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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 3 | Gradient based restoration of coal mine images obtained by underground wireless transmissions显示文摘Curvature-driven diffusion (CDD) principles were used to develop a novel gradient based image restora- tion algorithm. The algorithm fills in blocks of missing data in a wireless image after transmission through the network. When images are transmitted over fading channels, especially in the severe circum- stances of a coal mine, blocks of the image may be destroyed by the effects of noise. Instead of using com- mon retransmission query protocols the lost data is reconstructed by using the adaptive curvature-driven diffusion (ACDD) image restoration algorithm in the gradient domain of the destroyed image. Missing blocks are restored by the method in two steps: In step one, the missing blocks are filled in the gradient domain by the ACDD algorithm; in step two, and the image is reconstructed from the reformed gradients by solving a Poisson equation. The proposed method eliminates the staircase effect and accelerates the convergence rate. This is demonstrated by experimental results. | Lu Zhaolin Qian Jiansheng Li Leida | 2011 | Mining Science and Technology2011，21，6： | 2 |
| 4 | An assessment of regional water resource based on water footprint:A case study of Chonqqing Municipality显示文摘 | Wang Zhaolin Yang Qingyuan Lu Chunyang | 2007 | Journal of Southwest University (Natural Science Edition)2007，29，8： | 1 |
| 5 | Low-loading gold in situ doped with sulfur by biomolecule-assisted approach for promoted electrochemical carbon dioxide reduction显示文摘For electrochemical carbon dioxide reduction(CO_(2)RR),CO_(2)-to-CO conversion is considered an ideal route towards carbon neutrality for practical applications.Gold(Au)is known as a promising catalyst with high selectivity for CO;however,it suffers from high cost and low mass-specific activity.In this study,we design and prepare a catalyst featuring uniform S-doped Au nanoparticles on N-doped carbon support(denoted as S-Au/NC)by an in situ synthesis strategy using biomolecules.The S-Au/NC displays high activity and selectivity for CO in CO_(2)RR with a Au loading as low as 0.4 wt.%.The Faradaic efficiency of CO(FECO)for S-Au/NC is above 95%at−0.75 V(vs.RHE);by contrast,the FECO of Au/NC(without S)is only 58%.The Tafel slope is 77.4 mV·dec−1,revealing a favorable kinetics process.Furthermore,S-Au/NC exhibits an excellent long-term stability for CO_(2)RR.Density functional theory(DFT)calculations reveal that the S dopant can boost the activity by reducing the free energy change of the potential-limiting step(formation of the*COOH intermediate).This work not only demonstrates a model catalyst featuring significantly reduced use of noble metals,but also establishes an in situ synthesis strategy for preparing high-performance catalysts. | Meijie Tan Xiaoqian Han Sen Ru Chao Zhang Zhouru Ji Zhaolin Shi Guomeng Qiao Yunying Wang Ruixue Cui Qiquan Luo Jiqing Jiao Yaguang Li Tongbu Lu | 2023 | Nano Research2023，16，2： | 1 |
| 6 | Genetic polymorphisms in alveolar macrophage response-related genes, and risk of silicosis and pulmonary tuberculosis in Chinese iron miners显示文摘 | Yabin Qu Yunxia Tang Duozhi Cao Fen Wu Jing Liu Guoliang Lu Zhongbin Zhang Zhaolin Xia | 2006 | International Journal of Hygiene and Environmental Health2006，，6： | 1 |
| 7 | A novel image denois- ing algorithm used for coal mine显示文摘 | LU Zhaolin HU Xiaojuan QIAN Jiansheng | 2012 | Journal of Information & Com- putational Science2012，5，9： | 1 |
| 8 | An efficient algorithm for detecting particle contact in non-uniform size particulate system显示文摘Algorithms for detecting particle collision play an important role in the discrete element method (DEM) for the simulation of granular flow systems since the time taken to detect the contact pairs usually occupies a considerable proportion of the total CPU time for the simulation. In this study, we developed a new octree algorithm called multi-octree algorithm, for detecting candidate contact pairs. The so-called multioctree algorithm adopts the topology of octree for detecting possible contacts, in which the particles are managed by hierarchical classification according to particle size and then mapped to different level nodes of an octree, instead of mapping all particles into the leaf nodes of an octree in Vemuri-octree algorithm. The present algorithm speeds up the detecting process by reducing the number of candidate particles for possible contacts. A non-uniform size particulate system with three particle sizes was simulated by the multi-octree and the Vemuri-octree algorithms simultaneously. The simulation results showed that the multi-octree algorithm is relatively insensitive to the volumetric fraction of particles and particle shapes, and takes much shorter time to find candidate particles for possible contacts than the Vemuri-octree algorithm for non-uniform size particulate systems. | Luyi Lu Zhaolin GU Kangbin Lei Sheng Wang Kiwamu Kase | 2010 | Particuology2010，8，2： | 1 |
| 9 | Experimental demonstration of negative refraction imaging in both amplitude andphase 显示文摘 | LU Zhaolin SHI Shouyuan Schuetz C | 2005 | Optics Express(S1094-4087)2005，13，6： | 1 |
| 10 | Image inpainting based on adaptive total variation model显示文摘 | LU Zhaolin QIAN Jiansheng LI Leida | 2011 | IEICE Transactions on Fundamentals of Electronics Communications and Computer Sciences2011，94，7： | 1 |
| 11 | Rotation invariant watermark embedding based on scale-adapted characteristic regions显示文摘 | Li Leida Yuan Xiaoping Lu Zhaolin | 2010 | Information Sciences2010，180，15： | 1 |
| 12 | An in-situ generated composite solid-state electrolyte towards high-voltage lithium metal batteries显示文摘The solid-state electrolyte(SSE) has promising applications in next-generation lithium(Li) metal batteries(LMBs) because of its significantly enhanced safety and more compatible interface characteristics than flammable traditional liquid electrolytes.However,only a few attempts have achieved high-performance high-voltage LMBs,which is attributed to the fact that both high ionic conductivity and good compatibility with electrodes can hardly be achieved simultaneously.Herein,a composite solid-state electrolyte(CSE) based on star-shaped siloxane-based polymer electrolyte coupled with Li_(6.75)La_(3)Zr_(1.75)Ta_(0.25)O_(12)(LLZTO)ceramic fillers is designed and prepared through a facile in-situ polymerization method.The obtained CSE exhibits high ionic conductivity(i.e.,1.68 × 10^(-4) S cm^(-1) at a temperature of 60 ℃),superior anodic stability,and high Li-ion transference number(i.e.,0.53) because of the multifunctional synergistic effect of the polymer electrolyte with LLZTO ceramic fillers.Moreover,the as-developed CSE shows excellent compatibility with Li anodes.As a result,the as-developed CSE enables the development of long-life 4.4-V-class solid-state LMBs with a Li CoO_(2) cathode,with 79.7% capacity retention and 99.74% average Coulombic efficiency after 500 cycles at a 0.5 C rate.Postmortem analysis of cycled batteries confirms that such superior battery performance can be mainly ascribed to the formation of a compatible electrode/electrolyte interface.Furthermore,excellent safety features can be observed in LiCoO_(2)/Li pouch batteries.This work provides an important guide for the rational design of SSEs for high-voltage LMBs. | Qinglei Wang Tiantian Dong Qian Zhou Zili Cui Xuehui Shangguan Chenglong Lu Zhaolin Lv Kai Chen Lang Huang Huanrui Zhang Guanglei Cui | 2022 | Science China Chemistry2022，65，5： | 0 |
| 13 | An effector of Erysiphe necator translocates to chloroplasts and plasma membrane to suppress host immunity in grapevine显示文摘The powdery mildew(Erysiphe necator)is a prevalent pathogen hampering grapevine growth in the vineyard.An arsenal of candidate secreted effector proteins(CSEPs)was encoded in the E.necator genome,but it is largely unclear what role CSEPs plays during the E.necator infection.In the present study,we identified a secreted effector CSEP080 of E.necator,which was located in plant chloroplasts and plasma membrane.Transient expressing CSEP080 promotes plant photosynthesis and inhibits INF1-induced cell death in tobacco leaves.We found that CSEP080 was a necessary effector for the E.necator pathogenicity,which interacted with grapevine chloroplast protein VviB6f(cytochrome b6-f complex iron–sulfur subunit),affecting plant photosynthesis.Transient silencing VviB6f increased the plant hydrogen peroxide production,and the plant resistance to powdery mildew.In addition,CSEP080 manipulated the VviPE(pectinesterase)to promote pectin degradation.Our results demonstrated the molecular mechanisms that an effector of E.necator translocates to host chloroplasts and plasma membrane,which suppresses with the grapevine immunity system by targeting the chloroplast protein VviB6f to suppress hydrogen peroxide accumulation and manipulating VviPE to promote pectin degradation. | Bo Mu Zhaolin Teng Ruixin Tang Mengjiao Lu Jinfu Chen Xiangnan Xu Ying-Qiang Wen | 2023 | Horticulture Research2023，10，9： | 0 |
| 14 | Charging states on atmospheric aerosol particles affected by meteorological conditions显示文摘Previous studies on haze formation focused mainly on the various chemical components in aerosol particles and their physicochemical effects on particle behaviour(e.g.,generation,growth,and agglomeration).This paper describes the measurement of the charging state on atmospheric aerosol particles,which could be affected by meteorological conditions.A series of experiments on particle charging state and meteorological factors was undertaken on the roof of the west 4th building on the Qujiang Campus at Xi'an Jiaotong University(China).Measurements were conducted approximately 20 m above ground level,Our results showed that most atmospheric particles carried net negative or positive charge and that the electric charge on the particles varied diurnally and seasonally.The average amount of charge on particles was higher in winter than in summer.The number concentration of charged particles was higher during the day than overnight.Obvious difference in the average charge of aerosol particles was found between sand-dust days and haze days.A strong relationship was found between the PM2.s concentration,charge amount on particles,and humidity.Our findings show that particle formation and growth could partly be attributed to variation in particle charging state,which is related to meteorological conditions including atmospheric humidity. | Yuanping He Zhaolin Gu Weizhen Lu Liyuan Zhang Daizhou Zhang Tomoaki Okuda Chuck Wah Yu | 2020 | Particuology2020，18，5： | 0 |
| 15 | Progress at NTSC towards an optical lattice for a strontium clock显示文摘We report on studies of an optical lattice for a strontium clock performed at the National Time Service Center. Follow-ing tw o-stage laser cooling and trapping,88 Sr cold atoms w ith population of 105 and a longitudinal temperature of 8. 4 μK are loaded into a one-dimensional optical lattice. Spectroscopic analysis of the1S0-3P0 transition gives a linew idth of 180 Hz measured using magnetic field-induction,w hich mixes the3P1 state w ith the3P0 state. Rabi oscillations are observed. Because of the inhomogeneous excitation among the atoms,the Rabi π-pulse excitation at 5 ms show s a near 65% excitation of atoms. The transverse velocity distribution of the atomic beam and the absolute frequencies of the four inter-combination transitions of the isotopes w as measured precisely using velocity-selective fluorescence spectroscopy. By optical injection of tw o cascade external-cavity diode lasers,a single comb line at 689 nm from an optical femtosecond laser comb is filtered and amplified w ith a 37-d B side-mode suppression and a linew idth of less than 240 Hz. We describe recent w ork on a space optical clock concerning the physical vacuum system,thermal analysis,and a permanent-magnet Zeeman slow er for a space strontium optical clock. The first six mode frequencies are obtained and the corresponding oscillation modes are described in detail. We also simulate and analyze thermal profiles for both the physical and optical units installed in the cooling system. When the injected cooling w ater has a temperature of 21℃ or28℃,the units meet operational requirements for temperatures in a space environment. Using a series of permanent magnets,a Zeeman slow er is built that can w ithstand space launching and operating conditions for the space optical clock. | KONG Dehuan YIN Mojuan LU Benquan HAN Jianxin WANG Yebing XU Qinfang REN Zhaolin CHANG Hong | 2015 | Instrumentation2015，2，4： | 0 |
| 16 | An image segmentation method of pulverized coal for particle size analysis显示文摘An important index to evaluate the process efficiency of coal preparation is the mineral liberation degree of pulverized coal,which is greatly influenced by the particle size and shape distribution acquired by image segmentation.However,the agglomeration effect of fine powders and the edge effect of granular images caused by scanning electron microscopy greatly affect the precision of particle image segmentation.In this study,we propose a novel image segmentation method derived from mask regional convolutional neural network based on deep learning for recognizing fine coal powders.Firstly,an atrous convolution is introduced into our network to learn the image feature of multi-sized powders,which can reduce the missing segmentation of small-sized agglomerated particles.Then,a new mask loss function combing focal loss and dice coefficient is used to overcome the false segmentation caused by the edge effect.The final comparative experimental results show that our method achieves the best results of 94.43%and 91.44%on AP50 and AP75 respectively among the comparison algorithms.In addition,in order to provide an effective method for particle size analysis of coal particles,we study the particle size distribution of coal powders based on the proposed image segmentation method and obtain a good curve relationship between cumulative mass fraction and particle size. | Xin Li Shiyin Li Liang Dong Shuxian Su Xiaojuan Hu Zhaolin Lu | 2023 | International Journal of Mining Science and Technology2023，33，9： | 0 |
| 17 | Trade-offs between ion-conducting and mechanical properties: The case of polyacrylate electrolytes显示文摘Polymer electrolytes(PEs)have been long recognized as the key materials to enable energy-dense batteries and render flexible energy devices practically viable,owing to their chemical and mechanical reliability.However,much of their promise is yet to be realized.The roomtemperature ion conductivity of existing PEs still falls short of the implementation criterion of 10^(-4) S cm^(-1) on the promise of acceptable mechanical properties,thereby precluding their practical application.The twin but inversely related duties of polymers,that is,functioning as both an ion-conducting medium and a structural backbone,underlie this issue but are less elucidated systematically.The polyacrylate(PA)family is among promising polymer matrices on account of ester polarity,electrode compatibility,chemical tunability,and mechanical durability.The extensive applicability of PA in plasticized gels,dry solids,and emerging composites makes PA-based PEs representative to illustrate the trade-off between ion conduction and mechanical strength.We herein seek to outline the stated long-standing conflict exemplified by PA-based PEs,focusing on crucial strategies toward balancing and reconciling the two mutually exclusive properties,with the intention of offering designing guidelines for next-generation PEs. | Guoli Lu Yaojian Zhang Jianjun Zhang Xiaofan Du Zhaolin Lv Junzhe Du Zhiming Zhao Yue Tang Jingwen Zhao Guanglei Cui | 2023 | Carbon Energy2023，5，2： | 0 |
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