|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Liraglutide alleviates cardiac fibrosis through inhibiting P4hα-1 expression in STZ-induced diabetic cardiomyopathy显示文摘Diabetic cardiomyopathy is an important contributor to morbidity and mortality of diabetic patients by causing heart failure.Interstitial and perivascular fibrosis plays a crucial role in diabetic cardiomyopathy.However,there is a lack of effective specific treatments available for diabetic cardiomyopathy.In the present study,we aim to explore the effects of Liraglutide,a GLP-1 analogue,on diabetic cardiomyopathy in STZ-induced diabetic rats fed with high-fat diet.A total of 60 male Wistar rats were randomly assigned to three groups,i.e.normal group,model group,and Liraglutide group,with 20 rats in each group.Serum levels of TC,TG,LDL-C,NEFA,and hydroxyproline were measured using commercial kits.Cardiac function was evaluated by QRS waves,LVEDd,LVESd,and LVEF.Myocardial fibrosis was measured by immunohistochemistry.Our results demonstrated that chronic administration of Liraglutide decreased the level of blood glucose and significantly alleviated lipid metabolic disturbance compared with the model group.Furthermore,Liraglutide was found to improve the damaged cardiac function.In line with this,we also found that the alleviation of cardiac dysfunction was associated with the decreased fibrosis in diabetic myocardial tissues,which was reflected by the decreased expressions of P4hα-1,COL-1,COL-3,MMP-1,and MMP-9.Our results thus suggest that Liraglutide might have a myocardial protective effect by inhibiting P4hα-1-mediated myocardial fibrosis. | Tong Zhao Huiqiang Chen Fei Xu Juan Wang Yusheng Liu Xiaowei Xing Linlin Guo Mingxiang Zhang Qinghua Lu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 9 |
| 2 | Robust Dataset Classification Approach Based on Neighbor Searching and Kernel Fuzzy C-Means显示文摘Dataset classification is an essential fundament of computational intelligence in cyber-physical systems(CPS).Due to the complexity of CPS dataset classification and the uncertainty of clustering number,this paper focuses on clarifying the dynamic behavior of acceleration dataset which is achieved from micro electro mechanical systems(MEMS)and complex image segmentation.To reduce the impact of parameters uncertainties with dataset classification,a novel robust dataset classification approach is proposed based on neighbor searching and kernel fuzzy c-means(NSKFCM)methods.Some optimized strategies,including neighbor searching,controlling clustering shape and adaptive distance kernel function,are employed to solve the issues of number of clusters,the stability and consistency of classification,respectively.Numerical experiments finally demonstrate the feasibility and robustness of the proposed method. | Li Liu Aolei Yang Wenju Zhou Xiaofeng Zhang Minrui Fei Xiaowei Tu | 2015 | IEEE/CAA Journal of Automatica Sinica2015，2，3： | 7 |
| 3 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 4 | Patterns and security technologies for co-extraction of coal and gas in deep mines without entry pillars显示文摘 | Nong Zhang Fei Xue Nianchao Zhang Xiaowei Feng | 2015 | International Journal of Coal Science & Technology2015，2，1： | 5 |
| 5 | Mea6 controls VLDL transport through the coordinated regulation of COPil assembly显示文摘 | Yaqing Wang Liang Liu Hongsheng Zhang Junwan Fan FengZhang Mei Yu Lei Shi Lin Yang Sin Man Lam Huimin Wang Xiaowei Chen Yingchun Wang Fei Gao Guanghou Shui Zhiheng Xu | 2016 | Cell Research2016，26，7： | 4 |
| 6 | Effect of rolling deformation on microstructure and texture of spray-deposited magnesium alloy containing Mg-Nd-Zn typed LPSO显示文摘Billets of Mg-9Al-3Zn-1Mn-6Ca-2Nd alloy were produced by spray-deposition(the Osprey process).Effect of rolling deformation(T = 350?C, ε = 5%, 10%, and 15%, respectively) on microstructure and texture evolution of the Mg-9Al-3Zn-1Mn-6Ca-2Nd alloy was investigated by scanning electron microscopy(SEM), transmission electron microscopy(TEM) and X-ray diffraction(XRD). Results show that at pass reduction of ε = 5%, 10% and 15% at 350?C respectively, Mg-Nd-Zn typed 24R-LPSO structure was formed in(Ca, Nd)Al2phase(C15 Laves phase). With the increase in pass reduction(i.e. 5%, 10% and 15%), the texture pole density level of basal texture(0002) changed little and pyramidal texture(10 1ˉ3) were increased.In contrast, those of prismatic texture {101ˉ0} <11 2ˉ0> were increased initially and followed by a reduction, indicating texture randomization in the grain-refined Mg alloy. The combined contribution of LPSO phase and C15 phase was key to randomize the texture of the grain-refined Mg alloy. It was noted that the microcosmic plastic deformation of LPSO phase and nanometer-sized dispersed C15 phase impeded dislocation movement, led to dislocation tangles, and facilitated recrystallization. | Zhenliang Li Fei Liu Aiping Yuan Baoyu Duan Yiming Li Xiaowei Li | 2017 | Journal of Materials Science & Technology2017，33，7： | 3 |
| 7 | Effect of competition on spatial patterns of oak forests on the Chinese Loess Plateau显示文摘Reforestation or natural forest regeneration is an alternative measure for controlling soil erosion in degraded land on the Chinese Loess Plateau(CLP). However, our understanding of the temporal dynamics and the spatial patterns of forest regeneration remains inadequate. Two oak forests at different development stages were investigated to determine the spatial patterns of competitions(intraspecies and interspecies) during different successional stages. The intraspecies and interspecies spatial relationships among different tree diameters at breast height were analyzed at multiple scales by Kriging interpolation method and univariate and bivariate O-ring statistics. Our analytical results indicated that self-correlation and competition intensity were relatively high between oak and pine trees in the early development stage of oak forests due to their clumped distributions of heavy seeds. Birch trees had a lower competition in comparison to oak trees although birch was the dominant species. Therefore, asymmetric competition of oak trees was most likely to have led to their edge dispersal and their success in replacing the pioneer species. Asymmetric competition means that larger individuals obtained a disproportionately large share of the resources and suppressed the growth of smaller individuals. Kriging interpolation analysis showed a tendency towards homogenization caused by interspecies competition during the succession of oak forests. Our results demonstrated that the competition was the driving factor in the spatial distribution of oak forests on the CLP. | KANG Di DENG Jian QIN Xiaowei HAO Fei GUO Shujuan HAN Xinhui YANG Gaihe | 2017 | Journal of Arid Land2017，9，1： | 3 |
| 8 | Compositional and structural study of ash deposits spatially distributed in superheaters of a large biomass-fired CFB boiler显示文摘Recognizing the nature and formation progress of the ash deposits is essential to resolve the deposition problem hindering the wide application of large-scale biomass-fired boilers.Therefore,the ash deposits in the superheaters of a 220 t/h biomass-fired CFB boiler were studied,including the platen(PS),the high-temperature(HTS),the upper and the lower low-temperature superheaters(LTS).The results showed that the deposits in the PSs and HTSs were thin(several millimeters)and compact,consisting of a yellow outer layer and snow-white inner layer near the tube surface.The deposits in the upper LTS appeared to be toughly sintered ceramic,while those in the lower LTS were composed of dispersive coarse ash particles with an unsintered surface.Detailed characterization of the cross-section and the initial layers in the deposits revealed that the dominating compositions in both the PSs and the HTSs were Cl and K(approximately 70%)in the form of KCl.Interestingly,the cross-section of the deposition in the upper LTS exhibited a unique lamellar structure with a major composition of Ca and S.The contents of Ca and Si increased from approximately 10%to approximately 60%in the deposits from the high temperature surfaces to the low temperature ones.It was concluded that the vaporized mineral matter such as KCl played the most important role in the deposition progress in the PS and the HTS.In addition,although the condensation of KCl in the LTSs also happened,the deposition of ash particles played a more important role. | Yishu XU Xiaowei LIU Jiuxin QI Tianpeng ZHANG Minghou XU Fangfang FEI Dingqing LI | 2021 | Frontiers in Energy2021，15，2： | 3 |
| 9 | Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes显示文摘The vagina contains at least a billion microbial cells,dominated by lactobacilli.Here we perform metagenomic shotgun sequencing on cervical and fecal samples from a cohort of 516 Chinese women of reproductive age,as well as cervical,fecal,and salivary samples from a second cohort of 632 women.Factors such as pregnancy history,delivery history,cesarean section,and breastfeeding were all more important than menstrual cycle in shaping the microbiome,and such information would be necessary before trying to interpret differences between vagino-cervical microbiome data.Greater proportion of Bifidobacterium breve was seen with older age at sexual debut.The relative abundance of lactobacilli especially Lactobacillus crispatus was negatively associated with pregnancy history.Potential markers for lack of menstrual regularity,heavy flow,dysmenorrhea,and contraceptives were also identified.Lactobacilli were rare during breastfeeding or post-menopause.Other features such as mood fluctuations and facial speckles could potentially be predicted from the vagino-cervical microbiome.Gut and salivary microbiomes,plasma vitamins,metals,amino acids,and hormones showed associations with the vagino-cervical microbiome.Our results offer an unprecedented glimpse into the microbiota of the female reproductive tract and call for international collaborations to better understand its long-term health impact other than in the settings of infection or pre-term birth. | Zhuye Jie Chen Chen Lilan Hao Fei Li Liju Song Xiaowei Zhang Jie Zhu Liu Tian Xin Tong Kaiye Cai Zhe Zhang Yanmei Ju Xinlei Yu Ying Li Hongcheng Zhou Haorong Lu Xuemei Qiu Qiang Li Yunli Liao Dongsheng Zhou Heng Lian Yong Zuo Xiaomin Chen Weiqiao Rao Yan Ren Yuan Wang Jin Zi Rong Wang Na Liu Jinghua Wu Wei Zhang Xiao Liu Yang Zong Weibin Liu Liang Xiao Yong Hou Xun Xu Huanming Yang Jian Wang Karsten Kristiansen Huijue Jia | 2022 | Genomics, Proteomics & Bioinformatics2022，20，2： | 2 |
| 10 | Porous tantalum-composited gelatin nanoparticles hydrogel integrated with mesenchymal stem cell-derived endothelial cells to construct vascularized tissue in vivo显示文摘The ideal scaffold material of angiogenesis should have mechanical strength and provide appropriate physiological microporous structures to mimic the extracellular matrix environment.In this study,we constructed an integrated three-dimensional scaffold material using porous tantalum(pTa),gelatin nanoparticles(GNPs)hydrogel,and seeded with bone marrow mesenchymal stem cells(BMSCs)-derived endothelial cells(ECs)for vascular tissue engineering.The characteristics and biocompatibility of pTa and GNPs hydrogel were evaluated by mechanical testing,scanning electron microscopy,cell counting kit,and live-cell assay.The BMSCs-derived ECs were identified by flow cytometry and angiogenesis assay.BMSCs-derived ECs were seeded on the pTa-GNPs hydrogel scaffold and implanted subcutaneously in nude mice.Four weeks after the operation,the scaffold material was evaluated by histomorphology.The superior biocompatible ability of pTa-GNPs hydrogel scaffold was observed.Our in vivo results suggested that 28 days after implantation,the formation of the stable capillary-like network in scaffold material could be promoted significantly.The novel,integrated pTa-GNPs hydrogel scaffold is biocompatible with the host,and exhibits biomechanical and angiogenic properties.Moreover,combined with BMSCs-derived ECs,it could construct vascular engineered tissue in vivo.This study may provide a basis for applying pTa in bone regeneration and autologous BMSCs in tissue-engineered vascular grafts. | Zhenhua Zhao Mang Wang Fei Shao Ge Liu Junlei Li Xiaowei Wei Xiuzhi Zhang Jiahui Yang Fang Cao Qiushi Wang Huanan Wang Dewei Zhao | 2021 | Regenerative Biomaterials2021，8，6： | 2 |
| 11 | Properties of New Mullite-SiC Bricks for CDQ Shafts显示文摘Currently the service life of CDQ shafts in China is mainly restricted by the properties of the inclined flue bricks.In this work,based on the systematic analysis of the damage mechanism of inclined flue refractories,high performance mullite-SiC bricks were developed.The bricks were produced by corundum,andalusite,SiC and other high purity raw materials.Metal silicon and alumina ultra micropowder were added to form dispersion multi-phase structure,fortifying the matrix and improving the microstructure.The products have excellent properties such as low porosity,high density,good wear resistance,high refractoriness under load,and good thermal shock resistance.The products can replace the ordinary mullite-SiC bricks and obtain a good service life. | MA Shulong WEI Yingfeng WANG Zhifeng MA Fei XIA Wenbin ZHOU Xiaowei | 2017 | China's Refractories2017，26，1： | 2 |
| 12 | Active canopy sensing of winter wheat nitrogen status: An evaluation of two sensor systems显示文摘 | Qiang Cao Yuxin Miao Guohui Feng Xiaowei Gao Fei Li Bin Liu Shanchao Yue Shanshan Cheng Susan L. Ustin R. Khosla | 2014 | Computers and Electronics in Agriculture2014，，： | 1 |
| 13 | A novel rock bolting system exploiting steel particles显示文摘The effectiveness of rock bolting in ground control has been extensively investigated,mainly for resin based systems.Alternative coupling materials are needed to have good mechanical performance and to reduce the economic impact.This study proposed a new bolting system exploiting steel particles as coupling material.The applicability of this system was assessed by laboratory and field pullout tests,assisted by digital imaging correlation(DIC),infrared thermography(IRT)and acoustic emission(AE).The results indicated that,for a 20 mm diameter bolt,the suitable steel particle size and corresponding inner diameter of borehole were 1.4 and 28 mm,respectively.For bolts installed in steel tubes,the particles improved the loading capacity compared to the resin bonded ones.Additional pullout tests on cement blocks indicated that steel particles can be effective for hard rock,whilst resin was a better choice for bolting of soft rock.Similar understanding was obtained by pullout tests in engineering fields,which demonstrated that the steel particles coupled bolts can provide favorable effects in hard rock mass,while the effects were negligible when installed in extremely soft coal mass.The wide set of multi-technique measurements helped to understand the mechanisms involved in the performance of the bolting system with coupling steel particles. | Xiaowei Feng Fei Xue Valter Carvelli Tongyang Zhao Fengzhen He Dehua Wang | 2022 | International Journal of Mining Science and Technology2022，32，5： | 1 |
| 14 | Minimal two-spheres with constant curvature in the quaternionic projective space显示文摘In this paper we completely classify the homogeneous two-spheres,especially,the minimal homogeneous ones in the quaternionic projective space HPn.According to our classification,more minimal constant curved two-spheres in HPnare obtained than what Ohnita conjectured in the paper'Homogeneous harmonic maps into complex projective spaces.Tokyo J Math,1990,13:87–116'. | Jie Fei Chiakuei Peng Xiaowei Xu | 2020 | Science China Mathematics2020，63，5： | 1 |
| 15 | Improving estimation of summer maize nitrogen status with red edge-based spectral vegetation indices显示文摘 | Fei Li Yuxin Miao Guohui Feng Fei Yuan Shanchao Yue Xiaowei Gao Yuqing Liu Bin Liu Susan L. Ustin Xinping Chen | 2013 | Field Crops Research2013，，： | 1 |
| 16 | Identification of interaction between HIV-1 glycoprotein 41 and integrase显示文摘Human immunodeficiency virus-1(HIV-1) encodes 15 viral proteins. Protein-protein interactions play a large role in the function of these proteins. In this study, we attempted to identify novel interactions between the HIV-1 proteins to better understand the role played by viral protein-protein interactions in the life cycle of HIV-1. Genes encoding the 15 viral proteins from the HIV-1 strain AD8 were inserted into the plasmids of a yeast two-hybrid system. By screening 120 pairs of proteins, interactions between seven pairs were found. This led to the discovery of an interaction between the HIV-1 proteins integrase(IN) and glycoprotein 41(gp41), which was confirmed by both co-immunoprecipitation(Co-IP) assays and fluorescence resonance energy transfer(FRET)imaging in live cells. In addition, it was found that the amino acids at positions 76–100 of gp41 are required for it to bind to IN. Deletion of this region from gp41 prevented its interaction with IN and reduced the production of HIV-1 in 293 T cells. This study provides new information on HIV-1protein-protein interactions which improves the understanding of the biological functions of gp41 and IN during the virus life cycle. | Xiaowei Zhang Fei Zhang Xiaohe Ma Xing Zhao Wei Li Zhiping Zhang Jibin Zhang Xian-En Zhang Zongqiang Cui | 2016 | Virologica Sinica2016，31，5： | 0 |
| 17 | Homer1a reduces inflammatory response after retinal ischemia/reperfusion injury显示文摘Elevated intraocular pressure(IOP)is one of the causes of retinal ischemia/reperfusion injury,which results in NRP3 inflammasome activation and leads to visual damage.Homerla is repo rted to play a protective role in neuroinflammation in the cerebrum.However,the effects of Homerla on NLRP3inflammasomes in retinal ischemia/reperfusion injury caused by elevated IOP remain unknown.In our study,animal models we re constructed using C57BL/6J and Homer1^(flox/-)/Homerla^(+/-)/Nestin-Cre^(+/-)mice with elevated IOP-induced retinal ischemia/repe rfusion injury.For in vitro expe riments,the oxygen-glucose deprivation/repe rfusion injury model was constructed with M uller cells.We found that Homerla ove rexpression amelio rated the decreases in retinal thickness and Muller cell viability after ischemia/reperfusion injury.Furthermore,Homerla knockdown promoted NF-κB P65^(Ser536)activation via caspase-8,NF-κB P65 nuclear translocation,NLRP3 inflammasome formation,and the production and processing of interleukin-1βand inte rleukin-18.The opposite results we re observed with Homerla ove rexpression.Finally,the combined administration of Homerla protein and JSH-23 significantly inhibited the reduction in retinal thickness in Homer1^(flox/-)Homer1a^(+/-)/Nestin-Cre^(+/-)mice and apoptosis in M uller cells after ischemia/reperfusion injury.Taken together,these studies demonstrate that Homer1a exerts protective effects on retinal tissue and M uller cells via the caspase-8/NF-KB P65/NLRP3 pathway after I/R injury. | Yanan Dou Xiaowei Fei Xin He Yu Huan Jialiang Wei Xiuquan Wu Weihao Lyu Zhou Fei Xia Li Fei Fei | 2024 | Neural Regeneration Research2024，19，7： | 0 |
| 18 | Genetic architecture of leaf morphology revealed by integrated trait module in Catalpa bungei显示文摘Leaves are crucial for maintaining plant growth and development via photosynthesis,and their function is simultaneously regulated by a suite of phenotypic traits.Although much is known about the genetic architecture of individual leaf traits,unraveling the genetic basis of complex leafmorphology remains a challenge.Based on the functional correlation and coordination ofmulti-traits,we divided 15 leaf morphological traits into three modules,comprising size(area,length,width,and perimeter),shape(leaf lobes,aspect ratio,circularity,rectangularity,and the relevant ratios),and color(red,green,and blue)for an ornamental tree species,Catalpa bungei.A total of 189 significant single-nucleotide polymorphisms were identified in the leaves of C.bungei:35,82,and 76 in the size,shape,and color modules,respectively.Four quantitative trait loci were common between the size and shape modules,which were closely related according to phenotype correlation,genetic mapping,and mRNA analysis.The color module was independent of them.Synergistic changes in the aspect ratio,leaf lobe,and circularity suggest that these traits could be the core indicators of the leaf shape module.The LAS and SRK genes,associated with leaf lobe and circularity,were found to function in plant defense mechanisms and the growth of leaves.The associations between the SRK and CRK2 genes and the leaf lobe and circularity traits were further verified by RT-qPCR.Our findings demonstrate the importance of integrating multi-trait modules to characterize leaf morphology and facilitate a holistic understanding of the genetic architecture of intraspecific leaf morphology diversity. | Miaomiao Zhang Bingyang Liu Yue Fei Xiaowei Yang Linjiao Zhao Chaozhong Shi Yueying Zhang Nan Lu Chuangye Wu Wenjun Ma Junhui Wang | 2023 | Horticulture Research2023，10，4： | 0 |
| 19 | Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO显示文摘The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector.Some of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator detectors.In this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/g.With ten years of data acquisition,approximately 60,000 signal and 30,000 background events are expected.This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework.IfDelta m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith angle.Moreover,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment. | Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera Daojin Hong YuenKeung Hor Shaojing Hou Yee Hsiung Bei-Zhen Hu Hang Hu Jianrun Hu Jun Hu Shouyang Hu Tao Hu Zhuojun Hu Chunhao Huang Guihong Huang Hanxiong Huang Qinhua Huang Wenhao Huang Xingtao Huang Yongbo Huang Jiaqi Hui Wenju Huo Cédric Huss Safeer Hussain Antonio Insolia Ara Ioannisian Daniel Ioannisyan Roberto Isocrate Kuo-Lun Jen Xiaolu Ji Xingzhao Ji Huihui Jia Junji Jia Siyu Jian Di Jiang Xiaoshan Jiang Ruyi Jin Xiaoping Jing Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Kampmann Li Kang Michael Karagounis Narine Kazarian Amir Khan Waseem Khan Khanchai Khosonthongkee Patrick Kinz Denis Korablev Konstantin Kouzakov Alexey Krasnoperov Svetlana Krokhaleva Zinovy Krumshteyn Andre Kruth Nikolay Kutovskiy Pasi Kuusiniemi Tobias Lachenmaier Cecilia Landini Sébastien Leblanc Frederic Lefevre Liping Lei Ruiting Lei Rupert Leitner Jason Leung Demin Li Fei Li Fule Li Haitao Li Huiling Li Jiaqi Li Jin Li Kaijie Li Mengzhao Li Nan Li Nan Li Qingjiang Li Ruhui Li Shanfeng Li Shuaijie Li Tao Li Weidong Li Weiguo Li Xiaomei Li Xiaonan Li Xinglong Li Yi Li Yufeng Li Zhibing Li Ziyuan Li Hao Liang Hao Liang Jingjing Liang Jiajun Liao Daniel Liebau Ayut Limphirat Sukit Limpijumnong Guey-Lin Lin Shengxin Lin Tao Lin Jiajie Ling Ivano Lippi Fang Liu Haidong Liu Hongbang Liu Hongjuan Liu Hongtao Liu Hu Liu Hui Liu Jianglai Liu Jinchang Liu Min Liu Qian Liu Qin Liu Runxuan Liu Shuangyu Liu Shubin Liu Shulin Liu Xiaowei Liu Yan Liu Alexey Lokhov Paolo Lombardi Claudio Lombardo Kai Loo Chuan Lu Haoqi Lu Jingbin Lu Junguang Lu Shuxiang Lu Xiaoxu Lu Bayarto Lubsandorzhiev Sultim Lubsandorzhiev Livia Ludhova Fengjiao Luo Guang Luo Pengwei Luo Shu Luo Wuming Luo Vladimir Lyashuk Qiumei Ma Si Ma Xiaoyan Ma Xubo Ma Jihane Maalmi Yury Malyshkin Fabio Mantovani Francesco Manzali Xin Mao Yajun Mao Stefano MMari Filippo Marini Sadia Marium Cristina Martellini Gisele Martin-Chassard Agnese Martini Davit Mayilyan Axel Müller Ints Mednieks Yue Meng Anselmo Meregaglia Emanuela Meroni David Meyhöfer Mauro Mezzetto Jonathan Miller Lino Miramonti Salvatore Monforte Paolo Montini Michele Montuschi Nikolay Morozov Pavithra Muralidharan Massimiliano Nastasi Dmitry VNaumov Elena Naumova Igor Nemchenok Alexey Nikolaev Feipeng Ning Zhe Ning Hiroshi Nunokawa Lothar Oberauer Juan Pedro Ochoa-Ricoux Alexander Olshevskiy Domizia Orestano Fausto Ortica Hsiao-Ru Pan Alessandro Paoloni Nina Parkalian Sergio Parmeggiano Teerapat Payupol Yatian Pei Nicomede Pelliccia Anguo Peng Haiping Peng Frédéric Perrot Pierre-Alexandre Petitjean Fabrizio Petrucci Luis Felipe Piñeres Rico Oliver Pilarczyk Artyom Popov Pascal Poussot Wathan Pratumwan Ezio Previtali Fazhi Qi Ming Qi Sen Qian Xiaohui Qian Hao Qiao Zhonghua Qin Shoukang Qiu Muhammad Rajput Gioacchino Ranucci Neill Raper Alessandra Re Henning Rebber Abdel Rebii Bin Ren Jie Ren Taras Rezinko Barbara Ricci Markus Robens Mathieu Roche Narongkiat Rodphai Aldo Romani Bedřich Roskovec Christian Roth Xiangdong Ruan Xichao Ruan Saroj Rujirawat Arseniy Rybnikov Andrey Sadovsky Paolo Saggese Giuseppe Salamanna Simone Sanfilippo Anut Sangka Nuanwan Sanguansak Utane Sawangwit Julia Sawatzki Fatma Sawy Michaela Schever Jacky Schuler Cédric Schwab Konstantin Schweizer Dmitry Selivanov Alexandr Selyunin Andrea Serafini Giulio Settanta Mariangela Settimo Muhammad Shahzad Vladislav Sharov Gang Shi Jingyan Shi Yongjiu Shi Vitaly Shutov Andrey Sidorenkov FedorŠimkovic Chiara Sirignano Jaruchit Siripak Monica Sisti Maciej Slupecki Mikhail Smirnov Oleg Smirnov Thiago Sogo-Bezerra Julanan Songwadhana Boonrucksar Soonthornthum Albert Sotnikov Ondrej Sramek Warintorn Sreethawong Achim Stahl Luca Stanco Konstantin Stankevich DušanŠtefánik Hans Steiger Jochen Steinmann Tobias Sterr Matthias Raphael Stock Virginia Strati Alexander Studenikin Gongxing Sun Shifeng Sun Xilei Sun Yongjie Sun Yongzhao Sun Narumon Suwonjandee Michal Szelezniak Jian Tang Qiang Tang Quan Tang Xiao Tang Alexander Tietzsch Igor Tkachev Tomas Tmej Konstantin Treskov Andrea Triossi Giancarlo Troni Wladyslaw Trzaska Cristina Tuve Stefan van Waasen Johannes van den Boom Guillaume Vanroyen Nikolaos Vassilopoulos Vadim Vedin Giuseppe Verde Maxim Vialkov Benoit Viaud Cristina Volpe Vit Vorobel Lucia Votano Pablo Walker Caishen Wang Chung-Hsiang Wang En Wang Guoli Wang Jian Wang Jun Wang Kunyu Wang Lu Wang Meifen Wang Meng Wang Ruiguang Wang Siguang Wang Wei Wang Wenshuai Wang Xi Wang Xiangyue Wang Yangfu Wang Yaoguang Wang Yi Wang Yifang Wang Yuanqing Wang Yuman Wang Zhe Wang Zheng Wang Zhimin Wang Zongyi Wang Apimook Watcharangkool Lianghong Wei Wei Wei Yadong Wei Liangjian Wen Christopher Wiebusch Steven Chan-Fai Wong Bjoern Wonsak Diru Wu Fangliang Wu Qun Wu Wenjie Wu Zhi Wu Michael Wurm Jacques Wurtz Christian Wysotzki Yufei Xi Dongmei Xia Yuguang Xie Zhangquan Xie Zhizhong Xing Benda Xu Donglian Xu Fanrong Xu Jilei Xu Jing Xu Meihang Xu Yin Xu Yu Xu Baojun Yan Xiongbo Yan Yupeng Yan Anbo Yang Changgen Yang Huan Yang Jie Yang Lei Yang Xiaoyu Yang Yifan Yang Haifeng Yao Zafar Yasin Jiaxuan Ye Mei Ye Ugur Yegin Frédéric Yermia Peihuai Yi Xiangwei Yin Zhengyun You Boxiang Yu Chiye Yu Chunxu Yu Hongzhao Yu Miao Yu Xianghui Yu Zeyuan Yu Chengzhuo Yuan Ying Yuan Zhenxiong Yuan Ziyi Yuan Baobiao Yue Noman Zafar Andre Zambanini Pan Zeng Shan Zeng Tingxuan Zeng Yuda Zeng Liang Zhan Feiyang Zhang Guoqing Zhang Haiqiong Zhang Honghao Zhang Jiawen Zhang Jie Zhang Jingbo Zhang Peng Zhang Qingmin Zhang Shiqi Zhang Tao Zhang Xiaomei Zhang Xuantong Zhang Yan Zhang Yinhong Zhang Yiyu Zhang Yongpeng Zhang Yuanyuan Zhang Yumei Zhang Zhenyu Zhang Zhijian Zhang Fengyi Zhao Jie Zhao Rong Zhao Shujun Zhao Tianchi Zhao Dongqin Zheng Hua Zheng Minshan Zheng Yangheng Zheng Weirong Zhong Jing Zhou Li Zhou Nan Zhou Shun Zhou Xiang Zhou Jiang Zhu Kejun Zhu Honglin Zhuang Liang Zong Jiaheng Zou | 2021 | Chinese Physics C2021，45，2： | 0 |
| 20 | Prevention of urinary tract infection using a silver alloy hydrogel-coated catheter in critically ill patients: A single-center prospective randomized controlled study显示文摘Background:A new type of silver alloy hydrogel-coated(SAH)catheter has been shown to prevent bacterial adhesion and colonization by generating a microcurrent,and to block the retrograde infection pathway.However,these have only been confirmed in ordinary patients.This study aims to evaluate the effectiveness of a SAH catheter for preventing urinary tract infections in critically ill patients.Methods:This was a prospective single-center,single-blind,randomized,controlled study.A total of 132 patients requiring indwelling catheterization in the intensive care unit(ICU)of the First Affiliated Hospital of the University of Science and Technology of China between October 2022 and February 2023 and who met the study inclusion/exclusion criteria were randomly divided into two groups.Patients in the SAH catheter group received a SAH catheter,while patients in the conventional catheter group received a conventional siliconized latex Foley catheter.The main outcome measure was the incidence of catheter-associated urinary tract infections(CAUTIs).Secondary outcome indicators included urine positivity for white blood cells and positive urine cultures on 3 days,7 days,10 days,and 14 days after catheterization,number of viable bacteria in the catheter biofilm on day 14,pathogenic characteristics of positive urine cultures,length of ICU stay,overall hospital stay,ICU mortality,and 28-day mortality.All the data were compared between the two groups.Results:A total of 68 patients in the conventional catheter group and 64 patients in the SAH catheter group were included in the study.On day 7 after catheter placement,the positivity rate for urinary white blood cells was significantly higher in the conventional catheter group than in the SAH catheter group(33.8%vs.15.6%,P=0.016).On day 10,the rates of positive urine cultures(27.9%vs.10.9%,P=0.014)and CAUTIs(22.1%vs.7.8%,P=0.023)were significantly higher in the conventional catheter group than in the SAH catheter group.On day 14,the numbers of viable bacteria isolated from the catheter tip([3.21±1.91]×10^(6) colony-forming units[cfu]/mL vs.[7.44±2.22]×10^(4) cfu/mL,P<0.001),balloon segment([7.30±1.99]×10^(7) cfu/mL vs.[3.48±2.38]×10^(5) cfu/mL,P<0.001),and tail section([6.41±2.07]×10^(5) cfu/mL vs.[8.50±1.46]×10^(3) cfu/mL,P<0.001)were significantly higher in the conventional catheter group than in the SAH catheter group.The most common bacteria in the urine of patients in both groups were Escherichia coli(n=13)and Pseudomonas aeruginosa(n=6),with only one case of Candida in each group.There were no significant differences between the two groups in terms of ICU hospitalization time,total hospitalization time,ICU mortality,and 28-day mortality.Conclusion:SAH catheters can effectively inhibit the formation of catheter-related bacterial biofilms in critically ill patients and reduce the incidence of CAUTIs,compared with conventional siliconized latex Foley catheters;however,regular replacement of the catheter is still necessary. | Menglong Zhao Shike Geng Lei Zhang Xiaoqin Fan Fei Tong Xianlin Meng Tianfeng Wang Xiaowei Fang Qing Mei Aijun Pan | 2024 | Journal of Intensive Medicine2024，4，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员