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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 3 | Percent free prostate-specific antigen for prostate cancer diagnosis in Chinese men with a PSA of 4.0-10.0 ng/mL:Results from the Chinese Prostate Cancer Consortium显示文摘Objective:To test the diagnostic performance of percent free prostate-specific antigen(%fPSA)in predicting any prostate cancer(PCa)and high-grade prostate cancer(HGPCa)in a retrospective multi-center biopsy cohort with a PSA level of 4.0e10.0 ng/mL in China.Methods:Consecutive patients with a PSA of 4.0-10.0 ng/mL who underwent transrectal ultrasound-guided biopsy were enrolled at 16 Chinese medical centers from January 1st,2010 to December 31st,2013.Total and free serum PSA determinations were performed using three types of electro-chemiluminescence immunoassays recalibrated to the World Health Organization(WHO)standard.The diagnostic accuracy of PSA,%fPSA,and %fPSA in combination with PSA(%fPSA t PSA)was determined using the area under the receiver operating characteristic(ROC)curve(AUC).Results:A total of 2310 consecutive men with PSA levels between 4.0 and 10.0 ng/mL were included,and the detection rate of PCa was 25.1%.The AUC of%fPSA and %fPSA t PSA in predicting any PCa was superior to PSA alone in men aged≥60 years(0.623 vs.0.534,p<0.0001)but not in men aged 40e59 years(0.517 vs.0.518,p=0.939).Similar result was yield in predicting HGPCa.Conclusion:In a clinical setting of Chinese men with 4.0e10.0 ng/mL PSA undergoing initial prostate biopsy,adding %fPSA to PSA can moderately improve the diagnostic accuracy for any PCa and HGPCa compared with PSA alone in patients≥60 but not in patients aged 40-59 years. | Rui Chen Liping Xie Xiaobing Cai Yiran Huang Liqun Zhou Lulin Ma Xu Gao Chuanliang Xu Shancheng Ren Pengfei Shao Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Li Lu Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tie Zhou Fubo Wang Biming He Yinghao Sun | 2015 | Asian Journal of Urology2015，2，2： | 8 |
| 4 | Overactive bladder symptom score to evaluate efficacy of solifenacin for the treatment of overactive bladder symptoms显示文摘 | Liu Ming Wang Jianye Yang Yong An Ruihua Wen Jianguo Guan Zhichen Zheng Shaobin Wang Dongwen Song Bo Liao Limin Guo Hongqian Xiao Jiaquan Sun Yinghao Shen Zhoujun Kong Chuize He Dalin Huang Yiran Wang Xiaofeng Zhang Xu Li Hanzhong Huang Jian Zhao Xiaokun Zeng Puqing Song Xishuang Ye Zhangqun | 2014 | Chinese Medical Journal2014，，2： | 7 |
| 5 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 6 | A phase 3,double-blind,randomized placebo-controlled efficacy and safety study of abiraterone acetate in chemotherapynaı¨ve patients with mCRPC in China,Malaysia,Thailand and Russia显示文摘Objective:This double-blind,placebo-controlled phase 3 study was designed to compare efficacy and safety of abiraterone acetate+prednisone(abiraterone)to prednisone alone in chemotherapy-naı¨ve,asymptomatic or mildly symptomatic metastatic castrationresistant prostate cancer(mCRPC)patients from China,Malaysia,Thailand and Russia.Methods:Adult chemotherapy-naı¨ve patients with confirmed prostate adenocarcinoma,Eastern Cooperative Oncology Group(ECOG)performance status(PS)grade 0e1,ongoing androgen deprivation(serum testosterone<50 ng/dL)with prostate specific antigen(PSA)or radiographic progression were randomized to receive abiraterone acetate(1000 mg,QD)t prednisone(5 mg,BID)or placebo t prednisone(5 mg,BID),until disease progression,unacceptable toxicity or consent withdrawal.Primary endpoint was improvements in time to PSA progression(TTPP).Results:Totally,313 patients were randomized(abiraterone:n Z 157;prednisone:n Z 156);and baseline characteristics were balanced.At clinical cut-off(median follow-up time:3.9 months),80% patients received treatment(abiraterone:n Z 138,prednisone:n Z 112).Median time to PSA progression was not reached with abiraterone versus 3.8 months for prednisone,attaining 58%reduction in PSA progression risk(HR=0.418;p<0.0001).Abirateronetreated patients had higher confirmed PSA response rate(50%vs.21%;relative odds=2.4;p<0.0001)and were 5 times more likely to achieve radiographic response than prednisonetreated patients(22.9%vs.4.8%,p=0.0369).Median survival was not reached.Most common(≥10% abiraterone vs.prednisone-treated)adverse events:bone pain(7%vs.14%),pain in extremity(6%vs.12%),arthralgia(10%vs.8%),back pain(7%vs.11%),and hypertension(15%vs.14%).Conclusion:Interim analysis confirmed favorable benefit-to-risk ratio of abiraterone in chemotherapy-naı¨ve men with mCRPC,consistent with global study,thus supporting use of abiraterone in this patient population. | Dingwei Ye Yiran Huang Fangjian Zhou Keji Xie Vsevolod Matveev Changling Li Boris Alexeev Ye Tian Mingxing Qiu Hanzhong Li Tie Zhou Peter De Porre Margaret Yu Vahid Naini Hongchuan Liang Zhuli Wu Yinghao Sun | 2017 | Asian Journal of Urology2017，4，2： | 3 |
| 7 | Hardness, quench sensitivity, and electrical conductivity of 7xxx Al alloys with high Zn concentrations显示文摘In this study,7 xxx(Al-Zn-Mg-Cu)alloys with high Zn concentrations were fabricated by increasing the Zn contents of 7085 Al alloys.The hardness,quench sensitivity,and electrical conductivity of the alloys and a 7085 Al alloy under peak-aged state were studied.The high Zn concentration alloys had higherη′phase densities and lower quantities of Mg solid atoms than the 7085 Al alloy and thus exhibited higher hardness and electrical conductivity.The high Zn concentration alloys also exhibited slightly higher quench sensitivity than 7085 Al alloy,and the depth of the quenching layer of the alloy with 11.27 wt%Zn content reached 100 mm.This work confirmed that the novel 7 xxx alloy with high Zn concentration showed balanced performance,exhibiting enhanced hardness and conductivity and reasonable quench sensitivity compared with the 7085 commercial Al alloy. | PENG YingHao LIU ChongYu MA ZongYi JIANG HongJie HUANG HongFeng | 2020 | Science China(Technological Sciences)2020，63，6： | 3 |
| 8 | Long Noncoding RNA MALAT-1 is a New Potential Therapeutic Target for Castration-Resistant Prostate Cancer显示文摘 | Shancheng Ren Yawei Liu Weidong Xu Yi Sun Ji Lu Fubo Wang Min Wei Jian Shen Jianguo Hou Xu Gao Chuanliang Xu Jiaoti Huang Yi Zhao Yinghao Sun | 2013 | The Journal of Urology2013，，： | 2 |
| 9 | Influence of Bedding and Mineral Composition on Mechanical Properties and Its Implication for Hydraulic Fracturing of Shale Oil Reservoirs显示文摘The premise of hydraulic fracturing is to have an accurate and detailed understanding of the rock mechanical properties and fracture propagation law of shale reservoirs. In this paper,a comprehensive evaluation of the mechanical properties of the shale oil reservoir in the south of Songliao Basin is carried out. Based on the experiments and the in-situ stress analysis, the fracture propagation law of three types of shale reservoirs is obtained,and the suggestions for fracturing are put forward. The results have shown that the fracture propagation of pure shale and low mature reservoir is easy to open along the bedding plane under compression loading,which is greatly influenced by the bedding. Sand-bearing shale is slightly better,the fractures of which are not easy to open along the bedding plane. The mechanical experimental results show that all the samples have the characteristics of low compressive strength,low Young’s modulus and strong anisotropy,indicating that the shale oil reservoir is certain plastic,which is related to its high clay mineral content and controlled by the bedding development. Compared with pure shale and low mature shale,the sandbearing shale has less clay content and less developed bedding,which maybe the main reason for its slightly better brittleness. Overall,the expansion of hydraulic fracture is controlled by in-situ stress and bedding. Because of the development of bedding,it is easy to form horizontal fractures. Thus it is not suitable for horizontal well fracturing.Because of the high content of clay minerals,the applicability of conventional slick hydraulic fracturing fluid is poor. It is suggested to use vertical well or directional well to carry out volume fracturing. In this way,the effect of bedding can be effectively used to open and connect the bedding and form a larger fracture network. | WANG Xiaoqiong XU Jianguo ZHAO Chenxu LIU Tongyuan GE Hongkui SHEN Yinghao WU Shan YU Jiayao HUANG Rongyan | 2020 | Earthquake Research in China2020，34，2： | 2 |
| 10 | A comprehensive analysis of the Bencao(herbal)small RNA Atlas reveals novel RNA therapeutics for treating human diseases显示文摘Cross-kingdom herbal mi RNA was first reported in 2012.Using a modified herbal extraction protocol,we obtained 73,677,287sequences by RNA-seq from 245 traditional Chinese Medicine(TCM),of which 20,758,257 were unique sequences.We constructed a Bencao(herbal)small RNA(s RNA)Atlas(http://gffzz4a3adbfa122d4a47hxkk05xwxcfcw69vf.ffgz.tsg.suse.edu.cn),annotated the sequences by sequence-based clustering,and created a nomenclature system for Bencao s RNAs.The profiles of 21,757 mi RNAs in the Atlas were highly consistent with those of plant mi RNAs in mi RBase.Using software tools,our results demonstrated that all human genes might be regulated by s RNAs from the Bencao s RNA Atlas,part of the predicted human target genes were experimentally validated,suggesting that Bencao s RNAs might be one of the main bioactive components of herbal medicines.We established roadmaps for oligonucleotide drugs development and optimization of TCM prescriptions.Moreover,the decoctosome,a lipo-nano particle consisting of 0.5%–2.5%of the decoction,demonstrated potent medical effects.We propose a Bencao(herbal)Index,including small-molecule compounds(SM),protein peptides(P),nucleic acid(N),non-nucleic and non-proteinogenic large-molecule compounds(LM)and elements from Mendeleev's periodic table(E),to quantitatively measure the medical effects of botanic medicine.The Bencao s RNA Atlas is a resource for developing gene-targeting oligonucleotide drugs and optimizing botanical medicine,and may provide potential remedies for the theory and practice of one medicine. | Yinghao Cao Yexuan Lin Na Sun Xinyi Du Yixin Dong Song Mei Xingyu Deng Xiaobei Li Shaoting Guo Kegong Tang Jiaqi Liu Xiangyu Qiao Dandan Zhao Yuhao Qin Cong Zhang Tianyi Xin Xiaohu Shi Congzhao Zhou Tao Dong De-an Guo Benedikt MKessler Dong Xu Jingyuan Song Fengming Huang Xiaoyue Wang Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，10： | 2 |
| 11 | Fly Ash/Paraffin Composite Phase Change Material Used to Treat Thermal and Mechanical Properties of Expansive Soil in Cold Regions显示文摘Phase change materials(PCMs)can store large amounts of energy in latent heat and release it during phase changes,which could be used to improve the freeze-thaw performance of soil.The composite phase change material was prepared with paraffin as the PCM and 8%Class C fly ash(CFA)as the supporting material.Laboratory tests were conducted to reveal the influence of phase change paraffin composite Class C fly ash(CFA-PCM)on the thermal properties,volume changes and mechanical properties of expansive soil.The results show that PCM failed to establish a good improvement effect due to leakage.CFA can effectively adsorb phase change materials,and the two have good compatibility.CFA-PCM reduces the volume change and strength attenuation of the soil,and 8 wt.%PCM is the optimal content.CFA-PCM turns the phase change latent heat down of the soil and improves its thermal stability.CFA-PCM makes the impact small of freeze-thaw on soil pore structure damage and improves soil volume change and mechanical properties on a macroscopic scale.In addition,CFA-8 wt.%PCM treated expansive soil has apparent advantages in resisting repeated freeze-thaw cycles,providing a reference for actual engineering design. | Yong Chen Yinghao Huang Min Wu Shuo Wang | 2022 | Journal of Renewable Materials2022，10，4： | 2 |
| 12 | FeCo-based mesoporous carbon shells modified N-doped porous carbon spheres for oxygen reduction reaction显示文摘Fe Co-based non-noble metal electrocatalysts(NNMEs)of Fe Co/MCS-NPCS was fabricated by immobilization of hemin on mesoporous carbon shells modified N-doped porous carbon spheres(MCS-NPCS).The obtained Fe Co/MCS-NPCS exhibits a half-wave potential(E1/2)of 0.851 V versus the reversible hydrogen electrode(vs.RHE)and a limited-diffusion current density(JL)of 5.45 m A cm^(-2).In addition,Fe Co/MCS-NPCS shows comparable oxygen reduction reaction(ORR)performances to 20 wt%Pt/C in terms of E1/2 and JL and better electrochemical properties,including the methanol tolerance and durability in alkaline solution.Such outstanding electrochemical activities of Fe Co/MCS-NPCS can be ascribed to Fe and/or Co-based nitrides and carbides as well as N-doped carbon matrixes modified with mesoporous carbon shells.This research introduces a promising path to design and synthesize highly efficient Fe Co–N–C electrocatalysts towards ORR. | Xinxin Jin Yan Xie Chaoyue Zhao Yinghao Xu Yang Lv He Wang Li Chen Jiahui Huang | 2021 | Progress in Natural Science:Materials International2021，31，4： | 1 |
| 13 | Changeof Mechanical Behavior Between Solidified andRemolded Solidified Dredged Materials显示文摘 | Huang Yinghao Zhu Wei Qian Xuede | 2011 | EngineeringGeology2011，119，4： | 1 |
| 14 | Silencing of CXCR4 by RNA interference inhibits cell growth and metastasisin human renal cancer cells显示文摘 | Linhui Wang Ting Huang Wei Chen Xiaofeng Gao Tie Zhou Zhenjie Wu Yinghao Sun | 2012 | Oncology Reports2012，，6： | 1 |
| 15 | BAX and CDKN1A polymorphisms correlated with clinical outcomes of gastric cancer patients treated with postoperative chemotherapy显示文摘 | Xiaoting Wang Youdong Lin Fenghua Lan Yinghao Yu Xuenong Ouyang Wei Liu Feilai Xie Xuzhou Wang Qiaojia Huang | 2014 | Medical Oncology2014，，： | 1 |
| 16 | Change of Mechanical Behavior Between Solidified and Remolded Solidified Dredged Materials显示文摘 | Huang Yinghao Zhu Wei Qian Xuede | 2011 | Engineering Geology2011，119，34： | 1 |
| 17 | Silencing of CXCR4 by RNA interference inhibits cell growth and metastasisin human renal cancer cells显示文摘 | Linhui Wang Ting Huang Wei Chen Xiaofeng Gao Tie Zhou Zhenjie Wu Yinghao Sun | 2012 | Oncology Reports2012，，6： | 1 |
| 18 | Prognostic value of differential CCND1 expression in patients with resected gastric adenocarcinoma显示文摘 | Liqiang Ma Xiaoting Wang Fenghua Lan Yinghao Yu Xuenong Ouyang Wei Liu Feilai Xie Qiaojia Huang | 2015 | Medical Oncology2015，，1： | 1 |
| 19 | Promotion of photocatalytic steam reforming of methane over Ag^0/Ag^+-SrTiO3显示文摘Methane(CH4)is not only used as a fuel but also as a promising clean energy source for hydrogen generation.The steam reforming of CH4(SRM)using photocatalysts can realize the production of syngas(CO+H2)with low energy consumption.In this work,Ag0/Ag+-loaded SrTi03 nanocomposites were successfully prepared through a photodeposition method.When the loading amount of Ag is 0.5 mol%,the atom ratio of Ag+to Ag0 was found to be 51:49.In this case,a synergistic effect of Ago and Ag+was observed,in which Ago was proposed to improve the adsorption of H2 O to produce hydroxyl radicals and enhance the utilization of light energy as well as the separation of charge carriers.Meanwhile,Ag0 was regarded as the reduction reaction site with the function of an electron trapping agent.In addition,Ag+adsorbed the CH4 molecules and acted as the oxidation reaction sites in the process of photocatalytic SRM to further promote electron-hole separation.As a result,0.5 mol%Ag-SrTi03 exhibited enhancement of photocatalytic activity for SRM with the highest CO production rate of 4.3μmol g-1 h-1,which is ca.5 times higher than that of pure SrTi03.This work provides a facile route to fabricate nanocomposite with cocatalyst featuring different functions in promoting photocatalytic activity for SRM. | Bingqing Tan Yinghao Ye Zeai Huang Liqun Ye Minzhi Ma Ying Zhou | 2020 | Chinese Chemical Letters2020，31，6： | 0 |
| 20 | DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells显示文摘氧化地损坏的蛋白质的及时移动为暴露于氧化压力的房间是批评的;然而,为变清的细胞的机制氧化了蛋白质不是清楚的。我们的学习揭示可以在指向氧化蛋白质起一个作用并且移开他们的蛋白质修正的一种新奇类型。在这个过程, DSS1 (在裂口传递 / 切开脚 1 删除了) ,进化地保存的小蛋白质,被结合到氧化压力在 vitro 并且在 vivo 导致的蛋白质,暗示氧化蛋白质是 DSS1 顾客。指向 DSS1 蛋白质的随后的 ubiquitination 使内收被观察了,建议顾客蛋白质通过 ubiquitin-proteasome 小径被降级。到它的顾客的 DSS1 附件被证实是未辩别出的 ATPase 调制的一个酶的过程。我们作为 DSSylation 说出这新奇蛋白质修正在哪个 DSS1 作为一个修饰词玩,谁的附件可以显示目标蛋白质导致他们的随后的 ubiquitination 的签名,从而降级的成员 proteasome 他们。 | Yinghao Zhang Fang-Mei Chang Jianjun Huang Jacob J. Junco Shivani K. Maffi Hannah I. Pridgen Gabriel Catano Hong Dang Xiang Ding Fuquan Yang Dae Joon Kim Thomas J. Slaga Rongqiao He Sung-Jen Wei | 2014 | Protein & Cell2014，5，2： | 0 |
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