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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 3 | The First Two Imported Cases of SARS-CoV-2 Omicron Variant—Tianjin Municipality,China,December 13,2021显示文摘On December 9,2021,2 international passengers arrived in Tianjin Binhai International Airport from Warsaw,Poland via airplane and tested positive for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which causes coronavirus disease 2019(COVID-19),using nucleic acid tests.The first case(Patient A)was a flight crew member,a 35-year-old male,who had returned to Warsaw on the same flight on December 10,2021.The second case(Patient B)was a 17-year-old female student,who has been transferred to Haihe Hospital for isolation.Both cases are Polish nationality that had recently lived in Warsaw,Poland.According to the investigation,neither patient had disease symptoms nor medication history.Patient B received the Pfizer/BNT162b2 vaccine on September 27,2021.Patient A was vaccinated on May 25,2021,but no further vaccine information was collected as Patient A had left China.No other infections from this flight have been detected. | Zhaolin Tan Zhixiao Chen Aiping Yu Xiaoyan Li Yenan Feng Xiang Zhao Wenbo Xu Xu Su | 2022 | China CDC weekly2022，4，4： | 5 |
| 4 | Novel wavelet neural network algorithm for continuous and noninvasive dynamic estimation of blood pressure from photoplethysmography显示文摘This paper proposes a novel wavelet neural network algorithm for the continuous and noninvasive dynamic estimation of blood pressure(BP). Unlike prior algorithms, the proposed algorithm capitalizes on the correlation between photoplethysmography(PPG) and BP. Complete BP waveforms are reconstructed based on PPG signals to extract systolic blood pressure(SBP) and diastolic blood pressure(DBP). To improve the robustness, Daubechies wavelet is implemented as the hidden layer node function for the neural network. An optimized neural network structure is proposed to reduce the computational complexity. Further, this paper investigates an inhomogeneous resilient backpropagation(IRBP) algorithm to calculate the weight of hidden layer nodes. The IRBP improves the convergence speed and reconstruction accuracy. Multiparameter intelligent monitoring in Intensive Care(MIMIC) databases, which contain a variety of physiological parameters captured from patient monitors, are used to validate this algorithm. The standard deviation σ between reconstructed and actual BP signals is 4.4797 mm Hg, which satisfies the American National Standards of the Association for the Advancement of Medical Instrumentation. The reconstructed BP waveform can be used to extract the SBP and DBP, whose standard deviations σ are 2.91 mm Hg and 2.41 mm Hg respectively. | Peng LI Ming LIU Xu ZHANG Xiaohui HU Bo PANG Zhaolin YAO Hongda NHEN | 2016 | Science China(Information Sciences)2016，59，4： | 5 |
| 5 | Simulation of micro-behaviors including nucleation,growth,and aggregation in particle system显示文摘A new method for the solution of population balance equations(PBE) describing the micro-processes such as nucleation,growth,aggregation of particle swarms in a multiphase system is proposed.The method is based on the fixed pivot moment and allows arbitrary number of moments to be tracked si-multaneously.By expressing PBEs for both batch and continuous operations in a general form,and using weighted residual method to derive the moment equations,different moments can be tracked directly.The numerical density function is assumed to be a summation of several weighted Dirac Delta functions,and the integral and derivative terms in PBEs are transformed to a summation in order to reduce computational cost.Simulations of a batch nucleation-growth process and a continuous ag-gregation-growth process have demonstrated good agreement with the corresponding analytical solu-tions,with relative errors less than 108%.Simulation of a combined nucleation-growth-aggregation process,which does not have an analytical solution,is also included,so as to reproduce the mi-cro-behaviors of such a complex system,demonstrating the feasibility and reliability of this method. | GU ZhaoLin SU JunWei JIAO JianYing XU X Yun | 2009 | Science China Chemistry2009，52，2： | 4 |
| 6 | The Biocontrol Effects of the Bacillus licheniformis W10 Strain and Its Antifungal Protein Against Brown Rot in Peach显示文摘The biocontrol effects of Bacillus licheniformis W10 bacterial suspension and its antifungal protein on peach brown rot caused by Monilinia fructicola in storage peach fruits and the effects on fruit quality were investigated. The results showed that the fruit disease suppression of B. licheniformis W10 bacterial suspension and antifungal protein were significantly higher than that of the control. Inoculation of bacterial suspension and antifungal protein prior to M. fructicola gave a better biocontrol effect, and the higher concentrations of bacterial(1 × 1010 cfu · m L-1) and antifungal protein(3.0 mg · m L-1) performed better control effects. The environmental conditions, such as temperature and humidity, affected biocontrol effects of W10 bacterial suspension and antifungal protein. The influence of environment conditions on the activity of antifungal protein was less than that on bacterial suspension. Moreover, lower temperature(4 ℃) and relative humidity(RH 70%–75%) were favorable to prevent peach brown rot by W10 bacterial suspension and its antifungal protein. The W10 bacterial suspension and antifungal protein amended with calcium [0.1% Ca(NO3)2] could enhance the biocontrol effects, and obviously put off the occurrence of peach brown rot. In addition, the bacterial suspension and antifungal protein significantly reduced the natural decay rates of peach fruits during storage, and the effects were equal to carbendazim. Moreover, both W10 bacterial suspension and antifungal protein treatments did not have effects on external and internal fruit appearance, such as chromatic aberration parameter L* of flesh, flesh firmness, soluble solids content and weight loss. Therefore, the B. licheniformis W10 is a potential biocontrol factor for peach brown rot. | JI Zhaolin HE Huiwen ZHOU Huijuan HAN Feng TONG Yunhui YE Zhengwen XU Jingyou | 2015 | Horticultural Plant Journal2015，1，3： | 4 |
| 7 | A NEW ALGORITHM FOR COMPUTING THE INVERSE AND GENERALIZED INVERSE OF THE SCALED FACTOR CIRCULANT MATRIX显示文摘为发现一个非退化的放大因素 circulant 矩阵的逆的一个新算法被欧几里得的算法介绍。扩展被做计算组逆和单个放大因素 circulant 矩阵的 Moore-Penrose 逆。数字例子被举表明建议算法的实现。 | Zhaolin Jiang Zongben Xu | 2008 | Journal of Computational Mathematics2008，26，1： | 2 |
| 8 | Norm estimates of w-circulant operator matrices and isomorphic operators for w-circulant algebra显示文摘An n × n ω-circulant matrix which has a specific structure is a type of important matrix. Several norm equalities and inequalities are proved for ω-circulant operator matrices with ω = e^(iθ)(0≤θ < 2π) in this paper. We give the special cases for norm equalities and inequalities, such as the usual operator norm and the Schatten p-norms. Pinching type inequality is also proposed for weakly unitarily invariant norms. Meanwhile,we present that the set of ω-circulant matrices with complex entries has an idempotent basis. Based on this basis, we introduce an automorphism on the ω-circulant algebra and then show different operators on linear vector space that are isomorphic to the ω-circulant algebra. The function properties, other idempotent bases and a linear involution are discussed for ω-circulant algebra. These results are closely related to the special structure of ω-circulant matrices. | JIANG ZhaoLin XU TingTing | 2016 | Science China Mathematics2016，59，2： | 1 |
| 9 | Discrete element simu- lation of particle flow in arbitrarily complex geometries 显示文摘 | SU Junwei GU Zhaolin XU Xiaoyun | 2011 | Chemical EngineeringSeience2011，66，： | 1 |
| 10 | Novel method for the evaluation of data quality based on fuzzy control显示文摘One of the goals of data collection is preparing for decision-making, so high quality requirement must be satisfied. Rational evaluation of data quality is an effective way to identify data problem in time, and the quality of data after this evaluation is satisfactory with the requirement of decision maker. A fuzzy neural network based research method of data quality evaluation is proposed. First, the criteria for the evaluation of data quality are selected to construct the fuzzy sets of evaluating grades, and then by using the learning ability of NN, the objective evaluation of membership is carried out, which can be used for the effective evaluation of data quality. This research has been used in the platform of 'data report of national compulsory education outlay guarantee' from the Chinese Ministry of Education. This method can be used for the effective evaluation of data quality worldwide, and the data quality situation can be found out more completely, objectively, and in better time by using the method. | Ban Xiaojuan Ning Shurong Xu Zhaolin Cheng Peng | 2008 | Journal of Systems Engineering and Electronics2008，19，3： | 1 |
| 11 | Algorithms for Finding the Inverses of Factor Block Circulant Matrices显示文摘In this paper,algorithms for finding the inverse of a factor block circulant matrix, a factor block retrocirculant matrix and partitioned matrix with factor block circulant blocks over the complex field are presented respectively.In addition,two algorithms for the inverse of a factor block circulant matrix over the quaternion division algebra are proposed. | Zhaolin Jiang Zongben Xu Shuping Gao | 2006 | Numerical Mathematics A Journal of Chinese Universities(English Series)2006，15，1： | 1 |
| 12 | Efficient algorithm for finding the inverse and group inverse of FLS r-circulantmatrix 显示文摘 | Jiang Zhaolin Xu Zongben | 2005 | Applied Mathematics and Computation2005，18，12： | 1 |
| 13 | A periodic-review inventory system with supply interruptions显示文摘 | LI Zhaolin XU S H HAYYA J | 2004 | Probability in the Engineering and Informational Sciences2004，18，1： | 1 |
| 14 | A neural network-based commutation optimization strategy and drive system design for brushless DC motor显示文摘An optimized commutation method based on backpropagation(BP)neural network is proposed to resolve the low stability and high-power consumption caused by inaccurate commutation point prediction in conventional commutation strategy during acceleration and deceleration.This article also builds a complete brushless DC motor drive system based on the GD32F103 micro control unit(MCU),with an Artix-7 XC7A35T field programmable gate array(FPGA)to meet the performance requirements of neural network calculation for real-time motor commutation control.Experimental results show that the proposed optimization strategy can effectively improve the system stability during system acceleration and deceleration,and reduce the current spikes generated during speed chan-ges.The system power consumption is reduced by about 11.7%on average. | 刘宇翔 Yao Zhaolin Yuan Fang Liu Ming Li Xiang Zhang Xu | 2021 | High Technology Letters2021，27，4： | 1 |
| 15 | Dogs lacking Apolipoprotein E show advanced atherosclerosis leading to apparent clinical complications显示文摘Atherosclerotic cardiovascular disease resulting from dysregulated lipid metabolism is the leading cause of morbidity and mortality worldwide.Apolipoprotein E(ApoE)plays a critical role in cholesterol metabolism.Knockouts in lipid-metabolizing proteins including ApoE in multiple model organisms such as mice and rats exhibiting elevated levels of cholesterol have been widely used for dissecting the pathology of atherosclerosis,but few of these animal models exhibit advanced atherosclerotic plaques leading to ischemia-induced clinical symptoms,limiting their use for translational studies.Here we report hypercholesterolemia and severe atherosclerosis characterized by stenosis and occlusion of arteries,together with clinical manifestations of stroke and gangrene,in ApoE knockout dogs generated by CRISPR/Cas9 and cloned by somatic cell nuclear transfer technologies.Importantly,the hypercholesterolemia and atherosclerotic complications in F0 mutants are recapitulated in their offspring.As the ApoE-associated atherosclerosis and clinical manifestations in mutant dogs are more similar to that in human patients compared with those in other animal models,these mutant dogs will be invaluable in developing and evaluating new therapies,including endovascular procedures,against atherosclerosis and related disorders. | Hui Zhao Jianping Zhao Di Wu Zhaolin Sun Yang Hua Min Zheng Yumei Liu Qi Yang Xiahe Huang Yuan Li Yueshan Piao Yingchun Wang Sin Man Lam Huijuan Xu Guanghou Shui Yongjun Wang Haifeng Yao Liangxue Lai Zhuo Du Jidong Mi Enqi Liu Xunming Ji Yong Q.Zhang | 2022 | Science China(Life Sciences)2022，65，7： | 0 |
| 16 | An effector of Erysiphe necator translocates to chloroplasts and plasma membrane to suppress host immunity in grapevine显示文摘The powdery mildew(Erysiphe necator)is a prevalent pathogen hampering grapevine growth in the vineyard.An arsenal of candidate secreted effector proteins(CSEPs)was encoded in the E.necator genome,but it is largely unclear what role CSEPs plays during the E.necator infection.In the present study,we identified a secreted effector CSEP080 of E.necator,which was located in plant chloroplasts and plasma membrane.Transient expressing CSEP080 promotes plant photosynthesis and inhibits INF1-induced cell death in tobacco leaves.We found that CSEP080 was a necessary effector for the E.necator pathogenicity,which interacted with grapevine chloroplast protein VviB6f(cytochrome b6-f complex iron–sulfur subunit),affecting plant photosynthesis.Transient silencing VviB6f increased the plant hydrogen peroxide production,and the plant resistance to powdery mildew.In addition,CSEP080 manipulated the VviPE(pectinesterase)to promote pectin degradation.Our results demonstrated the molecular mechanisms that an effector of E.necator translocates to host chloroplasts and plasma membrane,which suppresses with the grapevine immunity system by targeting the chloroplast protein VviB6f to suppress hydrogen peroxide accumulation and manipulating VviPE to promote pectin degradation. | Bo Mu Zhaolin Teng Ruixin Tang Mengjiao Lu Jinfu Chen Xiangnan Xu Ying-Qiang Wen | 2023 | Horticulture Research2023，10，9： | 0 |
| 17 | High precision intelligent flexible grasping front-end with CMOS interface for robots application显示文摘This paper presents a high-precision intelligent flexible robot grasping front-end with an integrated capacitive tactile sensor array and a conditioning chip. The capacitive tactile sensor is the primary part of the front-end, it determines the overall performance. The micro-needle array sandwich structure in the tactile sensor increases the repeatability and stability, and ensures the sensitivity. The assembled sensor exhibits a saturation at 10.53 N(421 k Pa) with a sensitivity of 1.9%/k Pa. Furthermore, a conditioning chip is utilized in a custom readout interface to achieve better performance by reducing signal attenuation, and to increase the compatibility of the front-end. The chip is optimized for the parasitic shunt capacitance in the capacitor array. A dual bidirectional charge-discharge conversion method and a two-port detection method are matched to achieve the goal of reducing the shunting influence, and attenuating the offset voltage or the noise input effects. A prototype of the interface has been fabricated using 180-nm CMOS technology. Sensor with the value of 0.5 p F shunted by capacitors of 47 p F has been detected with an error of 1% within 100 μs. | Xiaohui HU Xu ZHANG Ming LIU Yuanfang CHEN Peng LI Jialin LIU Zhaolin YAO Weihua PEI Chun ZHANG Hongda CHEN | 2016 | Science China(Information Sciences)2016，59，3： | 0 |
| 18 | Simultaneously transmitting and reflecting(STAR)RISs for 6G:fundamentals,recent advances,and future directions显示文摘Simultaneously transmitting and reflecting reconfigurable intelligent surfaces(STAR-RISs)have been attracting significant attention in both academia and industry for their advantages of achieving 360°coverage and enhanced degrees-of-freedom.This article first identifies the fundamentals of STAR-RIS,by discussing the hardware models,channel models,and signal models.Then,three representative categorizing approaches for STAR-RISs are introduced from the phase-shift,directional,and energy consumption perspectives.Furthermore,the beamforming design of STAR-RISs is investigated for both independent and coupled phase-shift cases.As a recent advance,a general optimization framework,which has high compatibility and provable optimality regardless of the application scenarios,is proposed.As a further advance,several promising applications are discussed to demonstrate the potential benefits of applying STAR-RISs in sixth-generation wireless communication.Lastly,a few future directions and research opportunities are highlighted. | Yuanwei LIU Jiaqi XU Zhaolin WANG Xidong MU Jianhua ZHANG Ping ZHANG | 2023 | Frontiers of Information Technology & Electronic Engineering2023，24，12： | 0 |
| 19 | Progress at NTSC towards an optical lattice for a strontium clock显示文摘We report on studies of an optical lattice for a strontium clock performed at the National Time Service Center. Follow-ing tw o-stage laser cooling and trapping,88 Sr cold atoms w ith population of 105 and a longitudinal temperature of 8. 4 μK are loaded into a one-dimensional optical lattice. Spectroscopic analysis of the1S0-3P0 transition gives a linew idth of 180 Hz measured using magnetic field-induction,w hich mixes the3P1 state w ith the3P0 state. Rabi oscillations are observed. Because of the inhomogeneous excitation among the atoms,the Rabi π-pulse excitation at 5 ms show s a near 65% excitation of atoms. The transverse velocity distribution of the atomic beam and the absolute frequencies of the four inter-combination transitions of the isotopes w as measured precisely using velocity-selective fluorescence spectroscopy. By optical injection of tw o cascade external-cavity diode lasers,a single comb line at 689 nm from an optical femtosecond laser comb is filtered and amplified w ith a 37-d B side-mode suppression and a linew idth of less than 240 Hz. We describe recent w ork on a space optical clock concerning the physical vacuum system,thermal analysis,and a permanent-magnet Zeeman slow er for a space strontium optical clock. The first six mode frequencies are obtained and the corresponding oscillation modes are described in detail. We also simulate and analyze thermal profiles for both the physical and optical units installed in the cooling system. When the injected cooling w ater has a temperature of 21℃ or28℃,the units meet operational requirements for temperatures in a space environment. Using a series of permanent magnets,a Zeeman slow er is built that can w ithstand space launching and operating conditions for the space optical clock. | KONG Dehuan YIN Mojuan LU Benquan HAN Jianxin WANG Yebing XU Qinfang REN Zhaolin CHANG Hong | 2015 | Instrumentation2015，2，4： | 0 |
| 20 | SARS-CoV-2 Genomic Sequencing Revealed N501Y and L452R Mutants of S/A Lineage in Tianjin Municipality, China显示文摘Dear Editor,Coronavirus Disease 2019(COVID-19)outbreak caused by sever acute respiratory syndrome coronavirus 2(SARSCo V-2)presents a global pandemic which has resulted in more than 4 million people death in the world.In China,the initial transmission of COVID-19 has already been blocked by strict control strategies and effective treatment for patients.All local COVID-19 outbreaks after April2020 were related to overseas importing.Up to February2021,207 imported COVID-19 cases have been reported in Tianjin,China(Tianjin Health Commission,2021). | Xiaoyan Li Xin Gao Ming Zou Zhichao Zhuang Zhaolin Tan Baolu Zheng Aiping Yu Xu Su | 2021 | Virologica Sinica2021，36，5： | 0 |
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