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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Topic enhanced deep structured semantic models for knowledge base question answering显示文摘Knowledge Base Question Answering(KBQA) is a hot research topic in natural language processing(NLP). The most challenging problem in KBQA is how to understand the semantic information of natural language questions and how to bridge the semantic gap between the natural language questions and the structured fact triples in knowledge base. This paper focuses on simple questions which can be answered by a single fact triple in knowledge base. We propose a topic enhanced deep structured semantic model for KBQA. The proposed method considers the task of KBQA as a matching problem between questions and the subjects and predicates in knowledge base. And the proposed model consists of two stages to match the subjects and predicates, respectively. In the first stage, we propose a Convolutional based Topic Entity Extraction Model(CTEEM) to extract topic entities mentioned in questions. With the extracted entities, we can retrieve the relevant candidate fact triples from knowledge base and obviously decrease the amount of noising candidates. In the second stage, we employ Deep Structured Semantic Models(DSSMs) to compute the semantic relevant score between questions and predicates in the candidates. And we combine the semantic level and the lexical level scores to rank the candidates. We evaluate the proposed method on KBQA dataset released by NLPCC-ICCPOL 2016. The experimental results show that our proposed method achieves the third place among the 21 submitted systems.Furthermore, we also extend the DSSM by using Bi LSTM and integrate a convolutional structure on the top of Bi LSTM layers. Our experimental results show that the extension models can further improve the performance. | Zhiwen XIE Zhao ZENG Guangyou ZHOU Weijun WANG | 2017 | Science China(Information Sciences)2017，60，11： | 10 |
| 3 | Histopathology of Porcine kobuvirus in Chinese piglets显示文摘Dear Editor,Kobuvirus,classified as a new genus within the Picornaviridae family in 1999,is a non-enveloped virus with single-stranded,positive-sense genomic RNA(Pringle,1999).This genus contains 3 species currently recoganized:Aichivirus A(Ai V),Aichivirus B(BKo V),and Aichivirus C(PKo V).PKo V was first detected in | Fan Yang Xiaowan Liu Yuancheng Zhou Wenting Lyu Siyao Xu Zhiwen Xu Ling Zhu | 2015 | Virologica Sinica2015，30，5： | 9 |
| 4 | Analysis of surface orange peel of aluminum-alloy automobile sheet by using of EBSD and X-ray diffraction显示文摘The formation cause of orange peel of aluminum-alloy automotive sheet after tensile deformation was analysed by using X-ray diffraction and electron back-scattered diffraction(EBSD).The test results showed that formation cause of surface orange peel after tensile deformation related to product texture and nonuniform deformation during the tensile process.The grain size has significant effect on deformation uniform and texture formation.Coarse grains were easy to produce nonuniform deformation and texture,which would produce surface orange peel after tensile deformation. | Ma Mingtu Sun Zhifu Wang Zhiwen Lu Hongzhou Zhou Mingbo | 2012 | Engineering Sciences2012，10，6： | 7 |
| 5 | Expert Consensus on the Care and Management of Patients with Cognitive Impairment in China显示文摘The cognitive disease consensus was prepared by panels of health and public representatives based on actual clinical practice in Geriatric Departments in Chinese hospitals and a systematic literature review. This consensus reflects the medical knowledge accumulated by those experts and provides information about professional medical care and advice.A multidisciplinary panel of specialists(neurologists,psychiatrists, and nursing specialists) reports an expert consensus on the medical knowledge accumulated from those experts and provides information about professional medical care and advice. The recommendations focus on the care and management of older adults with mild cognitive impairment,the objectives and methods of maintaining cognition and training, the assessments and measures of daily care for patients at different stages of dementia, the assessments and coping strategies for the behavioral and psychological symptoms of dementia, principles and suggestions for an appropriate living environment, arrangements for recreational activities, the care and management of patients with endstage dementia, and suggestions for addressing stress in caregivers. | 无 Yuliang Han Jianjun Jia Xia Li Yang Lv Xuan Sun Shanshan Wang Yongjun Wang Zhiwen Wang Jintao Zhang Jiong Zhou Yuying Zhou | 2020 | Neuroscience Bulletin2020，36，3： | 7 |
| 6 | Computer-aided ionic liquid design for alkane/cycloalkane extractive distillation process显示文摘A computer-aided ionic liquid design(CAILD) study is presented for the frequently encountered alkane/cycloalkane separations in petrochemical industry. Exhaustive experimental data are first collected to extend the UNIFAC-IL model for this system, where the proximity effect in alkanes and cycloalkanes is considered specifically by defining distinct groups. The thermodynamic performances of a large number of ILs for 4 different alkane/cycloalkane systems are then compared to select a representative example of such separations. By applying n-heptane/methylcyclohexane extractive distillation as a case study, the CAILD task is cast as a mixed-integer nonlinear programming(MINLP) problem based on the obtained task-specific UNIFAC-IL model and two semi-empirical models for IL physical properties. The top 5 IL candidates determined by solving the MINLP problem are subsequently introduced into Aspen Plus for process simulation and economic analysis, which finally identify 1-hexadecyl-methylpiperidinium tricyanomethane([C_(16)MPip][C(CN)_3]) as the best entrainer for this separation. | Zhen Song Xinxin Li He Chao Fan Mo Teng Zhou Hongye Cheng Lifang Chen Zhiwen Qi | 2019 | Green Energy & Environment2019，4，2： | 6 |
| 7 | Defects and failure types of solid insulation in gas‐insulated switchgear:In situ study and case analysis显示文摘The gas‐insulated switchgear(GIS)has been widely used in modern ultra‐high voltage systems.However,once it fails,its fully enclosed feature brings challenges in its diagnosis and maintenance.As the failure rate of GIS due to insulator failure has been increasing in recent years,it is necessary and important to understand the commonly existing defects presented in the insulator.First,the manufacturing process of GIS insulators is intro-duced here.The defect types commonly existing in the insulator are categorised.The failure of GIS due to insulator defects that occurred in recent years are reviewed and discussed.The content in this study is useful for engineers and scientists to study on the GIS solid insulation defects and their failure mechanisms. | Yunqi Xing Zhiwen Wang Lin Liu Yuan Xu Yang Yang Shan Liu Fusheng Zhou Shun He Chuanyang Li | 2022 | High Voltage2022，7，1： | 4 |
| 8 | Metallothionein expression induced by nickel accumulation in the midgut of Spodoptera litura Fabricius larvae exposed to nickel显示文摘Metallothionein expression induced by nickel accumulation in the midgut of Spodoptera litura Fabri- cius larvae was investigated by exposing S. litura larvae to the artificial diets amended with different doses of nickel for 3 generations. Nickel accumulations in the midgut of 6th instar larvae were detected by Inductively Coupled Plasma-Atomic Emission Spectrometer (ICP-AES), and the induced metal- lothionein expression in the midgut of 5th and 6th instar larvae in 120 h were quantified using cad- mium-hemoglobin total saturation methods. The accumulated nickel in the midgut of the 6th instar larvae within a generation increased with the increase of the nickel doses in the treated diets and showed significant dose-dependence with the nickel doses in diets. Metallothioneins induced by nickel accumulated in the larval midgut also increased with nickel doses in diets and with the increasing stressing time in a generation. Results also suggested that the metallothionein expression was differ- ent with the time of S. litura larvae stressed by nickel. | SUN HongXia ZHOU Qiang TANG WenCheng SHU YingHua ZOU ZhiWen ZHANG GuRent | 2007 | Chinese Science Bulletin2007，52，23： | 4 |
| 9 | Progress in octahedral spherical hohlraum study显示文摘In this paper,we give a review of our theoretical and experimental progress in octahedral spherical hohlraum study.From our theoretical study,the octahedral spherical hohlraums with 6 Laser Entrance Holes(LEHs)of octahedral symmetry have robust high symmetry during the capsule implosion at hohlraum-to-capsule radius ratio larger than 3.7.In addition,the octahedral spherical hohlraums also have potential superiority on low backscattering without supplementary technology.We studied the laser arrangement and constraints of the octahedral spherical hohlraums,and gave a design on the laser arrangement for ignition octahedral hohlraums.As a result,the injection angle of laser beams of 50°-60°was proposed as the optimum candidate range for the octahedral spherical hohlraums.We proposed a novel octahedral spherical hohlraum with cylindrical LEHs and LEH shields,in order to increase the laser coupling efficiency and improve the capsule symmetry and to mitigate the influence of the wall blowoff on laser transport.We studied on the sensitivity of the octahedral spherical hohlraums to random errors and compared the sensitivity among the octahedral spherical hohlraums,the rugby hohlraums and the cylindrical hohlraums,and the results show that the octahedral spherical hohlraums are robust to these random errors while the cylindrical hohlraums are the most sensitive.Up till to now,we have carried out three experiments on the spherical hohlraum with 2 LEHs on Shenguang(SG)laser facilities,including demonstration of improving laser transport by using the cylindrical LEHs in the spherical hohlraums,spherical hohlraum energetics on the SGIII prototype laser facility,and comparisons of laser plasma instabilities between the spherical hohlraums and the cylindrical hohlraums on the SGIII laser facility. | Ke Lan Jie Liu Zhichao Li Xufei Xie Wenyi Huo Yaohua Chen Guoli Ren Chunyang Zheng Dong Yang Sanwei Li Zhiwen Yang Liang Guo Shu Li Mingyu Zhang Xiaoying Han Chuanlei Zhai Lifei Hou Yukun Li Keli Deng Zheng Yuan Xiayu Zhan Feng Wang Guanghui Yuan Haijun Zhang Bobin Jiang Lizhen Huang Wei Zhang Kai Du Runchang Zhao Ping Li Wei Wang Jingqin Su Xuewei Deng Dongxia Hu Wei Zhou Huaiting Jia Yongkun Ding Wanguo Zheng Xiantu He | 2016 | Matter and Radiation at Extremes2016，1，1： | 2 |
| 10 | A Neural Network Method for Monitoring Snowstorm: A Case Study in Southern China显示文摘It has been observed that low temperature, rainfall, snowfall, frost have never occurred over the past 50 years in the southern China, and weather in this area is very complex, so the monitoring equipments are few. Optical and thermal infrared remote sensing is influenced much by clouds, so the passive microwave Advanced Microwave Scanning Radiometer-Earth Observing System(AMSR-E) data are the best choice to monitor and analyze the development of disaster. In order to improve estimation accuracy, the dynamic learning neural network was used to retrieve snow depth. The difference of brightness temperatures of TB18.7V and TB36.5V, TB18.7H and TB36.5H, TB23.8V and TB89 V, TB23.8H and TB89 H are made as four main input nodes and the snow depth is the only one output node of neural network. The mean and the standard deviation of retrieval errors are about 4.8 cm and 6.7 cm relative to the test data of ground measurements. The application analysis indicated that the neural network can be utilized to monitor the change of snow intensity distribution through passive microwave data in the complex weather of the southern China. | MAO Kebiao MA Ying XIA Lang SHEN Xinyi SUN Zhiwen HE Tianjue ZHOU Guanhua | 2014 | Chinese Geographical Science2014，24，5： | 2 |
| 11 | Aggf1 attenuates hepatic inflammation and activation of hepatic stellate cells by repressing Ccl2 transcription显示文摘Liver injury represents a continuum of pathophysiological processes involving a complex interplay between hepatocytes, macrophages, and hepatic stellate cells. The mechanism whereby these intercellular interactions contribute to liver injury and fibrosis is not completely understood. We report here that angiogenic factor with G patch and FHA domains 1(Aggfl) was downregulated in the livers of cirrhotic patients compared to healthy controls and in primary hepatocytes in response to carbon tetrachloride(CC14) stimulation. Overexpression of Aggfl attenuated macrophage chemotaxis. Aggfl interacted with NF-κB to block its binding to the Ccl2 gene promoter and repressed Ccl2 transcription in hepatocytes. Macrophages cultured in the conditioned media collected from Aggfloverexpressing hepatocytes antagonized HSC activation. Taken together, our data illustrate a novel role for Aggfl in regulating hepatic inflammation and provide insights on the development of interventional strategies against cirrhosis. | Wenping Xu Sheng Zeng Min Li Zhiwen Fan Bisheng Zhou | 2017 | The Journal of Biomedical Research2017，31，5： | 2 |
| 12 | Biological Characteristics of Fusarium oxysporum f. sp.niveum Isolated from Watermelon Cultivated in Plastic Greenhouse and Indoor Toxicity Determination of Different Fungicides in Hainan Province of China显示文摘[Objective]The paper was to study biological characteristics of Fusarium oxysporum f.sp.niveum in watermelon cultivated in plastic greenhouse in Hainan Province of China and to determine indoor toxicity of fungicides.[Method]Effects of various factors on mycelial growth and spore germination were studied,and the lethal temperature of spores and indoor toxicity of fungicides were also determined.[Result]The fungal mycelium had a better growth rate on watermelon juice medium than the others.The optimum temperature for mycelial growth and spore germination were 28℃and 30℃,and the optimum pH values were7-8 and 7-9,respectively.Light-dark alternation was conducive for mycelial growth.The lethal temperature of spore was 60℃for 5 min.The fungal mycelium grew better while taking fructose and glucose as carbon sources and yeast extract and peptone as nitrogen sources.Toxicity determination showed that 50%prochloraz-manganese chloride complex WP had the greatest inhibition effect on mycelial growth,with the EC50value of 0.730 9μg/mL;followed by 32.5%benzoic azoxystrobin SC,30%benzoylate·propiconazol EC,10%difenoconazole WG,25%bromothalonil·carbendazim WP and 25%bromothalonil WP,with the EC50values from 1.884 7μg/mL to 8.161 0μg/mL.[Conclusion]The study provided basic data for field control against F.oxysporum f.sp.niveum on watermelon cultivated in plastic greenhouse in Hainan Province. | Fan Hongyan Zhou Wenjing Wang Xianghe Luo Zhiwen He Fan | 2013 | Plant Diseases and Pests2013，4，5： | 2 |
| 13 | An OSGi-based in- frastructure for context-aware multimedia services 显示文摘 | YU Zhiwen ZHOU Xingshe YU Zhiyong | 2006 | IEEE Communications Magazine2006，44，10： | 1 |
| 14 | Teaching Practice of CDIO in Operating System Cour se显示文摘 | GU Jianhua ZHOU Xingshe YU Zhiwen | 2012 | The 3rd International Annual Conference on Teaching Management and Curriculum Construction2012，，2： | 1 |
| 15 | MicroRNA?373 is upregulated and targets TNFAIP1 in human gastric cancer,contributing to tumorigenesis显示文摘 | Xiaoting Zhang Xiaofeng Li Zhiwen Tan Xizhi Liu Celi Yang Xiaofeng Ding Xiang Hu Jianlin Zhou Shuanglin Xiang Chang Zhou Jian Zhang | 2013 | Oncology Letters2013，，5： | 1 |
| 16 | Bronsted acidic ionic liquids and their use as dual solvent - catalysts for Fischer esterifications 显示文摘 | FANG DONG ZHOU XINLI YE ZHIWEN | 2006 | Ind Eng Chem Res2006，45，24： | 1 |
| 17 | Preparative chromatographic purification of diastereomers of silybin and their quantification in human plasma by liquid chromatography–tandem mass spectrometry显示文摘 | Wei Li Jianping Han Zhiwen Li Xinxin Li Shuiping Zhou Changxiao Liu | 2007 | Journal of Chromatography B2007，，1： | 1 |
| 18 | In vitro generation of osteochondral differentiation of human marrow mesenchymal stem cells in novel collagen–hydroxyapatite layered scaffolds显示文摘 | Jiaan Zhou Caixia Xu Gang Wu Xiaodong Cao Liangming Zhang Zhichen Zhai Zhiwen Zheng Xiaofeng Chen Yingjun Wang | 2011 | Acta Biomaterialia2011，，11： | 1 |
| 19 | Monte Carlo simulation of the electromagnetic wave propagation in the duststorm显示文摘Monte Carlo simulations of the extinction rate of electromagnetic wave propagation in the duststorm were presented. The numerical procedure was based on the multiple scattering and independent scattering. The calculated multiple scattering attenuation rate is in good agreement with the measured one,but differs significantly from those obtained under the independent scattering assumption. At the same time,the factors of size parameter,frequency of incident wave,the angle of incident,and sands permittivity and water content have been considered in the attenuation of electromagnetic wave propagation in the duststorm. Numerical results obtained showed that the attenuation rate increases as the fractional volume,frequency of incident wave and sands permittivity increase,and as the angle of incident increases,the attenuation rate decreases. | GAO ZhiWen ZHOU YouHe ZHENG XiaoJing | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，8： | 1 |
| 20 | COUPLED THERMO-MECHANICAL ANALYSIS OF FUNCTIONALLY GRADIENT WEAK/MICRO-DISCONTINUOUS INTERFACE WITH GRADED FINITE ELEMENT METHOD显示文摘Coupled thermo-mechanical analysis of two bonded functionally graded materials subjected to thermal loads is conducted in this study with the graded finite element method. The thermal-mechanical properties of the bi-material interfaces are classified based on discontinuity degrees of their material properties and their derivatives at the interfaces. Numerical results indicate that discontinuity exerts remarkable effect on the temperature profile and stress value at the interface of two bonded functionally-graded materials. Under the thermal flux loading conditions, the stronger the interface discontinuity is, the smaller the heat flux is. | Zhiwen Gao Kang Yong Lee Youhe Zhou | 2012 | Acta Mechanica Solida Sinica2012，25，4： | 1 |
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