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| 1 | Inhibitory effect of IGF-Ⅱ antisense RNA on malignant phenotype of hepatocellular carcinoma显示文摘INIRODUCTIONAccording to the therapeutic effect and strategy ofantisense RNA for hepatoccllular carcinoma(HCC),we have specifically synthesized partialcDNA of human insulin-like growth factor Ⅱ(IGF-Ⅱ)and constructed IGF-Ⅱ cDNA antisenseeukaryotic expression vector.The constructedvector was introduced into hepatoma cell lineSMMC-7721 to block the intrinsic IGF-Ⅱexpression.The biological behavior changes ofhepatoma cells were observed.All these | Dong Hua Yang Ming Qing Zhang Jiang Du Chong Xu Oiao Ming Liang Ji Fang Mao Han Rong Qin Zi Rong Fan Department of Gastroenterology,Zhujiang Hospital,the First Military Medical University,Guangzhou 510282,China Laboratory of Molecular Biology,Zhujiang Hospital,the First Military Medical University,Guangzhou,China Departrnent of Biochemistry,the Second Military Medical University,Shanghai,China | 2000 | World Journal of Gastroenterology2000，6，2： | 54 |
| 2 | Astragalus polysaccharide reduces hepatic endoplasmic reticulum stress and restores glucose homeostasis in a diabetic KKAy mouse model显示文摘Aim:To examine the potential effects of Astragalus polysaccharide (APS) onhepatic endoplasmic reticulum (ER) stress in vivo and in vitro and its link withhypoglycemia activity,thus establishing the mechanism underlying the hypogly-cemic action of APS.Methods:The obese and type 2 diabetic KKAy mousemodel,which is the yellow offspring of the KK mice expressed A^y gene (700mg·kg^(-1)·d^(-1),8 weeks) and a high glucose-induced HepG2 cell model (200 μg/mL,24 h)were treated with APS.The oral glucose tolerance test was measured to reflexinsulin sensitivity with the calculated homeostasis model assessment (HOMA-IR) index.XBP 1 (XhoI site-binding protein 1) transcription and splicing,an indica-tor of ER stress,was analyzed by RT-PCR and real-time PCR.The expression andactivation of glycogen synthase kinase 3 beta (GSK3β),an insulin signaling protein,was measured by Western blotting.Results:APS can alleviate ER stress in cul-tured cells in vivo.The hyperglycemia status,systemic insulin sensitivity,fattyliver disease,and insulin action in the liver of diabetic mice were partly normalizedor improved in response to APS administration.Conclusion:Our results indicatethat APS enables insulin-sensitizing and hypoglycemic activity at least in part byenhancing the adaptive capacity of the ER,which can further promote insulinsignal transduction.Thus,APS has promising application in the treatment of type2 diabetes. | Xian-qing MAO Yong WU Ke WU Ming LIU Jing-fang ZHANG Feng ZOU Jing-ping OU-YANG | 2007 | Acta Pharmacologica Sinica2007，28，12： | 32 |
| 3 | The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women显示文摘Objective To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus(GDM). Methods A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks' gestation(WG). Logistic regression analysis was applied to explore the relationships of maternal body composition and dietary intake with the risk of GDM morbidity. Results Age, pre-pregnant body weight(BW), and body mass index(BMI) were associated with increased risk of GDM. Fat mass(FM), fat mass percentage(FMP), extracellular water(ECW), BMI, BW, energy, protein, fat, and carbohydrates at 21-24 WG were associated with an increased risk of GDM. In contrast, fat free mass(FFM), muscular mass(MM), and intracellular water(ICW) were associated with a decreased risk of GDM. Conclusion Maternal body composition and dietary intake during the second trimester of pregnancy were associated with the risk of GDM morbidity. | Xu Qing Gao Zhi Ying Li Li Ming Wang Lu Zhang Qian Teng Yue Zhao Xia Ge Sheng Jing Hong Jiang Yang Yong Tao Liu Xiao Jun Lyu Chun Jian Mao Lun Yu Xiao Ming Liu Ying Hua Kong Ai Jing Yang Xue Yan Liu Zhao Zhang Yong Wang Jin Zhang Xin Sheng Xue Chang Yong Lu Yan Ping | 2016 | Biomedical and Environmental Sciences2016，29，1： | 29 |
| 4 | Effect of specimen size on energy dissipation characteristics of red sandstone under high strain rate显示文摘In this experiment, red sandstone specimens, having slenderness ratios of 0.5, 0.7, 0.9 and 1.1 respectively, were subjected to blow tests using a Split Hopkinson Pressure Bar(SHPB) system at a pressure of 0.4 atmospheres. In this paper, we have analyzed the effect of slenderness ratio on the mechanical properties and energy dissipation characteristics of red sandstone under high strain rates. The processes of compaction, elastic deformation and stress softening deformation of specimens contract with an increase in slenderness ratio, whilst the nonlinear deformation process extends correspondingly. In addition, degrees of damage of specimens reduced gradually and the type of destruction showed a transformation trend from stretching failure towards shear failure when the slenderness ratio increased. A model of dynamic damage evolution in red sandstone was established and the parameters of the constitutive model at different ratios of length to diameter were determined. By comparison with the experimental curve, the accuracy of the model, which could reflect the stress–strain dynamic characteristics of red sandstone, was verified. From the view of energy dissipation, an increase in slenderness ratio of a specimen decreased the proportion of energy dissipation and caused a gradual fall in the capability of energy dissipation during the specimen failure process. To some extent, the study indicated the effects of slenderness ratios on the mechanical properties and energy dissipation characteristics of red sandstone under the high strain rate, which provides valuable references to related engineering designs and academic researches. | Li Ming Mao Xianbiao Lu Aihong Tao Jing Zhang Guanghui Zhang Lianying Li Chong | 2014 | International Journal of Mining Science and Technology2014，24，2： | 24 |
| 5 | TANDEM and GMAW Twin Wire Welding of Q690 Steel Used in Hydraulic Support显示文摘Compared with using semi-automatic gas shielded arc welding, using automatic TANDEM twin wire welding and twin wire gas metal arc welding (GMAW) to weld Q690 steel, a low-alloy high-strength structural steel used in the hydraulic support in the fully-mechanized mining face, the welding speed, deposition rate, production environment and welding quality can be obviously improved. Compared with GMAW twin wire welding, a refined microstructure in the weld and heat-affected zone (HAZ), narrow HAZ and improved joint strength were achieved with TANDEM on Q690. Also, due to the push-pull pulsed way in TANDEM welding, the droplet transfer, distribution on heat flow and interaction between two arcs were completely different from those in GMAW twin wire system. The heat input of TANDEM is only about 76.6% of GMAW, and correspondingly, the welding speed and welding seam can be obviously improved. The complete oscillation caused by TANDEM pulsed current occurred in the welding pool, which refined the grains in the microstructure. The results show that TANDEM twin wire welding is very suitable in the welding of Q690 used in the hydraulic support. | FANG Chen-fu MENG Xiao-hui HU Qing-xian WANG Feng-jiang REN He WANG Hai-song GUO Yu MAO Ming | 2012 | Journal of Iron and Steel Research(International)2012，19，5： | 22 |
| 6 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 7 | NIR-induced highly sensitive detection of latent finger- marks by NaYF4:Yb,Er upconversion nanoparticles in a dry powder state显示文摘通常在犯罪场面发现 fingermarks 的大多数是潜伏的并且,这样为检测潜伏的 fingermarks 的一个有效方法是很重要的。然而,传统的发展中技术有象低察觉敏感,高背景干扰,复杂操作,和高毒性那样的缺点。处理这挑战,我们采用了荧光灯 NaYF 4:Yb,Er upconversion nanoparticles (UCNP ) 它能发荧光可见的光什么时候由 980 nm 使对人安全的在红外线附近的光激动,到污点,各种各样的底层上的潜伏的 fingermarks 出现。 UCNP 成功地被用作一篇小说荧光灯为有包括非渗入的材料(玻璃,大理石,铝合金表,不锈钢表,铝陪衬,和塑料卡片)的各种各样的底层上的高敏感,低背景,高效率,和低毒性的潜伏的 fingermarks 的察觉的标签,渗入半的材料(地板皮革,陶器的瓦,木头地板,和油漆木头),和象报纸的各种各样的类型那样的渗透的材料。这个工作证明 UCNP 是一万用荧光灯为几乎任何东西上的 fingermarks 的灵巧的察觉的标签材料,在法庭的科学启用他们的实际应用。 | Meng Wang Ming Li Mingying Yang Xiaomei Zhang Aoyang Yu Ye Zhu Penghe Qiu Chuanbin Mao | 2015 | Nano Research2015，8，6： | 20 |
| 8 | Recurrent gain-of-function USP8 mutations in Cushing's disease显示文摘库欣的疾病,引起过量皮质醇生产的也已知的同样促肾上腺皮质的荷尔蒙(ACTH )-secreting 垂体腺瘤(舞步) ,占多达 85%corticotrophin 依赖的库欣的症候群盒子。然而,在这疾病的基因改变是不清楚的。这里,我们执行了从 12 秘密 ACTH 舞步导出并且匹配血样品的 DNA 定序的 whole-exome,它在候选人基因揭示了体的变化的三种类型, USP8 (编码 ubiquitin 特定的朊酶 8 ) ,专门在 exon 14 在 12 秘密 ACTH 舞步中的 8 个。我们进一步评估了体的 USP8 变化在另外由定序的 Sanger 的 258 舞步。进一步定序指向在 108 秘密 ACTH 舞步(62.04%) 中的 67 个识别了 USP8 变体的 17 种类型的一个总数。然而,任何一个都没在舞步的另外的类型这些变化被检测(n = 150 ) 。这些变化在 USP8 的 14-3-3 绑定主题以内聚集并且破坏在 USP8 和 14-3-3 蛋白质之间的相互作用,导致保护 EGFR 免受 lysosomal 降级的伤害的一个提高的能力。因此,有 EGFR 表示,提高的 EGFR 蛋白质丰富和 mRNA 表示的更高的发生 POMC 铺平的变异的 USP8 显示的舞步,它编码 ACTH 的先锋。有变异的 USP8 的舞步在尺寸是显著地更小的并且比野类型的舞步有更高的 ACTH 生产。在里面通过手术 resected 主要变异 USP8 的肿瘤房间, USP8 击倒或堵住的 EGFR 有效地稀释 ACTH 分泌物。一起拿,体的 gain-of-function USP8 变化是普通的并且在库欣的疾病贡献 ACTH 生产过剩。USP8 或 EGFR 的抑制为对待变异 USP8 的 corticotrophin 腺瘤是有希望的。我们的学习在库欣的疾病加亮潜在地功能的变异的基因并且提供卓见进这疾病的治疗学。 | Zeng-Yi Ma Zhi-Jian Song Jian-Hua Chen Yong-Fei Wang Shi-Qi Li Liang-Fu Zhou Ying Mao Yi-Ming Li Rong-Gui Hu Zhao-Yun Zhang Hong-Ying Ye Ming Shen Xue-Fei Shou Zhi-Qiang Li Hong Peng Qing-Zhong Wang Dai-Zhan Zhou Xiao-Lan Qin Jue Ji Jie Zheng Hong Chen Yin Wang Dao-Ying Geng Wei-Jun Tang Chao-Wei Fu Zhi-Feng Shi Yi-Chao Zhang Zhao Ye Wen-Qiang He Qi-Lin Zhang Qi-Sheng Tang Rong Xie Jia-Wei Shen Zu-Jia Wen Juan Zhou Tao Wang Shan Huang Hui-Jia Qiu Ni-Dan Qiao Yi Zhang Li Pan Wei-Min Bao Ying-Chao Liu Chuan-Xin Huang Yong-Yong Shi Yao Zhao | 2015 | Cell Research2015，25，3： | 16 |
| 9 | Strontium ranelate reduces cartilage degeneration and subchondral bone remodeling in rat osteoarthritis model显示文摘 | De-gang YU Hui-feng DING Yuan-qing MAO Ming LIU Bo YU Xin ZHAO Xiao-qing WANG Yang LI Guang-wang LIU Shao-bo NIE Shen LIU Zhen-an ZHU | 2013 | Acta Pharmacologica Sinica2013，34，3： | 13 |
| 10 | Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Treatment of severe Coronavirus Disease 2019(COVID-19)is challenging.We performed a phase 2 trial to assess the efficacy andsafety of human umbilical cord-mesenchymal stem cells(UC-MScs)to treat severe coViD-19 patients with lung damage,based onour phase 1 data.In this randomized,double-blind,and placebo-controlled trial,we recruited 101 severe coVID-19 patients withlung damage.They were randomly assigned at a 2:1 ratio to receive either UC-MSCs(4×10^(7)cells per infusion)or placebo on day 0,3,and 6.The primary endpoint was an altered proportion of whole lung lesion volumes from baseline to day 28.Other imagingoutcomes,6-minute walk test(6-MWT),maximum vital capacity,diffusing capacity,and adverse events were recorded and analyzed.In all,100 COVID-19 patients were finally received either UC-MSCs in=65)or placebo(n=35).UC-MSCs administrationexerted numerical improvement in whole lung lesion volume from baseline to day 28 compared with the placebo(the mediandifference was-13.31%,95%Cl-29.14%,2.13%,P=0.08).UC-MSCs significanty reduced the proportions of solid componentlesion volume compared with the placebo(median difference:-15.45%;95%CI-30.82%,-0.39%;P=0.043).The 6-MWT showedan increased distance in patients treated with UC-MSCs(difference:27.00 m;95%CI 0.00,57.00;P=0.057).The incidence of adverseevents was similar in the two groups.These results suggest that UC-MSCs treatment is a safe and potentially effective therapeuticapproach for COVID-19 patients with lung damage.A phase 3 trial is required to evaluate effects on reducing mortality andpreventing long-term pulmonary disability. | Lei Shi Hai Huang Xuechun Lu Xiaoyan Yan Xiaojing Jiang Ruonan Xu Siyu Wang Chao Zhang Xin Yuan Zhe Xu Lei Huang Jun-Liang Fu Yuanyuan Li Yu Zhang Wei-Qi Yao Tianyi Liu Jinwen Song Liangliang Sun Fan Yang Xin Zhang Bo Zhang Ming Shi Fanping Meng Yanning Song Yongpei Yu Jiqiu Wen Qi Li Qing Mao Markus Maeurer Alimuddin Zumla Chen Yao Wei-Fen Xie Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 13 |
| 11 | Helicobacter pylori infection and esophageal cancer risk:An updated meta-analysis显示文摘AIM:To clarify the association between Helicobacter pylori(H.pylori)infection and the risk of esophageal carcinoma through a meta-analysis of published data.METHODS:Studies which reported the association between H.pylori infection and esophageal cancer published up to June 2013 were included.The odds ratios(ORs)and corresponding 95%CIs of H.pyloriinfection on esophageal cancer with respect to health control groups were evaluated.Data were extracted independently by two investigators and discrepancies were resolved by discussion with a third investigator.The statistical software,STATA(version 12.0),was applied to investigate heterogeneity among individual studies and to summarize the studies.A meta-analysis was performed using a fixed-effect or random-effect method,depending on the absence or presence of significant heterogeneity.RESULTS:No significant association between H.pylori infection and esophageal squamous cell carcinoma(ESCC)risk was found in the pooled overall population(OR=0.97,95%CI:0.76-1.24).However,significant associations between H.pylori infection and ESCC risk were found in Eastern subjects(OR=0.66,95%CI:0.43-0.89).Similarly,cytotoxin-associated gene-A(CagA)positive strains of infection may decrease the risk of ESCC in Eastern subjects(OR=0.77,95%CI:0.65-0.92),however,these associations were not statistically significant in Western subjects(OR=1.26,95%CI:0.97-1.63).For esophageal adenocarcinoma(EAC)the summary OR for H.pylori infection and CagA positive strains of infection were 0.59(95%CI:0.51-0.68)and 0.56(95%CI:0.45-0.70),respectively.CONCLUSION:H.pylori infection is associated with a decreased risk of ESCC in Eastern populations and a decreased risk of EAC in the overall population. | Fa-Jun Xie Yi-Ping Zhang Qiu-Qing Zheng Hong-Chuan Jin Fa-Liang Wang Ming Chen Lan Shao De-Hong Zou Xin-Min Yu Wei-Min Mao | 2013 | World Journal of Gastroenterology2013，19，36： | 11 |
| 12 | Optimal Auxiliary Frequency Control of Wind Turbine Generators and Coordination with Synchronous Generators显示文摘Auxiliary frequency control of a wind turbine generator(WTG) has been widely used to enhance the frequencysecurity of power systems with high penetration of renewableenergy. Previous studies recommend two types of control schemes,including frequency droop control and emulated inertia control,which simulate the response characteristics of the synchronousgenerator (SG). This paper plans to further explore the optimalauxiliary frequency control of the wind turbine based on previousresearch. First, it is determined that the virtual inertia control haslittle effect on the maximum rate of change of frequency (MaxROCOF)if the time delay of the control link of WTG is taken intoconsideration. Secondly, if a WTG operates in maximum powerpoint tracking (MPPT) mode and uses the rotor deceleration forfrequency modulation, its optimal auxiliary frequency control willcontain only droop control. Furthermore, if the droop control isproperly delayed, better system frequency response (SFR) willbe obtained. The reason is that coordination between the WTGand SG is important for SFR when the frequency modulationcapability of the WTG is limited. The frequency modulationcapability of the WTG is required to be released more properly.Therefore, when designing optimal auxiliary frequency controlfor the WTG, a better control scheme is worth further study. | Ming Sun Yong Min Lei Chen Kaiyuan Hou Deming Xia Hangyin Mao | 2021 | CSEE Journal of Power and Energy Systems2021，7，1： | 10 |
| 13 | An Optimal Coordination Control Strategy of Micro-Grid Inverter and Energy Storage Based on Variable Virtual Inertia and Damping of VSG显示文摘The virtual inertia and virtual damping affect both the dynamic stability of the virtual synchronous generator(VSG)and the configuration of energy storage,but there is a conflict between them while selecting the virtual inertia and virtual damping.An optimal coordination control strategy of micro-grid inverter and energy storage based on variable virtual inertia and damping is proposed to mitigate this conflict.With the integrated optimal constraint of the VSG frequency variation and the energy storage capacity,the virtual inertia and damping of VSG are configured dynamically,adopting linear quadratic optimal control.It can suppress the oscillations of the active power and frequency to improve the stability of VSG and optimally configure the energy storage capacity of VSG simultaneously.The proposed strategy aims to improve the control performance of micro-grid inverter and the system economy.The simulation and experimental results verify the effectiveness of the strategy. | Xing Zhang Fubin Mao Haizhen Xu Fang Liu Ming Li | 2017 | Chinese Journal of Electrical Engineering2017，3，3： | 10 |
| 14 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 15 | Xieite,a new mineral of high-pressure FeCr_2O_4 polymorph显示文摘Xieite,a new mineral,occurs in the shock vein of the Suizhou meteorite.The mineral has an ortho-rhombic structure and its space group is Bbmm.The cell parameters are a = 9.462(6),b = 9.562(9),c = 2.916(1).The crystal-chemical formula is(Fe0.87Mg0.13Mn0.01)1.01(Cr1.62Al0.25Ti0.08V0.02)1.97O4,or simply formula FeCr2O4.Stronger X-ray diffraction lines are [d(),I/Io]:(2.675,100),(2.389,20),(2.089,10),(1.953,90),(1.566,60),(1.439,15),(1.425,15),(1.337,40).Xieite is a high pressure polymorph of FeCr2O4 and formed by solid-state transformation of chromite under shock-induced high pressure and tem-perature,in association with other high-pressure minerals including ringwoodite,majorite,lingunite and tuite.The P-T condition for the formation of xieite is estimated to be 18―23 GPa and 1800―1950℃,respectively.Xieite has recently been approved by the Commission on New Minerals,Nomenclature and Classification of the International Mineralogical Association(IMA 2007-056).The mineral name,xieite,is named after Xiande Xie. | CHEN Ming SHU JinFu MAO Ho-kwang | 2008 | Chinese Science Bulletin2008，53，21： | 9 |
| 16 | Reaction between Ti and boron nitride based investment shell molds used for casting titanium alloys显示文摘The aim of this paper was to study the reaction between a Ti-6Al-4V alloy and boron nitride based investment shell molds used for invest- ment casting titanium. In BN based investment shell molds, the face coatings are made of pretreated hexagonal boron nitride (hBN) with a few yttria (Y2O3) and colloidal yttria as binder. The Ti-6Al-4V alloy was melted in a controlled atmosphere induction furnace with a segment water-cooled copper crucible. The cross-section of reaction interface between Ti alloys and shell mold was investigated by electron probe micro-analyzer (EPMA) and microhardness tester. The results show that the reaction is not serious, the thickness of the reacting layer is about 30-50 μm, and the thickness of α-case is about 180-200 μm. Moreover the α-case formation mechanism was also discussed. | LILT Hongbao SHEN Bin ZHU Ming ZHOU Xing MAO Xiemin | 2008 | Rare Metals2008，27，6： | 9 |
| 17 | Stress and deformation analysis on deep surrounding rock at different time stages and its application显示文摘Based on the characteristics of the deep circular tunnel, the surrounding rock was divided into three regions: the cracked region, the plastic region and the viscoelastic region. The process of rock stress deformation and change was divided into three stages after the roadway excavation. By using the elastic-plastic mechanics theory, the analytical solutions of the surrounding stress and displacement at different stages and the radii of cracked and plastic regions were formulated. We additionally explained the surrounding rock stress and displacement which appeared in practical project. Simultaneously, based on the problem which emerged from a mine in Xuzhou during the excavating process of rock roadway's transport, we got the theoretical solutions for the stress and displacement in the process of rock roadway's excavation and considered that the broken area of rock roadway was largely loosing circle. The results indicate that according to the rheological characteristics of surrounding rock, in the primeval excavation of rock roadway, we should increase the length of anchor bolt and cooperate it with anchor nets cable-U steel supporting frame. In addition, when the deformation rate of the surrounding rock is descending after the 15 days' excavation, we should use the ''three anchor'' supporting method (anchor bolt spray, anchor note and anchor rope) and set aside about 20 cm as the reserved deformation layer. | Li Ming Mao Xianbiao Yu Yuanlin Li Kai Ma Chao Peng Yan | 2012 | International Journal of Mining Science and Technology2012，22，3： | 9 |
| 18 | Cystathionine-γ-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis显示文摘Cystathionine-γ-lyase(CSE),an enzyme associated with hydrogen sulfide(H2S)production,is an important endogenous regulator of inflammation.Jumonji domain-containing protein 3(JMJD3)is implicated in the immune response and inflammation.Here,we investigated the potential contribution of JMJD3 to endogenous CSE-mediated inflammation in rheumatoid arthritis(RA).Upregulated CSE and JMJD3 were identified in synovial fibroblasts(SFs)from RA patients as well as in the joints of arthritic mice.Knocking down CSE augmented inflammation in IL-1β-induced SFs by increasing JMJD3 expression.In addition,CSE−/−mice with collagen-induced arthritis(CIA)developed severe joint inflammation and bone erosion.Conversely,overexpressing CSE inhibited JMJD3 expression by the transcription factor Sp-1 and was accompanied by reduced inflammation in IL-1β-treated SFs.Furthermore,JMJD3 silencing or the administration of the JMJD3 inhibitor GSK-J4 significantly decreased the inflammatory response in IL-1β-treated SFs,mainly by controlling the methylation status of H3K27me3 at the promoter of its target genes.GSK-J4 markedly attenuated the severity of arthritis in CIA mice.In conclusion,suppressing JMJD3 expression by the transcription factor Sp-1 is likely responsible for the ability of CSE to negatively modulate the inflammatory response and reduce the progression of RA. | Weijun Wu Ming Qin Wanwan Jia Zheng Huang Zhongzheng Li Di Yang Mengwei Huang Chenxi Xiao Fen Long Jianchun Mao Philip K.Moore Xinhua Liu Yi Zhun Zhu | 2019 | Cellular & Molecular Immunology2019，16，8： | 9 |
| 19 | Neurotoxic role of interleukin-17 in neural stem cell differentiation after intracerebral hemorrhage显示文摘Interleukin 17(IL-17)and its main producer,T cell receptorγδcells,have neurotoxic effects in the pathogenesis of intracerebral hemorrhage(ICH),aggravating brain injuries.To investigate the correlation between IL-17 and ICH,we dynamically screened serum IL-17 concentrations using enzyme-linked immunosorbent assay and explored the clinical values of IL-17 in ICH patients.There was a significant negative correlation between serum IL-17 level and neurological recovery status in ICH patients(r=–0.498,P<0.01).To study the neurotoxic role of IL-17,C57 BL/6 mice were used to establish an ICH model by injecting autologous blood into the caudate nucleus.Subsequently,the mice were treated with mouse neural stem cells(NSCs)and/or IL-17 neutralizing antibody for 72 hours.Flow cytometry,brain water content detection,Nissl staining,and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling results indicated that NSC transplantation significantly reduced IL-17 expression in peri-hematoma tissue,but there was no difference in T cell receptorγδcells.Compared with the ICH group,there were fewer apoptotic bodies and more Nissl bodies in the ICH+NSC group and the ICH+NSC+IL-17 group.To investigate the potential effect of IL-17 on directional differentiation of NSCs,we cultured mouse NSCs(NE-4 C)alone or co-cultured them with T cell receptorγδcells,which were isolated from mouse peripheral blood mononuclear cells,for 7 days.The results of western blot assays revealed that IL-17 secreted by T cell receptorγδcells reduced the differentiation of NSCs into astrocytes and neurons,while IL-17 neutralization relieved the inhibition of directional differentiation into astrocytes rather than neurons.In conclusion,serum IL-17 levels were elevated in the early stage of ICH and were negatively correlated with outcome in ICH patients.Animal experiments and cytological investigations therefore demonstrated that IL-17 probably has neurotoxic roles in ICH because of its inhibitory effects on the directional differentiation of NSCs.The application of IL-17 neutralizing antibody may promote the directional differentiation of NSCs into astrocytes.This study was approved by the Clinical Research Ethics Committee of Anhui Medical University of China(For human study:Approval No.20170135)in December 2016.All animal handling and experimentation were reviewed and approved by the Institutional Animal Care and Use Committee of Anhui Medical University(approval No.20180248)in December 2017. | Lu Gao Ping-Ping Li Tian-Yu Shao Xiang Mao Hao Qi Bing-Shan Wu Ming Shan Lei Ye Hong-Wei Cheng | 2020 | Neural Regeneration Research2020，15，7： | 8 |
| 20 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
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