP4F2 rs2108622: A minor significant genetic factor of warfarin dose in Han Chinese patients with mechanical heart valve replacement显示文摘 | Cen HJ Zeng WT Leng XY | 2010 | Br J Clin Pharmacol2010，70，2： | 1 |
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