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| 1 | An Improved Particle Swarm Optimization for Feature Selection显示文摘 | Yuanning Liu | 2011 | Journal of Bionic Engineering2011，8，2： | 13 |
| 2 | Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice显示文摘Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse Col1 a1-Cre transgene minimally impacts bone mass in mice, but deleting Kindlin-2 using the 10-kb mouse Dmp1-Cre transgene, which targets osteocytes and mature osteoblasts, results in striking osteopenia in mice. Kindlin-2 loss reduces the osteoblastic population but increases the osteoclastic and adipocytic populations in the bone microenvironment. Kindlin-2 loss upregulates sclerostin in osteocytes,downregulates β-catenin in osteoblasts, and inhibits osteoblast formation and differentiation in vitro and in vivo. Upregulation ofβ-catenin in the mutant cells reverses the osteopenia induced by Kindlin-2 deficiency. Kindlin-2 loss additionally increases the expression of RANKL in osteocytes and increases osteoclast formation and bone resorption. Kindlin-2 deletion in osteocytes promotes osteoclast formation in osteocyte/bone marrow monocyte cocultures, which is significantly blocked by an anti-RANKLneutralizing antibody. Finally, Kindlin-2 loss increases osteocyte apoptosis and impairs osteocyte spreading and dendrite formation.Thus, we demonstrate an important role of Kindlin-2 in the regulation of bone homeostasis and provide a potential target for the treatment of metabolic bone diseases. | Huiling Cao Qinnan Yan Dong Wang Yumei Lai Bo Zhou Qi Zhang Wenfei Jin Simin Lin Yiming Lei Liting Ma Yuxi Guo Yishu Wang Yilin Wang Xiaochun Bai Chuanju Liu Jian QFeng Chuanyue Wu Di Chen Xu Cao Guozhi Xiao | 2020 | Bone Research2020，8，1： | 8 |
| 3 | COVID-19 Cases Spread Through the K350 Train-Jilin and Heilongjiang Provinces,China,January 2021显示文摘As of 16∶00 on January 13,2021,95 positive cases of coronavirus disease 2019(COVID-19)were reported in Suihua City of Heilongjiang Province and an additional 35 cases have been linked across 7 cities in 3 provinces:Qiqihar City(7 cases),Mudanjiang City(4 cases),Harbin City(3 cases),and Yichun City(1 case)of Heilongjiang Province;Changchun City(9 cases)and Tonghua City(6 cases)of Jilin Province;and Weihai City of Shandong Province(1 case). | Lei Zhou Laishun Yao Peter Hao Chao Li Qinglong Zhao Huiling Dong Jinhua Dou Shengnan Wang George F.Gao Qun Li Biao Huang | 2021 | China CDC weekly2021，3，8： | 5 |
| 4 | Microelectronics-embedded channel bridging and signal regeneration of injured spinal cords显示文摘Due to the dificulty in spinal cord regeneration with biological methods,the microelectronic neural bridge,a new concept based on microelectronic technology,is presented.The microelectronic system has been realized in the forms of hybrid and integrated circuits.The integrated circuits forneural signal detection,stimulation,and regeneration are realized in a CMOS process.In animal experiments with 100 toads,48 rats,and 3 rabbits,nerve signals have been successfully detected from spinal cords and sciatic nerves,and functional electrical stimulation has been carried out for spinal cords and sciatic nerves.When the microelectronic system is bridged between the controlling and stimulated nerve,the relevant motion of legs and nerve signal waveforms,which are stimulated by the evoked or spontaneous nerve signal through such a system,have been observed.Therefore,the feasibility of the presented method was demonstrated. | Zhigong Wang Xiaosong Gu Xiaoying Lǔ Zhenglin Jiang Wenyuan Li Guangming Lǔ Yufeng Wang Xiaoyan Shen Xintai Zhao Huiling Wang Zhenyu Zhang Hongmei Shen Yang Wu Weixing Shen Jingyang Zhang Dong Chen Xiaoyi Mao Huaxiang Shen | 2009 | Progress in Natural Science:Materials International2009，19，10： | 5 |
| 5 | Fusaricidins in Paenibacillus polymyxa A21 and their antagonistic activity against Botrytis cinerea on tomato显示文摘Four kinds of antifungal compounds from an extract of Paenibacillus polymyxa A21 with molecular masses of 883.56, 897.59, 947.55, and 961.58 Da were characterized as the members of fusaricidin-type of antibiotics according to LC-MS analysis. Fusaricidins isolated from culture filtrate displayed high antagonistic activity against several plant fungal pathogens, especially Botrytis cinerea, the causal agent of gray mold. The fusaricidins biosynthetic gene cluster(BGC) from A21 was cloned by PCR and comparative cluster analysis revealed that gene fus TE, the 3′ boundary of the fusaricidin BGC in strain PKB1, was not present in fusaricidin BGC of A21, indicating that fus TE is not necessary for fusaricidin synthesis. Fusaricidin extract from A21 significantly reduced gray mold disease incidence and severity on tomato. The m RNA levels for three pathogenesis-related proteins(PRs) revealed that treatment of tomato leaves with fusaricidin extract induced the expression of PR genes to different levels, suggesting that one reason for the reduction of gray mold infection by fusaricidin is induction of PR proteins, which lead to increased resistance to pathogens. This is the first report of the application of fusaricidins to control tomato gray mold and the comparative cluster analysis provides important molecular basis for research on fusaricidin biosynthesis. | Weicheng LIU Xiaoli WU Xuelian BAI Hong ZHANG Dan DONG Taotao ZHANG Huiling WU | 2018 | Frontiers of Agricultural Science and Engineering2018，5，2： | 4 |
| 6 | A novel sprayable thermosensitive hydrogel coupled with zinc modified metformin promotes the healing of skin wound显示文摘A novel sprayable adhesive is established(ZnMet-PF127)by the combination of a thermosensitive hydrogel(Pluronic F127,PF127)and a coordination complex of zinc and metformin(ZnMet).Here we demonstrate that ZnMet-PF127 potently promotes the healing of traumatic skin defect and burn skin injury by promoting cell proliferation,angiogenesis,collagen formation.Furthermore,we find that ZnMet could inhibit reactive oxygen species(ROS)production through activation of autophagy,thereby protecting cell from oxidative stress induced damage and promoting healing of skin wound.ZnMet complex exerts better effects on promoting skin wound healing than ZnCl2 or metformin alone.ZnMet complex also displays excellent antibacterial activity against Staphylococcus aureus or Escherichia coli,which could reduce the incidence of skin wound infections.Collectively,we demonstrate that sprayable PF127 could be used as a new drug delivery system for treatment of skin injury.The advantages of this sprayable system are obvious:(1)It is convenient to use;(2)The hydrogel can cover irregular skin defect sites evenly in a liquid state.In combination with this system,we establish a novel sprayable adhesive(ZnMet-PF127)and demonstrate that it is a potential clinical treatment for traumatic skin defect and burn skin injury. | Zhengwei Liu Wanze Tang Jiayi Liu Yingying Han Qinnan Yan Yuechao Dong Xiaomei Liu Dazhi Yang Guixing Ma Huiling Cao | 2023 | Bioactive Materials2023，，2： | 3 |
| 7 | Reactive MnO_(2) template-assisted synthesis of double-shelled PPy hollow nanotubes to boost microwave absorption显示文摘Microwave absorbing materials(MAMs)with wide effective absorption bandwidth(EAB)and low filling ratio are highly desirable for practical applications.Rational design in components and structures is one of the effective strategies to achieve MAMs with high performance.Herein,double-shelled hollow(DSH)polypyrrole(PPy)nanotubes were synthesized with hydrochloric acid(HCl)and sodium pstyrene sulfonate(SS)co-doping polymerization process using manganese dioxide(MnO_(2))nanorods as a self-sacrifice template.With the increase of HCl concentration,the 1D MnO_(2) core diminishes gradually to form the MnO_(2)@PPy coaxial nanostructures and finally the DSH PPy nanotube,which tunes the microwave absorption performance.Importantly,the DSH PPy nanotubes exhibit excellent microwave absorption of an optimal reflection loss of–50.4 dB and a wide EAB of 7.7 GHz with a low filling ratio of 5 wt%in a paraffin wax matrix.The excellent microwave absorption is believed to be mainly attributed to the enhanced synergistic effects of interfacial polarization and conduction loss arising from the unique DSH structure and the co-doping polymerization. | Huiling Gu Ji Huang Na Li Hua Yang Gang Chen Chengjun Dong Chunhong Gong Hongtao Guan | 2023 | Journal of Materials Science & Technology2023，，15： | 3 |
| 8 | Cleaning using nanobubbles: Defouling by electrochemical generation of bubbles显示文摘 | Zhihua Wu Hongbing Chen Yaming Dong Huiling Mao Jielin Sun Shenfu Chen Vincent S.J. Craig Jun Hu | 2008 | Journal of Colloid And Interface Science2008，，1： | 1 |
| 9 | Decaffeination of fresh green tea leaf (Camellia sinensis) by hot water treatment显示文摘 | Huiling Liang Yuerong Liang Junjie Dong | 2007 | Food Chemistry2007，101，： | 1 |
| 10 | Co-occurrence of genes for antibiotic resistance and arsenic biotransformation in paddy soils显示文摘Paddy soils are potential hotspots of combined contamination with arsenic(As) and antibiotics, which may induce co-selection of antibiotic resistance genes(ARGs) and As biotransformation genes (ABGs), resulting in dissemination of antimicrobial resistance and modification in As biogeochemical cycling. So far, little information is available for these coselection processes and specific patterns between ABGs and ARGs in paddy soils. Here, the16S rRNA amplicon sequencing and high-throughput quantitative PCR and network analysis were employed to investigate the dynamic response of ABGs and ARGs to As stress and manure application. The results showed that As stress increased the abundance of ARGs and mobile genetic elements (MGEs), resulting in dissemination risk of antimicrobial resistance. Manure amendment increased the abundance of ABGs, enhanced As mobilization and methylation in paddy soil, posing risk to food safety. The frequency of the co-occurrence between ABGs and ARGs, the host bacteria carrying both ARGs and ABGs were increased by As or manure treatment, and remarkably boosted in soils amended with both As and manure. Multidrug resistance genes were found to have the preference to be co-selected with ABGs, which was one of the dominant co-occurring ARGs in all treatments, and manure amendment increased the frequency of Macrolide-Lincosamide-Streptogramin B resistance(MLSB) to co-occur with ABGs. Bacillus and Clostridium of Firmicutes are the dominant host bacteria carrying both ABGs and ARGs in paddy soils. This study would extend our understanding on the co-selection between genes for antibiotics and metals, also unveil the hidden environmental effects of combined pollution. | Huiling Cui Dong Zhu Longjun Ding YifeiWang Jianqiang Su Guilan Duan Yongguan Zhu | 2023 | Journal of Environmental Sciences2023，，3： | 1 |
| 11 | The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication显示文摘The coronavirus disease 2019(COVID-19)is a highly transmissible disease caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)that poses a major threat to global public health.Although COVID-19 primarily affects the respiratory system,causing severe pneumonia and acute respiratory distress syndrome in severe cases,it can also result in multiple extrapulmonary complications. | Qin Ning Di Wu Xiaojing Wang Dong Xi Tao Chen Guang Chen Hongwu Wang Huiling Lu Ming Wang Lin Zhu Junjian Hu Tingting Liu Ke Ma Meifang Han Xiaoping Luo | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 1 |
| 12 | Tea extraction methods in relation to control of tea catechins显示文摘 | LIANG Huiling LIANG Yuerong DONG Juejie | 2007 | Journal of the Science of Food and Agriculture2007，87，9： | 1 |
| 13 | Cleaning using nanobubbles: Defouling by electrochemical generation of bubbles显示文摘 | Zhihua Wu Hongbing Chen Yaming Dong Huiling Mao Jielin Sun Shenfu Chen Vincent S.J. Craig Jun Hu | 2008 | Journal of Colloid And Interface Science2008，，1： | 1 |
| 14 | Identification of the proliferation/differentiation switch in the cellular network of multicel- lular organisms显示文摘 | Xia Kai Xue Huiling Dong Dong | 2006 | PLoS Computational Biol2006，2，11： | 1 |
| 15 | Network Convergence and Service Convergence显示文摘Convergence is the main trend for future network development. The multi-service bearer network,built upon the Internet Protocol/Multi-protocol Label Switching (IP/MPLS) technology,is a converged network with Quality of Service (QoS) guarantee for business and enterprise customers. The integrated and unified service provisioning platform (including both service execution and development enviroments) can provide integrated audio,video and data services over multiple access networks. However,achieving network convergence and service convergence are long-term goals,which can only be realized step by step after comprehensive consideration of many factors like market demands,technologies,services and costs. | Zhao Huiling Dong Bin (Beijing Research Institute,China Telecom Corporation Limited,Beijing 100035,China) | 2007 | ZTE Communications2007，5，2： | 0 |
| 16 | Extraction,separation and refining of microcrystalline cellulose from wheat straw using various pretreatments显示文摘This study focused on the manufacture of microcrystalline cellulose(MCC)from wheat straw using environmentally-friendly solvents.Raw cellulose was separated from wheat straw after thermal decomposition of lignin followed by dissolution of lignin using a recyclable ethanol/acetic acid/water solvent system.Then,pure cellulose was produced using a four-step refining process,including chelating,O_(3),H_(2)O_(2),and xylanase treatments.Finally,MCC was obtained through hydrolysis,drying,and mechanical treatments.The effects of acetic acid,O_(3),H_(2)O_(2),NaOH,pretreatment time,and temperature on the properties of wheat straw cellulose(including Kappa number,yield,α-cellulose content,crystallinity,KMnO4 value,degree of polymerization(DP),and brightness)were investigated.The results showed that the addition of acetic acid enhanced lignin removal and hemicellulose degradation,improving the purity of the raw cellulose.The optimized acetic acid dosage in the wheat straw thermal decomposition step was 2%(w/w).The optimized O_(3)dosage was 1.2%(w/w).The optimized conditions for H_(2)O_(2)treatment were found to be 3%(w/w)H_(2)O_(2)and 1.8%(w/w)NaOH at 70°C for 120 min.The KMnO4 value was 2.0,brightness was 84.1%ISO,the viscosity was 934 mL/g,and the DP was 626 for refined cellulose.Xylanase effectively improved theα-cellulose content of wheat straw cellulose.With an optimized xylanase dosage of 1.5 IU/g,theα-cellulose content was 94.7%,the brightness was 85.6%ISO,and the DP was 615 for wheat straw cellulose. | Li Jinbao Dong Huiling Xiu Huijuan Zhang Meiyun Kamireddy Srinivas Reddy Zhang Xuefei Ji Yun | 2016 | International Journal of Agricultural and Biological Engineering2016，9，2： | 0 |
| 17 | Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO显示文摘The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector.Some of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator detectors.In this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/g.With ten years of data acquisition,approximately 60,000 signal and 30,000 background events are expected.This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework.IfDelta m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith angle.Moreover,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment. | Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera Daojin Hong YuenKeung Hor Shaojing Hou Yee Hsiung Bei-Zhen Hu Hang Hu Jianrun Hu Jun Hu Shouyang Hu Tao Hu Zhuojun Hu Chunhao Huang Guihong Huang Hanxiong Huang Qinhua Huang Wenhao Huang Xingtao Huang Yongbo Huang Jiaqi Hui Wenju Huo Cédric Huss Safeer Hussain Antonio Insolia Ara Ioannisian Daniel Ioannisyan Roberto Isocrate Kuo-Lun Jen Xiaolu Ji Xingzhao Ji Huihui Jia Junji Jia Siyu Jian Di Jiang Xiaoshan Jiang Ruyi Jin Xiaoping Jing Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Kampmann Li Kang Michael Karagounis Narine Kazarian Amir Khan Waseem Khan Khanchai Khosonthongkee Patrick Kinz Denis Korablev Konstantin Kouzakov Alexey Krasnoperov Svetlana Krokhaleva Zinovy Krumshteyn Andre Kruth Nikolay Kutovskiy Pasi Kuusiniemi Tobias Lachenmaier Cecilia Landini Sébastien Leblanc Frederic Lefevre Liping Lei Ruiting Lei Rupert Leitner Jason Leung Demin Li Fei Li Fule Li Haitao Li Huiling Li Jiaqi Li Jin Li Kaijie Li Mengzhao Li Nan Li Nan Li Qingjiang Li Ruhui Li Shanfeng Li Shuaijie Li Tao Li Weidong Li Weiguo Li Xiaomei Li Xiaonan Li Xinglong Li Yi Li Yufeng Li Zhibing Li Ziyuan Li Hao Liang Hao Liang Jingjing Liang Jiajun Liao Daniel Liebau Ayut Limphirat Sukit Limpijumnong Guey-Lin Lin Shengxin Lin Tao Lin Jiajie Ling Ivano Lippi Fang Liu Haidong Liu Hongbang Liu Hongjuan Liu Hongtao Liu Hu Liu Hui Liu Jianglai Liu Jinchang Liu Min Liu Qian Liu Qin Liu Runxuan Liu Shuangyu Liu Shubin Liu Shulin Liu Xiaowei Liu Yan Liu Alexey Lokhov Paolo Lombardi Claudio Lombardo Kai Loo Chuan Lu Haoqi Lu Jingbin Lu Junguang Lu Shuxiang Lu Xiaoxu Lu Bayarto Lubsandorzhiev Sultim Lubsandorzhiev Livia Ludhova Fengjiao Luo Guang Luo Pengwei Luo Shu Luo Wuming Luo Vladimir Lyashuk Qiumei Ma Si Ma Xiaoyan Ma Xubo Ma Jihane Maalmi Yury Malyshkin Fabio Mantovani Francesco Manzali Xin Mao Yajun Mao Stefano MMari Filippo Marini Sadia Marium Cristina Martellini Gisele Martin-Chassard Agnese Martini Davit Mayilyan Axel Müller Ints Mednieks Yue Meng Anselmo Meregaglia Emanuela Meroni David Meyhöfer Mauro Mezzetto Jonathan Miller Lino Miramonti Salvatore Monforte Paolo Montini Michele Montuschi Nikolay Morozov Pavithra Muralidharan Massimiliano Nastasi Dmitry VNaumov Elena Naumova Igor Nemchenok Alexey Nikolaev Feipeng Ning Zhe Ning Hiroshi Nunokawa Lothar Oberauer Juan Pedro Ochoa-Ricoux Alexander Olshevskiy Domizia Orestano Fausto Ortica Hsiao-Ru Pan Alessandro Paoloni Nina Parkalian Sergio Parmeggiano Teerapat Payupol Yatian Pei Nicomede Pelliccia Anguo Peng Haiping Peng Frédéric Perrot Pierre-Alexandre Petitjean Fabrizio Petrucci Luis Felipe Piñeres Rico Oliver Pilarczyk Artyom Popov Pascal Poussot Wathan Pratumwan Ezio Previtali Fazhi Qi Ming Qi Sen Qian Xiaohui Qian Hao Qiao Zhonghua Qin Shoukang Qiu Muhammad Rajput Gioacchino Ranucci Neill Raper Alessandra Re Henning Rebber Abdel Rebii Bin Ren Jie Ren Taras Rezinko Barbara Ricci Markus Robens Mathieu Roche Narongkiat Rodphai Aldo Romani Bedřich Roskovec Christian Roth Xiangdong Ruan Xichao Ruan Saroj Rujirawat Arseniy Rybnikov Andrey Sadovsky Paolo Saggese Giuseppe Salamanna Simone Sanfilippo Anut Sangka Nuanwan Sanguansak Utane Sawangwit Julia Sawatzki Fatma Sawy Michaela Schever Jacky Schuler Cédric Schwab Konstantin Schweizer Dmitry Selivanov Alexandr Selyunin Andrea Serafini Giulio Settanta Mariangela Settimo Muhammad Shahzad Vladislav Sharov Gang Shi Jingyan Shi Yongjiu Shi Vitaly Shutov Andrey Sidorenkov FedorŠimkovic Chiara Sirignano Jaruchit Siripak Monica Sisti Maciej Slupecki Mikhail Smirnov Oleg Smirnov Thiago Sogo-Bezerra Julanan Songwadhana Boonrucksar Soonthornthum Albert Sotnikov Ondrej Sramek Warintorn Sreethawong Achim Stahl Luca Stanco Konstantin Stankevich DušanŠtefánik Hans Steiger Jochen Steinmann Tobias Sterr Matthias Raphael Stock Virginia Strati Alexander Studenikin Gongxing Sun Shifeng Sun Xilei Sun Yongjie Sun Yongzhao Sun Narumon Suwonjandee Michal Szelezniak Jian Tang Qiang Tang Quan Tang Xiao Tang Alexander Tietzsch Igor Tkachev Tomas Tmej Konstantin Treskov Andrea Triossi Giancarlo Troni Wladyslaw Trzaska Cristina Tuve Stefan van Waasen Johannes van den Boom Guillaume Vanroyen Nikolaos Vassilopoulos Vadim Vedin Giuseppe Verde Maxim Vialkov Benoit Viaud Cristina Volpe Vit Vorobel Lucia Votano Pablo Walker Caishen Wang Chung-Hsiang Wang En Wang Guoli Wang Jian Wang Jun Wang Kunyu Wang Lu Wang Meifen Wang Meng Wang Ruiguang Wang Siguang Wang Wei Wang Wenshuai Wang Xi Wang Xiangyue Wang Yangfu Wang Yaoguang Wang Yi Wang Yifang Wang Yuanqing Wang Yuman Wang Zhe Wang Zheng Wang Zhimin Wang Zongyi Wang Apimook Watcharangkool Lianghong Wei Wei Wei Yadong Wei Liangjian Wen Christopher Wiebusch Steven Chan-Fai Wong Bjoern Wonsak Diru Wu Fangliang Wu Qun Wu Wenjie Wu Zhi Wu Michael Wurm Jacques Wurtz Christian Wysotzki Yufei Xi Dongmei Xia Yuguang Xie Zhangquan Xie Zhizhong Xing Benda Xu Donglian Xu Fanrong Xu Jilei Xu Jing Xu Meihang Xu Yin Xu Yu Xu Baojun Yan Xiongbo Yan Yupeng Yan Anbo Yang Changgen Yang Huan Yang Jie Yang Lei Yang Xiaoyu Yang Yifan Yang Haifeng Yao Zafar Yasin Jiaxuan Ye Mei Ye Ugur Yegin Frédéric Yermia Peihuai Yi Xiangwei Yin Zhengyun You Boxiang Yu Chiye Yu Chunxu Yu Hongzhao Yu Miao Yu Xianghui Yu Zeyuan Yu Chengzhuo Yuan Ying Yuan Zhenxiong Yuan Ziyi Yuan Baobiao Yue Noman Zafar Andre Zambanini Pan Zeng Shan Zeng Tingxuan Zeng Yuda Zeng Liang Zhan Feiyang Zhang Guoqing Zhang Haiqiong Zhang Honghao Zhang Jiawen Zhang Jie Zhang Jingbo Zhang Peng Zhang Qingmin Zhang Shiqi Zhang Tao Zhang Xiaomei Zhang Xuantong Zhang Yan Zhang Yinhong Zhang Yiyu Zhang Yongpeng Zhang Yuanyuan Zhang Yumei Zhang Zhenyu Zhang Zhijian Zhang Fengyi Zhao Jie Zhao Rong Zhao Shujun Zhao Tianchi Zhao Dongqin Zheng Hua Zheng Minshan Zheng Yangheng Zheng Weirong Zhong Jing Zhou Li Zhou Nan Zhou Shun Zhou Xiang Zhou Jiang Zhu Kejun Zhu Honglin Zhuang Liang Zong Jiaheng Zou | 2021 | Chinese Physics C2021，45，2： | 0 |
| 18 | Current Effect of“4+7”Drug Centralized Volume Procurement and Suggestions for Future Improvement显示文摘Objective To explore the impact of the“4+7”city drug centralized procurement policy implemented from April 1st,2019 on China’s pharmaceutical market and the differences between this pilot scheme and the first volume procurement,so as to put forward some suggestions for this policy and improve the drug price formation mechanism.Methods The characteristics of the“4+7”volume procurement policy and its improvements were summarized through literature research,and the distribution of the winning enterprises in volume procurement was shown by the chart.Then the overall situation of pharmaceutical enterprises in China was analyzed.Results and Conclusion According to the main distribution of enterprises in the alliance region,we can see that the first round of bid-winning enterprises with 25 varieties are mainly distributed in the eastern coastal cities of Jiangsu,Zhejiang,Shandong,and Guangdong,which shows a trend of developing to provinces of Sichuan,Hubei,and Hunan.With the increase of volume procurement inland cities will be included in the future.This pilot scheme of volume procurement is a reform of the entire pharmaceutical industry.It has improved the market structure and promoted the transformation and upgrading of regional medicine representatives.The most important thing is to enable the public to better enjoy the benefits brought by the low-priced drugs.However,for some pharmaceutical enterprises and drug retail industry,it is a challenge.Therefore,it is necessary to improve the policy and strengthen market supervision and management. | Piao Huiling Wei Xingchen Wang Nan Wang Xing Zhou Yusheng Dong Li | 2020 | Asian Journal of Social Pharmacy2020，15，4： | 0 |
| 19 | The role of E3 ubiquitin ligases in bone homeostasis and related diseases显示文摘The ubiquitin-proteasome system(UPS)dedicates to degrade intracellular proteins to modulate demic homeostasis and functions of organisms.These enzymatic cascades mark and modifies target proteins diversly through covalently binding ubiquitin molecules.In the UPS,E3 ubiquitin ligases are the crucial constituents by the advantage of recognizing and presenting proteins to proteasomes for proteolysis.As the major regulators of protein homeostasis,E3 ligases are indispensable to proper cell manners in diverse systems,and they are well described in physiological bone growth and bone metabolism.Pathologically,classic bone-related diseases such as metabolic bone diseases,arthritis,bone neoplasms and bone metastasis of the tumor,etc.,were also depicted in a UPS-dependent manner.Therefore,skeletal system is versatilely regulated by UPS and it is worthy to summarize the underlying mechanism.Furthermore,based on the current status of treatment,normal or pathological osteogenesis and tumorigenesis elaborated in this review highlight the clinical significance of UPS research.As a strategy possibly remedies the limitations of UPS treatment,emerging PROTAC was described comprehensively to illustrate its potential in clinical application.Altogether,the purpose of this review aims to provide more evidence for exploiting novel therapeutic strategies based on UPS for bone associated diseases. | Yuechao Dong Yangshan Chen Guixing Ma Huiling Cao | 2023 | Acta Pharmaceutica Sinica B2023，13，10： | 0 |
| 20 | Microglial Depletion does not Afect the Laterality of Mechanical Allodynia in Mice显示文摘Mechanical allodynia(MA),including punctate and dynamic forms,is a common and debilitating symptom suffered by millions of chronic pain patients.Some peripheral injuries result in the development of bilateral MA,while most injuries usually led to unilateral MA.To date,the control of such laterality remains poorly understood.Here,to study the role of microglia in the control of MA laterality,we used genetic strategies to deplete microglia and tested both dynamic and punctate forms of MA in mice.Surprisingly,the depletion of central microglia did not prevent the induction of bilateral dynamic and punctate MA.Moreover,in dorsal root ganglion-dorsal root-sagittal spinal cord slice preparations we recorded the low-threshold Aβ-fiber stimulation-evoked inputs and outputs of superficial dorsal horn neurons.Consistent with behavioral results,microglial depletion did not prevent the opening of bilateral gates for Aβpathways in the superficial dorsal horn.This study challenges the role of microglia in the control of MA laterality in mice.Future studies are needed to further understand whether the role of microglia in the control of MA laterality is etiology-or species-specific. | Quan Ma Dongmei Su Jiantao Huo Guangjuan Yin Dong Dong Kaifang Duan Hong Cheng Huiling Xu Jiao Ma Dong Liu Bin Mou Jiyun Peng Longzhen Cheng | 2023 | Neuroscience Bulletin2023，39，8： | 0 |
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