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| 1 | Prognostic significance of combined fibrinogen concentration and neutrophil-to-lymphocyte ratio in patients with resectable non-small cell lung cancer显示文摘Objective:Cancer-associated inflammation and coagulation cascades play vital roles in cancer progression and survival.In this study,we investigated the significance of the combination of preoperative fibrinogen and the neutrophil-to-lymphocyte ratio(NLR)in predicting the survival of patients with non-small cell lung cancer(NSCLC).Methods:We retrospectively enrolled 589 patients with NSCLC who underwent surgery.The univariate and multivariate Cox survival analyses were used to evaluate the prognostic indicators,including the combination of fibrinogen and NLR(F-NLR).The cut-off values for fibrinogen,NLR,and clinical laboratory variables were defined by the receiver operating characteristic(ROC)curve analysis.According to the ROC curve,the recommended cut-off values for fibrinogen and the NLR were 3.48 g/L and 2.30,respectively.Patients with both a high NLR(≥2.30)and hyperfibrinogenemia(≥3.48 g/L)were given a score of 2,whereas those with one or neither were scored as 1 or 0,respectively.Results:Our results showed that F-NLR was an independent prognostic indicator for disease-free survival(DFS)[hazard ratio(HR),1.466;95%confidence interval(CI),1.243–1.730;P<0.001]and overall survival(OS)(HR,1.512;95%CI,1.283–1.783;P<0.001).The five-year OS rates were 66.1%,53.5%,and 33.3%for the F-NLR=0,F-NLR=1,and F-NLR=2,respectively(P<0.001).Correspondingly,their five-year DFS rates were 62.2%,50.3%,and 30.4%,respectively(P<0.001).In the subgroup analyses of the pathological stages,the F-NLR level was significantly correlated with DFS and OS in stage I and IIIA cancers.Conclusions:Preoperative F-NLR score can be used as a valuable prognostic marker for patients with resectable early-stage NSCLC. | Wuhao Huang Shengguang Wang Hua Zhang Bin Zhang Changli Wang | 2018 | Cancer Biology & Medicine2018，15，1： | 27 |
| 2 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 3 | Biocompatibility of bio-Mg-Zn alloy within bone with heart, liver, kidney and spleen显示文摘A magnesium-zinc alloy rod was implanted into the marrow cavity of the distal femur in New Zealand rabbits. The femur with the implanted alloy was compared with the contralateral femur in which a bone tunnel without implant was formed as a control. Degradation of the magnesium-zinc alloy was analyzed via X-ray, scanning electron microscopy, and element energy spectrum analysis. Serum magnesium, liver and kidney function tests, and myocardial enzymes were measured. Heart, liver, kidney and spleen were sectioned for pathological analysis, and the effects of the implanted material on the histology and function of important organs were analyzed. Magnesium-zinc alloy was resorbed from the bone marrow cavity of the femur; 87% of the alloy was degraded within 14 weeks after the surgery. There were no significant differences in serum magnesium, liver or kidney function tests, or myocardial enzymes be- fore the surgery and after degradation of the magnesium-zinc alloy. Histology of the heart, liver, kidney, and spleen did not change. This study demonstrated that magnesium-zinc alloy can be resorbed in bone, and that the degradation products have good biocompatibility with heart, liver, kidney, and spleen. | HE YaoHua TAO HaiRong ZHANG Yan JIANG Yao ZHANG ShaoXiang ZHAO ChangLi LI JiaNan ZHANG BeiLei SONG Yang ZHANG XiaoNong | 2009 | Chinese Science Bulletin2009，54，3： | 18 |
| 4 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 5 | Sponge-like nickel phosphide-carbon nanotube hybrid electrodes for efficient hydrogen evolution over a wide pH range显示文摘经由水的电解的划算的氢生产为氢进化反应要求有效、持久的地球丰富的催化剂(她的) 在一个宽 pH 范围上。此处,我们报导像海绵的镍磷化物碳 nanotube (Ni x P/CNT ) 被非结晶的 Ni x P 催化剂到 threedimensional (3D ) 上多孔的 CNT 支持。这些混合物在酸、中立、基本的媒介为持续的氢进化展出优异催化活动。特别地, Ni x P/CNT 电极产生 10 和 100 mAapy 的 cathodic 水流,但是总是 regressed onanticoagulation。传单限制和最大的厚度的功课在二个组之间是显著地不同的( P ? P ?=? 0.005 )并且传单限制分数由一中部 1 [ quartiles 0 ; 2 ]( P ?=? 0.013 ),而在 anticoagulation 组,在 2.57 的最大的厚度 regressed ?甘油的 n 作为副产品。最后的紧张生产了 9.8 ? l 33 ?%( 从 205 ~ 272 ? mg/L ) 。直角的策略 inte?? | Shuying Wang Li Zhang Xiao Li Changli Li Rujing Zhang Yingjiu Zhang Hongwei Zhu | 2017 | Nano Research2017，10，2： | 8 |
| 6 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 7 |
| 7 | Removal of dispersant-stabilized carbon nanotubes by regular coagulants显示文摘Coagulation followed by sedimentation,as a conventional technique in the water treatment plant,can be the first line of defense against exposures of carbon nanotubes(CNTs) to aquatic organisms and human beings,which has been rarely documented.This study investigated the removal of dispersant-stabilized CNT suspensions by poly aluminum chloride(PACl) and KAl(SO 4) 2 ·12H 2 O(alum),with a focus on the effects of dispersant type,coagulant type and dosage.PACl performed better than alum in the removal of tannic acid-,humic acid-,and sodium dodecyl benzenesulfonate-stabilized CNTs,but worse for polyethylene glycol octylphenyl ether(TX100)-stabilized CNTs.Neither coagulant could effectively precipitate cetyltrimethyl ammonium bromide-stabilized CNTs.The removal by PACl first increased up to a plateau and then decreased with the continued increase of coagulant dosage.However,the removal rates leveled off but did not decrease after achieving their highest level with the continued addition of alum.The coagulation and flocculation of the CNT suspensions by PACl could be regulated mainly by the mechanism of adsorption charge neutralization,whereas the coagulation by alum mainly involved electrical double-layer compression. | Ni Liu Changli Liu Jing Zhang Daohui Lin | 2012 | Journal of Environmental Sciences2012，24，8： | 6 |
| 8 | Research on an Mg–Zn alloy as a degradable biomaterial显示文摘 | Shaoxiang Zhang Xiaonong Zhang Changli Zhao Jianan Li Yang Song Chaoying Xie Hairong Tao Yan Zhang Yaohua He Yao Jiang Yujun Bian | 2009 | Acta Biomaterialia2009，，2： | 5 |
| 9 | Dendritic cell-activated cytokine-induced killer cells enhance the anti-tumor effect of chemotherapy on non-small cell lung cancer in patients after surgery显示文摘 | Hui Li Changli Wang Jinpu Yu Shui Cao Feng Wei Weihong Zhang Ying Han Xiu-bao Ren | 2009 | Cytotherapy2009，，8： | 5 |
| 10 | Site-Dependent Osseointegration of Biodegradable High-Purity Magnesium for Orthopedic Implants in Femoral Shaft and Femoral Condyle of New Zealand Rabbits显示文摘Magnesium(Mg) has been widely accepted as osteoconductive biomaterial, but osseointegration of Mg device at different implantation sites is still unclear. In the present study, high-purity magnesium(HP Mg)pins were implanted into femoral shaft and condyle of New Zealand rabbits concurrently. 2, 8, 12 and 16 weeks after surgery, rabbit femurs were harvested for micro-computed tomography(micro-CT) scanning and subsequent histological examinations. HP Mg pins were retrieved for scanning electron microscope and energy dispersive spectrum(SEM/EDS) analyses. HP Mg pins at both implantation sites performed stable corrosion with mineral deposition and bone incorporation on surface. However, difference in distribution of contact osteogenesis centers and biological properties of peri-implant bone tissues was detected between femoral shaft and femoral condyle. In femoral condyle, contact osteogenesis centers originated from both periosteum and cancellous bones and the whole HP Mg pin was encapsuled in trabecular bone at 16 weeks.Meanwhile, bone volume to total bone volume(BV/TV) and bone mineral density(BMD) of peri-implant bone tissues were above those of normal bone tissues. In femoral shaft, contact osteogenesis centers were only from periosteum and direct bone contact was confined in cortical bone, while BV/TV and BMD kept lower than normal. Furthermore, new formation of peri-implant bone tissues was more active in femoral condyle than in femoral shaft at 16 weeks. Therefore, although HP Mg performed good biocompatibility and corrosion behavior in vivo, its bioadaption of osseointegration at different implantations sites should be taken into consideration. Bone metaphysic was suitable for Mg devices where peri-implant bone tissues regenerated rapidly and the biological properties were close to normal bone tissues. | Pengfei Cheng Changli Zhao Pei Han Jiahua Ni Shaoxiang Zhang Xiaonong Zhang Yimin Chai | 2016 | Journal of Materials Science & Technology2016，32，9： | 4 |
| 11 | Cisplatin resistance in lung cancer is mediated by MACC1 expression through PI3K/AKT signaling pathway activation显示文摘 | Qiang Zhang Bin Zhang Leina Sun Qingna Yan Yu Zhang Zhenfa Zhang Yanjun Su Changli Wang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，8： | 3 |
| 12 | Research of a novel biodegradable surgical staple made of high purity magnesium显示文摘Surgical staples made of pure titanium and titanium alloys are widely used in gastrointestinal anastomosis.However the Ti staple cannot be absorbed in human body and produce artifacts on computed tomography(CT)and other imaging examination,and cause the risk of incorrect diagnosis.The bioabsorbable staple made from polymers that can degrade in human body environment,is an alternative.In the present study,biodegradable high purity magnesium staples were developed for gastric anastomosis.U-shape staples with two different interior angles,namely original 90and modified 100,were designed.Finite element analysis(FEA)showed that the residual stress concentrated on the arc part when the original staple was closed to B-shape,while it concentrated on the feet for the modified staple after closure.The in vitro tests indicated that the arc part of the original staple ruptured firstly after 7 days immersion,whereas the modified one kept intact,demonstrating residual stress greatly affected the corrosion behavior of the HP-Mg staples.The in vivo implantation showed good biocompatibility of the modified Mg staples,without inflammatory reaction 9 weeks post-operation.The Mg staples kept good closure to the Anastomosis,no leaking and bleeding were found,and the staples exhibited no fracture or severe corrosion cracks during the degradation. | Hongliu Wu Changli Zhao Jiahua Ni Shaoxiang Zhang Jingyi Liu Jun Yan Yigang Chen Xiaonong Zhang | 2016 | Bioactive Materials2016，1，2： | 3 |
| 13 | High-purity magnesium pin enhances bone consolidation in distraction osteogenesis via regulating Ptch protein activating Hedgehog-alternative Wnt signaling显示文摘Magnesium alloys are promising biomaterials for orthopedic implants because of their degradability,osteogenic effects,and biocompatibility.Magnesium has been proven to promote distraction osteogenesis.However,its mechanism of promoting distraction osteogenesis is not thoroughly studied.In this work,a high-purity magnesium pin developed and applied in rat femur distraction osteogenesis.Mechanical test,radiological and histological analysis suggested that high-purity magnesium pin can promote distraction osteogenesis and shorten the consolidation time.Further RNA sequencing investigation found that alternative Wnt signaling was activated.In further bioinformatics analysis,it was found that the Hedgehog pathway is the upstream signaling pathway of the alternative Wnt pathway.We found that Ptch protein is a potential target of magnesium and verified by molecular dynamics that magnesium ions can bind to Ptch protein.In conclusion,HP Mg implants have the potential to enhance bone consolidation in the DO application,and this process might be via regulating Ptch protein activating Hedgehog-alternative Wnt signaling. | Musha Hamushan Weijie Cai Yubo Zhang Zun Ren Jiafei Du Shaoxiang Zhang Changli Zhao Pengfei Cheng Xiaonong Zhang Hao Shen Pei Han | 2021 | Bioactive Materials2021，6，6： | 3 |
| 14 | PtNi-W/C with Atomically Dispersed Tungsten Sites Toward Boosted ORR in Proton Exchange Membrane Fuel Cell Devices显示文摘The performance of proton exchange membrane fuel cells is heavily dependent on the microstructure of electrode catalyst especially at low catalyst loadings.This work shows a hybrid electrocatalyst consisting of PtNi-W alloy nanocrystals loaded on carbon surface with atomically dispersed W sites by a two-step straightforward method.Single-atomic W can be found on the carbon surface,which can form protonic acid sites and establish an extended proton transport network at the catalyst surface.When implemented in membrane electrode assembly as cathode at ultra-low loading of 0.05 mgPt cm^(−2),the peak power density of the cell is enhanced by 64.4%compared to that with the commercial Pt/C catalyst.The theoretical calculation suggests that the single-atomic W possesses a favorable energetics toward the formation of*OOH whereby the intermediates can be efficiently converted and further reduced to water,revealing a interfacial cascade catalysis facilitated by the single-atomic W.This work highlights a novel functional hybrid electrocatalyst design from the atomic level that enables to solve the bottle-neck issues at device level. | Huawei Wang Jialong Gao Changli Chen Wei Zhao Zihou Zhang Dong Li Ying Chen Chenyue Wang Cheng Zhu Xiaoxing Ke Jiajing Pei Juncai Dong Qi Chen Haibo Jin Maorong Chai Yujing Li | 2023 | Nano-Micro Letters2023，15，9： | 3 |
| 15 | Groundwater Systems and Eco-hydrological Features in the Main Karst Regions of China显示文摘Different karst water features and related water resources are present both in southern and northern China.There are over 3,358 well-developed karst ground river systems with total discharges in the dry season of about 420×108 m3 in the main karst regions in the southern part of China.Exploitation rates are only 8-15%.Over 100 larger karst spring systems in the main karst regions of northern China cover a catchment area from 500 km2 to over 4,000 km2,of which the average discharge appears to be from about 1 m3/s to 13 m3/s and the exploitation rates are 70-80%.Six aspects of the eco-hydrological features of some typical karst regions in China comprising water environment,ecological features,materials and structures between parent rock and soil,bio-geological processes and palynological studies(spore-pollen)are discussed.Qualitative evaluation of eco-geology and rocky desertification in the karst regions should be based on the main karst ecological conditions as well as artificial,i.e.,man-made impacts. | LU Yaoru ZHANG Feng'e LIU Changli TONG Guobang ZHANG Yun | 2006 | Acta Geologica Sinica(English Edition)2006，80，5： | 3 |
| 16 | Increased osteoblast adhesion on nanophase Ti6Al4V显示文摘The objective of the present study was to prepare a novel nanostructured surface of Ti6Al4V alloy by the severe plastic deformation (SPD) and the chemical treatment process and to evaluate the adhesion of osteoblast on the nanophase titanium alloy. In the in vitro study, the primary cultured osteoblasts of neonatal rat calvaria were cultured on the nanophase and the as-received smooth Ti6Al4V substrates. Then osteoblasts adhesion behaviors on different substrates were observed by the fluorescence mi-croscopy, scanning electron microscopy (SEM) and RT-PCR analysis. The results of our research showed increased osteoblast adhesion on the nanophase titanium alloy compared with the as-received case. On the nanophase substrate, the presence of extensive filopodia, strong cellular adhesion and early cellular confluency could be observed. In addition, the expression of the adhesion-related integrin β1 mRNA was also higher on the nanophase substrate. It suggested that the nano technology could be further considered for orthopedic implant applications. | JI WeiPing HAN Pei ZHAO ChangLi JIANG Yao ZHANG XiaoNong | 2008 | Chinese Science Bulletin2008，53，11： | 3 |
| 17 | 中医干预类临床证据分级系统构建思路探讨显示文摘证据分级水平是进行临床决策的重要考虑因素。中医药领域完全照搬国际常用证据评价体系存在一定局限性,故提出中医临床证据分级思路,即在遵循国际证据分级标准基础上,充分考虑中医药临床实践特点,以GRADE(Grades of Recommendation,Assessment,Development,and Evaluation)证据评价系统为基础,结合中医古籍证据及现代名医经验证据分级标准,进而整合形成中医干预类临床证据分级系统,其中古籍证据从医案来源、诊疗内容的全面性和传承性三方面进行评价,现代名医经验证据根据名医的资质、经验内容完整性、经验传承性进行评价。针对中医古籍、现代名医经验及现代研究多来源证据的整合,以定性综合为主,多来源证据的分级水平与现代研究GRADE证据评价保持一致,而中医古籍及现代名医经验作为辅助证据呈现,以期更加客观、全面地评价中医临床证据,进而指导临床实践。 | 刘少南 郭新峰 吴大嵘 ZHANG Anthony Lin XUE Charlie Changli 温泽淮 | 2023 | 中医杂志2023，64，18： | 2 |
| 18 | Comparative Study about Degradation of High-purity Magnesium Screw in Intact Femoral Intracondyle and in Fixation of Femoral Intracondylar Fracture显示文摘Bone screws encounter complex mechanical environment in fracture fixation of weight-bearing bone.In the present study, high-purity magnesium(HP Mg) screws were applied in fixation of rabbit femoral intracondylar fracture with 3 mm gap. In the control group, HP Mg screws of the same design were implanted at corresponding position of contralateral leg. At 4, 8 and 16 weeks after surgery, retrieved femurs went through micro-computed tomography(micro-CT) scanning and hard tissue processing. Under mechanical stress involved in fracture fixation, bending of screw bolt was observed at the portion exposed to facture gap at 4 weeks. Then local corrosion at the same portion was detected 16 weeks after surgery,which indicated the accumulation effect of mechanical stress on Mg corrosion. HP Mg screws in the fracture group had no significant difference with the control group in screw volume, surface area, surfaceto-volume ratio(S/V). And peri-implant bone volume/tissues volume(BV/TV) and bone volume density(BMD) in the fracture group was comparable to that in the control group. Furthermore, histological analysis showed new formed bone tissues in fracture gap and fracture healing 16 weeks after surgery. Under mechanical stress, HP Mg screw suffered bolt bending and local corrosion at the portion exposed to fracture gap. But it had no influence on the integral corrosion behaviors, osseointegration of HP Mg screw and the fracture healing. Therefore, HP Mg screws possessed good potential in fracture fixation of weightbearing bones. | Pei Han Pengfei Cheng Changli Zhao Shaoxiang Zhang Runhua Zhou Xiaonong Zhang Yimin Chai | 2017 | Journal of Materials Science & Technology2017，33，3： | 2 |
| 19 | Study of Cell Behaviors on Anodized TiO_2 Nanotube Arrays with Coexisting Multi-Size Diameters显示文摘It has been revealed that the different morphologies of anodized TiO_2 nanotubes, especially nanotube diameters, triggered different cell behaviors. However, the influence of TiO_2 nanotubes with coexisting multi-size diameters on cell behaviors is seldom reported. In this work, coexisting four-diameter TiO_2 nanotube samples, namely,one single substrate with the integration of four different nanotube diameters(60, 150, 250, and 350 nm), were prepared by repeated anodization. The boundaries between two different diameter regions show well-organized structure without obvious difference in height. The adhesion behaviors of MC3T3-E1 cells on the coexisting fourdiameter TiO_2 nanotube arrays were investigated. The results exhibit a significant difference of cell density between smaller diameters(60 and 150 nm) and larger diameters(250 and 350 nm) within 24 h incubation with the coexistence of different diameters, which is totally different from that on the single-diameter TiO_2 nanotube arrays. The coexistence of four different diameters does not change greatly the cell morphologies compared with the singlediameter nanotubes. The findings in this work are expected to offer further understanding of the interaction between cells and materials. | Yifan Chen Jiahua Ni Hongliu Wu Ruopeng Zhang Changli Zhao Wenzhi Chen Feiqing Zhang Shaoxiang Zhang Xiaonong Zhang | 2016 | Nano-Micro Letters2016，8，1： | 2 |
| 20 | Beclin-1 Expression is a Predictor of Clinical Outcome in Patients with Esophageal Squamous Cell Carcinoma and Correlated to Hypoxia-Inducible Factor (HIF)-1α Expression显示文摘 | Yongshun Chen You Lu Changli Lu Lei Zhang | 2009 | Pathology & Oncology Research2009，，3： | 2 |
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