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| 1 | HER2 in gastric cancer: Comparative analysis of three different antibodies using whole-tissue sections and tissue microarrays显示文摘AIM:To compare the performance of three commercially available anti-human epidermalgrowth factor receptor 2(HER2)antibodies in whole-tissue sections and tissue microarrays(TMAs)of a series of gastric tumors.METHODS:We present a comparative analysis of three anti-HER2 antibodies(HercepTest,4B5 and SP3)using TMA and whole-tissue sections prepared from the same paraffin blocks of 199 gastric adenocarcinomas operated upon between January 2004 and December2008 at a Brazilian cancer hospital.The data on the patients’age,sex,the anatomical location of the tumor and the Lauren’s histological classification were collected from clinical and pathological records.The immunohistochemical(IHC)results were examined by two pathologists and the cases were classified as positive(3+),equivocal(2+)and negative(0 or 1+),according to the criteria of the IHC scoring system of gastric cancer.TMAs and whole-tissue sections were evaluated separately and independently.All cases yielding discordant IHC results and/or scored as 2+were subjected to dual-color in situ hybridization in order to determine the final HER2 status.Besides determining the sensitivity and predictive value for HER2-positive status,we measured the accuracy of each antibody by calculating the area under the receiver operating characteristic(ROC)curve.The agreement between the results obtained using the TMAs and those obtained using the whole-tissue sections was assessed by means of Kappa coefficient.RESULTS:Intratumoral heterogeneity of HER2 expression was observed with all antibodies.HER2-positive expression(3+)in the whole-tissue sections was observed in 23 cases(11.6%)using the 4B5 antibody,in 18 cases(9.1%)using the SP3 antibody and in 10 cases(5.1%)using the HercepTest antibody.In the TMAs,11 positive cases(5.6%)were identified using SP3 antibody,9(4.6%)using the 4B5 antibody and 6(3%)using the HercepTest antibody.The sensitivity using whole-tissue sections and TMA,respectively,was 95.2%and 42.9%with 4B5,90.5%and 66.7%with SP3 and 47.6%and42.9%with HercepTest.The accuracy,calculated from the area under the ROC curve,using whole-tissue sections and TMA,respectively,was 0.91 and 0.79 by 4B5,0.86 and 0.80 by SP3 and 0.73 and 0.71 by HercepTest.The concordance of the results obtained using wholetissue sections and TMA was 97.4%(Kappa 0.75)using HercepTest,85.6%(Kappa 0.56)using SP3 and 84.1%(Kappa 0.38)using 4B5.CONCLUSION:The use of the 4B5 antibody on wholetissue sections was the most accurate IHC method for evaluating HER2 expression in gastric adenocarcinoma. | Lucas Faria Abraho-Machado Alexandre Andrade dos Anjos Jácome Durval Renato Wohnrath José Sebastio dos Santos Estela Cristina Carneseca José Humberto Tavares Guerreiro Fregnani Cristovam Scapulatempo-Neto | 2013 | World Journal of Gastroenterology2013，19，38： | 12 |
| 2 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 3 | Supergiant Barocaloric Effects in Acetoxy Silicone Rubber over a Wide Temperature Range:Great Potential for Solid-state Cooling显示文摘Solid-state cooling based on caloric effects is considered a viable alternative to replace the conventional vapor-compression refrigeration systems.Regarding barocaloric materials,recent results show that elastomers are promising candidates for cooling applications around room-temperature.In the present paper,we report supergiant barocaloric effects observed in acetoxy silicone rubber—a very popular,low-cost and environmentally friendly elastomer.Huge values of adiabatic temperature change and reversible isothermal entropy change were obtained upon moderate applied pressures and relatively low strains.These huge barocaloric changes are associated both to the polymer chain rearrangements induced by confined compression and to the first-order structural transition.The results are comparable to the best barocaloric materials reported so far,opening encouraging prospects for the application of elastomers in near future solid-state cooling devices. | William Imamura Erik Oda Usuda Lucas Soares Paixao Nicolau Molina Bom Angelo Marcio Gomes Alexandre Magnus Gomes Carvalho | 2020 | Chinese Journal of Polymer Science2020，38，9： | 2 |
| 4 | SAFETY AND EFFICACY OF PARTIAL NEPHRECTOMY FOR ALL T1 TUMORS BASED ON AN INTERNATIONAL MULTICENTER EXPERIENCE显示文摘 | JEAN-JACQUES PATARD OLEG SHVARTS JOHN S. LAM ALLAN J. PANTUCK HYUNG L. KIM VINCENZO FICARRA LUCA CINDOLO KEN-RYU HAN ALEXANDRE DE LA TAILLE JACQUES TOSTAIN WALTER ARTIBANI CLAUDE C. ABBOU BERNARD LOBEL DOMINIQUE K. CHOPIN ROBERT A. FIGLIN PETER F.A. MULDE | 2004 | The Journal of Urology2004，，6： | 2 |
| 5 | High nitrogen deposition alters the decomposition of bog plant litter and reduces carbon accumulation显示文摘 | Luca B Alexandre B Jonathan H | | 0，，03： | 1 |
| 6 | Prognostic Value of Renal Vein and Inferior Vena Cava Involvement in Renal Cell Carcinoma显示文摘 | Bernd Wagner Jean-Jacques Patard Arnaud Méjean Karim Bensalah Grégory Verhoest Richard Zigeuner Vincenzo Ficarra Jacques Tostain Peter Mulders Denis Chautard Jean-Luc Descotes Alexandre de la Taille Laurent Salomon Tommaso Prayer-Galetti Luca Cindolo Anto | 2008 | European Urology2008，，2： | 1 |
| 7 | Immune and Stress Responses Covary with Melanin-Based Coloration in the Barn Swallow显示文摘 | Nicola Saino Luca Canova Alessandra Costanzo Diego Rubolini Alexandre Roulin Anders Pape M?ller | 2013 | Evolutionary Biology2013，，4： | 1 |
| 8 | Serum levels of LH, FSH, estradiol and progesterone in female rats experimentally infected by Trypanosoma evansi显示文摘 | Luciana Faccio Aleksandro S. Da Silva Alexandre A. Tonin Raqueli T. Fran?a Lucas T. Gressler Maíra M. Copetti Camila B. Oliveira Manuela B. Sangoi Rafael N. Moresco Nathieli B. Bottari Marta M.M.F. Duarte Silvia G. Monteiro | 2013 | Experimental Parasitology2013，，1： | 1 |
| 9 | Joint design of Gaussianized spectrum-based features and least-square linear classifier for automatic acoustic environment classification in heating aids显示文摘 | Lucas Cuadra Roberto Gil-Pita Enrique Alexandre | 2010 | Signal Processing2010，90，8： | 1 |
| 10 | Studies on copper(II)- and zinc(II)-mixed ligand complexes of humic acid显示文摘 | Alexandre G.S. Prado Jocilene D. Torres Paolla C. Martins Jonas Pertusatti Lucas B. Bolzon Elaine A. Faria | 2006 | Journal of Hazardous Materials2006，，3： | 1 |
| 11 | Partial Versus Radical Nephrectomy in Patients With Adverse Clinical or Pathologic Characteristics显示文摘 | Claudio Jeldres Jean-Jacques Patard Umberto Capitanio Paul Perrotte Nazareno Suardi Maxime Crepel Vincenzo Ficarra Luca Cindolo Alexandre de La Taille Jacques Tostain Christian Pfister Baptiste Albouy Marc Colombel Arnaud Méjean Hervé Lang Didier Jacqmin | 2009 | Urology2009，，6： | 1 |
| 12 | Frequency, Clinical Presentation and Evolution of Renal Oncocytomas: Multicentric Experience from a European Database显示文摘 | Leo Romis Luca Cindolo Jean Jacques Patard Giovanni Messina Vincenzo Altieri Laurent Salomon Claude Clement Abbou Dominique Chopin Bernard Lobel Alexandre de La Taille | 2003 | European Urology2003，，1： | 1 |
| 13 | Robot-assisted adrenalectomy:Step-by-step technique and surgical outcomes at a high-volume robotic center显示文摘Objective In the last years,robotic surgery was introduced in several different settings with good perioperative results.However,its role in the management of adrenal masses is still debated.In order to provide a contribution to this field,we described our step-by-step technique for robotic adrenalectomy(RA)and related modifications according to the type of adrenal mass treated.Methods We retrospectively analyzed 27 consecutive patients who underwent RA at Onze-Lieve-Vrouw hospital(Aalst,Belgium)between January 2009 and October 2022.Demographic,intra-and post-operative,and pathological data were retrieved from our prospectively maintained institutional database.Continuous variables are summarized as median and interquartile range(IQR).Categorical variables are reported as frequencies(percentages).Results Twenty-seven patients underwent RA were included in the study.Median age,body mass index,and Charlson's comorbidity index were 61(IQR:49-71)years,26(IQR:24-29)kg/m^(2),and 2(IQR:0-3),respectively,and 16(59.3%)patients were male.Median tumor size at computed tomography scan was 6.0(IQR:3.5-8.0)cm.Median operative time and blood loss were 105(IQR:82-120)min and 175(IQR:94-250)mL,respectively.No intraoperative complications were recorded.Overall postoperative complications rate was 11.1%,with a postoperative transfusion rate of 3.7%.A total of 10(37.0%)patients harbored malignant adrenal masses.Among them,3(11.1%)had adrenocortical carcinoma,6(22.2%)secondary metastasis,and 1(3.7%)malignant pheochromocytoma on final pathological exam.Only 1(10.0%)patient had positive surgical margins.Conclusion We described our step-by-step technique for RA,which can be safely performed even in case of high challenging settings as malignant tumors,pheochromocytoma,and large masses.The standardization of perioperative protocol should be encouraged to maximize the outcomes of this complex surgical procedure. | Federico Piramide Carlo Andrea Bravi Marco Paciotti Luca Sarchi Luigi Nocera Adele Piro Maria Peraire Lores Eleonora Balestrazzi Angelo Mottaran Rui Farinha Hubert Nicolas Pieter De Backer Frederiek D'hondt Peter Schatteman Ruben De Groote Geert De Naeyer Alexandre Mottrie | 2023 | Asian Journal of Urology2023，10，4： | 0 |
| 14 | Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO显示文摘The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector.Some of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator detectors.In this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/g.With ten years of data acquisition,approximately 60,000 signal and 30,000 background events are expected.This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework.IfDelta m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith angle.Moreover,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment. | Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera Daojin Hong YuenKeung Hor Shaojing Hou Yee Hsiung Bei-Zhen Hu Hang Hu Jianrun Hu Jun Hu Shouyang Hu Tao Hu Zhuojun Hu Chunhao Huang Guihong Huang Hanxiong Huang Qinhua Huang Wenhao Huang Xingtao Huang Yongbo Huang Jiaqi Hui Wenju Huo Cédric Huss Safeer Hussain Antonio Insolia Ara Ioannisian Daniel Ioannisyan Roberto Isocrate Kuo-Lun Jen Xiaolu Ji Xingzhao Ji Huihui Jia Junji Jia Siyu Jian Di Jiang Xiaoshan Jiang Ruyi Jin Xiaoping Jing Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Kampmann Li Kang Michael Karagounis Narine Kazarian Amir Khan Waseem Khan Khanchai Khosonthongkee Patrick Kinz Denis Korablev Konstantin Kouzakov Alexey Krasnoperov Svetlana Krokhaleva Zinovy Krumshteyn Andre Kruth Nikolay Kutovskiy Pasi Kuusiniemi Tobias Lachenmaier Cecilia Landini Sébastien Leblanc Frederic Lefevre Liping Lei Ruiting Lei Rupert Leitner Jason Leung Demin Li Fei Li Fule Li Haitao Li Huiling Li Jiaqi Li Jin Li Kaijie Li Mengzhao Li Nan Li Nan Li Qingjiang Li Ruhui Li Shanfeng Li Shuaijie Li Tao Li Weidong Li Weiguo Li Xiaomei Li Xiaonan Li Xinglong Li Yi Li Yufeng Li Zhibing Li Ziyuan Li Hao Liang Hao Liang Jingjing Liang Jiajun Liao Daniel Liebau Ayut Limphirat Sukit Limpijumnong Guey-Lin Lin Shengxin Lin Tao Lin Jiajie Ling Ivano Lippi Fang Liu Haidong Liu Hongbang Liu Hongjuan Liu Hongtao Liu Hu Liu Hui Liu Jianglai Liu Jinchang Liu Min Liu Qian Liu Qin Liu Runxuan Liu Shuangyu Liu Shubin Liu Shulin Liu Xiaowei Liu Yan Liu Alexey Lokhov Paolo Lombardi Claudio Lombardo Kai Loo Chuan Lu Haoqi Lu Jingbin Lu Junguang Lu Shuxiang Lu Xiaoxu Lu Bayarto Lubsandorzhiev Sultim Lubsandorzhiev Livia Ludhova Fengjiao Luo Guang Luo Pengwei Luo Shu Luo Wuming Luo Vladimir Lyashuk Qiumei Ma Si Ma Xiaoyan Ma Xubo Ma Jihane Maalmi Yury Malyshkin Fabio Mantovani Francesco Manzali Xin Mao Yajun Mao Stefano MMari Filippo Marini Sadia Marium Cristina Martellini Gisele Martin-Chassard Agnese Martini Davit Mayilyan Axel Müller Ints Mednieks Yue Meng Anselmo Meregaglia Emanuela Meroni David Meyhöfer Mauro Mezzetto Jonathan Miller Lino Miramonti Salvatore Monforte Paolo Montini Michele Montuschi Nikolay Morozov Pavithra Muralidharan Massimiliano Nastasi Dmitry VNaumov Elena Naumova Igor Nemchenok Alexey Nikolaev Feipeng Ning Zhe Ning Hiroshi Nunokawa Lothar Oberauer Juan Pedro Ochoa-Ricoux Alexander Olshevskiy Domizia Orestano Fausto Ortica Hsiao-Ru Pan Alessandro Paoloni Nina Parkalian Sergio Parmeggiano Teerapat Payupol Yatian Pei Nicomede Pelliccia Anguo Peng Haiping Peng Frédéric Perrot Pierre-Alexandre Petitjean Fabrizio Petrucci Luis Felipe Piñeres Rico Oliver Pilarczyk Artyom Popov Pascal Poussot Wathan Pratumwan Ezio Previtali Fazhi Qi Ming Qi Sen Qian Xiaohui Qian Hao Qiao Zhonghua Qin Shoukang Qiu Muhammad Rajput Gioacchino Ranucci Neill Raper Alessandra Re Henning Rebber Abdel Rebii Bin Ren Jie Ren Taras Rezinko Barbara Ricci Markus Robens Mathieu Roche Narongkiat Rodphai Aldo Romani Bedřich Roskovec Christian Roth Xiangdong Ruan Xichao Ruan Saroj Rujirawat Arseniy Rybnikov Andrey Sadovsky Paolo Saggese Giuseppe Salamanna Simone Sanfilippo Anut Sangka Nuanwan Sanguansak Utane Sawangwit Julia Sawatzki Fatma Sawy Michaela Schever Jacky Schuler Cédric Schwab Konstantin Schweizer Dmitry Selivanov Alexandr Selyunin Andrea Serafini Giulio Settanta Mariangela Settimo Muhammad Shahzad Vladislav Sharov Gang Shi Jingyan Shi Yongjiu Shi Vitaly Shutov Andrey Sidorenkov FedorŠimkovic Chiara Sirignano Jaruchit Siripak Monica Sisti Maciej Slupecki Mikhail Smirnov Oleg Smirnov Thiago Sogo-Bezerra Julanan Songwadhana Boonrucksar Soonthornthum Albert Sotnikov Ondrej Sramek Warintorn Sreethawong Achim Stahl Luca Stanco Konstantin Stankevich DušanŠtefánik Hans Steiger Jochen Steinmann Tobias Sterr Matthias Raphael Stock Virginia Strati Alexander Studenikin Gongxing Sun Shifeng Sun Xilei Sun Yongjie Sun Yongzhao Sun Narumon Suwonjandee Michal Szelezniak Jian Tang Qiang Tang Quan Tang Xiao Tang Alexander Tietzsch Igor Tkachev Tomas Tmej Konstantin Treskov Andrea Triossi Giancarlo Troni Wladyslaw Trzaska Cristina Tuve Stefan van Waasen Johannes van den Boom Guillaume Vanroyen Nikolaos Vassilopoulos Vadim Vedin Giuseppe Verde Maxim Vialkov Benoit Viaud Cristina Volpe Vit Vorobel Lucia Votano Pablo Walker Caishen Wang Chung-Hsiang Wang En Wang Guoli Wang Jian Wang Jun Wang Kunyu Wang Lu Wang Meifen Wang Meng Wang Ruiguang Wang Siguang Wang Wei Wang Wenshuai Wang Xi Wang Xiangyue Wang Yangfu Wang Yaoguang Wang Yi Wang Yifang Wang Yuanqing Wang Yuman Wang Zhe Wang Zheng Wang Zhimin Wang Zongyi Wang Apimook Watcharangkool Lianghong Wei Wei Wei Yadong Wei Liangjian Wen Christopher Wiebusch Steven Chan-Fai Wong Bjoern Wonsak Diru Wu Fangliang Wu Qun Wu Wenjie Wu Zhi Wu Michael Wurm Jacques Wurtz Christian Wysotzki Yufei Xi Dongmei Xia Yuguang Xie Zhangquan Xie Zhizhong Xing Benda Xu Donglian Xu Fanrong Xu Jilei Xu Jing Xu Meihang Xu Yin Xu Yu Xu Baojun Yan Xiongbo Yan Yupeng Yan Anbo Yang Changgen Yang Huan Yang Jie Yang Lei Yang Xiaoyu Yang Yifan Yang Haifeng Yao Zafar Yasin Jiaxuan Ye Mei Ye Ugur Yegin Frédéric Yermia Peihuai Yi Xiangwei Yin Zhengyun You Boxiang Yu Chiye Yu Chunxu Yu Hongzhao Yu Miao Yu Xianghui Yu Zeyuan Yu Chengzhuo Yuan Ying Yuan Zhenxiong Yuan Ziyi Yuan Baobiao Yue Noman Zafar Andre Zambanini Pan Zeng Shan Zeng Tingxuan Zeng Yuda Zeng Liang Zhan Feiyang Zhang Guoqing Zhang Haiqiong Zhang Honghao Zhang Jiawen Zhang Jie Zhang Jingbo Zhang Peng Zhang Qingmin Zhang Shiqi Zhang Tao Zhang Xiaomei Zhang Xuantong Zhang Yan Zhang Yinhong Zhang Yiyu Zhang Yongpeng Zhang Yuanyuan Zhang Yumei Zhang Zhenyu Zhang Zhijian Zhang Fengyi Zhao Jie Zhao Rong Zhao Shujun Zhao Tianchi Zhao Dongqin Zheng Hua Zheng Minshan Zheng Yangheng Zheng Weirong Zhong Jing Zhou Li Zhou Nan Zhou Shun Zhou Xiang Zhou Jiang Zhu Kejun Zhu Honglin Zhuang Liang Zong Jiaheng Zou | 2021 | Chinese Physics C2021，45，2： | 0 |
| 15 | Assessment of Cognitive skills via Human-robot Interaction and Cloud Computing显示文摘Technological advances are increasing the range of applications for artificial intelligence, especially through its embodiment within humanoid robotics platforms. This promotes the development of novel systems for automated screening of neurological conditions to assist the clinical practitioners in the detection of early signs of mild cognitive impairments. This article presents the implementation and the experimental validation of the first robotic system for cognitive assessment, based on one of the most popular platforms for social robotics, Softbank 'Pepper', which administers and records a set of multi-modal interactive tasks to engage the user cognitive abilities. The robot intelligence is programmed using the state-of-the-art IBM Watson AI Cloud services, which provide the necessary capabilities for improving the social interaction and scoring the tests. The system has been tested by healthy adults (N= 35) and we found a significant correlation between the automated scoring and one of the most widely used Paper-and-Pencil tests. We conclude that the system can be considered as a screening instrument for cognitive assessment. | Alessandro Di Nuovo Simone Varrasi Alexandr Lucas Daniela Conti John McNamara Alessandro Soranzo | 2019 | Journal of Bionic Engineering2019，16，3： | 0 |
| 16 | Observation of a single protein by ultrafast X-ray diffraction显示文摘The idea of using ultrashort X-ray pulses to obtain images of single proteins frozen in time has fascinated and inspired many.It was one of the arguments for building X-ray free-electron lasers.According to theory,the extremely intense pulses provide sufficient signal to dispense with using crystals as an amplifier,and the ultrashort pulse duration permits capturing the diffraction data before the sample inevitably explodes.This was first demonstrated on biological samples a decade ago on the giant mimivirus.Since then,a large collaboration has been pushing the limit of the smallest sample that can be imaged.The ability to capture snapshots on the timescale of atomic vibrations,while keeping the sample at room temperature,may allow probing the entire conformational phase space of macromolecules.Here we show the first observation of an X-ray diffraction pattern from a single protein,that of Escherichia coli GroEL which at 14 nm in diameter is the smallest biological sample ever imaged by X-rays,and demonstrate that the concept of diffraction before destruction extends to single proteins.From the pattern,it is possible to determine the approximate orientation of the protein.Our experiment demonstrates the feasibility of ultrafast imaging of single proteins,opening the way to single-molecule time-resolved studies on the femtosecond timescale. | Tomas Ekeberg Dameli Assalauova Johan Bielecki Rebecca Boll Benedikt J.Daurer Lutz A.Eichacker Linda E.Franken Davide E.Galli Luca Gelisio Lars Gumprecht Laura H.Gunn Janos Hajdu Robert Hartmann Dirk Hasse Alexandr Ignatenko Jayanath Koliyadu Olena Kulyk Ruslan Kurta Markus Kuster Wolfgang Lugmayr Jannik Lübke Adrian P.Mancuso Tommaso Mazza Carl Nettelblad Yevheniy Ovcharenko Daniel E.Rivas Max Rose Amit K.Samanta Philipp Schmidt Egor Sobolev Nicusor Timneanu Sergey Usenko Daniel Westphal Tamme Wollweber Lena Worbs Paul Lourdu Xavier Hazem Yousef Kartik Ayyer Henry N.Chapman Jonas A.Sellberg Carolin Seuring Ivan A.Vartanyants Jochen Küpper Michael Meyer Filipe R.N.C.Maia | 2024 | Light(Science & Applications)2024，13，1： | 0 |
| 17 | 气候变化下维管植物对大气碳同化和泥炭碳分解的调控作用显示文摘气候变化可以通过促进维管植物的生长来改变泥炭地植物群落的组成。然而,这种植被变化如何影响泥炭地碳动态仍然不清楚。为了评估植被变化对碳吸收和释放的影响,我们在两处以泥炭藓为主的泥炭地上进行了维管植物去除实验,这两处泥炭地代表了沿气候梯度下自然植被演替的不同阶段。对净生态系统CO_(2)交换量的周期性测量表明,维管植物在确保净碳吸收潜力方面发挥着关键作用,尤其是在气候变暖的情况下。然而,维管植物的存在也增强了生态系统呼吸量,通过利用呼吸作用产生的CO_(2)中放射性碳(bomb-^(14)C)特征的季节变化,我们证明根际激发效应增强了泥炭碳的异养分解。观察到的泥炭碳分解的根际激发效应与溶解有机物的更高度腐殖化相匹配,在植物的生长季之后仍然很明显。我们的研究结果强调了根际激发效应在泥炭地中的相关性,特别是在评估与气候变化相关的植被群落组成发生变化的泥炭地未来碳汇功能时。 | Konstantin Gavazov Remy Albrecht Alexandre Buttler Ellen Dorrepaal Mark H.Garnett Sebastien Gogo Frank Hagedorn Robert T.E.Mills Bjorn J.M.Robroek Luca Bragazza 鲁蕴哲(译) 徐汇遥(译) 胡雅琴(译) 谭薇(译) 赵红艳(译) | 2023 | 腐植酸2023，，1： | 0 |
| 18 | Non-exhaustive double effort test is reliable and estimates the firs ventilatory threshold intensity in running exercise显示文摘Purpose: The present study aimed to investigate the reliability of the non-exhaustive double effort(NEDE) test in running exercise and its associations with the ventilatory thresholds(VT_1 and VT_2) and the maximal lactate steady state(MLSS).Methods: Ten healthy male adults(age: 23 ± 4 years, height: 176.6 ± 6.4 cm, body mass: 76.6 ± 10.7 kg) performed 4 procedures:(1) a ramp test for VT_1 and VT_2 determinations measured by ratio of expired ventilation to O_2 uptake(VE/VO_2) and expired ventilation to CO_2 output(VE/VCO_2) equivalents, respectively;(2) the NEDE test measured by blood lactate concentration(NEDE_(LAC)) and heart rate responses(NEDE_(HR));(3) a retest of NEDE for reliability analysis; and(4) continuous efforts to determine the MLSS intensity. The NEDE test consisted of4 sessions at different running intensities. Each session was characterized by double efforts at the same running velocity(E1 and E2, 180 s), separated by a passive recovery period(90 s rest). LAC and HR values after E1 and E2(in 4 sessions) were used to estimate the intensity equivalent to'null delta' by linear fit. This parameter represents, theoretically, the intensity equivalent to maximal aerobic capacity.Results: The intraclass correlation coefficient indicated significant reliability for NEDE_(LAC)(0.93) and NEDE_(HR)(0.79)(both p < 0.05). There were significant correlations, no differences, and strong agreement with the intensities predicted by NEDE_(LAC)(10.1 ± 1.9 km/h) and NEDE_(HR)(9.8 ± 2.0 km/h) to VT_1(10.2 ± 1.1 km/h). In addition, despite significantly lower MLSS intensity(12.2 ± 1.2 km/h), NEDE_(LAC) and NEDE_(HR) intensities were highly correlated with this parameter(0.90 and 0.88, respectively).Conclusion: The NEDE test applied to running exercise is reliable and estimates the VT_1 intensity. Additionally, NEDE intensities were lower but still correlated with VT_2 and MLSS. | Lucas Dantas Maia Forte Fúlvia Barros Manchado-Gobatto Roberta Cunha Matheus Rodrigues Maria Ceclia Gallani Claudio Alexandre Gobatto | 2018 | Journal of Sport and Health Science2018，7，2： | 0 |
| 19 | Sub-percent precision measurement of neutrino oscillation parameters with JUNO显示文摘JUNO is a multi-purpose neutrino observatory under construction in the south of China.This publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the experiment.The sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite detector.It is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data collection.In the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering hypothesis.The new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters. | Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram Abid Aleem 安丰鹏 安琪 Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste 白伟东 Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩 蔡啸 蔡严克 蔡志岩 Riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚 曹国富 曹俊 Rossella Caruso Cédric Cerna Chi Chan 常劲帆 Yun Chang 陈国明 陈平平 Po-An Chen 陈少敏 Xurong Chen 陈义学 陈羽 陈志源 陈梓康 程捷 程雅苹 Yu Chin Cheng Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille 邓智 邓子艳 Wilfried Depnering Marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich Marcos Dracos Frédéric Druillole 杜然 杜书先 Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Donghua Fan 樊磊 方建 方文兴 Marco Fargetta Dmitry Fedoseev 费政勇 Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男 高峰 Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar 龚光华 宫辉 Yuri Gornushkin Alexandre Göttel Marco Grassi Vasily Gromov 顾旻皓 谷肖飞 古宇 关梦云 管宇铎 Nunzio Guardone 郭聪 郭竞渊 郭万磊 Xinheng Guo 郭宇航 Paul Hackspacher Caren Hagner 韩然 Yang Han 何苗 Wei He Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强 侯少静 Yee Hsiung Bei-Zhen Hu 胡航 Jianrun Hu 胡俊 胡守扬 胡涛 胡宇翔 胡焯钧 黄桂鸿 黄翰雄 黄凯旋 黄文昊 Xin Huang 黄性涛 黄永波 惠加琪 霍雷 霍文驹 Cédric Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini Ignacio Jeria 季筱璐 贾慧慧 贾俊基 蹇司玉 蒋荻 蒋炜 江晓山 荆小平 Cécile Jollet Jari Joutsenvaara Leonidas Kalousis Philipp Kampmann 康丽 Rebin Karaparambil Narine Kazarian Amina Khatun Khanchai Khosonthongkee Denis Korablev Konstantin Kouzakov Alexey Krasnoperov Nikolay Kutovskiy Pasi Kuusiniemi Tobias Lachenmaier Cecilia Landini Sébastien Leblanc Victor Lebrin Frederic Lefevre 雷瑞庭 Rupert Leitner Jason Leung Daozheng Li 李德民 李飞 李福乐 李高嵩 Huiling Li 李梦朝 李民 李楠 Nan Li 李清江 李茹慧 李瑞 黎山峰 李涛 李腾 李卫东 李卫国 李笑梅 李小男 李兴隆 李仪 李依宸 李玉峰 Zepeng Li 李兆涵 李志兵 李紫源 李宗海 梁浩 梁昊 廖佳军 Ayut Limphirat Guey-Lin Lin 林盛鑫 林韬 凌家杰 Ivano Lippi 刘芳 刘海东 刘昊天 刘宏邦 刘红娟 刘洪涛 Hui Liu 刘江来 刘金昌 刘敏 刘倩 刘钦 Runxuan Liu 刘树彬 刘术林 刘小伟 刘熙文 Yan Liu Yunzhe Liu Alexey Lokhov Paolo Lombardi Claudio Lombardo Kai Loo 陆川 路浩奇 陆景彬 吕军光 路书祥 Bayarto Lubsandorzhiev Sultim Lubsandorzhiev Livia Ludhova Arslan Lukanov Daibin Luo Fengjiao Luo 罗光 罗舒 罗武鸣 罗晓杰 Vladimir Lyashuk 马帮争 马冰 马秋梅 马斯 马骁妍 马续波 Jihane Maalmi 麦景宇 Yury Malyshkin Roberto Carlos Mandujano Fabio Mantovani Francesco Manzali 冒鑫 冒亚军 Stefano M.Mari Filippo Marini Cristina Martellini Gisele Martin-Chassard Agnese Martini Matthias Mayer Davit Mayilyan Ints Mednieks Artur Meinusch 孟月 Anselmo Meregaglia Emanuela Meroni David Meyhö Mauro Mezzetto Jonathan Miller Lino Miramonti Marta Colomer Molla Paolo Montini Michele Montuschi Axel Müller Massimiliano Nastasi Dmitry V.Naumov Elena Naumova Diana Navas-Nicolas Igor Nemchenok Minh Thuan Nguyen Thi 宁飞鹏 宁哲 Hiroshi Nunokawa Lothar Oberauer Juan Pedro Ochoa-Ricoux Alexander Olshevskiy Domizia Orestano Fausto Ortica Rainer Othegraven Alessandro Paoloni Sergio Parmeggiano 裴亚田 Luca Pelicci Nicomede Pelliccia 彭安国 彭海平 彭宇 彭昭缘 Frédéric Perrot Pierre-Alexandre Petitjean Fabrizio Petrucci Oliver Pilarczyk Luis Felipe Piñeres Artyom Popov Pascal Poussot Ezio Previtali 齐法制 祁鸣 钱森 钱小辉 钱圳 乔浩 秦中华 丘寿康 Gioacchino Ranucci Neill Raper Reem Rasheed Alessandra Re Henning Rebber Abdel Rebii Mariia Redchuk 任斌 任杰 Barbara Ricci Mariam Rifai Mathieu Roche Narongkiat Rodphai Aldo Romani Bedřich Roskovec 阮锡超 Arseniy Rybnikov Andrey Sadovsky Paolo Saggese Simone Sanfilippo Anut Sangka Utane Sawangwit Julia Sawatzki Michaela Schever Cédric Schwab Konstantin Schweizer Alexandr Selyunin Andrea Serafini Giulio Settanta Mariangela Settimo Zhuang Shao Vladislav Sharov Arina Shaydurova 石京燕 史娅楠 Vitaly Shutov Andrey Sidorenkov FedorŠimkovic Chiara Sirignano Jaruchit Siripak Monica Sisti Maciej Slupecki Mikhail Smirnov Oleg Smirnov Thiago Sogo-Bezerra Sergey Sokolov Julanan Songwadhana Boonrucksar Soonthornthum Albert Sotnikov OndřejŠrámek Warintorn Sreethawong Achim Stahl Luca Stanco Konstantin Stankevich DušanŠtefánik Hans Steiger Jochen Steinmann Tobias Sterr Matthias Raphael Stock Virginia Strati Alexander Studenikin 苏俊 孙世峰 孙希磊 孙勇杰 孙永昭 孙正阳 Narumon Suwonjandee Michal Szelezniak 唐健 唐强 唐泉 唐晓 Vidhya Thara Hariharan Eric Theisen Alexander Tietzsch Igor Tkachev Tomas Tmej Marco Danilo Claudio Torri Konstantin Treskov Andrea Triossi Giancarlo Troni Wladyslaw Trzaska Alexandros Tsagkarakis Cristina Tuve Nikita Ushakov Vadim Vedin Giuseppe Verde Maxim Vialkov Benoit Viaud Cornelius Moritz Vollbrecht Cristina Volpe Katharina Von Sturm Vit Vorobel Dmitriy Voronin Lucia Votano Pablo Walker 王彩申 Chung-Hsiang Wang 王恩 王国利 王坚 王俊 汪璐 Meifen Wang 王孟 Meng Wang 王瑞光 王思广 王维 王为 王文帅 王玺 王湘粤 王仰夫 王耀光 王毅 王义 王贻芳 王元清 Yuman Wang 王喆 王铮 王志民 Zongyi Wang Apimook Watcharangkool 魏微 魏巍 韦雯露 魏亚东 温凯乐 温良剑 Christopher Wiebusch 黄振辉 Bjoern Wonsak 吴帝儒 吴群 吴智 Michael Wurm Jacques Wurtz Christian Wysotzki 习宇飞 夏冬梅 Xiang Xiao 谢小川 谢宇广 Zhangquan Xie 辛钊 邢志忠 续本达 徐程 徐东莲 徐繁荣 许杭锟 徐吉磊 徐晶 徐美杭 徐音 闫保军 Taylor Yan Wenqi Yan 严雄波 Yupeng Yan 杨长根 杨成峰 Huan Yang 杨洁 杨雷 杨晓宇 Yifan Yang 姚海峰 叶佳璇 叶梅 叶子平 Frédéric Yermia Na Yin 尤郑昀 俞伯祥 余炽业 喻纯旭 余泓钊 于淼 于向辉 于泽源 于泽众 袁岑溪 袁成卓 袁影 袁振雄 岳保彪 Noman Zafar Vitalii Zavadskyi 曾珊 曾婷轩 曾裕达 占亮 张爱强 张斌 张斌婷 张飞洋 Guoqing Zhang 张宏浩 张家梁 张家文 张杰 Jin Zhang 张景波 张金楠 Mohan Zhang 张鹏 张清民 张石其 张澍 张涛 张晓梅 张鑫 张玄同 Xueyao Zhang 张银鸿 张易于 张永鹏 张宇 张圆圆 张玉美 张振宇 张志坚 Fengyi Zhao 赵洁 赵荣 赵润泽 赵书俊 Dongqin Zheng 郑华 郑阳恒 Weirong Zhong 周静 周莉 周楠 周顺 周彤 周详 朱江 朱景森 朱康甫 朱科军 朱志航 庄博 庄红林 宗亮 邹佳恒 | 2022 | Chinese Physics C2022，46，12： | 0 |
| 20 | Behavioral study with Erythrina velutina fractions显示文摘Objective:To study the behavioral effects of semi purified fraction prepared from the stem bark of Erythrina velutina on mice.Methods:Three chloroformic fractions(CA) at 50 or 100 mg/kg(CA1,CA2 and CA3) were tested in two behavioral tests;plus maze and open field.Results:In the plus maze test,it was observed a decrease in the number of entries in the closed arms(NECA) CA2 at both doses as compared to the control group.In the open field test,CA2 and CA3 fractions decreased the number of squares crossed and the time of permanence on the bar,increased the number of falls at both doses in the rota rod test.The CA2 fraction decreased the NECA,but this data did not characterize an anxiolytic effect.It was the consequence from decrease of locomotor activity(LA) observed in the open field test,that the decrease of LA and rearing,the number of falls and the decrease in time of permanence on the bar in rota rod test were observed after treatment with CA2 and CA3 at both doses,suggesting sedative effect.Conclusion:The present work demonstrated that CA2 and CA3 fractions have impairing effect on LA and motor coordination. | Silvania Maria Mendes Vasconcelos Natalia Martins Lima Lucas Siqueira de Lucena Alexandre Cesar Praxedes Rodrigues Edilberto Rocha Silveira Carlos Clayton Torres Aguiar Paula Matias Soares Francisca Clea Florenco de Sousa Glauce Socorro de Barros Viana | 2009 | Asian Pacific Journal of Tropical Medicine2009，2，5： | 0 |
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