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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Can transgenic rice cause ecological risks through transgene escape?显示文摘Alien transgene escape from genetically engineered rice to non-transgenic varieties or close wild relatives (including weedy rice) may lead to unpredictable ecological risks. However, for transgene escape to occur three conditions need to be met: (i) spatially, transgenic rice and its non-transgenic counterparts or wild relatives should have sympatric distributions; (ii) temporally, the flowering time of transgenic rice and the non-transgenic varieties or wild relatives should overlap; and (iii) biologically, transgenic rice and its wild relative species should have such a sufficiently close relationship that their interspecific hybrids can have normal generative reproduction. This paper presents research data on the geographic distribution, flowering habits, interspecific hybridization, and gene flow of cultivated rice (Oryza sativa) and its closely related wild relatives containing the AA genome. The objective is to estimate the possibility of transgene escape to non-transgenic rice varieties and wild relatives of rice, which may result in unpredictable ecological risks. | LU Baorong , SONG Zhiping and CHEN Jiakuan(Ministry of Education Key Laboratory for Biodiversity and Ecological Engineering, Institute of Biodiversity Science, Fudan University, Shanghai 200433, China) | 2003 | Progress in Natural Science:Materials International2003，13，1： | 21 |
| 3 | Morphology of platelet Golgi apparatus and their significance after acute cerebral infarction显示文摘Blood samples were harvested from the antecubital vein of 20 fasting patients with acute cerebral infarction at 1, 7 and 15 days after onset to prepare blood platelet suspension. Fasting antecubital vein blood was collected from an additional 20 normal adults as controls. Under transmission elec-tron microscope, platelet Golgi tubules and vesicles became significantly thickened, enlarged, and irregular after acute cerebral infarction. Alpha granules in platelets significantly reduced in number, especially 1 day after cerebral infarction. Under immunoelectron microscopy, a few alpha granules aggregated around Golgi tubules and vesicles after infarction. These results suggested that platelet Golgi apparatus displayed significant morphological changes, which were possibly associated with enhanced synthetic and secretory functions of activated platelets after acute cerebral infarction. This study used Golgi apparatus blocking agent Brefeldin A to block Golgi apparatus in an aim to study the effects of Golgi apparatus on CD40L expression on the surface of activated platelets. Flow cytometry revealed that CD40L expression on activated platelet surfaces decreased significantly when Golgi apparatus was blocked, which indicated that Golgi apparatus participated in the syn-thesis and transport of CD40L to the platelet surface. | Wei Lu Dong Xu Ranran Tu Zhiping Hu | 2013 | Neural Regeneration Research2013，8，23： | 13 |
| 4 | Counteraction of ABA-Mediated Inhibition of Seed Germination and Seedling Establishment by ABA Signaling Terminator in Arabidopsis显示文摘Seed germination and seedling establishment are important for the reproductive success of plants,but seeds and seedlings typically encounter constantly changing environmental conditions.By inhibiting seed germination and post-germinative growth through the PYR1/PYL/RCAR ABA receptors and PP2C co-receptors,the phytohormone abscisic acid(ABA)prevents premature germination and seedling growth under unfavorable conditions.However,little is known about how the ABA-mediated inhibition of seed germination and seedling establishment is thwarted.Here,we report that ABA Signaling Terminator(ABT),a WD40 protein,efficiently switches off ABA signaling and is critical for seed germination and seedling establishment.ABT is induced by ABA in a PYR1/PYL/RCAR-PP2C-dependent manner.Overexpression of ABT promotes seed germination and seedling greening in the presence of ABA,whereas knockout of ABT has the opposite effect.We found that ABT interacts with the PYR1/PYL/RCAR and PP2C proteins,interferes with the interaction between PYR1/PYL4 and ABI1/ABI2,and hampers the inhibition of ABI1/ABI2 by ABA-bound PYR1/PYL4,thereby terminating ABA signaling.Taken together,our results reveal a core mechanism of ABA signaling termination that is critical for seed germination and seedling establishment in Arabidopsis. | Zhijuan Wang Ziyin Ren Chunhong Cheng Tao Wang Hongtao Ji Yang Zhao Zhiping Deng Liya Zhi Jingjing Lu Xinying Wu Shimin Xu Mengmeng Cao Hongtao Zhao Liu Liu Jiankang Zhu Xia Li | 2020 | Molecular Plant2020，13，9： | 10 |
| 5 | Direct generation of an ultrafast vortex beam in a CVD-graphene-based passively mode-locked Pr:LiYF4 visible laser显示文摘We report on the direct generation of passively mode-locked vortex lasers in the visible spectral region, for the first time to the best of our knowledge, using a Pr :Li YF4(Pr:YLF) crystal as the gain medium. A stable mode-locked TEM00 mode has been achieved with a maximum average output power of 75 m W using a graphene saturable absorber mirror. The mode-locked pulse width is measured to be as short as about 73.4 ps at a repetition rate of about 140 MHz, and the laser wavelength is at about 721 nm with spectral width of about 0.5 nm. By slightly misaligning the laser resonator, a first-order Laguerre-Gaussian mode(LG0,1) has also been obtained with output power reduced to about 22 m W. The achieved LG0,1 mode has been verified via a home made improved Fizeau interferometer. This work provides a simple and universal method for direct generation of an ultrafast vortex laser,which can be readily extended to other spectral regions by using different laser gain mediums. | Nan Li Junjie Huang Bin Xu Yaqi Cai Jie Lu Linjie Zhan Zhengqian Luo Huiying Xu Zhiping Cai Weiwei Cai | 2019 | Photonics Research2019，7，11： | 9 |
| 6 | Causes of the Extreme Hot Midsummer in Central and South China during 2017:Role of the Western Tropical Pacific Warming显示文摘This study investigates why an extreme hot midsummer occurred in Central and South China(CSC) during 2017. It is shown that the western North Pacific subtropical high(WNPSH) was abnormally intensified and westward-extending,resulting in anomalous high pressure and consequent extreme heat over CSC. The abnormal WNPSH was favored by the warming of the western tropical Pacific(WTP), which was unrelated to ENSO and manifested its own individual effect.The WTP warming enhanced the convection in-situ and led to anomalous high pressure over CSC via a local meridional circulation. The influence of the WTP was confirmed by CAM4 model experiments. A comparison between the 2017 midsummer and 2010 midsummer(with a stronger WNPSH but weaker extreme heat) indicated that the influence of the WNPSH on extreme heat can be modulated by the associated precipitation in the northwestern flank.The role of the WTP was verified by regression analyses on the interannual variation of the WTP sea surface temperature anomaly(SSTA). On the other hand, the WTP has undergone prominent warming during the past few decades, resulting from decadal to long-term changes and favoring extreme warm conditions. Through a mechanism similar to the interannual variation, the decadal to long-term changes have reinforced the influence of WTP warming on the temperature over CSC,contributing to the more frequent hot midsummers recently. It is estimated that more than 50% of the temperature anomaly over CSC in the 2017 midsummer was due to the WTP warming, and 40% was related to the decadal to long-term changes of the WTP SSTA. | Ruidan CHEN Zhiping WEN Riyu LU Chunzai WANG | 2019 | Advances in Atmospheric Sciences2019，36，5： | 7 |
| 7 | Pressure Drop in Cyclone Separator at High Pressure显示文摘为密封的传播的使流体化的床的设计,实验在高压力并且在大气的温度在高度在直径和 300 公里与 120 公里在小气旋被进行。从进气旋的看台管子的漏气的影响特殊被集中。一个半实验的模型为旋风分离器的压力落下的预言被开发在不同与装载的漏气和入口固体的效果操作压力。当在气旋压力的重要角色落下,装载的 operate 压力,漏气和入口固体行动。压力落下与与从储水塔增加漏气的流动率并且与增加装载的入口固体增加压力和减少增加。 | Zhu Zhiping Na Yongjie Lu Qinggang | 2008 | Journal of Thermal Science2008，17，3： | 7 |
| 8 | Danhong injection A modulator for Golgi structural stability after cerebral ischemiareperfusion injury显示文摘The cerebral ischemia-reperfusion model was established using the suture occlusion method,and rats were intraperitoneally given 8 mL/kg Danhong injection once a day prior to mode establishment.Rat brain tissues were harvested at 6,24,48,72 hours after reperfusion Immunohistochemical staining showed that transforming growth factor-β1 expression increased while Golgi matrix protein GM130 expression decreased after cerebral ischemia-reperfusion Danhong injection was shown to significantly up-regulate the expression of transforming growth factor-β1 and GM130,and expression levels peaked at 7 days after reperfusion.At 7 days after cerebral ischemia-reperfusion,Golgi morphology was damaged in untreated rats,while Golg morphology breakage was not observed after intervention with Danhong injection.These experimental findings indicate that Danhong injection can up-regulate the expression of transforming growth factor-β1 and GM130,and maintain Golgi stability,thus playing a neuroprotective role in rats after cerebral ischemia-reperfusion. | Yan Wang Zhiping Hu Wei Lu | 2013 | Neural Regeneration Research2013，8，25： | 6 |
| 9 | Effect of Pressure on Minimum Fluidization Velocity显示文摘在 0.5, 1.0, 1.5 和 2.0 MPa 的不同压力下面的石英沙和玻璃祷告的最小的使液化速度被调查。最小的使液化速度与增加压力减少。到最小的使液化速度的压力的影响比为更小的为更大的粒子是更强烈的。基于测试结果和 Ergun 方程,最小的使液化速度的一个经验方程被建议,计算结果比得上另外的研究人员鈥 ? 结果。 | Zhu Zhiping Na Yongjie Lu Qinggang | 2007 | Journal of Thermal Science2007，16，3： | 5 |
| 10 | Retraction Note to:SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion显示文摘The authors have retracted this article1.After the publication of this article,it came to the authors attention that in order to support the conclusions of the study,the authors should have used primary T cells instead of T-cell lines.In addition,there are concerns that the flow cytometry methodology applied here was flawed.These points resulted in the conclusions being considered invalid. | Xinling Wang Wei Xu Gaowei Hu Shuai Xia Zhiping Sun Zezhong Liu Youhua Xie Rong Zhang Shibo Jiang Lu Lu | 2020 | Cellular & Molecular Immunology2020，17，8： | 5 |
| 11 | Proteomic Study Identifies Proteins Involved in Brassinosteroid Regulation of Rice Growth显示文摘Brassinosteroids (BRs) are essential hormones for growth and development of plant. In rice, BRs regulate multiple developmental processes and affect many important traits such as height, leaf angle, fertility and seed filling. We identified brassinosteroid-regulated proteins in rice using proteomic approaches and performed functional analysis of some BR-regulated proteins by overexpression experiments. Using two-dimensional difference gel electrophoresis (2-D DIGE) followed by protein identification by mass spectrometry, we compared proteomic differences in the shoots and roots of the BR-insensitive mutant d61-4 and BR-deficient mutant brd1-3. We identified a large number of proteins differentially expressed in the mutants compared with wild type control. These include a glycine-rich RNA-binding protein (OsGRP1) and a DREPP2 protein, which showed reduced levels in the BR mutants. Overexpression of these two proteins partially suppressed the dwarf phenotype of the Arabidopsis BR-insensitive mutant bri1-5. In contrast to the reduced protein level, the RNA level of OsGRP1 was not significantly affected in the BR mutants or by BR treatment, suggesting BR regulation of OsGRP1 at the posttranslational level. This study identifies many BR-regulated proteins and demonstrates that OsGRP1 functions downstream in the BR signal transduction pathway to promote cell expansion. | Fengru Wang Ming-Yi Bai Zhiping Deng Juan A. Oses-Prieto Alma L. Burlingame Tiegang Lu Kang Chong Zhi-Yong Wang | 2010 | Journal of Integrative Plant Biology2010，52，12： | 4 |
| 12 | Physicochemical Properties and Gasification Reactivity of the Ultrafine Semi-char derived from a Bench-scale Fluidized Bed Gasifier显示文摘Zhundong coalfield is the largest intact coalfield worldwide and fluidized bed gasification has been considered as a promising way to achieve its clean and efficient utilization. The purpose of this study is to investigate the physicochemical properties and gasification reactivity of the ultrafine semi-char, derived from a bench-scale fluidized bed gasifier, using Zhundong coal as fuel. The results obtained are as follows. In comparison to the raw coal, the carbon and ash content of the semi-char increase after partial gasification, but the ash fusion temperatures of them show no significant difference. Particularly, 76.53% of the sodium in the feed coal has released to the gas phase after fluidized bed gasification. The chemical compositions of the semi-char are closely related to its particle size, attributable to the distinctly different natures of diverse elements. The semi-char exhibits a higher graphitization degree, higher BET surface area, and richer meso-and macropores, which results in superior gasification reactivity than the coal char. The chemical reactivity of the semi-char is significantly improved by an increased gasification temperature, which suggests the necessity of regasification of the semi-char at a higher temperature. Consequently, it will be considered feasible that these carbons in the semi-char from fluidized bed gasifiers are reclaimed and reused for the gasification process. | ZHANG Yukui ZHANG Haixia ZHU Zhiping NA Yongjie LU Qinggang | 2017 | Journal of Thermal Science2017，26，4： | 4 |
| 13 | Impacts of Two Types of El Ni o on the MJO during Boreal Winter显示文摘The features of the MJO during two types of El Ni no events are investigated in this paper using the daily NCEP-2reanalysis data, OLR data from NOAA, and Real-time Multivariate MJO index for the period 1979–2012. The results indicate that the MJO exhibits distinct features during eastern Pacific(EP) El Ni no events, as compared to central Pacific(CP) El Ni no events. First, the intensity of the MJO is weakened during EP El Ni no winters from the tropical eastern Indian Ocean to the western Pacific, but enhanced during CP El Ni no winters. Second, the range of the MJO eastward propagation is different during the two types of El Ni no events. During EP El Ni no winters, the MJO propagates eastwards to 120?W, but only to 180?during CP El Ni no winters. Finally, the frequency in eight phases of the MJO may be affected by the two types of El Ni no. Phases 2 and 3 display a stronger MJO frequency during EP El Ni no winters, but phases 4 and 5 during CP El Ni no winters. | Bo PANG Zesheng CHEN Zhiping WEN Riyu LU | 2016 | Advances in Atmospheric Sciences2016，33，8： | 3 |
| 14 | Grid Model for High-accuracy Coordinate Transformation of China Geodetic Coordinate System 2000显示文摘After implementing CGCS2000,establishing grid models for high-accuracy coordinate transformation which are mainly used to transform border lines and coordinate grids of topographic maps becomes an important issue in mapping applications.Consequently,a grid model for high-accuracy coordinate transformation of CGCS2000 is proposed.Specifically,we firstly analyze a minimum curvature equation of coordinate transformation,which possesses the characteristics of both the global and local smoothness,achieving better consistency with the consecutive smoothness for the coordinate transformation of map’s linear feature.Then an iterative calculation method of grid nodes and an approach for establishing regional grid models based on collocation by two-step minimization are proposed.Meanwhile,a data structure of grid model is constructed.Finally we give the optimized grid interval and transformation accuracy in China corresponding to the proposed grid model.Using 48 433 points of 2000 National Geodetic Control Network of China,we take the proposed model into practice by constructing grid models for coordinate transformation from BJS54 and XAS80 to CGCS2000,and the external positional accuracies for both models are 0.26 m and 0.03 m respectively. | Zhiping LU Ziqing WEI Jun LI Chong GUO | 2019 | Journal of Geodesy and Geoinformation Science2019，2，1： | 3 |
| 15 | Circulating Fluidized Bed Gasification of Low Rank Coal:Influence of O2/C Molar Ratio on Gasification Performance and Sulphur Transformation显示文摘To promote the utilization efficiency of coal resources,and to assist with the control of sulphur during gasification and/or downstream processes,it is essential to gain basic knowledge of sulphur transformation associated with gasification performance.In this research we investigated the influence of O_2/C molar ratio both on gasification performance and sulphur transformation of a low rank coal,and the sulphur transformation mechanism was also discussed.Experiments were performed in a circulating fluidized bed gasifier with O_2/C molar ratio ranging from 0.39 to 0.78 mol/mol.The results showed that increasing the O_2/C molar ratio from 0.39 to 0.78 mol/mol can increase carbon conversion from 57.65%to 91.92%,and increase sulphur release ratio from 29.66%to63.11%.The increase of O_2/C molar ratio favors the formation of H_2S,and also favors the retained sulphur transforming to more stable forms.Due to the reducing conditions of coal gasification,H_2S is the main form of the released sulphur,which could be formed by decomposition of pyrite and by secondary reactions.Bottom char shows lower sulphur content than fly ash,and mainly exist as sulphates.X-ray photoelectron spectroscopy(XPS)measurements also show that the intensity of pyrite declines and the intensity of sulphates increases for fly ash and bottom char,and the change is more obvious for bottom char.During CFB gasification process,bigger char particles circulate in the system and have longer residence time for further reaction,which favors the release of sulphur species and can enhance the retained sulphur transforming to more stable forms. | ZHANG Haixia ZHANG Yukui ZHU Zhiping LU Qinggang | 2016 | Journal of Thermal Science2016，25，4： | 3 |
| 16 | Unsteady cooperative flow in compression system显示文摘When there are several bodies with relative motion in a flow field,such as the flow in the compression system of modern aero-engine,the flow field will have certain special features,one of which is that the time-space structure of such multi-bodies unsteady vorticity flow field would be either of unsteady natural flow(UNF)pattern or of unsteady cooperative flow(UCF)pattern.If we further examine the aerodynamic design system of aero-engine,there is no mechanism for the unsteady cooperative flow to occur,in other words the flow field must be of the unsteady natural flow type.If certain technical measures can be adopted to transform UNF into UCF,the aerodynamic performances will surely be improved.This is the main task the author and their colleague have been devoted to and the results are reviewed in the present paper with emphases laid on basic ideas,technical approaches and experimental verifications. | Sheng Zhou Yajun Lu Anping Hou Wei Yuan Zhiping Li | 2012 | Propulsion and Power Research2012，1，1： | 2 |
| 17 | Identification and Analysis of High-Frequency Oscillations in the Eyewalls of Tropical Cyclones显示文摘High-frequency oscillations, with periods of about 2 hours, are first identified by applying wavelet analysis to observed minutely wind speeds around the eye and eyewall of tropical cyclones(TCs). Analysis of a model simulation of Typhoon Hagupit(2008) shows that the oscillations also occur in the TC intensity, vertical motion, convergence activity and air density around the eyewall. Sequences of oscillations in these variables follow a certain order. | CHEN Shumin Youyu LU LI Weibiao WEN Zhiping | 2015 | Advances in Atmospheric Sciences2015，32，5： | 2 |
| 18 | Innovation on Distant Hybridization of Saline-tolerant Mud Flat Spartina and Rice Germplasm显示文摘To explore saline-tolerant high yield Spartina and rice germplasm resources,innovate upon distant hybridization technology,and develop new saline-tolerant mud flat Spartina germplasm,autonomous patent for invention was used to study distant hybridization of Spartina and rice in 2005- 2016. The study adopted tidal flat planting screening,phenotypic screening,molecular marker assisted selection,to find biological evidences of new germplasm,and also applied crossbreeding,conventional breeding,and molecular breeding,to select new saline-tolerant Spartina and rice varieties. With 12 years of efforts,the team developed 1498 crossbreeding combinations and established pedigree file and seed bank,tested 307 crossbreeding materials(57 hybrid seeds showed parental genetic components of Spartina and Rice); obtained Spartina/ Rice distant hybridization and seed setting,transplanting,hybridization material economic traits,and molecular biological experimental evidences; Rice♀× Spartina ♂ hybridization success rate of 1. 04- 1. 39%; obtained authorization of patent for invention of Distant Hybridization Methods for Spartina and Rice; formulated procedures for high yield cultivation of Spartina-Rice,planted 33. 33 hm2Spartina-Rice in coastal saline and alkaline land,cultivated 10 new saline-tolerant Spartina-Rice varieties,and the rice yield up to 5. 925- 8. 28 t / hm2. Results indicate that Spartina-Rice is saline-tolerant high yield rice germplasm,developed through sexual hybridization,conventional breeding,and molecular breeding technologies,and is optimal crop for saline and alkaline land. Success of Spartina-Rice solves the problem of saline-tolerant crop badly for transformation of saline and alkaline land,the problem of feeds for herbivores,as well as problem of environmental pollution resulted from straw burning. Besides,it is of essential scientific significance for resource utilization,increase of agricultural efficiency,grain security,and farmland strategy,so it has broad application prospect. | Qikang CHEN Bo CHEN Huilan LU Hui ZHOU Zhiping MEI | 2016 | Asian Agricultural Research2016，8，11： | 2 |
| 19 | Changes in secretory pathway Ca^(2+)-ATPase 2 following focal cerebral ischemia/reperfusion injury显示文摘This study aimed to investigate changes in secretory pathway Ca2+-ATPase 2 expression following cerebral ischemia/reperfusion injury, and to define the role of Ca2+-ATPases in oxidative stress. A rat model of cerebral ischemia/reperfusion injury was established using the unilateral middle cerebral artery occlusion method. Immunohistochemistry and reverse transcription-PCR assay results showed that compared with the control group, the expression of secretory pathway Ca2+-ATPase 2 protein and mRNA in the cerebral cortex and hippocampus of male rats did not significantly change during the ischemic period. However, secretory pathway Ca2+-ATPase 2 protein and mRNA expression reduced gradually at 1, 3, and 24 hours during the reperfusion period. Our experimental findings indicate that levels of secretory pathway Ca2+-ATPase 2 protein and mRNA expression in brain tissue change in response to cerebral ischemia/reperfusion injury. | Tonglin Lu Zhiping Hu Liuwang Zeng Zheng Jiang | 2013 | Neural Regeneration Research2013，8，1： | 2 |
| 20 | Self-heating Probe Instrument and Method for Measuring High Temperature Melting Volume Change Rate of Material显示文摘The castings defects are affected by the melting volume change rate of material. The change rate has an important effect on running safety of the high temperature thermal storage chamber, too. But the characteristics of existing measuring installations are complex structure, troublesome operation and low precision. In order to measure the melting volume change rate of material accurately and conveniently, a self-designed measuring instrument, self-heating probe instrument, and measuring method are described. Temperature in heating cavity is controlled by PID temperature controller; melting volume change rate υ and molten density are calculated based on the melt volume which is measured by the instrument. Positive and negative υ represent expansion and shrinkage of the sample volume after melting, respectively. Taking eutectic LiF+CaF2 for example, its melting volume change rate and melting density at 1 123 K are -20.6% and 2 651 kg/m-3 measured by this instrument, which is only 0.71% smaller than literature value. Density and melting volume change rate of industry pure aluminum at 973 K and analysis pure NaCl at 1 123 K are detected by the instrument too. The measure results are agreed with report values. Measuring error sources are analyzed and several improving measures are proposed. In theory, the measuring errors of the change rate and molten density which are measured by the self-designed instrument is nearly 1/20-1/50 of that measured by the refitted mandril thermal expansion instrument. The self-designed instrument and method have the advantages of simple structure, being easy to operate, extensive applicability for material, relatively high accuracy, and most importantly, temperature and sample vapor pressure have little effect on the measurement accuracy. The presented instrument and method solve the problems of complicated structure and procedures, and large measuring errors for the samples with high vapor pressure by existing installations. | WANG Junwei WANG Zhiping LU Yang CHENG Bo | 2013 | Chinese Journal of Mechanical Engineering2013，26，2： | 2 |
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