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| 1 | Burden of Gastrointestinal Disease in the United States: 2012 Update显示文摘 | Anne F. Peery Evan S. Dellon Jennifer Lund Seth D. Crockett Christopher E. McGowan William J. Bulsiewicz Lisa M. Gangarosa Michelle T. Thiny Karyn Stizenberg Douglas R. Morgan Yehuda Ringel Hannah P. Kim Marco Dacosta DiBonaventura Charlotte F. Carroll Je | 2012 | Gastroenterology2012，，5： | 15 |
| 2 | Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats显示文摘AIM: To investigate whether ezetimibe ameliorates hepatic steatosis and induces autophagy in a rat model of obesity and type 2 diabetes. METHODS: Male age-matched lean control LETO and obese and diabetic OLETF rats were administered either PBS or ezetimibe(10 mg/kg per day) via stomach gavage for 20 wk. Changes in weight gain and energy intake were regularly monitored. Blood and liver tissue were harvested after overnight fasting at the end of study. Histological assessment was performed in liver tissue. The concentrations of glucose, insulin, triglycerides(TG), free fatty acids(FFA), and total cholesterol(TC) in blood and TG, FFA, and TG in livertissue were measured. m RNA and protein abundance involved in autophagy was analyzed in the liver. To investigate the effect of ezetimibe on autophagy and reduction in hepatic fat accumulation, human Huh7 hepatocytes were incubated with ezetimibe(10 μmol/L) together with or without palmitic acid(PA, 0.5 mmol/L, 24 h). Transmission electron microscopy(TEM) was employed to demonstrate effect of ezetimibe on autophagy formation. Autophagic flux was measured with bafilomycin A1, an inhibitor of autophagy and following immunoblotting for autophagy-related protein expression.RESULTS: In the OLETF rats that received ezetimibe(10 mg/kg per day), liver weight were significantly decreased by 20% compared to OLETF control rats without changes in food intake and body weight(P < 0.05). Lipid parameters including TG, FFA, and TC in liver tissue of ezetimibe-administrated OLETF rats were dramatically decreased at least by 30% compared to OLETF controls(P < 0.01). The serum glucose, insulin, HOMA-IR, and lipid profiles were also improved by ezetimibe(P < 0.05). In addition, autophagy-related m RNA expression including ATG5, ATG6, and ATG7 and the protein level of microtubule-associated protein light chain 3(LC3) were significantly increased in the liver in rats that received ezetimibe(P < 0.05). Likewise, for hepatocytes cultured in vitro, ezetimibe treatment significantly decreased PA-induced fat accumulation and increased PA-reduced m RNA and protein expression involved in autophagy(P < 0.05). Ezetimibe-increased autophagosomes was observed in TEM analysis. Immunoblotting analysis of autophagy formation with an inhibitor of autophagy demonstrated that ezetimibe-increased autophagy resulted from increased autophagic flux. CONCLUSION: The present study demonstrates that ezetimibe-mediated improvement in hepatic steatosis might involve the induction of autophagy. | Eugene Chang Lisa Kim Se Eun Park Eun-Jung Rhee Won-Young Lee Ki-Won Oh Sung-Woo Park Cheol-Young Park | 2015 | World Journal of Gastroenterology2015，21，25： | 3 |
| 3 | A phase II trial of second‐line axitinib following prior antiangiogenic therapy in advanced hepatocellular carcinoma显示文摘 | Mairéad G. McNamara Lisa W. Le Anne M. Horgan Alex Aspinall Kelly W. Burak Neesha Dhani Eric Chen Mehrdad Sinaei Glen Lo Tae Kyoung Kim Patrik Rogalla Oliver F. Bathe Jennifer J. Knox | 2015 | Cancer2015，，10： | 2 |
| 4 | Detection of Left Ventricular Thrombus by Delayed-Enhancement Cardiovascular Magnetic Resonance显示文摘 | Jonathan W. Weinsaft Han W. Kim Dipan J. Shah Igor Klem Anna Lisa Crowley Rhoda Brosnan Olga G. James Manesh R. Patel John Heitner Michele Parker Eric J. Velazquez Charles Steenbergen Robert M. Judd Raymond J. Kim | 2008 | Journal of the American College of Cardiology2008，，2： | 1 |
| 5 | Occurrence of tetracycline resistance genes tet(M) and tet(S) in bacteria from marine aquaculture sites 显示文摘 | Seok-Ryel Kim Lisa Nonaka Satoru Suzuki | 2004 | FEMS Microbiology Letters2004，237，： | 1 |
| 6 | Growth of ZrC thin films by aerosol-assisted MOCVD显示文摘 | Yong Sun Won Young Seok Kim Venu G. Varanasi Olga Kryliouk Timothy J. Anderson Chatu T. Sirimanne Lisa McElwee-White | 2007 | Journal of Crystal Growth2007，，2： | 1 |
| 7 | Marcinkeviciene mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl peptidase-IV and its inhibition by saxagliptin ( BMS-477118 ) 显示文摘 | Young B Kim Lisa M Kopcho Mark S Kirby | 2006 | Arch Biochem Biophys2006，445，： | 1 |
| 8 | Effects of substrate loading on enzymatic hydrolysis and viscosity of pretreated barley straw 显示文摘 | Lisa Rosgaard Pavle Andric Kim Dam-Johansen | 2007 | Applied Biochemistry and Biotechnology2007，143，1： | 1 |
| 9 | Burden of Gastrointestinal Disease in the United States: 2012 Update显示文摘 | Anne F. Peery Evan S. Dellon Jennifer Lund Seth D. Crockett Christopher E. McGowan William J. Bulsiewicz Lisa M. Gangarosa Michelle T. Thiny Karyn Stizenberg Douglas R. Morgan Yehuda Ringel Hannah P. Kim Marco Dacosta DiBonaventura Charlotte F. Carroll Je | 2012 | Gastroenterology2012，，5： | 1 |
| 10 | A model of destination branding:Integrating the concepts of the branding and destination image 显示文摘 | Hai-lin Qu Lisa Hyunjung Kim Holly Hyunjung Ira | 2011 | Tourism Manage- ment2011，32，3： | 1 |
| 11 | A modelof destination branding : Integrating the concepts of thebranding and destination image 显示文摘 | HailinQu’Lisa Hyunjung Kim Holly Hyunjung Im | 2011 | Tourism management2011，，32： | 1 |
| 12 | Efficacy and Safety of Metronidazole for Pulmonary Multidrug-Resistant Tuberculosis显示文摘 | Matthew W. Carroll Doosoo Jeon James M. Mountz Jong Doo Lee Yeon Joo Jeong Nadeem Zia Myungsun Lee Jongseok Lee Laura E. Via Soyoung Lee Seok-Yong Eum Sung-Joong Lee Lisa C. Goldfeder Ying Cai Boyoung Jin Youngran Kim Taegwon Oh Ray Y. Chen Lori E. Dodd W | 2013 | Antimicrobial Agents and Chemotherapy2013，，8： | 1 |
| 13 | Burden of Gastrointestinal Disease in the United States: 2012 Update显示文摘 | Anne F. Peery Evan S. Dellon Jennifer Lund Seth D. Crockett Christopher E. McGowan William J. Bulsiewicz Lisa M. Gangarosa Michelle T. Thiny Karyn Stizenberg Douglas R. Morgan Yehuda Ringel Hannah P. Kim Marco Dacosta DiBonaventura Charlotte F. Carroll Je | 2012 | Gastroenterology2012，，5： | 1 |
| 14 | A Model of Destination Branding: Integrating the Concepts of the Branding and Des- tination Image显示文摘 | Hailin Qu Lisa Hyunjung Kim Holly Hyunjung Im | 2011 | Tourism Management2011，32，3： | 1 |
| 15 | Cytokine modulation of atopic dermatitis filaggrin skin expression显示文摘 | Michael D. Howell Byung Eui Kim Peisong Gao Audrey V. Grant Mark Boguniewicz Anna DeBenedetto Lynda Schneider Lisa A. Beck Kathleen C. Barnes Donald Y.M. Leung | 2009 | The Journal of Allergy and Clinical Immunology2009，，3： | 1 |
| 16 | Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer’s disease显示文摘 | Yi Li Juha O. Rinne Lisa Mosconi Elizabeth Pirraglia Henry Rusinek Susan DeSanti Nina Kemppainen Kjell N?gren Byeong-Chae Kim Wai Tsui Mony J. Leon | 2008 | European Journal of Nuclear Medicine and Molecular Imaging2008，，12： | 1 |
| 17 | Burden of Gastrointestinal Disease in the United States: 2012 Update显示文摘 | Anne F. Peery Evan S. Dellon Jennifer Lund Seth D. Crockett Christopher E. McGowan William J. Bulsiewicz Lisa M. Gangarosa Michelle T. Thiny Karyn Stizenberg Douglas R. Morgan Yehuda Ringel Hannah P. Kim Marco Dacosta DiBonaventura Charlotte F. Carroll Je | 2012 | Gastroenterology2012，，5： | 1 |
| 18 | Efficacy and Safety of Hyaluronan Treatment in Combination Therapy With Home Exercise for Knee Osteoarthritis Pain显示文摘 | Todd P. Stitik Marcia F. Blacksin Doreen M. Stiskal Jong H. Kim Patrick M. Foye Lisa Schoenherr Eun-Seok Choi Boqing Chen Howard J. Saunders Scott F. Nadler | 2007 | Archives of Physical Medicine and Rehabilitation2007，，： | 1 |
| 19 | Upper abdominal normal organ contouring guidelines and atlas: A Radiation Therapy Oncology Group consensus显示文摘 | Salma K. Jabbour Sameh A. Hashem Walter Bosch Tae Kyoung Kim Steven E. Finkelstein Bethany M. Anderson Edgar Ben-Josef Christopher H. Crane Karyn A. Goodman Michael G. Haddock Joseph M. Herman Theodore S. Hong Lisa A. Kachnic Harvey J. Mamon Jason R. Pant | 2014 | Practical Radiation Oncology2014，，： | 1 |
| 20 | Burden of Gastrointestinal Disease in the United States: 2012 Update显示文摘 | Anne F. Peery Evan S. Dellon Jennifer Lund Seth D. Crockett Christopher E. McGowan William J. Bulsiewicz Lisa M. Gangarosa Michelle T. Thiny Karyn Stizenberg Douglas R. Morgan Yehuda Ringel Hannah P. Kim Marco Dacosta DiBonaventura Charlotte F. Carroll Je | 2012 | Gastroenterology2012，，5： | 1 |
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