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| 1 | MRS and diffusion tensor image in mild traumatic brain injuries显示文摘Objective:To analyze characters of magnetic resonance spectroscopy(MRS) and diffusion tensor imaging(DTI) in the diagnosis of mild trauma brain injuries(MTBI) in frontal lobe and to compare with conventional magnetic resonance imaging(MRI).Methods:A total of 21 patients were selected,who all aged 12-51 years old and had injury within 24 hours.Computer tomography (CT) and the Glasgow Coma Scale were used to evaluate the degree of injury.All patients were diagnosed as MTBI,and 19 had conventional MRI,MRS and DTI.The major parameters of MRS were Probe-P sequence,TE= 144 or 35 ms,and both single voxel spectrum and chemical shift imging were included.The major parameters of DTI were diffusion directions =15,b value = 1000 s/mm^2. Frational anisotropic(FA) map and average ADC map were obtained to evaluate DTI result. Positive deletion ratio was observed and the imaging changes were compared between injured side and normal side.Results:All 21 patients had CT scan and Glasgow scale.A total of 19 patients had conventional MRI.DTI and MRS.Results of CT and conventional MRI showed no significant abnormality in lobe,and Glasgow scale showed mild type.MRS result showed significant decrease in N-acetyl aspartate(NAA) and NAA/creatine(Cr) in 13 cases(68.4%) (P<0.001),and increase in lactic acid(Lac) in 7 cases(36.8%).FA mapping of the frontal lobe displayed significant changes in 7 cases(36.8%),with 5 out of the 7 cases having increase in FA value.And there was no significant difference in average ADC.Conclusions:MRS and DTI might be more sensible than other methods,such as CT and conventional MRI in diagnosis of MTBI.The particular changes were reduced NAA and increased Lac for MRS.and increased FA values for DTI. | Jing Chen Hu Jin Ying Zhang Qizhou Liang Haiyan Liao Ziyi Guo Xiangjun Han | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，1： | 6 |
| 2 | Challenges and opportunities for carbon neutrality in China’s building sector—Modelling and data显示文摘The building sector is one of the largest energy user and carbon emitter globally.To achieve China’s national carbon target,the building sector in China needs to achieve carbon peaking and neutrality targets by 2030 and 2060,respectively.However,data deficiency on building energy and emissions become barriers for tracking the status of building energy and emissions,and identify potential opportunities for achieving dual carbon targets.To address these shortcomings,this study established an integrated China Building Energy and Emission Model(CBEEM).With CBEEM,this study evaluated the building-construction and building-operation energy and emissions in China,and revealed the status quo and potential challenge and opportunities.According to modelling results,building operation energy use of China was 1.06 billion tce in 2020,accounting for 21%of China’s total primary energy consumption.Building construction energy consumption was 0.52 billion tce in 2020,accounting for another 10%of total primary energy consumption.Key messages found on building carbon emissions are:building construction embodied emissions were 1.5 billion tCO_(2) in 2020 and are declining slowly,building operational carbon emissions were 2.2 billion tCO_(2) in 2020 and are still increasing.International comparisons between China and other countries on building stock,energy use intensity and carbon emission intensity were conducted as well,and help shed a light on the challenges for decarbonization of China’s building sector.Finally,technology perspectives to achieve carbon neutrality target were discussed and related policy suggestions were provided. | Shan Hu Yang Zhang Ziyi Yang Da Yan Yi Jiang | 2022 | Building Simulation2022，15，11： | 4 |
| 3 | A novel intelligent verification platform based on a structured analysis model显示文摘An intelligent verification platform based on a structured analysis model is presented.Using an abstract model mechanism with specific signal interfaces for user callback,the unified structured analysis data,shared by the electronic system level design,functional verification,and performance evaluation,enables efficient management review,auto-generation of code,and modeling in the transaction level.We introduce the class tree,flow parameter diagram,structured flow chart,and event-driven finite state machine as structured analysis models.As a sand table to carry maps from different perspectives and levels via an engine,this highly reusable platform provides the mapping topology to search for unintended consequences and the graph theory for comprehensive coverage and smart test cases.Experimental results show that the engine generates efficient test sequences,with a sharp increase in coverage for the same vector count compared with a random test. | XIE Zheng WANG XinAn LIAN ZhiBin LUO YongGui HU ZiYi | 2013 | Science China(Information Sciences)2013，56，6： | 4 |
| 4 | Theory and verification of operator design methodology显示文摘Non-recurring-engineering(NRE)and time-to-market play an increasingly important role in the field of IC design.Meanwhile,with the continuous development of IC manufacturing technology,it is necessary to propose a novel design methodology to shorten design cycle and enhance design efficiency.In this paper,operator design methodology(ODM)is presented and an H.264 encoder is implemented as a verification.According to the flow of ODM,the register transfer level(RTL)design of H.264 encoder has been accomplished with 15 man-months,which is lower than the average 19 man-months in the field of traditional application specific integrated circuit(ASIC)design.Moreover,with the advantage of operator design library,the design has a comparable performance with other ASIC implementations.The obtained design can support a real-time video encoding of 720p at 60 frames per second or 1080p at 30 frames per second,working at 167 MHz with SMIC 0.13 μm CMOS technology.These results provide good evidence for the practicability and efficiency of ODM. | HU Ziyi ZHAO Yong WANG XinAn HUANG Ru WANG Teng ZHANG Xing | 2012 | Science China(Information Sciences)2012，55，2： | 3 |
| 5 | Identification of various food residuals on denim based on hyperspectral imaging system and combination optimal strategy显示文摘As the science and technology develop,crime methods and scenes have become increasingly complex and diverse.Trace evidence analysis has become amore and more important criminal investigation technology and liquid is the main form of trace evidence.Food can provide not only energy,but clues to solve crimes.In this study,we build a hyperspectral imaging system to detect liquid residue traces,including apple juice,coffee,cola,milk and tea,on denims with light,middle and dark colors.The obtained hyperspectral images are first subjected to spectral calibration and hyperspectral data pretreatment.Subsequently,Partial Least Squares(PLS)is applied to select the informative wavelengths from the preprocessed spectra.For modeling phase,the combination optimal strategy,support vector machine(SVM)combined with random forest(RF),is developed to establish classification models.The experimental results demonstrate that the combination optimal model can achieve TPR,FPR,Precision,Recall,F1,and AUC of 83.5%,2.30%,79.7%,83.5%,81.6%,and 94.7%for classifying fabrics contaminated by various food residuals.With respect to the classification of liquid and fabric types,the combination optimalmodel also yields satisfactory classification performance.In future work,wewill expand the types of liquid,and make appropriate adjustment to algorithms for improving the robustness of classification models.This research may play a positive role in the construction of a harmonious society. | Yuzhen Chen Ziyi Xu Wencheng Tang Menghan Hu Douning Tang Guangtao Zhai Qingli Li | 2021 | Artificial Intelligence in Agriculture2021，，1： | 2 |
| 6 | A novel CD4+CTL subtype characterized by chemotaxis and inflammation is involved in the pathogenesis of Graves’orbitopathy显示文摘Graves*orbitopathy(GO),the most severe manifestation of Graves'hyperthyroidism(GH),is an autoimmune-mediated inflammatory disorder,and treatments often exhibit a low efficacy.CD4+T cells have been reported to play vital roles in GO progression.To explore the pathogenic CD4-f T cell types that drive GO progression,we applied single-cell RNA sequencing(scRNA-Seq),T cell receptor sequencing(TCR-Seq),flow cytometry,immunofluorescence and mixed lymphocyte reaction(MLR)assays to evaluate CD4+T cells from GO and GH patients.scRNA-Seq revealed the novel GO-spedfic cell type CD4+cytotoxic T lymphocytes(CTLs),which are characterized by chemotactic and inflammatory features.The clonal expansion of this CD4+CTL population,as demonstrated by TCR-Seq,along with their strong cytotoxic response to autoantigens,localization in orbital sites,and potential relationship with disease relapse provide strong evidence for the pathogenic roles of GZMB and IFN-y-secreting CD4+CTLs in GO.Therefore,cytotoxic pathways may become potential therapeutic targets for GO. | Yue Wang Ziyi Chen Tingjie Wang Hui Guo Yufeng Liu Ningxin Dang Shiqian Hu Liping Wu Chengsheng Zhang Kai Ye Bingyin Shi | 2021 | Cellular & Molecular Immunology2021，18，3： | 2 |
| 7 | Enhancing the stability of astaxanthin by encapsulation in poly (1-lactic acid) microspheres using a supercritical anti-solvent process显示文摘To improve the physicochemical properties of astaxanthin, it was encapsulated in poly (1-lactic acid)(PLLA) using a supercritical anti-solvent (SAS) process with dichloromethane/acetone mixture as the solvent, and supercritical CO2 as the anti-solvent. The effects of altering five SAS operating cond让ions, solvent ratio, temperature, pressure, concentration of carrier, and flow rate, on the microstructure of particles were investigated using an orthogonal experimental design. Under the optimal conditions, astaxanthin/PLLA particles were produced with an encapsulation efficiency of 91.5% and a mean particle size of 954.6 nm. SEM images showed that most astaxanthin/PLLA particles were uniform microspheres. FT-IR spectra showed that the chemical structure of astaxanthin was unchanged by the SAS process. The results of chromatic difference, X-ray diffraction, thermogravimetric, and differential scanning calorimetry analyses showed that astaxanthin had been encapsulated in the PLLA matrix in an amorphous state. Overall, astaxanthin/PLLA microspheres greatly enhanced the stability of astaxanthin during storage, and the levels of residual solvents were far lower than the ICH lim让s. This means that astaxanthin/PLLA microspheres prepared using SAS show great potential for use in many food, cosmetic, and pharmaceutical formulations. | Guijin Liu Man Hu Ziyi Zhao Qing Lin Dongwei Wei Yanbin Jiang | 2019 | Particuology2019，17，3： | 2 |
| 8 | Morphology-dependent catalytic properties of nano- cupric oxides in the Rochow reaction显示文摘四种 CuO 催化剂与控制得好像叶子(L-CuO ) ,象花(F-CuO ) , sea-urchin-like (U-CuO ) ,并且像燕麦片(O-CuO ) 形态学被各种各样的 chelating ligands 帮助的一个灵巧的降水方法综合。高分辨率的传播电子显微镜学和快 Fourier 转变显示的红外线的光谱学 L-CuO, F-CuO, U-CuO,和 O-CuO 的主导的水晶方面是 { 001 } , { 110 } , { 001 } ,并且 { 110 } ,以及 { 001 } 并且 { 110 } 分别地。当为 Rochow 反应测试了时,他们的催化表演依赖于他们的结构,这被发现。在四 CuO 催化剂之中, L-CuO 展出了最好的催化性质,与为氧和最高的 reducibility 的最强壮的吸附能力一起,它主要因为它的大部分暴露了 { 001 } 方面和大特定的表面区域。另外, Cu 3 Si 合金阶段,是在 Si 表面的反应区域产生了的最重要的反应中介,为不同催化剂被测量。基于调查结果,详细反应机制被建议。这个工作证明氧化物催化剂的那控制形状的合成能是有效策略设计并且发展有效催化剂。 | Yu Zhang Yongjun Ji Jing Li Hezhi Liu Xiao Hu Ziyi Zhong Fabing Su | 2018 | Nano Research2018，11，2： | 2 |
| 9 | Estimating the Economics of Electrical Energy Storage Based on Different Policies in China显示文摘This paper assesses the value of bulk grid-scale energy storage(GES) technologies in six electric power districts of China. The economic feasibility of GES under three different types of compensation mechanisms was analyzed. Based on a careful investigation of China’s existing power system, a unit commitment model that comprehensively reflects the production costs(including reduction of fuel consumption, grid loss, ancillary services and so on) of the entire power grid has been proposed. The benefits of GES can be obtained by comparing the production costs of two different scenarios: with and without GES. Results show that under the current scheduling methods and compensation mechanisms, in most provinces in China, the energy storage’s revenue is lower than the value that it brings. | DING Jie XU Yujie WANG Ziyi HU Shan CHEN Haisheng | 2020 | Journal of Thermal Science2020，29，2： | 1 |
| 10 | Identification of publication characteristics and research trends in the management of gallbladder cancer显示文摘Background:To date,no comprehensive analysis of gallbladder cancer(GBC)management has been reported.We aimed to identify the publication characteristics and research trends in managing GBC over the past three decades.Methods:We selected the 100 most cited articles and performed a bibliometric analysis to summarize the publication characteristics,explore research hotspots,and identify research trends in the management of GBC.Results:The total citations of the included articles ranged from 123 to 1822.Period II(2001–2010)yielded the highest number of included articles,whereas the lowest was in Period III(2011–2020).The United States and Japan published the most papers,in which the Memorial Sloan–Kettering Cancer Center and Nagoya University were the leading institutions,respectively.The most influential authors were Blumgart LH and Fong YM from the United States.Cooperation among countries,institutions,and authors was weak.The Annals of Surgery contributed the most articles with the highest number of total citations.The most researched topic was surgery,followed by systemic therapy and adjuvant therapy.Since Period I,the percentage of surgery-related publications continuously decreased(Periods II and III versus Period I,both p<0.001),with a concomitant increase in those of adjuvant therapy(Period III versus Period I,p=0.004)and systemic therapy(Period II versus Period I,p=0.004;Period III versus Period I,p=0.002).Conclusions:Surgery remains the preferred treatment,while there is a tendency toward adjuvant and systemic therapy in GBC management.An increase in local and international collaboration for managing GBC is required. | Jiasheng Cao Jiahao Hu Jiliang Shen Bin Zhang Win Topatana Shijie Li Tianen Chen Sarun Jeungpanich Yitong Tian Ziyi Lu Shuyou Peng Xiujun Cai Mingyu Chen | 2022 | iLIVER2022，1，2： | 0 |
| 11 | Design and in-situ construct BiOI/Bi/TiO_(2)photocatalysts with metal-mediated heterostructures employing oxygen vacancies in TiO_(2)nanosheets显示文摘The conventional p-n heterojunction photocatalysts suffer from the incompatibility between the interfacial charge transfer efficiency and the redox ability of charge carriers.To optimize the interfacial charge transfer of the conventional BiOI/TiO_(2) p-n photocatalyst,we synthesized the BiOI/Bi/TiO_(2) ternary photocatalyst with sandwiched metallic bismuth(Bi~0)by the oxygen-vacancy assisted method.The DFT calculation and structural characterizations confirmed the reaction of the electron-rich oxygen vacancies in the 2D-TiO_(2) nanosheets(TiO_(2)-NS)with the adsorbed BiO~+species.This reaction broke the Bi-O bonds to form Bi^(0) nanoparticles in-situ at the interface but still maintained the p-n heterojunction well.The NO-TPD and XRD analyses for samples correlated the Bi~0 formation with the oxygen vacancy concentrations well.The sandwiched Bi~0 functioned as an electronic transfer mediator like that in the Z-scheme heterostructure.Comparing with 0.20 BiOI/TiO_(2)-NP(NP,Nanoparticles),0.20 BiOI/Bi/TiO_(2)-NS-a(NS,Nanosheet)showed a much improved catalytic performance,i.e.,duplicated apparent quantum yield(AQY)and triplicated reaction rate constant(k).Also,the formation mechanism and the reaction mechanism were investigated in detail.This work provides a new strategy for the improving of the conventional p-n photocatalysts and new insights into the nature of the photocatalysis. | Chenchen Zhang Wenbin Chen Dairong Hu Hanjie Xie Yibing Song Binbin Luo Yiwen Fang Wenhua Gao Ziyi Zhong | 2022 | Green Energy & Environment2022，7，4： | 0 |
| 12 | A Knowledge-enhanced Two-stage Generative Framework for Medical Dialogue Information Extraction显示文摘This paper focuses on term-status pair extraction from medical dialogues(MD-TSPE),which is essential in diagnosis dia-logue systems and the automatic scribe of electronic medical records(EMRs).In the past few years,works on MD-TSPE have attracted increasing research attention,especially after the remarkable progress made by generative methods.However,these generative methods output a whole sequence consisting of term-status pairs in one stage and ignore integrating prior knowledge,which demands a deeper un-derstanding to model the relationship between terms and infer the status of each term.This paper presents a knowledge-enhanced two-stage generative framework(KTGF)to address the above challenges.Using task-specific prompts,we employ a single model to com-plete the MD-TSPE through two phases in a unified generative form:We generate all terms the first and then generate the status of each generated term.In this way,the relationship between terms can be learned more effectively from the sequence containing only terms in the first phase,and our designed knowledge-enhanced prompt in the second phase can leverage the category and status candidates of the generated term for status generation.Furthermore,our proposed special status'not mentioned'makes more terms available and en-riches the training data in the second phase,which is critical in the low-resource setting.The experiments on the Chunyu and CMDD datasets show that the proposed method achieves superior results compared to the state-of-the-art models in the full training and low-re-sourcesettings. | Zefa Hu Ziyi Ni Jing Shi Shuang Xu Bo Xu | 2024 | Machine Intelligence Research2024，21，1： | 0 |
| 13 | Sources appointment and health risks of PM_(2.5)-bound trace elements in a coastal city of southeastern China显示文摘To gain a comprehensive understanding of sources and health risks of trace elements in an area of China with high population densities and low PM_(2.5)concentrations,15 trace elements(Al,K,Ca,Ti,V,Cr,Mn,Fe,Ni,Cu,Zn,As,Sn,Ba,Pb)in PM_(2.5)were monitored from December 2020 to November 2021 in a representative city,Xiamen.The concentrations of trace elements in Xiamen displayed an obvious seasonal variation and were dominated by K,Fe,Al,Ca and Zn.Based on Positive Matrix Factorization analysis,source appointment revealed that the major sources of trace elements in Xiamen were traffic,dust,biomass and firework combustion,industrial manufacture and shipping emission.According to health risk assessment combined with the source appointment results,it indicated that the average noncarcinogenic risk was below the threshold and cancer risk of four hazardous metals(Cr,Ni,As,Pb)exceeded the threshold(10^(-6)).Traffic-related source had almost half amount of contribution to the health risk induced by PM_(2.5)-bound trace elements.During the dust transport period or Spring Festival period,the health risks exceeded an acceptable threshold even an order of magnitude higher,suggesting that the serious health risks still existed in low PM_(2.5)environment at certain times.Health risk assessment reminded that the health risk reduction in PM_(2.5)at southeastern China should prioritize traffic-related hazardous trace elements and highlighted the importance of controlling vehicles emissions in the future. | Ziyi Lin Xiaolong Fan Gaojie Chen Youwei Hong Mengren Li Lingling Xu Baoye Hu Chen Yang Yanting Chen Zhiqian Shao Jinsheng Chen | 2024 | Journal of Environmental Sciences2024，，4： | 0 |
| 14 | RhoA/Rock activation represents a new mechanism for inactivating Wnt/β-catenin signaling in the aging-associated bone loss显示文摘The Wnt/β-catenin signaling pathway appears to be particularly important for bone homeostasis,whereas nuclear accumulation ofβ-catenin requires the activation of Rac1,a member of the Rho small GTPase family.The aim of the present study was to investigate the role of RhoA/Rho kinase(Rock)-mediated Wnt/β-catenin signaling in the regulation of aging-associated bone loss.We find that Lrp5/6-dependent and Lrp5/6-independent RhoA/Rock activation by Wnt3a activates Jak1/2 to directly phosphorylate Gsk3βat Tyr216,resulting in Gsk3βactivation and subsequentβ-catenin destabilization.In line with these molecular events,RhoA loss-or gain-of-function in mouse embryonic limb bud ectoderms interacts genetically with Dkk1 gain-of-function to rescue the severe limb truncation phenotypes or to phenocopy the deletion ofβ-catenin,respectively.Likewise,RhoA loss-of-function in pre-osteoblasts robustly increases bone formation while gain-of-function decreases it.Importantly,high RhoA/Rock activity closely correlates with Jak and Gsk3βactivities but inversely correlates withβ-catenin signaling activity in bone marrow mesenchymal stromal cells from elderly male humans and mice,whereas systemic inhibition of Rock therefore activates theβ-catenin signaling to antagonize aging-associated bone loss.Taken together,these results identify RhoA/Rock-dependent Gsk3βactivation and subsequentβ-catenin destabilization as a hitherto uncharacterized mechanism controlling limb outgrowth and bone homeostasis. | Wei Shi Chengyun Xu Ying Gong Jirong Wang Qianlei Ren Ziyi Yan Liu Mei Chao Tang Xing Ji Xinhua Hu Meiyu Qv Musaddique Hussain Ling-Hui Zeng Ximei Wu | 2021 | Cell Regeneration2021，10，1： | 0 |
| 15 | Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO显示文摘The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector.Some of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator detectors.In this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/g.With ten years of data acquisition,approximately 60,000 signal and 30,000 background events are expected.This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework.IfDelta m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith angle.Moreover,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment. | Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera Daojin Hong YuenKeung Hor Shaojing Hou Yee Hsiung Bei-Zhen Hu Hang Hu Jianrun Hu Jun Hu Shouyang Hu Tao Hu Zhuojun Hu Chunhao Huang Guihong Huang Hanxiong Huang Qinhua Huang Wenhao Huang Xingtao Huang Yongbo Huang Jiaqi Hui Wenju Huo Cédric Huss Safeer Hussain Antonio Insolia Ara Ioannisian Daniel Ioannisyan Roberto Isocrate Kuo-Lun Jen Xiaolu Ji Xingzhao Ji Huihui Jia Junji Jia Siyu Jian Di Jiang Xiaoshan Jiang Ruyi Jin Xiaoping Jing Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Kampmann Li Kang Michael Karagounis Narine Kazarian Amir Khan Waseem Khan Khanchai Khosonthongkee Patrick Kinz Denis Korablev Konstantin Kouzakov Alexey Krasnoperov Svetlana Krokhaleva Zinovy Krumshteyn Andre Kruth Nikolay Kutovskiy Pasi Kuusiniemi Tobias Lachenmaier Cecilia Landini Sébastien Leblanc Frederic Lefevre Liping Lei Ruiting Lei Rupert Leitner Jason Leung Demin Li Fei Li Fule Li Haitao Li Huiling Li Jiaqi Li Jin Li Kaijie Li Mengzhao Li Nan Li Nan Li Qingjiang Li Ruhui Li Shanfeng Li Shuaijie Li Tao Li Weidong Li Weiguo Li Xiaomei Li Xiaonan Li Xinglong Li Yi Li Yufeng Li Zhibing Li Ziyuan Li Hao Liang Hao Liang Jingjing Liang Jiajun Liao Daniel Liebau Ayut Limphirat Sukit Limpijumnong Guey-Lin Lin Shengxin Lin Tao Lin Jiajie Ling Ivano Lippi Fang Liu Haidong Liu Hongbang Liu Hongjuan Liu Hongtao Liu Hu Liu Hui Liu Jianglai Liu Jinchang Liu Min Liu Qian Liu Qin Liu Runxuan Liu Shuangyu Liu Shubin Liu Shulin Liu Xiaowei Liu Yan Liu Alexey Lokhov Paolo Lombardi Claudio Lombardo Kai Loo Chuan Lu Haoqi Lu Jingbin Lu Junguang Lu Shuxiang Lu Xiaoxu Lu Bayarto Lubsandorzhiev Sultim Lubsandorzhiev Livia Ludhova Fengjiao Luo Guang Luo Pengwei Luo Shu Luo Wuming Luo Vladimir Lyashuk Qiumei Ma Si Ma Xiaoyan Ma Xubo Ma Jihane Maalmi Yury Malyshkin Fabio Mantovani Francesco Manzali Xin Mao Yajun Mao Stefano MMari Filippo Marini Sadia Marium Cristina Martellini Gisele Martin-Chassard Agnese Martini Davit Mayilyan Axel Müller Ints Mednieks Yue Meng Anselmo Meregaglia Emanuela Meroni David Meyhöfer Mauro Mezzetto Jonathan Miller Lino Miramonti Salvatore Monforte Paolo Montini Michele Montuschi Nikolay Morozov Pavithra Muralidharan Massimiliano Nastasi Dmitry VNaumov Elena Naumova Igor Nemchenok Alexey Nikolaev Feipeng Ning Zhe Ning Hiroshi Nunokawa Lothar Oberauer Juan Pedro Ochoa-Ricoux Alexander Olshevskiy Domizia Orestano Fausto Ortica Hsiao-Ru Pan Alessandro Paoloni Nina Parkalian Sergio Parmeggiano Teerapat Payupol Yatian Pei Nicomede Pelliccia Anguo Peng Haiping Peng Frédéric Perrot Pierre-Alexandre Petitjean Fabrizio Petrucci Luis Felipe Piñeres Rico Oliver Pilarczyk Artyom Popov Pascal Poussot Wathan Pratumwan Ezio Previtali Fazhi Qi Ming Qi Sen Qian Xiaohui Qian Hao Qiao Zhonghua Qin Shoukang Qiu Muhammad Rajput Gioacchino Ranucci Neill Raper Alessandra Re Henning Rebber Abdel Rebii Bin Ren Jie Ren Taras Rezinko Barbara Ricci Markus Robens Mathieu Roche Narongkiat Rodphai Aldo Romani Bedřich Roskovec Christian Roth Xiangdong Ruan Xichao Ruan Saroj Rujirawat Arseniy Rybnikov Andrey Sadovsky Paolo Saggese Giuseppe Salamanna Simone Sanfilippo Anut Sangka Nuanwan Sanguansak Utane Sawangwit Julia Sawatzki Fatma Sawy Michaela Schever Jacky Schuler Cédric Schwab Konstantin Schweizer Dmitry Selivanov Alexandr Selyunin Andrea Serafini Giulio Settanta Mariangela Settimo Muhammad Shahzad Vladislav Sharov Gang Shi Jingyan Shi Yongjiu Shi Vitaly Shutov Andrey Sidorenkov FedorŠimkovic Chiara Sirignano Jaruchit Siripak Monica Sisti Maciej Slupecki Mikhail Smirnov Oleg Smirnov Thiago Sogo-Bezerra Julanan Songwadhana Boonrucksar Soonthornthum Albert Sotnikov Ondrej Sramek Warintorn Sreethawong Achim Stahl Luca Stanco Konstantin Stankevich DušanŠtefánik Hans Steiger Jochen Steinmann Tobias Sterr Matthias Raphael Stock Virginia Strati Alexander Studenikin Gongxing Sun Shifeng Sun Xilei Sun Yongjie Sun Yongzhao Sun Narumon Suwonjandee Michal Szelezniak Jian Tang Qiang Tang Quan Tang Xiao Tang Alexander Tietzsch Igor Tkachev Tomas Tmej Konstantin Treskov Andrea Triossi Giancarlo Troni Wladyslaw Trzaska Cristina Tuve Stefan van Waasen Johannes van den Boom Guillaume Vanroyen Nikolaos Vassilopoulos Vadim Vedin Giuseppe Verde Maxim Vialkov Benoit Viaud Cristina Volpe Vit Vorobel Lucia Votano Pablo Walker Caishen Wang Chung-Hsiang Wang En Wang Guoli Wang Jian Wang Jun Wang Kunyu Wang Lu Wang Meifen Wang Meng Wang Ruiguang Wang Siguang Wang Wei Wang Wenshuai Wang Xi Wang Xiangyue Wang Yangfu Wang Yaoguang Wang Yi Wang Yifang Wang Yuanqing Wang Yuman Wang Zhe Wang Zheng Wang Zhimin Wang Zongyi Wang Apimook Watcharangkool Lianghong Wei Wei Wei Yadong Wei Liangjian Wen Christopher Wiebusch Steven Chan-Fai Wong Bjoern Wonsak Diru Wu Fangliang Wu Qun Wu Wenjie Wu Zhi Wu Michael Wurm Jacques Wurtz Christian Wysotzki Yufei Xi Dongmei Xia Yuguang Xie Zhangquan Xie Zhizhong Xing Benda Xu Donglian Xu Fanrong Xu Jilei Xu Jing Xu Meihang Xu Yin Xu Yu Xu Baojun Yan Xiongbo Yan Yupeng Yan Anbo Yang Changgen Yang Huan Yang Jie Yang Lei Yang Xiaoyu Yang Yifan Yang Haifeng Yao Zafar Yasin Jiaxuan Ye Mei Ye Ugur Yegin Frédéric Yermia Peihuai Yi Xiangwei Yin Zhengyun You Boxiang Yu Chiye Yu Chunxu Yu Hongzhao Yu Miao Yu Xianghui Yu Zeyuan Yu Chengzhuo Yuan Ying Yuan Zhenxiong Yuan Ziyi Yuan Baobiao Yue Noman Zafar Andre Zambanini Pan Zeng Shan Zeng Tingxuan Zeng Yuda Zeng Liang Zhan Feiyang Zhang Guoqing Zhang Haiqiong Zhang Honghao Zhang Jiawen Zhang Jie Zhang Jingbo Zhang Peng Zhang Qingmin Zhang Shiqi Zhang Tao Zhang Xiaomei Zhang Xuantong Zhang Yan Zhang Yinhong Zhang Yiyu Zhang Yongpeng Zhang Yuanyuan Zhang Yumei Zhang Zhenyu Zhang Zhijian Zhang Fengyi Zhao Jie Zhao Rong Zhao Shujun Zhao Tianchi Zhao Dongqin Zheng Hua Zheng Minshan Zheng Yangheng Zheng Weirong Zhong Jing Zhou Li Zhou Nan Zhou Shun Zhou Xiang Zhou Jiang Zhu Kejun Zhu Honglin Zhuang Liang Zong Jiaheng Zou | 2021 | Chinese Physics C2021，45，2： | 0 |
| 16 | Packing Adjustment Towards High Mobility Luminescent Conjugated Polymers显示文摘Next generation display and lighting technology calls for thinner,cheaper and more-flexible unit devices.Polymer light emitting transistor(PLET),which integrates logic function of organic field effect transistor(OFET),luminescence function of organic light emitting diode(OLED),and potential mechanical properties,is believed to be the raising star in this field.However,great challenges remain in developing the core materials of PLETs,which simultaneously require the integration of high ambipolar mobility and strong solid-state luminescence properties.Herein,high mobility luminescent thienopyrroledione-benzodiathiadiazole-fluorene-based conjugated polymer was chosen as polymer backbone,and polymers TBT-1 and TBT-2(TBT=thienopyrroledione-benzodiathiadiazole-thienopyrrole-dione)with red luminescence were obtained by direct arylation polymerization(DArP).By introducing linear alkyl side chains,the packing orientation is changed from face-on in TBT-1 thin film to edge-on in TBT-2 thin film,which is beneficial for improving the field effect performance.The average hole and electron mobility of TBT-2 are 1.1×10^(-2)and 2.0×10^(-3)cm^(2)·V^(-1)·s^(-1),respectively.This work provides new design strategy for high mobility luminescent conjugated polymers,which can be used in PLETs. | ZHANG Yihan LIU Qingqing GAO Can XIE Ziyi HU Beining DONG Huanli | 2023 | Chemical Research in Chinese Universities2023，39，5： | 0 |
| 17 | RING finger 138 deregulation distorts NF-κB signaling and facilities colitis switch to aggressive malignancy显示文摘Prolonged activation of nuclear factor(NF)-кB signaling significantly contributes to the development of colorectal cancer(CRC).New therapeutic opportunities are emerging from targeting this distorted cell signaling transduction.Here,we discovered the critical role of RING finger 138(RNF138)in CRC tumorigenesis through regulating the NF-кB signaling,which is independent of its Ubiquitin-E3 ligase activity involved in DNA damage response.RNF138^(−/−) mice were hyper-susceptible to the switch from colitis to aggressive malignancy,which coincided with sustained aberrant NF-кB signaling in the colonic cells.Furthermore,RNF138 suppresses the activation of NF-кB signaling pathway through preventing the translocation of NIK and IKK-Beta Binding Protein(NIBP)to the cytoplasm,which requires the ubiquitin interaction motif(UIM)domain.More importantly,we uncovered a significant correlation between poor prognosis and the downregulation of RNF138 associated with reinforced NF-кB signaling in clinical settings,raising the possibility of RNF138 dysregulation as an indicator for the therapeutic intervention targeting NF-кB signaling.Using the xenograft models built upon either RNF138-dificient CRC cells or the cells derived from the RNF138-dysregulated CRC patients,we demonstrated that the inhibition of NF-кB signaling effectively hampered tumor growth.Overall,our work defined the pathogenic role of aberrant NF-кB signaling due to RNF138 downregulation in the cascade events from the colitis switch to colonic neoplastic transformation and progression,and also highlights the possibility of targeting the NF-кB signaling in treating specific subtypes of CRC indicated by RNF138-ablation. | Yalan Lu Rong Huang Jianming Ying Xingchen Li Tao Jiao Lei Guo Haitao Zhou Han Wang Amannisa Tuersuntuoheti Jianmei Liu Qichen Chen Yanhong Wang Luying Su Changyuan Guo Fu Xu Ziyi Wang Yan Lu Kai Li Junbo Liang Zhen Huang Xiao Chen Jinjie Yao Hanjie Hu Xiaowen Cheng Yufeng Wan Xinyan Chen Ning Zhang Shiying Miao Jianqiang Cai Linfang Wang Changzheng Liu Wei Song Hong Zhao | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 0 |
| 18 | RcSPL1-RcTAF15b regulates the flowering time of rose (Rosa chinensis)显示文摘Rose(Rosa chinensis),which is an economically valuable floral species worldwide,has three types,namely once-flowering(OF),occasional or re-blooming(OR),and recurrent or continuous flowering(CF).However,the mechanism underlying the effect of the age pathway on the duration of the CF or OF juvenile phase is largely unknown.In this study,we observed that the RcSPL1 transcript levels were substantially upregulated during the floral development period in CF and OF plants.Additionally,accumulation of RcSPL1 protein was controlled by rch-miR156.The ectopic expression of RcSPL1 in Arabidopsis thaliana accelerated the vegetative phase transition and flowering.Furthermore,the transient overexpression of RcSPL1 in rose plants accelerated flowering,whereas silencing of RcSPL1 had the opposite phenotype.Accordingly,the transcription levels of floral meristem identity genes(APETALA1,FRUITFULL,and LEAFY)were significantly affected by the changes in RcSPL1 expression.RcTAF15b protein,which is an autonomous pathway protein,was revealed to interact with RcSPL1.The silencing and overexpression of RcTAF15b in rose plants led to delayed and accelerated flowering,respectively.Collectively,the study findings imply that RcSPL1–RcTAF15b modulates the flowering time of rose plants. | Rui Yu Zhiying Xiong Xinhui Zhu Panpan Feng Ziyi Hu Rongxiang Fang Yuman Zhang Qinglin Liu | 2023 | Horticulture Research2023，10，6： | 0 |
| 19 | Yinjia pill inhibits persistent Chlamydia trachomatis infection显示文摘To the Editor:Chlamydia trachomatis(C.trachomatis)is obligate intracellular pathogens,often resulting in development of chronic disease and tissue damage as a consequence of the host inflammatory immune response as well as persistent infections,[1]which is associated with the activation of mitogen-activated protein kinase(MAPK)and extracellular regulated protein kinases(ERK)mediated by Toll-like receptors(TLRs)and myeloid differentiation primary response gene 88(MyD88).[2]Furthermore,C.trachomatis has evolved the ability to block the apoptosis of its host cells involving the interaction of autophagy and apoptosis.[3]Novel strategies to prevent and treat C.trachomatis infection effectively are needed. | Mei Luo Rongjing Hu Ziyi Zhao Lanshuang Li Ming Xia | 2022 | Chinese Medical Journal2022，135，23： | 0 |
| 20 | Effects of Househould Cleaning Methods on Carbendazim Residue in Apples显示文摘Carbendazim,belonging to fungicides,was commonly used for controlling crop diseases,resulting in frequent residues in fruits and vegetables.Washing was the initial step of household fruit processing for cleaning and reducing pollutant contents.However,the effect of washing on the removal of carbendazim in apples was not systemically studied.Thus,in this study,an analytical method was firstly established for the determination of carbendazim with great accuracy and precision through quick,simple,cheap,effective and safe(QuEChERS)method and ultra-performance liquid chromatography-fluorescence detection(UPLC-FLD).Then,the influencing factors were systematically researched to unveil their effects on the carbendazim residue in apples.The results indicated that water temperature,washing products and washing method could obviously affect the carbendazim content in apples.In addition,the best cleaning scheme for removal of carbendazim was soaking apples for 5 min in a cleaning solution,which was prepared by dissolving 8 g of commercial fruit washing soup with 500 ml of water at 45℃.Under this condition,the removal rate of carbendazim in the washing step reached 73.91%.This study will be helpful for providing guidance for household cleaning methods for controlling pesticide residues. | Zhiling HU Yuchao TIAN Qingling ZHU Haijian LIU Nan LUO Fan WANG Ziyi ZHANG Furong LIU Chang LIU Mengrong CHENG | 2023 | Agricultural Biotechnology2023，12，6： | 0 |
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